메뉴 건너뛰기




Volumn 25, Issue 1, 2011, Pages 40-47

Linking ecological immunology and evolutionary medicine: The case for apolipoprotein E

Author keywords

Alzheimer's disease; Apolipoprotein E; Darwinian medicine; Ecoimmunology; Immunity; Inflammation; Trade off

Indexed keywords

ALLELE; DIET; EVOLUTIONARY BIOLOGY; IMMUNE RESPONSE; IMMUNITY; INFECTIOUS DISEASE; INJURY; LIPID; PROTEIN; TRADE-OFF;

EID: 78751683188     PISSN: 02698463     EISSN: 13652435     Source Type: Journal    
DOI: 10.1111/j.1365-2435.2010.01780.x     Document Type: Article
Times cited : (15)

References (99)
  • 1
    • 0034808074 scopus 로고    scopus 로고
    • Changes in lifetime immunocompetence in male and female Gryllus texensis (formerly G-integer): trade-offs between immunity and reproduction
    • Adamo, S.A., Jensen, M. & Younger, M. (2001) Changes in lifetime immunocompetence in male and female Gryllus texensis (formerly G-integer): trade-offs between immunity and reproduction. Animal Behaviour, 62, 417-425.
    • (2001) Animal Behaviour , vol.62 , pp. 417-425
    • Adamo, S.A.1    Jensen, M.2    Younger, M.3
  • 2
    • 76149109787 scopus 로고    scopus 로고
    • Vertebrate sickness behaviour: an adaptive and integrated neuroendocrine immune response
    • Adelman, J.S. & Martin, L.B. (2009) Vertebrate sickness behaviour: an adaptive and integrated neuroendocrine immune response. Integrative and Comparative Biology, 49, 202-214.
    • (2009) Integrative and Comparative Biology , vol.49 , pp. 202-214
    • Adelman, J.S.1    Martin, L.B.2
  • 3
    • 42149152105 scopus 로고    scopus 로고
    • Pro-inflammatory cytokines modulate glial apolipoprotein e secretion
    • Aleong, R., Blain, J.F. & Poirier, J. (2008) Pro-inflammatory cytokines modulate glial apolipoprotein e secretion. Current Alzheimer Research, 5, 33-37.
    • (2008) Current Alzheimer Research , vol.5 , pp. 33-37
    • Aleong, R.1    Blain, J.F.2    Poirier, J.3
  • 4
    • 34250309634 scopus 로고    scopus 로고
    • The contribution of apolipoprotein e alleles on cognitive performance and dynamic neural activity over six decades
    • Alexander, D.M., Williams, L.M., Gatt, J.M., Dobson-Stone, C, Kuan, S.A., Todd, E.G. et al. (2007) The contribution of apolipoprotein e alleles on cognitive performance and dynamic neural activity over six decades. Biological Psychology, 75, 229-238.
    • (2007) Biological Psychology , vol.75 , pp. 229-238
    • Alexander, D.M.1    Williams, L.M.2    Gatt, J.M.3    Dobson-Stone, C.4    Kuan, S.A.5    Todd, E.G.6
  • 5
    • 20044373075 scopus 로고    scopus 로고
    • Individual quality mediates trade-offs between reproductive effort and immune function in tree swallows
    • Ardia, D.R. (2005) Individual quality mediates trade-offs between reproductive effort and immune function in tree swallows. Journal of Animal Ecology, 74, 517-524.
    • (2005) Journal of Animal Ecology , vol.74 , pp. 517-524
    • Ardia, D.R.1
  • 6
    • 78751694043 scopus 로고    scopus 로고
    • The role of constraints and limitation in driving individual variation in immune response
    • DOI:
    • Ardia, D.R., Parmentier, H.K. & Vogel, L.A. (2010) The role of constraints and limitation in driving individual variation in immune response. Functional Ecology, DOI:
    • (2010) Functional Ecology
    • Ardia, D.R.1    Parmentier, H.K.2    Vogel, L.A.3
  • 8
    • 78751691872 scopus 로고    scopus 로고
    • Ecological immunology and tolerance in plants and animals
    • DOI:
    • Baucom, R.S. & De Roode, J.C. (2010) Ecological immunology and tolerance in plants and animals. Functional Ecology, DOI:
    • (2010) Functional Ecology
    • Baucom, R.S.1    De Roode, J.C.2
  • 9
    • 73449126883 scopus 로고    scopus 로고
    • Apolipoprotein e interacts with hepatitis C virus nonstructural protein 5A and determines assembly of infectious particles
    • Benga, W.J., Krieger, S.E., Dimitrova, M., Zeisel, M.B., Parnot, M., Lupberger, J. et al. (2010) Apolipoprotein e interacts with hepatitis C virus nonstructural protein 5A and determines assembly of infectious particles. Hepatology, 51, 43-53.
