Inhibition of endogenous hedgehog signaling protects against acute liver injury after ischemia reperfusion

Pharmaceutical Research

Volumn 27, Issue 11, 2010, Pages 2492-2504

  Pratap, Akshay ^a   Panakanti, Ravikiran ^b   Yang, Ningning ^b   Eason, James D ^a   Mahato, Ram I ^b  

^a METHODIST UNIVERSITY HOSPITAL   (United States)

^b UNIVERSITY OF TENNESSEE HEALTH SCIENCE CENTER   (United States)

Author keywords

cyclopamine; Hedgehog signaling; liver ischemia reperfusion

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CYCLOPAMINE; CYTOKINE; MITOGEN ACTIVATED PROTEIN KINASE; SONIC HEDGEHOG PROTEIN; STRESS ACTIVATED PROTEIN KINASE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; CONTROLLED STUDY; DRUG ACTIVITY; ENZYME PHOSPHORYLATION; GENE EXPRESSION; HISTOPATHOLOGY; LIVER INJURY; LIVER ISCHEMIA; LIVER PROTECTION; NEUTROPHIL CHEMOTAXIS; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; RAT; REPERFUSION INJURY; SHAM PROCEDURE; SIGNAL TRANSDUCTION; SPRAGUE DAWLEY RAT; UPREGULATION;

ANIMALS; APOPTOSIS; BASE SEQUENCE; CYTOKINES; DNA PRIMERS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FLUORESCENT ANTIBODY TECHNIQUE; HEDGEHOG PROTEINS; INFLAMMATION MEDIATORS; LIVER DISEASES; MITOGEN-ACTIVATED PROTEIN KINASES; POLYMERASE CHAIN REACTION; RATS; RATS, SPRAGUE-DAWLEY; REPERFUSION INJURY; SIGNAL TRANSDUCTION; VERATRUM ALKALOIDS;

EID: 78549238506     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-010-0246-z     Document Type: Article

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