Genotoxicity evaluation of sesamin and episesamin

Mutation Research - Genetic Toxicology and Environmental Mutagenesis

Volumn 719, Issue 1-2, 2011, Pages 21-28

  Hori, Hisako ^a   Takayanagi, Tomomi ^a   Kamada, Yoko ^a   Shimoyoshi, Satomi ^a   Ono, Yoshiko ^b   Kitagawa, Yoshinori ^b   Shibata, Hiroshi ^b   Nagao, Minako ^c   Fujii, Wataru ^a   Sakakibara, Yutaka ^a  

^a SUNTORY LTD   (Japan)

^b Suntory Wellness Limited Research Center   (Japan)

^c KEIO UNIVERSITY   (Japan)

Author keywords

Episesamin; Gonotoxicity; Sesame; Sesamin

Indexed keywords

EPISESAMIN; PLANT MEDICINAL PRODUCT; SESAMIN; UNCLASSIFIED DRUG;

AMES TEST; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CHROMOSOME ABERRATION; COMET ASSAY; CYTOTOXICITY; DNA DAMAGE; GENOTOXICITY; IN VITRO STUDY; IN VIVO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; RAT;

ANIMALS; BONE MARROW CELLS; CELLS, CULTURED; CHROMOSOME ABERRATIONS; COMET ASSAY; CRICETINAE; CRICETULUS; DIOXOLES; DNA DAMAGE; DOSE-RESPONSE RELATIONSHIP, DRUG; ERYTHROCYTES; LIGNANS; LIVER EXTRACTS; MALE; MICE; MICE, INBRED ICR; MICRONUCLEUS TESTS; MICROSOMES, LIVER; MOLECULAR STRUCTURE; MUTAGENICITY TESTS; MUTATION; RATS; RATS, SPRAGUE-DAWLEY; SALMONELLA TYPHIMURIUM; SESAME OIL;

BACTERIA (MICROORGANISMS); CRICETULUS GRISEUS; MUS; RATTUS; SESAMUM INDICUM;

EID: 78650573861     PISSN: 13835718     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.mrgentox.2010.10.001     Document Type: Article

References (57)