    • (2010) Hepatology , vol.51 , pp. 43-53
    • Benga, W.J.1    Krieger, S.E.2    Dimitrova, M.3    Zeisel, M.B.4    Parnot, M.5    Lupberger, J.6
  • 11
    • 53649097589 scopus 로고    scopus 로고
    • The APOE4 genotype alters the response of microglia and macrophages to 17beta-estradiol
    • Brown, CM., Choi, E., Xu, Q., Vitek, M.P. & Colton, C.A. (2008) The APOE4 genotype alters the response of microglia and macrophages to 17beta-estradiol. Neurobiology of Aging, 29, 1783-1794.
    • (2008) Neurobiology of Aging , vol.29 , pp. 1783-1794
    • Brown, C.M.1    Choi, E.2    Xu, Q.3    Vitek, M.P.4    Colton, C.A.5
  • 12
    • 34347245595 scopus 로고    scopus 로고
    • Androgen-mediated immune function is altered by the apolipoprotein e gene
    • Brown, CM., Xu, Q., Okhubo, N., Vitek, M.P. & Colton, C.A. (2007) Androgen-mediated immune function is altered by the apolipoprotein e gene. Endocrinology, 148, 3383-3390.
    • (2007) Endocrinology , vol.148 , pp. 3383-3390
    • Brown, C.M.1    Xu, Q.2    Okhubo, N.3    Vitek, M.P.4    Colton, C.A.5
  • 13
    • 0036889423 scopus 로고    scopus 로고
    • Involvement of apolipoprotein e in the hematogenous route of herpes simplex virus type 1 to the central nervous system
    • Burgos, J.S., Ramirez, C, Sastre, I., Bullido, M.J. & Valdivieso, F. (2002) Involvement of apolipoprotein e in the hematogenous route of herpes simplex virus type 1 to the central nervous system. Journal of Virology, 76, 12394-12398.
    • (2002) Journal of Virology , vol.76 , pp. 12394-12398
    • Burgos, J.S.1    Ramirez, C.2    Sastre, I.3    Bullido, M.J.4    Valdivieso, F.5
  • 14
    • 0242643690 scopus 로고    scopus 로고
    • Apoe4 is more efficient than e3 in brain access by herpes simplex virus type 1
    • Burgos, J.S., Ramirez, C, Sastre, I., Bullido, M.J. & Valdivieso, F. (2003) Apoe4 is more efficient than e3 in brain access by herpes simplex virus type 1. Neuroreport, 14, 1825-1827.
    • (2003) Neuroreport , vol.14 , pp. 1825-1827
    • Burgos, J.S.1    Ramirez, C.2    Sastre, I.3    Bullido, M.J.4    Valdivieso, F.5
  • 16
    • 37049007864 scopus 로고    scopus 로고
    • Human apolipoprotein e is required for infectivity and production of hepatitis C virus in cell culture
    • Chang, K.S., Jiang, J., Cai, Z. & Luo, G. (2007) Human apolipoprotein e is required for infectivity and production of hepatitis C virus in cell culture. Journal of Virology, 81, 13783-13793.
    • (2007) Journal of Virology , vol.81 , pp. 13783-13793
    • Chang, K.S.1    Jiang, J.2    Cai, Z.3    Luo, G.4
  • 18
    • 0033398004 scopus 로고    scopus 로고
    • Apolipoprotein e (APOe) allele distribution in the world. Is APOe*4 a 'thrifty' allele?
    • Corbo, R.M. & Scacchi, R. (1999) Apolipoprotein e (APOe) allele distribution in the world. Is APOe*4 a 'thrifty' allele? Annals of Human Genetics, 63, 301-310.
    • (1999) Annals of Human Genetics , vol.63 , pp. 301-310
    • Corbo, R.M.1    Scacchi, R.2
  • 20
    • 0023860891 scopus 로고
    • Apolipoprotein e polymorphism and atherosclerosis
    • Davignon, J., Gregg, R.E. & Sing, C.F. (1988) Apolipoprotein e polymorphism and atherosclerosis. Arteriosclerosis, 8, 1-21.
