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Volumn 67, Issue 6, 2012, Pages 475-481

The hedgehog signaling pathway, a new therapeutic target for treatment of ischemic heart disease

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOPOIETIN 2; HYPOXIA INDUCIBLE FACTOR 1; PLATELET DERIVED GROWTH FACTOR; PROTEIN PATCHED 1; PROTEIN PATCHED 2; SONIC HEDGEHOG PROTEIN; TRANSCRIPTION FACTOR GLI2; VASCULOTROPIN;

EID: 84862581056     PISSN: 00317144     EISSN: None     Source Type: Journal    
DOI: 10.1691/ph.2012.1744     Document Type: Review
Times cited : (18)

References (81)
  • 1
    • 77649161196 scopus 로고    scopus 로고
    • Sonic Hedgehog gene delivery to the rodent heart promotes angiogenesis via iNOS/netrin-1/PKC pathway
    • Ahmed RP, Haider KH, Shujia J, Afzal MR, Ashraf M (2010) Sonic Hedgehog gene delivery to the rodent heart promotes angiogenesis via iNOS/netrin-1/PKC pathway. PLoS One 5: e8576.
    • (2010) PLoS One , vol.5
    • Ahmed, R.P.1    Haider, K.H.2    Shujia, J.3    Afzal, M.R.4    Ashraf, M.5
  • 2
    • 0031587830 scopus 로고    scopus 로고
    • Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor
    • Aza-Blanc P, Ramirez-Weber FA, Laget MP, Schwartz C, Kornberg TB (1997) Proteolysis that is inhibited by hedgehog targets Cubitus interruptus protein to the nucleus and converts it to a repressor. Cell 89: 1043-1053.
    • (1997) Cell , vol.89 , pp. 1043-1053
    • Aza-Blanc, P.1    Ramirez-Weber, F.A.2    Laget, M.P.3    Schwartz, C.4    Kornberg, T.B.5
  • 3
    • 66949128200 scopus 로고    scopus 로고
    • Therapeutic potential of plasma membrane-derived microparticles
    • Benameur T, Andriantsitohaina R, Martinez MC (2009) Therapeutic potential of plasma membrane-derived microparticles. Pharmacol Rep 61: 49-57.
    • (2009) Pharmacol Rep , vol.61 , pp. 49-57
    • Benameur, T.1    Andriantsitohaina, R.2    Martinez, M.C.3
  • 4
    • 77958555989 scopus 로고    scopus 로고
    • Microparticles carrying Sonic hedgehog favor neovascularization through the activation of nitric oxide pathway in mice
    • Benameur T, Soleti R, Porro C, Andriantsitohaina R, Martinez MC (2010) Microparticles carrying Sonic hedgehog favor neovascularization through the activation of nitric oxide pathway in mice. PLoS One 5: e12688.
    • (2010) PLoS One , vol.5
    • Benameur, T.1    Soleti, R.2    Porro, C.3    Andriantsitohaina, R.4    Martinez, M.C.5
  • 8
    • 0033748331 scopus 로고    scopus 로고
    • Gli2 functions in FGF signaling during antero-posterior patterning
    • Brewster R, Mullor JL, Ruiz i Altaba A (2000) Gli2 functions in FGF signaling during antero-posterior patterning. Development 127: 4395-4405.
    • (2000) Development , vol.127 , pp. 4395-4405
    • Brewster, R.1    Mullor, J.L.2    Ruiz I Altaba, A.3
  • 10
    • 1542614580 scopus 로고    scopus 로고
    • Outcomes of coronary artery bypass grafting versus percutaneous coronary intervention and medical therapy for multivessel disease with and without left ventricular dysfunction
    • Caines AE, Massad MG, Kpodonu J, Rebeiz AG, Evans A, Geha AS (2004) Outcomes of coronary artery bypass grafting versus percutaneous coronary intervention and medical therapy for multivessel disease with and without left ventricular dysfunction. Cardiology 101: 21-28.
