메뉴 건너뛰기




Volumn 11, Issue 7, 2010, Pages 459-463

New approaches to population stratification in genome-wide association studies

Author keywords

[No Author keywords available]

Indexed keywords

FAMILY; GENETIC ASSOCIATION; GENETIC VARIABILITY; GENOME WIDE ASSOCIATION; HUMAN; PHENOTYPE; POPULATION GENETIC STRUCTURE; POPULATION GENETICS; POPULATION MODEL; PRIORITY JOURNAL; REVIEW;

EID: 77953811255     PISSN: 14710056     EISSN: 14710064     Source Type: Journal    
DOI: 10.1038/nrg2813     Document Type: Review
Times cited : (865)

References (44)
  • 1
    • 42349112088 scopus 로고    scopus 로고
    • Genome-wide association studies for complex traits: Consensus, uncertainty and challenges
    • McCarthy, M. I. et al. Genome-wide association studies for complex traits: consensus, uncertainty and challenges. Nature Rev. Genet. 9, 356-369 (2008).
    • (2008) Nature Rev. Genet. , vol.9 , pp. 356-369
    • McCarthy, M.I.1
  • 2
    • 23044468633 scopus 로고    scopus 로고
    • Demonstrating stratification in a European American population
    • Campbell, C. D. et al. Demonstrating stratification in a European American population. Nature Genet. 37, 868-872 (2005).
    • (2005) Nature Genet. , vol.37 , pp. 868-872
    • Campbell, C.D.1
  • 3
    • 57549090341 scopus 로고    scopus 로고
    • Accounting for ancestry: Population substructure and genome-wide association studies
    • Tian, C., Gregersen, P. K. & Seldin, M. F. Accounting for ancestry: population substructure and genome-wide association studies. Hum. Mol. Genet. 17, R143-R150 (2008).
    • (2008) Hum. Mol. Genet. , vol.17
    • Tian, C.1    Gregersen, P.K.2    Seldin, M.F.3
  • 4
    • 38949212271 scopus 로고    scopus 로고
    • Analysis and application of European genetic substructure using 300 K SNP information
    • Tian, C. et al. Analysis and application of European genetic substructure using 300 K SNP information. PLoS Genet. 4, e4 (2008).
    • (2008) PLoS Genet. , vol.4
    • Tian, C.1
  • 5
    • 33646694298 scopus 로고    scopus 로고
    • Confounding from cryptic relatedness in case-control association studies
    • Voight, B. F. & Pritchard, J. K. Confounding from cryptic relatedness in case-control association studies. PLoS Genet. 1, e32 (2005).
    • (2005) PLoS Genet. , vol.1
    • Voight, B.F.1    Pritchard, J.K.2
  • 6
    • 33748786787 scopus 로고    scopus 로고
    • Genetic relatedness analysis: Modern data and new challenges
    • Weir, B. S., Anderson, A. D. & Hepler, A. B. Genetic relatedness analysis: modern data and new challenges. Nature Rev. Genet. 7, 771-780 (2006).
    • (2006) Nature Rev. Genet. , vol.7 , pp. 771-780
    • Weir, B.S.1    Anderson, A.D.2    Hepler, A.B.3
  • 7
    • 0032714352 scopus 로고    scopus 로고
    • Genomic control for association studies
    • Devlin, B. & Roeder, K. Genomic control for association studies. Biometrics 55, 997-1004 (1999).
    • (1999) Biometrics , vol.55 , pp. 997-1004
    • Devlin, B.1    Roeder, K.2
  • 8
    • 0033358548 scopus 로고    scopus 로고
    • Use of unlinked genetic markers to detect population stratification in association studies
    • Pritchard, J. K. & Rosenberg, N. A. Use of unlinked genetic markers to detect population stratification in association studies. Am. J. Hum. Genet. 65, 220-228 (1999).
    • (1999) Am. J. Hum. Genet. , vol.65 , pp. 220-228
    • Pritchard, J.K.1    Rosenberg, N.A.2
  • 9
    • 0035185344 scopus 로고    scopus 로고
    • Detecting association in a case-control study while correcting for population stratification
    • Reich, D. E. & Goldstein, D. B. Detecting association in a case-control study while correcting for population stratification. Genet. Epidemiol. 20, 4-16 (2001).
    • (2001) Genet. Epidemiol. , vol.20 , pp. 4-16
    • Reich, D.E.1    Goldstein, D.B.2
  • 10
    • 27644546712 scopus 로고    scopus 로고
    • Population structure, differential bias and genomic control in a large-scale, case-control association study