    • (1988) Arteriosclerosis , vol.8 , pp. 1-21
    • Davignon, J.1    Gregg, R.E.2    Sing, C.F.3
  • 21
    • 78751681239 scopus 로고    scopus 로고
    • Neuroendocrine-immune crosstalk in vertebrates and invertebrates: implications for host defence
    • DOI:
    • Demas, G.E., Adamo, S.A. & French, S.S. (2010) Neuroendocrine-immune crosstalk in vertebrates and invertebrates: implications for host defence. Functional Ecology, DOI:
    • (2010) Functional Ecology
    • Demas, G.E.1    Adamo, S.A.2    French, S.S.3
  • 22
    • 0029766916 scopus 로고    scopus 로고
    • Human apolipoprotein e4 domain interaction. Arginine 61 and glutamic acid 255 interact to direct the preference for very low density liproteins
    • Dong, L.M. & Weisgraber, K.H. (1996) Human apolipoprotein e4 domain interaction. Arginine 61 and glutamic acid 255 interact to direct the preference for very low density liproteins. Journal of Biological Chemistry, 271, 19053-19057.
    • (1996) Journal of Biological Chemistry , vol.271 , pp. 19053-19057
    • Dong, L.M.1    Weisgraber, K.H.2
  • 25
    • 78751700334 scopus 로고    scopus 로고
    • Evolutionary Medicine and Health: New Perspective
    • eds W.R. Trevathan, E.O. Smith & J.J. McKenna) - Oxford University Press, Oxford.
    • Ewald, P.W. (2008) Evolutionary perspective on the causes of chronic diseases: atherosclerosis as an illustration. Evolutionary Medicine and Health: New Perspective (eds W.R. Trevathan, E.O. Smith & J.J. McKenna ), pp. 350-367. Oxford University Press, Oxford.
    • (2008) Evolutionary perspective on the causes of chronic diseases: atherosclerosis as an illustration , pp. 350-367
    • Ewald, P.W.1
  • 27
    • 85013704834 scopus 로고    scopus 로고
    • The Biology of Human Longevity. Inflammation, Nutrition, and Aging in the Evolution of Lifespans
    • Academic, San Diego.
    • Finch, C.E. (2007) The Biology of Human Longevity. Inflammation, Nutrition, and Aging in the Evolution of Lifespans. Academic, San Diego.
    • (2007)
    • Finch, C.E.1
  • 28
    • 76549115951 scopus 로고    scopus 로고
    • Evolution in health and medicine Sackler colloquium: Evolution of the human lifespan and diseases of aging: roles of infection, inflammation, and nutrition
    • Finch, C.E. (2010) Evolution in health and medicine Sackler colloquium: Evolution of the human lifespan and diseases of aging: roles of infection, inflammation, and nutrition. Proceedings of the National Academy of Sciences of the United States of America, 107 (Suppl. 1), 1718-1724.
    • (2010) Proceedings of the National Academy of Sciences of the United States of America , vol.107 , Issue.SUPPL. 1 , pp. 1718-1724
    • Finch, C.E.1
  • 29
    • 34147096369 scopus 로고    scopus 로고
    • Systemic inflammation, infection, ApoE alleles, and Alzheimer disease: a position paper
    • Finch, C.E. & Morgan, T.E. (2007) Systemic inflammation, infection, ApoE alleles, and Alzheimer disease: a position paper. Current Alzheimer Research, 4, 185-189.
    • (2007) Current Alzheimer Research , vol.4 , pp. 185-189
    • Finch, C.E.1    Morgan, T.E.2
  • 30
    • 0032785877 scopus 로고    scopus 로고
    • The evolution of Alzheimer disease, the reproductive schedule, and apoE isoforms
    • Finch, C.E. & Sapolsky, R.M. (1999) The evolution of Alzheimer disease, the reproductive schedule, and apoE isoforms. Neurobiology of Aging, 20, 407-428.
    • (1999) Neurobiology of Aging , vol.20 , pp. 407-428
    • Finch, C.E.1    Sapolsky, R.M.2
  • 31
    • 1642270170 scopus 로고    scopus 로고
    • Meat-adaptive genes and the evolution of slower aging in humans
    • Finch, C.E. & Stanford, C.B. (2004) Meat-adaptive genes and the evolution of slower aging in humans. Quarterly Review of Biology, 79, 3-50.
    • (2004) Quarterly Review of Biology , vol.79 , pp. 3-50
    • Finch, C.E.1    Stanford, C.B.2
  • 33
    • 32544453017 scopus 로고    scopus 로고
    • [Alzheimer's disease and HSV-1 infection]
    • Geppert, A.M. (2006) [Alzheimer's disease and HSV-1 infection]. Neurologia i Neurochirurgia Polska, 40, 57-61.