1. Fukuda Y., Nagata M., Osawa T., Namiki M. Contribution of lignan analogues to antioxidative activity of refined unroasted sesame seed oil. J. Am. Oil Chem. Soc. 1986, 63:1027-1031.
2. Nakai M., Harada M., Nakahara K., Akimoto K., Shibata H., Miki W., Kiso Y. Novel antioxidative metabolites in rat liver with ingested sesamin. J. Agric. Food Chem. 2003, 51:1666-1670.
3. Ikeda T., Nishijima Y., Shibata H., Kiso Y., Ohnuki K., Fushiki T., Moritani T. Protective effect of sesamin administration on exercise-induced lipid peroxidation. Int. J. Sports Med. 2003, 24:530-534.
4. Kiso Y. Antioxidative roles of sesamin, a functional lignan in sesame seed, and its effect on lipid- and alcohol-metabolism in the liver: a DNA microarray study. BioFactors 2004, 21:191-196.
5. Hirose N, Inoue T., Nishihara K., Sugano M., Akimoto K., Shimizu S., Yamada H. Inhibition of cholesterol absorption and synthesis in rats by sesamin. J. Lipid Res. 1991, 32:629-638.
6. Peñalvo J.L., Hopia A., Adlercreutz H. Effect of sesamin on serum cholesterol and triglycerides levels in LDL receptor-deficient mice. Eur. J. Nutr. 2006, 45:439-444.
7. Nakabayashi A., Kitagawa Y., Suwa Y., Akimoto K., Asami S., Shimizu S., Hirose N., Sugano M., Yamada H. α-Tocopherol enhances the hypocholesterolemic action of sesamin in rats. Int. J. Vitam. Nutr. Res. 1995, 65:162-168.
8. Hirata F., Fujita K., Ishikura Y., Hosoda K., Ishikawa T., Nakamura H. Hypocholesterolemic effect of sesame lignan in humans. Atherosclerosis 1996, 122:135-136.
9. Kiso Y., Tsuruoka N., Kidokoro A., Matsumoto I., Abe K. Sesamin ingestion regulates the transcription levels of hepatic metabolizing enzymes for alcohol and lipids in rats. Alcohol Clin. Exp. Res. 2005, 29:116S-120S.
10. Kita S., Matsumura Y., Morimoto S., Akimoto K., Furuya M., Oka N., Tanaka T. Antihypertensive effect of sesamin. II. Protection against two-kidney, one-clip renal hypertension and cardiovascular hypertrophy. Biol. Pharm. Bull. 1995, 18:1283-1285.
11. Matsumura Y., Kita S., Morimoto S., Akimoto K., Furuya M., Oka N., Tanaka T. Antihypertensive effect of sesamin. I. Protection against deoxycorticosterone acetate-salt-induced hypertension and cardiovascular hypertrophy. Biol. Pharm. Bull. 1995, 18:1016-1019.
12. Nakano D., Takaoka M., Kiso Y., Matsumura Y. Antihypertensive effect of sesamin. Vasc. Dis. Prev. 2004, 1:233-241.
13. Lee C.C., Chen P.R., Lin S., Tsai S.C., Wang B.W., Chen W.W., Tsai C.E., Shyu K.G. Sesamin induces nitric oxide and decreases endothelin-1 production in HUVECs: possible implications for its antihypertensive effect. J. Hypertens. 2004, 22:2329-2338.
14. Nakano D., Kwak C.J., Fujii K., Ikemura K., Satake A., Ohkita M., Takaoka M., Ono Y., Nakai M., Tomimori N., Kiso Y., Matsumura Y. Sesamin metabolites induce an endothelial nitric oxide-dependent vasorelaxation through their antioxidative property-independent mechanisms: possible involvement of the metabolites in the antihypertensive effect of sesamin. J. Pharmacol. Exp. Ther. 2006, 318:328-335.
15. Miyawaki T., Aono H., Toyoda-Ono Y., Maeda H., Kiso Y., Moriyama K. Antihypertensive effects of sesamin in humans. J. Nutr. Sci. Vitaminol. 2009, 55:87-91.
16. Akimoto K., Kitagawa Y., Akamatsu T., Hirose N., Sugano M., Shimizu S., Yamada H. Protective effects of sesamin against liver damage caused by alcohol or carbon tetrachloride in rodents. Ann. Nutr. Metab. 1993, 37:218-224.
17. Yamashita K., Kagaya M., Higuti N., Kiso Y. Sesamin and α-tocopherol synergistically suppress lipid-peroxide in rats fed a high docosahexaenoic acid diet. BioFactors 2000, 11:11-13.
18. Kamal-Eldin A., Pettersson D., Appelqvist L.A. Sesamin (a compound from sesame oil) increases tocopherol levels in rats fed ad libitum. Lipids 1995, 30:499-505.
19. Yamashita K., Nohara Y., Katayama K., Namiki M. Sesame seed lignans and γ-tocopherol act synergistically to produce vitamin E activity in rats. J. Nutr. 1992, 122:2440-2446.
20. Hirose N., Doi F., Ueki T., Akazawa K., Chijiiwa K., Sugano M., Akimoto K., Shimizu S., Yamada H. Suppressive effect of sesamin against 7,12-dimethylbenz[a]-anthracene induced rat mammary carcinogenesis. Anticancer Res. 1992, 12:1259-1266.
21. Yamada Y., Obayashi M., Ishikawa T., Kiso Y., Ono Y., Yamashita K. Dietary tocotrienol reduces UVB-induced skin damage and sesamin enhances tocotrienol effects in hairless mice. J. Nutr. Sci. Vitaminol. 2008, 54:117-123.