    • Clayton, D. G. et al. Population structure, differential bias and genomic control in a large-scale, case-control association study. Nature Genet. 37, 1243-1246 (2005).
    • (2005) Nature Genet. , vol.37 , pp. 1243-1246
    • Clayton, D.G.1
  • 11
    • 67651028392 scopus 로고    scopus 로고
    • The impact of divergence time on the nature of population structure: An example from Iceland
    • Price, A. L. et al. The impact of divergence time on the nature of population structure: an example from Iceland. PLoS Genet. 5, e1000505 (2009).
    • (2009) PLoS Genet. , vol.5
    • Price, A.L.1
  • 12
    • 16544380910 scopus 로고    scopus 로고
    • Genomic control to the extreme
    • author reply in 36, 1131 (2004)
    • Devlin, B., Bacanu, S. A. & Roeder, K. Genomic control to the extreme. Nature Genet. 36, 1129-1130 (2004); author reply in 36, 1131 (2004).
    • (2004) Nature Genet. , vol.36 , pp. 1129-1130
    • Devlin, B.1    Bacanu, S.A.2    Roeder, K.3
  • 13
    • 0034118493 scopus 로고    scopus 로고
    • Inference of population structure using multilocus genotype data
    • Pritchard, J. K., Stephens, M. & Donnelly, P. Inference of population structure using multilocus genotype data. Genetics 155, 945-959 (2000).
    • (2000) Genetics , vol.155 , pp. 945-959
    • Pritchard, J.K.1    Stephens, M.2    Donnelly, P.3
  • 14
    • 0037147189 scopus 로고    scopus 로고
    • Genetic structure of human populations
    • Rosenberg, N. A. et al. Genetic structure of human populations. Science 298, 2381-2385 (2002).
    • (2002) Science , vol.298 , pp. 2381-2385
    • Rosenberg, N.A.1
  • 16
    • 69749099417 scopus 로고    scopus 로고
    • Fast model-based estimation of ancestry in unrelated individuals
    • Alexander, D. H., Novembre, J. & Lange, K. Fast model-based estimation of ancestry in unrelated individuals. Genome Res. 19, 1655-1664 (2009).
    • (2009) Genome Res. , vol.19 , pp. 1655-1664
    • Alexander, D.H.1    Novembre, J.2    Lange, K.3
  • 17
    • 0018080152 scopus 로고
    • Synthetic maps of human gene frequencies in Europeans
    • Menozzi, P., Piazza, A. & Cavalli-Sforza, L. Synthetic maps of human gene frequencies in Europeans. Science 201, 786-792 (1978).
    • (1978) Science , vol.201 , pp. 786-792
    • Menozzi, P.1    Piazza, A.2    Cavalli-Sforza, L.3
  • 19
  • 20
    • 42649093791 scopus 로고    scopus 로고
    • Interpreting principal component analyses of spatial population genetic variation
    • Novembre, J. & Stephens, M. Interpreting principal component analyses of spatial population genetic variation. Nature Genet. 40, 646-649 (2008).
    • (2008) Nature Genet. , vol.40 , pp. 646-649
    • Novembre, J.1    Stephens, M.2
  • 21
    • 33746512512 scopus 로고    scopus 로고
    • Principal components analysis corrects for stratification in genome-wide association studies
    • Price, A. L. et al. Principal components analysis corrects for stratification in genome-wide association studies. Nature Genet. 38, 904-909 (2006).
    • (2006) Nature Genet. , vol.38 , pp. 904-909
    • Price, A.L.1
  • 22
    • 0036668723 scopus 로고    scopus 로고
    • Association mapping, using a mixture model for complex traits
    • Zhu, X., Zhang, S., Zhao, H. & Cooper, R. S. Association mapping, using a mixture model for complex traits. Genet. Epidemiol. 23, 181-196 (2002).
    • (2002) Genet. Epidemiol. , vol.23 , pp. 181-196
    • Zhu, X.1    Zhang, S.2    Zhao, H.3    Cooper, R.S.4
  • 23
    • 34548292504 scopus 로고    scopus 로고
    • PLINK: A tool set for whole-genome association and population-based linkage analyses
    • Purcell, S. et al. PLINK: a tool set for whole-genome association and population-based linkage analyses. Am. J. Hum. Genet. 81, 559-575 (2007).
    • (2007) Am. J. Hum. Genet. , vol.81 , pp. 559-575
    • Purcell, S.1
  • 24
    • 40749138264 scopus 로고    scopus 로고