    • (2006) Neurologia i Neurochirurgia Polska , vol.40 , pp. 57-61
    • Geppert, A.M.1
  • 34
    • 40749128778 scopus 로고    scopus 로고
    • Apolipoprotein e4 enhances attachment of Chlamydophila (Chlamydias) pneumoniae elementary bodies to host cells
    • Gerard, H.C., Fomicheva, E., Whittum-Hudson, J.A. & Hudson, A.P. (2008) Apolipoprotein e4 enhances attachment of Chlamydophila (Chlamydias) pneumoniae elementary bodies to host cells. Microbial Pathogenesis, 44, 279-285.
    • (2008) Microbial Pathogenesis , vol.44 , pp. 279-285
    • Gerard, H.C.1    Fomicheva, E.2    Whittum-Hudson, J.A.3    Hudson, A.P.4
  • 36
    • 78751692918 scopus 로고    scopus 로고
    • Fitness consequences of immune responses: strengthening the empirical framework for ecoimmunology
    • in press)
    • Graham, A., Shuker, D., Pollitt, L., Auld, S., Wilson, A. & Little, T. (2010) Fitness consequences of immune responses: strengthening the empirical framework for ecoimmunology. Functional Ecology (in press)
    • (2010) Functional Ecology
    • Graham, A.1    Shuker, D.2    Pollitt, L.3    Auld, S.4    Wilson, A.5    Little, T.6
  • 37
    • 28044467336 scopus 로고    scopus 로고
    • Global impact of diarrheal diseases that are sampled by travelers: the rest of the hippopotamus
    • Guerrant, R.L., Oria, R., Bushen, O.Y., Patrick, P.D., Houpt, E. & Lima, A.A. (2005) Global impact of diarrheal diseases that are sampled by travelers: the rest of the hippopotamus. Clinical Infectious Diseases, 41 (Suppl. 8), S524-S530.
    • (2005) Clinical Infectious Diseases , vol.41 , Issue.SUPPL. 8
    • Guerrant, R.L.1    Oria, R.2    Bushen, O.Y.3    Patrick, P.D.4    Houpt, E.5    Lima, A.A.6
  • 38
    • 34249864457 scopus 로고    scopus 로고
    • Hunter-gatherer longevity: cross-cultural perspectives
    • Gurven, M. & Kaplan, H. (2007b) Hunter-gatherer longevity: cross-cultural perspectives. Population and Development Review, 33, 321-365.
    • (2007) Population and Development Review , vol.33 , pp. 321-365
    • Gurven, M.1    Kaplan, H.2
  • 39
    • 34249678481 scopus 로고    scopus 로고
    • Mortality experience of Tsimane Amerindians of Bolivia: regional variation and temporal trends
    • Gurven, M., Kaplan, H. & Supa, A.Z. (2007a) Mortality experience of Tsimane Amerindians of Bolivia: regional variation and temporal trends. American Journal of Human Biology, 19, 376-398.
    • (2007) American Journal of Human Biology , vol.19 , pp. 376-398
    • Gurven, M.1    Kaplan, H.2    Supa, A.Z.3
  • 40
    • 0018387954 scopus 로고
    • Seroepidemiology of infection with hepatitis A and B viruses in an isolated Pacific population
    • Gust, I.D., Lehmann, N.I., Dimitrakakis, M. & Zimmet, P. (1979) Seroepidemiology of infection with hepatitis A and B viruses in an isolated Pacific population. Journal of Infectious Diseases, 139, 559-563.
    • (1979) Journal of Infectious Diseases , vol.139 , pp. 559-563
    • Gust, I.D.1    Lehmann, N.I.2    Dimitrakakis, M.3    Zimmet, P.4
  • 41
    • 0026772772 scopus 로고
    • Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis
    • Hales, C.N. & Barke Jr, D. (1992) Type 2 (non-insulin-dependent) diabetes mellitus: the thrifty phenotype hypothesis. Diabetologia, 35, 595-601.
    • (1992) Diabetologia , vol.35 , pp. 595-601
    • Hales, C.N.1    Barke Jr, D.2
  • 42
    • 0028799668 scopus 로고
    • Arginine residues at codons 112 and 158 in the apolipoprotein e gene correspond to the ancestral state in humans
    • Hanlon, C.S. & Rubinsztein, D.C. (1995) Arginine residues at codons 112 and 158 in the apolipoprotein e gene correspond to the ancestral state in humans. Atherosclerosis, 112, 85-90.