    • (2004) Cardiology , vol.101 , pp. 21-28
    • Caines, A.E.1    Massad, M.G.2    Kpodonu, J.3    Rebeiz, A.G.4    Evans, A.5    Geha, A.S.6
  • 11
    • 69249245332 scopus 로고    scopus 로고
    • Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved
    • Chen MH, Wilson CW, Li YJ, Law KK, Lu CS, Gacayan R, Zhang X, Hui CC, Chuang PT (2009) Cilium-independent regulation of Gli protein function by Sufu in Hedgehog signaling is evolutionarily conserved. Genes Dev 23: 1910-1928.
    • (2009) Genes Dev , vol.23 , pp. 1910-1928
    • Chen, M.H.1    Wilson, C.W.2    Li, Y.J.3    Law, K.K.4    Lu, C.S.5    Gacayan, R.6    Zhang, X.7    Hui, C.C.8    Chuang, P.T.9
  • 12
    • 0142153787 scopus 로고    scopus 로고
    • The hedgehog signaling network
    • Cohen MM, Jr. (2003) The hedgehog signaling network. Am J Med Genet A 123A: 5-28.
    • (2003) Am J Med Genet A , vol.123 A , pp. 5-28
    • Cohen Jr., M.M.1
  • 14
    • 0032918412 scopus 로고    scopus 로고
    • Blood vessel maturation: Vascular development comes of age
    • Darland DC, D'Amore PA (1999) Blood vessel maturation: vascular development comes of age. J Clin Invest 103: 157-158.
    • (1999) J Clin Invest , vol.103 , pp. 157-158
    • Darland, D.C.1    D'Amore, P.A.2
  • 15
    • 33845768306 scopus 로고    scopus 로고
    • Analysis of talpid3 and wild-type chicken embryos reveals roles for Hedgehog signalling in development of the limb bud vasculature
    • Davey MG, James J, Paton IR, Burt DW, Tickle C (2007) Analysis of talpid3 and wild-type chicken embryos reveals roles for Hedgehog signalling in development of the limb bud vasculature. Dev Biol 301: 155-165.
    • (2007) Dev Biol , vol.301 , pp. 155-165
    • Davey, M.G.1    James, J.2    Paton, I.R.3    Burt, D.W.4    Tickle, C.5
  • 16
    • 0034682719 scopus 로고    scopus 로고
    • Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened
    • Denef N, Neubuser D, Perez L, Cohen SM (2000) Hedgehog induces opposite changes in turnover and subcellular localization of patched and smoothened. Cell 102: 521-531.
    • (2000) Cell , vol.102 , pp. 521-531
    • Denef, N.1    Neubuser, D.2    Perez, L.3    Cohen, S.M.4
  • 17
    • 62349099608 scopus 로고    scopus 로고
    • The effects of molsidomine on hypoxia inducible factor alpha and Sonic hedgehog in testicular ischemia/reperfusion injury in rats
    • Dokucu AI, Ozturk H, Tuncer MC, Yilmaz F (2009) The effects of molsidomine on hypoxia inducible factor alpha and Sonic hedgehog in testicular ischemia/reperfusion injury in rats. Int Urol Nephrol 41: 101-108.
    • (2009) Int Urol Nephrol , vol.41 , pp. 101-108
    • Dokucu, A.I.1    Ozturk, H.2    Tuncer, M.C.3    Yilmaz, F.4
  • 19
    • 72449209673 scopus 로고    scopus 로고
    • Sonic hedgehog is a potent chemoattractant for human monocytes: Diabetes mellitus inhibits Sonic hedgehog-induced monocyte chemotaxis
    • Dunaeva M, Voo S, van Oosterhoud C, Waltenberger J (2010) Sonic hedgehog is a potent chemoattractant for human monocytes: diabetes mellitus inhibits Sonic hedgehog-induced monocyte chemotaxis. Basic Res Cardiol 105: 61-71.