    • On the use of general control samples for genome-wide association studies: Genetic matching highlights causal variants
    • Luca, D. et al. On the use of general control samples for genome-wide association studies: genetic matching highlights causal variants. Am. J. Hum. Genet. 82, 453-463 (2008).
    • (2008) Am. J. Hum. Genet. , vol.82 , pp. 453-463
    • Luca, D.1
  • 25
  • 26
    • 38949093617 scopus 로고    scopus 로고
    • Application of ancestry informative markers to association studies in European Americans
    • Seldin, M. F. & Price, A. L. Application of ancestry informative markers to association studies in European Americans. PLoS Genet. 4, e5 (2008).
    • (2008) PLoS Genet. , vol.4
    • Seldin, M.F.1    Price, A.L.2
  • 27
    • 0027377799 scopus 로고
    • Transmission test for linkage disequilibrium: The insulin gene region and insulin-dependent diabetes mellitus (IDDM)
    • Spielman, R. S., McGinnis, R. E. & Ewens, W. J. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus (IDDM). Am. J. Hum. Genet. 52, 506-516 (1993).
    • (1993) Am. J. Hum. Genet. , vol.52 , pp. 506-516
    • Spielman, R.S.1    McGinnis, R.E.2    Ewens, W.J.3
  • 28
    • 33646188852 scopus 로고    scopus 로고
    • Family-based designs in the age of large-scale gene-association studies
    • Laird, N. M. & Lange, C. Family-based designs in the age of large-scale gene-association studies. Nature Rev. Genet. 7, 385-394 (2006).
    • (2006) Nature Rev. Genet. , vol.7 , pp. 385-394
    • Laird, N.M.1    Lange, C.2
  • 29
    • 0033909546 scopus 로고    scopus 로고
    • A general test of association for quantitative traits in nuclear families
    • Abecasis, G. R., Cardon, L. R. & Cookson, W. O. A general test of association for quantitative traits in nuclear families. Am. J. Hum. Genet. 66, 279-292 (2000).
    • (2000) Am. J. Hum. Genet. , vol.66 , pp. 279-292
    • Abecasis, G.R.1    Cardon, L.R.2    Cookson, W.O.3
  • 30
    • 0036908726 scopus 로고    scopus 로고
    • Power and design considerations for a general class of family-based association tests: Quantitative traits
    • DOI 10.1086/344696
    • Lange, C., DeMeo, D. L. & Laird, N. M. Power and design considerations for a general class of family-based association tests: quantitative traits. Am. J. Hum. Genet. 71, 1330-1341 (2002). (Pubitemid 36015888)
    • (2002) American Journal of Human Genetics , vol.71 , Issue.6 , pp. 1330-1341
    • Lange, C.1    DeMeo, D.L.2    Laird, N.M.3
  • 31
    • 73649129188 scopus 로고    scopus 로고
    • On the analysis of genome-wide association studies in family-based designs: A universal, robust analysis approach and an application to four genome-wide association studies
    • Won, S. et al. On the analysis of genome-wide association studies in family-based designs: a universal, robust analysis approach and an application to four genome-wide association studies. PLoS Genet. 5, e1000741 (2009).
    • (2009) PLoS Genet. , vol.5
    • Won, S.1
  • 32
    • 77950460630 scopus 로고    scopus 로고
    • On genome-wide association studies for family-based designs: An integrative analysis approach combining ascertained family samples with unselected controls
    • Lasky-Su, J. et al. On genome-wide association studies for family-based designs: an integrative analysis approach combining ascertained family samples with unselected controls. Am. J. Hum. Genet. 86, 573-580 (2010).
    • (2010) Am. J. Hum. Genet. , vol.86 , pp. 573-580
    • Lasky-Su, J.1
  • 33
    • 31744440502 scopus 로고    scopus 로고
    • A unified mixed-model method for association mapping that accounts for multiple levels of relatedness
    • Yu, J. et al. A unified mixed-model method for association mapping that accounts for multiple levels of relatedness. Nature Genet. 38, 203-208 (2006).
    • (2006) Nature Genet. , vol.38 , pp. 203-208
    • Yu, J.1
  • 34
    • 40849097776 scopus 로고    scopus 로고
    • Heritability in the genomics era\concepts and misconceptions