    • (1995) Atherosclerosis , vol.112 , pp. 85-90
    • Hanlon, C.S.1    Rubinsztein, D.C.2
  • 44
    • 0024010716 scopus 로고
    • The baboon apolipoprotein e gene: structure, expression, and linkage with the gene for apolipoprotein C-1
    • Hixson, J.E., Cox, L.A. & Borenstein, S. (1988) The baboon apolipoprotein e gene: structure, expression, and linkage with the gene for apolipoprotein C-1. Genomics, 2, 315-323.
    • (1988) Genomics , vol.2 , pp. 315-323
    • Hixson, J.E.1    Cox, L.A.2    Borenstein, S.3
  • 46
    • 72849106317 scopus 로고    scopus 로고
    • Apolipoprotein e but not B is required for the formation of infectious hepatitis C virus particles
    • Jiang, J. & Luo, G. (2009) Apolipoprotein e but not B is required for the formation of infectious hepatitis C virus particles. Journal of Virology, 83, 12680-12691.
    • (2009) Journal of Virology , vol.83 , pp. 12680-12691
    • Jiang, J.1    Luo, G.2
  • 47
    • 0033870714 scopus 로고    scopus 로고
    • The effects of hormones on sex differences in infection: from genes to behavior
    • Klein, S.L. (2000) The effects of hormones on sex differences in infection: from genes to behavior. Neuroscience and Biobehavioral Reviews, 24, 627-638.
    • (2000) Neuroscience and Biobehavioral Reviews , vol.24 , pp. 627-638
    • Klein, S.L.1
  • 48
    • 70350337978 scopus 로고    scopus 로고
    • Infection and inflammation in somatic maintenance, growth and longevity
    • Kopp, E.B. & Medzhitov, R. (2009) Infection and inflammation in somatic maintenance, growth and longevity. Evolutionary Applications, 2, 132-141.
    • (2009) Evolutionary Applications , vol.2 , pp. 132-141
    • Kopp, E.B.1    Medzhitov, R.2
  • 51
    • 41149137779 scopus 로고    scopus 로고
    • Neuroendocrine control of life histories: what do we need to know to understand the evolution of phenotypic plasticity?
    • Lessells, C.M. (2008) Neuroendocrine control of life histories: what do we need to know to understand the evolution of phenotypic plasticity? Philosophical Transactions of the Royal Society B-Biological Sciences, 363, 1589-1598.
    • (2008) Philosophical Transactions of the Royal Society B-Biological Sciences , vol.363 , pp. 1589-1598
    • Lessells, C.M.1
  • 52
    • 48349148598 scopus 로고    scopus 로고
    • Infection induces a positive acute phase apolipoprotein e response from a negative acute phase gene: role of hepatic LDL receptors
    • Li, L., Thompson, P.A. & Kitchens, R.L. (2008) Infection induces a positive acute phase apolipoprotein e response from a negative acute phase gene: role of hepatic LDL receptors. Journal of Lipid Research, 49, 1782-1793.
    • (2008) Journal of Lipid Research , vol.49 , pp. 1782-1793
    • Li, L.1    Thompson, P.A.2    Kitchens, R.L.3
  • 54
    • 0034007848 scopus 로고    scopus 로고
    • Trade-offs in evolutionary immunology: just what is the cost of immunity?
    • Lochmiller, R.L. & Deerenberg, C. (2000) Trade-offs in evolutionary immunology: just what is the cost of immunity? Oikos, 88, 87-98.
    • (2000) Oikos , vol.88 , pp. 87-98
    • Lochmiller, R.L.1    Deerenberg, C.2
  • 55
    • 0024299370 scopus 로고
    • Apolipoprotein e: cholesterol transport protein with expanding role in cell biology
    • Mahley, R.W. (1988) Apolipoprotein e: cholesterol transport protein with expanding role in cell biology. Science, 240, 622-630.
    • (1988) Science , vol.240 , pp. 622-630
    • Mahley, R.W.1
  • 60
    • 13444302665 scopus 로고    scopus 로고
    • Life history, maintenance, and the early origins of immune function
    • McDade, T.W. (2005) Life history, maintenance, and the early origins of immune function. American Journal of Human Biology, 17, 81-94.
    • (2005) American Journal of Human Biology , vol.17 , pp. 81-94
    • McDade, T.W.1
  • 62
    • 36048996547 scopus 로고    scopus 로고
    • Isoform-specific effects of ApoE on HSV immediate early gene expression and establishment of latency
    • Miller, R.M. & Federoff, H.J. (2008) Isoform-specific effects of ApoE on HSV immediate early gene expression and establishment of latency. Neurobiology of Aging, 29, 71-77.