    • (2010) Basic Res Cardiol , vol.105 , pp. 61-71
    • Dunaeva, M.1    Voo, S.2    Van Oosterhoud, C.3    Waltenberger, J.4
  • 20
    • 1942498907 scopus 로고    scopus 로고
    • The Notch target genes Hey1 and Hey2 are required for embryonic vascular development
    • Fischer A, Schumacher N, Maier M, Sendtner M, Gessler M (2004) The Notch target genes Hey1 and Hey2 are required for embryonic vascular development. Genes Dev 18: 901-911.
    • (2004) Genes Dev , vol.18 , pp. 901-911
    • Fischer, A.1    Schumacher, N.2    Maier, M.3    Sendtner, M.4    Gessler, M.5
  • 21
    • 1842346472 scopus 로고    scopus 로고
    • Molecular mechanisms of vasculogenesis and embryonic angiogenesis
    • Flamme I, Frolich T, Risau W (1997) Molecular mechanisms of vasculogenesis and embryonic angiogenesis. J Cell Physiol 173: 206-210.
    • (1997) J Cell Physiol , vol.173 , pp. 206-210
    • Flamme, I.1    Frolich, T.2    Risau, W.3
  • 22
    • 33745379407 scopus 로고    scopus 로고
    • Sonic hedgehog protein promotes bone marrow-derived endothelial progenitor cell proliferation, migration and VEGF production via PI 3-kinase/Akt signaling pathways
    • Fu JR, Liu WL, Zhou JF, Sun HY, Xu HZ, Luo L, Zhang H, Zhou YF (2006) Sonic hedgehog protein promotes bone marrow-derived endothelial progenitor cell proliferation, migration and VEGF production via PI 3-kinase/Akt signaling pathways. Acta Pharmacol Sin 27: 685-693.
    • (2006) Acta Pharmacol Sin , vol.27 , pp. 685-693
    • Fu, J.R.1    Liu, W.L.2    Zhou, J.F.3    Sun, H.Y.4    Xu, H.Z.5    Luo, L.6    Zhang, H.7    Zhou, Y.F.8
  • 23
    • 0033197535 scopus 로고    scopus 로고
    • Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development
    • Gerety SS, Wang HU, Chen ZF, Anderson DJ (1999) Symmetrical mutant phenotypes of the receptor EphB4 and its specific transmembrane ligand ephrin-B2 in cardiovascular development. Mol Cell 4: 403-414.
    • (1999) Mol Cell , vol.4 , pp. 403-414
    • Gerety, S.S.1    Wang, H.U.2    Chen, Z.F.3    Anderson, D.J.4
  • 24
    • 34347346140 scopus 로고    scopus 로고
    • The angiogenic factor thymidine phosphorylase up-regulates the cell adhesion molecule P-selectin in human vascular endothelial cells and is associated with P-selectin expression in breast cancers
    • Gunningham SP, Currie MJ, Morrin HR, Tan EY, Turley H, Dachs GU, Watson AI, Frampton C, Robinson BA, Fox SB (2007) The angiogenic factor thymidine phosphorylase up-regulates the cell adhesion molecule P-selectin in human vascular endothelial cells and is associated with P-selectin expression in breast cancers. J Pathol 212: 335-344.
    • (2007) J Pathol , vol.212 , pp. 335-344
    • Gunningham, S.P.1    Currie, M.J.2    Morrin, H.R.3    Tan, E.Y.4    Turley, H.5    Dachs, G.U.6    Watson, A.I.7    Frampton, C.8    Robinson, B.A.9    Fox, S.B.10
  • 25
    • 33845927886 scopus 로고    scopus 로고
    • Molecular pathways regulating pro-migratory effects of Hedgehog signaling
    • Hochman E, Castiel A, Jacob-Hirsch J, Amariglio N, Izraeli S (2006) Molecular pathways regulating pro-migratory effects of Hedgehog signaling. J Biol Chem 281: 33860-33870.
    • (2006) J Biol Chem , vol.281 , pp. 33860-33870
    • Hochman, E.1    Castiel, A.2    Jacob-Hirsch, J.3    Amariglio, N.4    Izraeli, S.5
  • 26
    • 77950463564 scopus 로고    scopus 로고
    • The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins
    • Humke EW, Dorn KV, Milenkovic L, Scott MP, Rohatgi R (2010) The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins. Genes Dev 24: 670-682.