    • Visscher, P. M., Hill, W. G. & Wray, N. R. Heritability in the genomics era\concepts and misconceptions. Nature Rev. Genet. 9, 255-266 (2008).
    • (2008) Nature Rev. Genet. , vol.9 , pp. 255-266
    • Visscher, P.M.1    Hill, W.G.2    Wray, N.R.3
  • 35
    • 77950301214 scopus 로고    scopus 로고
    • Variance component model to account for sample structure in genome-wide association studies
    • Kang, H. M. et al. Variance component model to account for sample structure in genome-wide association studies. Nature Genet. 42, 348-354 (2010).
    • (2010) Nature Genet. , vol.42 , pp. 348-354
    • Kang, H.M.1
  • 36
    • 77950299137 scopus 로고    scopus 로고
    • Mixed linear model approach adapted for genome-wide association studies
    • Zhang, Z. et al. Mixed linear model approach adapted for genome-wide association studies. Nature Genet. 42, 355-360 (2010).
    • (2010) Nature Genet. , vol.42 , pp. 355-360
    • Zhang, Z.1
  • 37
    • 40749128980 scopus 로고    scopus 로고
    • A unified association analysis approach for family and unrelated samples correcting for stratification
    • Zhu, X., Li, S., Cooper, R. S. & Elston, R. C. A unified association analysis approach for family and unrelated samples correcting for stratification. Am. J. Hum. Genet. 82, 352-365 (2008).
    • (2008) Am. J. Hum. Genet. , vol.82 , pp. 352-365
    • Zhu, X.1    Li, S.2    Cooper, R.S.3    Elston, R.C.4
  • 38
    • 78650152868 scopus 로고    scopus 로고
    • Convergence and prediction of principal component scores in high-dimensional settings
    • the press
    • Lee S., Zou F. & Wright F. A. Convergence and prediction of principal component scores in high-dimensional settings. Ann. Stat. (in the press).
    • Ann. Stat.
    • Lee, S.1    Zou, F.2    Wright, F.A.3
  • 39
    • 76049108917 scopus 로고    scopus 로고
    • ROADTRIPS: Case-control association testing with partially or completely unknown population and pedigree structure
    • Thornton, T. & McPeek, M. S. ROADTRIPS: case-control association testing with partially or completely unknown population and pedigree structure. Am. J. Hum. Genet. 86, 172-184 (2010).
    • (2010) Am. J. Hum. Genet. , vol.86 , pp. 172-184
    • Thornton, T.1    McPeek, M.S.2
  • 40
    • 67149093174 scopus 로고    scopus 로고
    • A kinship-based modification of the Armitage trend test to address hidden population structure and small differential genotyping errors
    • Rakovski, C. S. & Stram, D. O. A kinship-based modification of the Armitage trend test to address hidden population structure and small differential genotyping errors. PLoS ONE 4, e5825 (2009).
    • (2009) PLoS ONE , vol.4
    • Rakovski, C.S.1    Stram, D.O.2
  • 42
    • 70349956433 scopus 로고    scopus 로고
    • Finding the missing heritability of complex diseases
    • Manolio, T. A. et al. Finding the missing heritability of complex diseases. Nature 461, 747-753 (2009).
    • (2009) Nature , vol.461 , pp. 747-753
    • Manolio, T.A.1
  • 43
    • 77953810730 scopus 로고    scopus 로고
    • Association testing with principal-components-based correction for population stratification [abstract number 58]
    • online
    • Abney, M. & McPeek, M. S. Association testing with principal-components-based correction for population stratification [abstract number 58]. Proc. of the 58th Annual Meeting of The American Soc. of Human Genetics [online], http://www.ashg.org/2008meeting/abstracts/fulltext/(2008).
    • (2008) Proc. of the 58th Annual Meeting of the American Soc. of Human Genetics
    • Abney, M.1    McPeek, M.S.2
  • 44
    • 3843056691 scopus 로고    scopus 로고
    • Multiple rare alleles contribute to low plasma levels of HDL cholesterol
    • Cohen, J. C. et al. Multiple rare alleles contribute to low plasma levels of HDL cholesterol. Science 305, 2869-2872 (2004).
    • (2004) Science , vol.305 , pp. 2869-2872
    • Cohen, J.C.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.