    • (2008) Neurobiology of Aging , vol.29 , pp. 71-77
    • Miller, R.M.1    Federoff, H.J.2
  • 64
    • 78751686019 scopus 로고    scopus 로고
    • Trade-off between growth and immunocompetence: a meta-analysis of selection experiments
    • in review)
    • van der Most, P.J., de Jong, B., Parmentier, H.K. & Verhulst, S. (2010) Trade-off between growth and immunocompetence: a meta-analysis of selection experiments. Functional Ecology (in review)
    • (2010) Functional Ecology
    • van der Most, P.J.1    de Jong, B.2    Parmentier, H.K.3    Verhulst, S.4
  • 65
    • 3042647308 scopus 로고    scopus 로고
    • Estrogen facilitates neurite extension via apolipoprotein E in cultured adult mouse cortical neurons
    • Nathan, B.P., Barsukova, A.G., Shen, F., Mcasey, M. & Struble, R.G. (2004) Estrogen facilitates neurite extension via apolipoprotein E in cultured adult mouse cortical neurons. Endocrinology, 145, 3065-3073.
    • (2004) Endocrinology , vol.145 , pp. 3065-3073
    • Nathan, B.P.1    Barsukova, A.G.2    Shen, F.3    Mcasey, M.4    Struble, R.G.5
  • 66
    • 1642414421 scopus 로고    scopus 로고
    • Seasonal immune function and sickness responses
    • Nelson, R.J. (2004) Seasonal immune function and sickness responses. Trends in Immunology, 25, 187-192.
    • (2004) Trends in Immunology , vol.25 , pp. 187-192
    • Nelson, R.J.1
  • 67
    • 51349159977 scopus 로고    scopus 로고
    • The great opportunity: evolutionary applications to medicine and public health
    • Nesse, R.M. & Stearns, S.C. (2008) The great opportunity: evolutionary applications to medicine and public health. Evolutionary Applications, 1, 28-48.
    • (2008) Evolutionary Applications , vol.1 , pp. 28-48
    • Nesse, R.M.1    Stearns, S.C.2
  • 70
    • 0034057003 scopus 로고    scopus 로고
    • Ecological immunology: life history trade-offs and immune defense in birds
    • Norris, K. & Evans, M.R. (2000) Ecological immunology: life history trade-offs and immune defense in birds. Behavioral Ecology, 11, 19-26.
    • (2000) Behavioral Ecology , vol.11 , pp. 19-26
    • Norris, K.1    Evans, M.R.2
  • 73
    • 0029083242 scopus 로고
    • Lack of an association between apolipoprotein E epsilon 4 and Alzheimer's disease in elderly Nigerians
    • Osuntokun, B.O., Sahota, A., Ogunniyi, A.O., Gureje, O., Baiyewu, O., Adeyinka, A. et al. (1995) Lack of an association between apolipoprotein E epsilon 4 and Alzheimer's disease in elderly Nigerians. Annals of Neurology, 38, 463-465.
    • (1995) Annals of Neurology , vol.38 , pp. 463-465
    • Osuntokun, B.O.1    Sahota, A.2    Ogunniyi, A.O.3    Gureje, O.4    Baiyewu, O.5    Adeyinka, A.6
  • 74
    • 0040460767 scopus 로고
    • Demography in Roman Society
    • Johns Hopkins Press, Baltimore.
    • Parkin, T.G. (1992) Demography in Roman Society, Johns Hopkins Press, Baltimore.
    • (1992)
    • Parkin, T.G.1
  • 75
    • 70449723320 scopus 로고    scopus 로고
    • Reelin and apoE actions on signal transduction, synaptic function and memory formation
    • Rogers, J.T. & Weeber, E.J. (2008) Reelin and apoE actions on signal transduction, synaptic function and memory formation. Neuron Glia Biology, 4, 259-270.
    • (2008) Neuron Glia Biology , vol.4 , pp. 259-270
    • Rogers, J.T.1    Weeber, E.J.2
  • 77
    • 0027327267 scopus 로고
    • Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease
    • Saunders, A.M., Strittmatter, W.J., Schmechel, D., George-Hyslop, P.H., Pericak-Vance, M.A. et al. (1993) Association of apolipoprotein E allele epsilon 4 with late-onset familial and sporadic Alzheimer's disease. Neurology, 43, 1467-1472.