    • (2010) Genes Dev , vol.24 , pp. 670-682
    • Humke, E.W.1    Dorn, K.V.2    Milenkovic, L.3    Scott, M.P.4    Rohatgi, R.5
  • 27
    • 79956308325 scopus 로고    scopus 로고
    • Mechanisms and functions of Hedgehog signalling across the metazoa
    • Ingham PW, Nakano Y, Seger C (2011) Mechanisms and functions of Hedgehog signalling across the metazoa. Nat Rev Genet 12: 393-406.
    • (2011) Nat Rev Genet , vol.12 , pp. 393-406
    • Ingham, P.W.1    Nakano, Y.2    Seger, C.3
  • 28
    • 0038376002 scopus 로고    scopus 로고
    • Molecular regulation of vessel maturation
    • Jain RK (2003) Molecular regulation of vessel maturation. Nat Med 9: 685-693.
    • (2003) Nat Med , vol.9 , pp. 685-693
    • Jain, R.K.1
  • 30
    • 0032576777 scopus 로고    scopus 로고
    • Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb
    • Jiang J, Struhl G (1998) Regulation of the Hedgehog and Wingless signalling pathways by the F-box/WD40-repeat protein Slimb. Nature 391: 493-496.
    • (1998) Nature , vol.391 , pp. 493-496
    • Jiang, J.1    Struhl, G.2
  • 31
    • 1042289788 scopus 로고    scopus 로고
    • Fibroblast growth factor-2-mediated capillary morphogenesis of endothelial cells requires signals via Flt-1/vascular endothelial growth factor receptor-1: Possible involvement of c-Akt
    • Kanda S, Miyata Y, Kanetake H (2004) Fibroblast growth factor-2-mediated capillary morphogenesis of endothelial cells requires signals via Flt-1/vascular endothelial growth factor receptor-1: possible involvement of c-Akt. J Biol Chem 279: 4007-4016.
    • (2004) J Biol Chem , vol.279 , pp. 4007-4016
    • Kanda, S.1    Miyata, Y.2    Kanetake, H.3
  • 32
    • 58249124375 scopus 로고    scopus 로고
    • Characterization of sonic hedgehog as a novel NF-kappaB target gene that promotes NF-kappaB-mediated apoptosis resistance and tumor growth in vivo
    • Kasperczyk H, Baumann B, Debatin KM, Fulda S (2009) Characterization of sonic hedgehog as a novel NF-kappaB target gene that promotes NF-kappaB-mediated apoptosis resistance and tumor growth in vivo. FASEB J 23: 21-33.
    • (2009) FASEB J , vol.23 , pp. 21-33
    • Kasperczyk, H.1    Baumann, B.2    Debatin, K.M.3    Fulda, S.4
  • 33
    • 2142650739 scopus 로고    scopus 로고
    • Formation and remodeling of the coronary vascular bed in the embryonic avian heart
    • Kattan J, Dettman RW, Bristow J (2004) Formation and remodeling of the coronary vascular bed in the embryonic avian heart. Dev Dyn 230: 34-43.
    • (2004) Dev Dyn , vol.230 , pp. 34-43
    • Kattan, J.1    Dettman, R.W.2    Bristow, J.3
  • 34
    • 34948820616 scopus 로고    scopus 로고
    • Specification of multipotential cardiovascular progenitor cells during embryonic stem cell differentiation and embryonic development
    • Kattman SJ, Adler ED, Keller GM (2007) Specification of multipotential cardiovascular progenitor cells during embryonic stem cell differentiation and embryonic development. Trends Cardiovasc Med 17: 240-246.
    • (2007) Trends Cardiovasc Med , vol.17 , pp. 240-246
    • Kattman, S.J.1    Adler, E.D.2    Keller, G.M.3
  • 37
    • 46849087764 scopus 로고    scopus 로고
    • Hedgehog signaling is critical for maintenance of the adult coronary vasculature in mice
    • Lavine KJ, Kovacs A, Ornitz DM (2008a) Hedgehog signaling is critical for maintenance of the adult coronary vasculature in mice. J Clin Invest 118: 2404-2414.
    • (2008) J Clin Invest , vol.118 , pp. 2404-2414
    • Lavine, K.J.1    Kovacs, A.2    Ornitz, D.M.3
  • 38
    • 58149139571 scopus 로고    scopus 로고
    • Hedgehog signaling to distinct cell types differentially regulates coronary artery and vein development
    • Lavine KJ, Long F, Choi K, Smith C, Ornitz DM (2008b) Hedgehog signaling to distinct cell types differentially regulates coronary artery and vein development. Development 135: 3161-3171.
    • (2008) Development , vol.135 , pp. 3161-3171
    • Lavine, K.J.1    Long, F.2    Choi, K.3    Smith, C.4    Ornitz, D.M.5
  • 39
    • 34047132909 scopus 로고    scopus 로고
    • Rebuilding the coronary vasculature: Hedgehog as a new candidate for pharmacologic revascularization
    • Lavine KJ, Ornitz DM (2007) Rebuilding the coronary vasculature: hedgehog as a new candidate for pharmacologic revascularization. Trends Cardiovasc Med 17: 77-83.
    • (2007) Trends Cardiovasc Med , vol.17 , pp. 77-83
    • Lavine, K.J.1    Ornitz, D.M.2
  • 40
    • 33745129425 scopus 로고    scopus 로고
    • Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development
    • Lavine KJ, White AC, Park C, Smith CS, Choi K, Long F, Hui CC, Ornitz DM (2006) Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development. Genes Dev 20: 1651-1666.
    • (2006) Genes Dev , vol.20 , pp. 1651-1666
    • Lavine, K.J.1    White, A.C.2    Park, C.3    Smith, C.S.4    Choi, K.5    Long, F.6    Hui, C.C.7    Ornitz, D.M.8
  • 41
    • 0036070186 scopus 로고    scopus 로고
    • Sonic hedgehog and vascular endothelial growth factor act upstream of the Notch pathway during arterial endothelial differentiation
    • Lawson ND, Vogel AM, Weinstein BM (2002) sonic hedgehog and vascular endothelial growth factor act upstream of the Notch pathway during arterial endothelial differentiation. Dev Cell 3: 127-136.
    • (2002) Dev Cell , vol.3 , pp. 127-136
    • Lawson, N.D.1    Vogel, A.M.2    Weinstein, B.M.3
  • 43
    • 31544444710 scopus 로고    scopus 로고
    • Hedgehog and RAS pathways cooperate in the anterior-posterior specification and positioning of cardiac progenitor cells
    • Liu J, Qian L, Wessells RJ, Bidet Y, Jagla K, Bodmer R (2006) Hedgehog and RAS pathways cooperate in the anterior-posterior specification and positioning of cardiac progenitor cells. Dev Biol 290: 373-385.
    • (2006) Dev Biol , vol.290 , pp. 373-385
    • Liu, J.1    Qian, L.2    Wessells, R.J.3    Bidet, Y.4    Jagla, K.5    Bodmer, R.6
  • 44
    • 41449094683 scopus 로고    scopus 로고
    • Lives of a heart cell: Tracing the origins of cardiac progenitors
    • Martin-Puig S, Wang Z, Chien KR (2008) Lives of a heart cell: tracing the origins of cardiac progenitors. Cell Stem Cell 2: 320-331.
    • (2008) Cell Stem Cell , vol.2 , pp. 320-331
    • Martin-Puig, S.1    Wang, Z.2    Chien, K.R.3
  • 46
    • 77956269175 scopus 로고    scopus 로고
    • Frequent deregulations in the hedgehog signaling network and cross-talks with the epidermal growth factor receptor pathway involved in cancer progression and targeted therapies
    • Mimeault M, Batra SK (2010) Frequent deregulations in the hedgehog signaling network and cross-talks with the epidermal growth factor receptor pathway involved in cancer progression and targeted therapies. Pharmacol Rev 62: 497-524.