    • (1993) Neurology , vol.43 , pp. 1467-1472
    • Saunders, A.M.1    Strittmatter, W.J.2    Schmechel, D.3    George-Hyslop, P.H.4    Pericak-Vance, M.A.5
  • 80
    • 0030456227 scopus 로고    scopus 로고
    • Ecological immunology: costly parasite defences and trade-offs in evolutionary ecology
    • Sheldon, B.C. & Verhulst, S. (1996) Ecological immunology: costly parasite defences and trade-offs in evolutionary ecology. Trends in Ecology and Evolution, 11, 317-321.
    • (1996) Trends in Ecology and Evolution , vol.11 , pp. 317-321
    • Sheldon, B.C.1    Verhulst, S.2
  • 81
    • 78449282143 scopus 로고    scopus 로고
    • Chlamydia pneumoniae infection and Alzheimer's disease: a connection to remember?
    • DOI: .
    • Shima, K., Kuhlenbaumer, G. & Rupp, J. (2010) Chlamydia pneumoniae infection and Alzheimer's disease: a connection to remember? Medical Microbiology and Immunology, DOI: .
    • (2010) Medical Microbiology and Immunology
    • Shima, K.1    Kuhlenbaumer, G.2    Rupp, J.3
  • 82
    • 78650642815 scopus 로고    scopus 로고
    • Apolipoprotein E isoform-dependent effects on anxiety and cognition in female TR mice
    • DOI: .
    • Siegel, J.A., Haley, G.E. & Raber, J. (2010) Apolipoprotein E isoform-dependent effects on anxiety and cognition in female TR mice. Neurobiology of Aging, DOI: .
    • (2010) Neurobiology of Aging
    • Siegel, J.A.1    Haley, G.E.2    Raber, J.3
  • 83
    • 33747165894 scopus 로고    scopus 로고
    • APOE distribution in world populations with new data from India and the UK
    • Singh, P.P., Singh, M. & Mastana, S.S. (2006) APOE distribution in world populations with new data from India and the UK. Annals of Human Biology, 33, 279-308.
    • (2006) Annals of Human Biology , vol.33 , pp. 279-308
    • Singh, P.P.1    Singh, M.2    Mastana, S.S.3
  • 84
    • 3142706539 scopus 로고    scopus 로고
    • Meta-analysis: apolipoprotein E genotypes and risk for coronary heart disease
    • Song, Y., Stampfer, M.J. & Liu, S. (2004) Meta-analysis: apolipoprotein E genotypes and risk for coronary heart disease. Annals of Internal Medicine, 141, 137-147.
    • (2004) Annals of Internal Medicine , vol.141 , pp. 137-147
    • Song, Y.1    Stampfer, M.J.2    Liu, S.3
  • 85
    • 77953898603 scopus 로고    scopus 로고
    • APOE e4 and MBL-2 O/O genotypes are associated with neurocognitive impairment in HIV-infected plasma donors from Anhui province, China
    • Spector, S.A., Singh, K.K., Gupta, S., Cystique, LA., Jin, H. & Letendre, S. (2010) APOE e4 and MBL-2 O/O genotypes are associated with neurocognitive impairment in HIV-infected plasma donors from Anhui province, China. AIDS, 24, 1471-1479.
    • (2010) AIDS , vol.24 , pp. 1471-1479
    • Spector, S.A.1    Singh, K.K.2    Gupta, S.3    Cystique, L.A.4    Jin, H.5    Letendre, S.6
  • 86
    • 0033976301 scopus 로고    scopus 로고
    • Effects of pro-inflammatory cytokines on apolipoprotein E secretion by a human astrocytoma cell line (CCF-STTG1)
    • Starck, M., Bertrand, P., Pepin, S., Schiele, F., Siest, G. & Galteau, M.M. (2000) Effects of pro-inflammatory cytokines on apolipoprotein E secretion by a human astrocytoma cell line (CCF-STTG1). Cell Biochemistry and Function, 18, 9-16.
    • (2000) Cell Biochemistry and Function , vol.18 , pp. 9-16
    • Starck, M.1    Bertrand, P.2    Pepin, S.3    Schiele, F.4    Siest, G.5    Galteau, M.M.6
  • 87
    • 0038803973 scopus 로고    scopus 로고
    • Apolipoprotein E modulates immune activation by acting on the antigen-presenting cell
    • Tenger, C. & Zhou, X. (2003) Apolipoprotein E modulates immune activation by acting on the antigen-presenting cell. Immunology, 109, 392-397.