    • (2010) Pharmacol Rev , vol.62 , pp. 497-524
    • Mimeault, M.1    Batra, S.K.2
  • 47
    • 0036100340 scopus 로고    scopus 로고
    • Mechanisms of embryonic coronary artery development
    • Morabito CJ, Kattan J, Bristow J (2002) Mechanisms of embryonic coronary artery development. Curr Opin Cardiol 17: 235-241.
    • (2002) Curr Opin Cardiol , vol.17 , pp. 235-241
    • Morabito, C.J.1    Kattan, J.2    Bristow, J.3
  • 49
    • 79956219871 scopus 로고    scopus 로고
    • Hypoxia activates the hedgehog signaling pathway in a ligand-independent manner by upregulation of Smo transcription in pancreatic cancer
    • Onishi H, Kai M, Odate S, Iwasaki H, Morifuji Y, Ogino T, Morisaki T, Nakashima Y, Katano M (2011) Hypoxia activates the hedgehog signaling pathway in a ligand-independent manner by upregulation of Smo transcription in pancreatic cancer. Cancer Sci 102: 1144-1150.
    • (2011) Cancer Sci , vol.102 , pp. 1144-1150
    • Onishi, H.1    Kai, M.2    Odate, S.3    Iwasaki, H.4    Morifuji, Y.5    Ogino, T.6    Morisaki, T.7    Nakashima, Y.8    Katano, M.9
  • 52
    • 78549238506 scopus 로고    scopus 로고
    • Inhibition of endogenous hedgehog signaling protects against acute liver injury after ischemia reperfusion
    • Pratap A, Panakanti R, Yang N, Eason JD, Mahato RI (2010) Inhibition of endogenous hedgehog signaling protects against acute liver injury after ischemia reperfusion. Pharm Res 27: 2492-2504.
    • (2010) Pharm Res , vol.27 , pp. 2492-2504
    • Pratap, A.1    Panakanti, R.2    Yang, N.3    Eason, J.D.4    Mahato, R.I.5
  • 53
    • 79958273831 scopus 로고    scopus 로고
    • Cyclopamine attenuates acute warm ischemia reperfusion injury in cholestatic rat liver: Hope for marginal livers
    • Pratap A, Panakanti R, Yang N, Lakshmi R, Modanlou KA, Eason JD, Mahato RI (2011) Cyclopamine attenuates acute warm ischemia reperfusion injury in cholestatic rat liver: hope for marginal livers. Mol Pharm 8: 958-968.
    • (2011) Mol Pharm , vol.8 , pp. 958-968
    • Pratap, A.1    Panakanti, R.2    Yang, N.3    Lakshmi, R.4    Modanlou, K.A.5    Eason, J.D.6    Mahato, R.I.7
  • 54
    • 0027383291 scopus 로고
    • Segmental polarity in Drosophila melanogaster: Genetic dissection of fused in a Suppressor of fused background reveals interaction with costal-2
    • Preat T, Therond P, Limbourg-Bouchon B, Pham A, Tricoire H, Busson D, Lamour-Isnard C (1993) Segmental polarity in Drosophila melanogaster: genetic dissection of fused in a Suppressor of fused background reveals interaction with costal-2. Genetics 135: 1047-1062.
    • (1993) Genetics , vol.135 , pp. 1047-1062
    • Preat, T.1    Therond, P.2    Limbourg-Bouchon, B.3    Pham, A.4    Tricoire, H.5    Busson, D.6    Lamour-Isnard, C.7
  • 58
    • 0030952289 scopus 로고    scopus 로고
    • Mechanisms of angiogenesis
    • Risau W (1997) Mechanisms of angiogenesis. Nature 386: 671-674.
    • (1997) Nature , vol.386 , pp. 671-674
    • Risau, W.1
  • 59
    • 0030838880 scopus 로고    scopus 로고
    • Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2
    • Robbins DJ, Nybakken KE, Kobayashi R, Sisson JC, Bishop JM, Therond PP (1997) Hedgehog elicits signal transduction by means of a large complex containing the kinesin-related protein costal2. Cell 90: 225-234.
    • (1997) Cell , vol.90 , pp. 225-234
    • Robbins, D.J.1    Nybakken, K.E.2    Kobayashi, R.3    Sisson, J.C.4    Bishop, J.M.5    Therond, P.P.6
  • 60
    • 34547110771 scopus 로고    scopus 로고
    • Patched1 regulates hedgehog signaling at the primary cilium
    • Rohatgi R, Milenkovic L, Scott MP (2007) Patched1 regulates hedgehog signaling at the primary cilium. Science 317: 372-376.
    • (2007) Science , vol.317 , pp. 372-376
    • Rohatgi, R.1    Milenkovic, L.2    Scott, M.P.3
  • 61
    • 0035865049 scopus 로고    scopus 로고
    • Expression of ephrinB2 identifies a stable genetic difference between arterial and venous vascular smooth muscle as well as endothelial cells, and marks subsets of microvessels at sites of adult neovascularization
    • Shin D, Garcia-Cardena G, Hayashi S, Gerety S, Asahara T, Stavrakis G, Isner J, Folkman J, Gimbrone MA Jr, Anderson DJ (2001) Expression of ephrinB2 identifies a stable genetic difference between arterial and venous vascular smooth muscle as well as endothelial cells, and marks subsets of microvessels at sites of adult neovascularization. Dev Biol 230: 139-150.
    • (2001) Dev Biol , vol.230 , pp. 139-150
    • Shin, D.1    Garcia-Cardena, G.2    Hayashi, S.3    Gerety, S.4    Asahara, T.5    Stavrakis, G.6    Isner, J.7    Folkman, J.8    Gimbrone Jr., M.A.9    Anderson, D.J.10
  • 63
    • 71049189297 scopus 로고    scopus 로고
    • Sonic hedgehog regulates ischemia/hypoxia-induced neural progenitor proliferation
    • Sims JR, Lee SW, Topalkara K, Qiu J, Xu J, Zhou Z, Moskowitz MA (2009) Sonic hedgehog regulates ischemia/hypoxia-induced neural progenitor proliferation. Stroke 40: 3618-3626.
    • (2009) Stroke , vol.40 , pp. 3618-3626
    • Sims, J.R.1    Lee, S.W.2    Topalkara, K.3    Qiu, J.4    Xu, J.5    Zhou, Z.6    Moskowitz, M.A.7
  • 64
    • 0030754171 scopus 로고    scopus 로고
    • Costal2, a novel kinesin-related protein in the Hedgehog signaling pathway
    • Sisson JC, Ho KS, Suyama K, Scott MP (1997) Costal2, a novel kinesin-related protein in the Hedgehog signaling pathway. Cell 90: 235-245.
    • (1997) Cell , vol.90 , pp. 235-245
    • Sisson, J.C.1    Ho, K.S.2    Suyama, K.3    Scott, M.P.4
  • 65
    • 68249120584 scopus 로고    scopus 로고
    • Microparticles harbouring Sonic Hedgehog: Role in angiogenesis regulation
    • Soleti R, Martinez MC (2009) Microparticles harbouring Sonic Hedgehog: role in angiogenesis regulation. Cell Adh Migr 3: 293-295.
    • (2009) Cell Adh Migr , vol.3 , pp. 293-295
    • Soleti, R.1    Martinez, M.C.2
  • 66
    • 72949103044 scopus 로고    scopus 로고
    • Small-molecule modulators of the Sonic Hedgehog signaling pathway
    • Stanton BZ, Peng LF (2010) Small-molecule modulators of the Sonic Hedgehog signaling pathway. Mol Biosyst 6: 44-54.
    • (2010) Mol Biosyst , vol.6 , pp. 44-54
    • Stanton, B.Z.1    Peng, L.F.2
  • 67
    • 1542719878 scopus 로고    scopus 로고
    • Therapeutic angiogenesis: A biologic bypass
    • Syed IS, Sanborn TA, Rosengart TK (2004) Therapeutic angiogenesis: a biologic bypass. Cardiology 101: 131-143.