    • (2003) Immunology , vol.109 , pp. 392-397
    • Tenger, C.1    Zhou, X.2
  • 90
    • 47849105173 scopus 로고    scopus 로고
    • Infection and Alzheimer's disease: the APOE epsilon4 connection and lipid metabolism
    • Urosevic, N. & Martins, R.N. (2008) Infection and Alzheimer's disease: the APOE epsilon4 connection and lipid metabolism. Journal of Alzheimer's Disease, 13, 421-435.
    • (2008) Journal of Alzheimer's Disease , vol.13 , pp. 421-435
    • Urosevic, N.1    Martins, R.N.2
  • 91
    • 0017773790 scopus 로고
    • Polymorphism of apolipoprotein E and occurrence of dysbetalipoproteinaemia in man
    • Utermann, G., Hees, M. & Steinmetz, A. (1977) Polymorphism of apolipoprotein E and occurrence of dysbetalipoproteinaemia in man. Nature, 269, 604-607.
    • (1977) Nature , vol.269 , pp. 604-607
    • Utermann, G.1    Hees, M.2    Steinmetz, A.3
  • 94
    • 33750952697 scopus 로고    scopus 로고
    • Activation of estrogen receptor alpha increases and estrogen receptor beta decreases apolipoprotein E expression in hippocampus in vitro and in vivo
    • Wang, J.M., Irwin, R.W. & Brinton, R.D. (2006) Activation of estrogen receptor alpha increases and estrogen receptor beta decreases apolipoprotein E expression in hippocampus in vitro and in vivo. Proceedings of the National Academy of Sciences of the United States of America, 103, 16983-16988.
    • (2006) Proceedings of the National Academy of Sciences of the United States of America , vol.103 , pp. 16983-16988
    • Wang, J.M.1    Irwin, R.W.2    Brinton, R.D.3
  • 95
    • 0025171570 scopus 로고
    • Apolipoprotein E distribution among human plasma lipoproteins: role of the cysteine-arginine interchange at residue 112
    • Wozniak, M.A., Itzhaki, R.F., Faragher, E.B., James, M.W., Ryder, S.D. & Irving, W.L (1990) Apolipoprotein E distribution among human plasma lipoproteins: role of the cysteine-arginine interchange at residue 112. Journal of Lipid Research, 31, 1503-1511.
    • (1990) Journal of Lipid Research , vol.31 , pp. 1503-1511
    • Wozniak, M.A.1    Itzhaki, R.F.2    Faragher, E.B.3    James, M.W.4    Ryder, S.D.5    Irving, W.L.6
  • 96
    • 0035984436 scopus 로고    scopus 로고
    • Apolipoprotein E-epsilon 4 protects against severe liver disease caused by hepatitis C virus
    • Wozniak, M.A., Itzhaki, R.F. et al. (2002) Apolipoprotein E-epsilon 4 protects against severe liver disease caused by hepatitis C virus. Hepatology, 36, 456-463.
    • (2002) Hepatology , vol.36 , pp. 456-463
    • Wozniak, M.A.1    Itzhaki, R.F.2
  • 97
    • 41449115503 scopus 로고    scopus 로고
    • Meta-analysis of APOE4 allele and outcome after traumatic brain injury
    • Zhou, W., Xu, D., Peng, X., Zhang, Q., Jia, J. & Crutcher, K.A. (2008) Meta-analysis of APOE4 allele and outcome after traumatic brain injury. Journal of Neurotrauma, 25, 279-290.
    • (2008) Journal of Neurotrauma , vol.25 , pp. 279-290
    • Zhou, W.1    Xu, D.2    Peng, X.3    Zhang, Q.4    Jia, J.5    Crutcher, K.A.6
  • 98
    • 0026649351 scopus 로고
    • Cytokine regulation of macrophage apo E secretion: opposing effects of GM-CSF and TGF-beta
    • Zuckerman, S.H., Evans, G.F. & O'neal, L. (1992) Cytokine regulation of macrophage apo E secretion: opposing effects of GM-CSF and TGF-beta. Atherosclerosis, 96, 203-214.
    • (1992) Atherosclerosis , vol.96 , pp. 203-214
    • Zuckerman, S.H.1    Evans, G.F.2    O'neal, L.3
  • 99
    • 0025279136 scopus 로고
    • Reproductive strategies and disease susceptibility - an evolutionary viewpoint
    • Zuk, M. (1990) Reproductive strategies and disease susceptibility - an evolutionary viewpoint. Parasitology Today, 6, 231-233.
    • (1990) Parasitology Today , vol.6 , pp. 231-233
    • Zuk, M.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.