    • (2004) Cardiology , vol.101 , pp. 131-143
    • Syed, I.S.1    Sanborn, T.A.2    Rosengart, T.K.3
  • 69
    • 0037309083 scopus 로고    scopus 로고
    • Expression of rigf, a member of avian VEGF family, correlates with vascular patterning in the developing chick limb bud
    • Tamura K, Amano T, Satoh T, Saito D, Yonei-Tamura S, Yajima H (2003) Expression of rigf, a member of avian VEGF family, correlates with vascular patterning in the developing chick limb bud. Mech Dev 120: 199-209.
    • (2003) Mech Dev , vol.120 , pp. 199-209
    • Tamura, K.1    Amano, T.2    Satoh, T.3    Saito, D.4    Yonei-Tamura, S.5    Yajima, H.6
  • 71
    • 59149088483 scopus 로고    scopus 로고
    • Hedgehog signaling plays a cell-autonomous role in maximizing cardiac developmental potential
    • Thomas NA, Koudijs M, van Eeden FJ, Joyner AL, Yelon D (2008) Hedgehog signaling plays a cell-autonomous role in maximizing cardiac developmental potential. Development 135: 3789-3799.
    • (2008) Development , vol.135 , pp. 3789-3799
    • Thomas, N.A.1    Koudijs, M.2    Van Eeden, F.J.3    Joyner, A.L.4    Yelon, D.5
  • 73
    • 51949085076 scopus 로고    scopus 로고
    • Hedgehog: Functions and mechanisms
    • Varjosalo M, Taipale J (2008) Hedgehog: functions and mechanisms. Genes Dev 22: 2454-2472.
    • (2008) Genes Dev , vol.22 , pp. 2454-2472
    • Varjosalo, M.1    Taipale, J.2
  • 74
    • 0037062491 scopus 로고    scopus 로고
    • Orchestration of angiogenesis and arteriovenous contribution by angiopoietins and vascular endothelial growth factor (VEGF)
    • Visconti RP, Richardson CD, Sato TN (2002) Orchestration of angiogenesis and arteriovenous contribution by angiopoietins and vascular endothelial growth factor (VEGF). Proc Natl Acad Sci U S A 99: 8219-8224.
    • (2002) Proc Natl Acad Sci U S A , vol.99 , pp. 8219-8224
    • Visconti, R.P.1    Richardson, C.D.2    Sato, T.N.3
  • 77
    • 77953615901 scopus 로고    scopus 로고
    • Gli1 inhibition induces cell-cycle arrest and enhanced apoptosis in brain glioma cell lines
    • Wang K, Pan L, Che X, Cui D, Li C (2010) Gli1 inhibition induces cell-cycle arrest and enhanced apoptosis in brain glioma cell lines. J Neurooncol 98: 319-327.
    • (2010) J Neurooncol , vol.98 , pp. 319-327
    • Wang, K.1    Pan, L.2    Che, X.3    Cui, D.4    Li, C.5
  • 78
    • 34249941378 scopus 로고    scopus 로고
    • The roles of mesenchymal stem cells (MSCs) therapy in ischemic heart diseases
    • Wang XJ, Li QP (2007) The roles of mesenchymal stem cells (MSCs) therapy in ischemic heart diseases. Biochem Biophys Res Commun 359: 189-193.
    • (2007) Biochem Biophys Res Commun , vol.359 , pp. 189-193
    • Wang, X.J.1    Li, Q.P.2
  • 81
    • 0038625111 scopus 로고    scopus 로고
    • Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction
    • Zhu AJ, Zheng L, Suyama K, Scott MP (2003). Altered localization of Drosophila Smoothened protein activates Hedgehog signal transduction. Genes Dev 17: 1240-1252.
    • (2003) Genes Dev , vol.17 , pp. 1240-1252
    • Zhu, A.J.1    Zheng, L.2    Suyama, K.3    Scott, M.P.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.