22. Rajas-Molina M., Campos-Sánchez J., Analla M., Muñoz-Serrano A., Alonso-Moraga A. Genotoxicity of vegetable cooking oils in the drosophila wing spot test. Environ. Mol. Mutagen. 2005, 45:90-95.
23. Maron D.M., Ames B.N. Revised methods for the Salmonella mutagenicity test. Mutat. Res. 1983, 113:173-215.
24. Organization for Economic Co-operation and Development(OECD), OECD guideline for testing of chemicals, no. 471,Genetic Toxicology: Bacterial Reverse Mutation Test, 1997.
25. Gatehouse D., Haworth S., Cebula T., Gocke E., Kier L., Matsushima T., Melcion C., Nohmi T., Ohta T., Venitt S., Zeiger E. Recommendations for the performance of bacterial mutation assays. Mutat. Res. 1994, 312:217-233.
26. Ishidate M. Chromosome aberration tests in vitro for chemical mutagens in our environment. Tissue Cult. 1979, 5:115-122.
27. Organisation for Economic Co-operation and the Development (OECD), OECD Guideline for the testing of chemicals, no. 473, Genetic Toxicology: In Vitro Mammalian Chromosome Aberration Test, 1997.
28. Organization for Economic Co-operation and Development(OECD), OECD guideline for the testing of chemicals, no. 474,Genetic Toxicology: Mammalian Erythrocyte Micronucleus Test, 1997.
29. Kastenbaum M.A., Bowman K.O. Tables for determining the statistical significance of mutation frequencies. Mutat. Res. 1970, 9:527-549.
30. Hartmann A., Agurell E., Beevers C., Brendler-Schwaab S., Burlinson B., Clay P., Collins A., Smith A., Speit G., Thybaud V., Tice R.R. Recommendations for conducting the in vivo alkaline Comet assay. Mutagenesis 2003, 18:45-51.
31. Burlinson B., Tice R.R., Speit G., Agurell E., Brendler-Schwaab S.Y., Collins A.R., Escobar P., Honma M., Kumaravel T.S., Nakajima M., Sasaki Y.F., Thybaud V., Uno Y., Vasquez M., Hartmann A. Fourth international workgroup on genotoxicity testing: results of the in vivo Comet assay workgroup. Mutat. Res. 2007, 627:31-35.
32. Tice R.R., Agurell E., Anderson D., Burlinson B., Hartmann A., Kobayashi H., Miyamae Y., Rojas E., Ryu J.-C., Sasaki Y.F. Single cell gel/Comet assay: guidelines for in vitro and in vivo genetic toxicology testing. Environ. Mol. Mutagen. 2000, 35:206-221.
33. Hilliard C.A., Armstrong M.J., Bradt C.I., Hill R.B., Greenwood S.K., Galloway S.M. Chromosome aberrations in vitro related to cytotoxicity of nonmutagenic chemicals and metabolic poisons. Environ. Mol. Mutagen. 1998, 31:316-326.
34. Clement M.V., Long L.H., Ramalingam J., Halliwell B. The cytotoxicity of dopamine may be an artefact of cell culture. J. Neurochem. 2002, 81:414-421.
35. Long L.H., Clement M.V., Halliwell B. Artifacts in cell culture: rapid generation of hydrogen peroxide on addition of (-)-epigallocatechin, (-)-epigallocatechin gallate, (+)-catechin, and quercetin to commonly used cell culture media. Biochem. Biophys. Res. Commun. 2000, 273:50-53.
36. Furukawa A., Oikawa S., Murata M., Hiraku Y., Kawanishi S. (-)-Epigallocatechin gallate causes oxidative damage to isolated and cellular DNA. Biochem. Pharmacol. 2003, 66:1769-1778.
37. Elbling L., Weiss R.M., Teufelhofer O., Uhl M., Knasmueller S., Schulte-Hermann R., Berger W., Micksche M. Green tea extract and (-)-epigallocatechin-3-gallate, the major tea catechin, exert oxidant but lack antioxidant activities. FASEB J. 2005, 19:807-809.
38. Long L.H, Kirkland D., Whitwell J., Halliwell B. Different cytotoxic and clastogenic effects of epigallocatechin gallate in various cell-culture media due to variable rates of its oxidation in the culture medium. Mutat Res. 2007, 634:177-183.
39. Takumi-Kobayashi A., Ogura R., Morita O., Nishiyama N., Kasamatsu T. Involvement of hydrogen peroxide in chromosomal aberrations induced by green tea catechins in vitro and implications for risk assessment. Mutat. Res. 2008, 657:13-18.
40. Metodiewa D., Jaiswal A.K., Cenas N., Dickancaité E., Segura-Aguilar J. Quercetin may act as a cytotoxic prooxidant after its metabolic activation to semiquinone and quinoidal product. Free Radic. Biol. Med. 1999, 26:107-116.
41. Boots A.W., Kubben N., Haenen G.R.M.M., Bast A. Oxidized quercetin reacts with thiols rather than with ascorbate: implication for quercetin supplementation. Biochem. Biophys. Res. Commun. 2003, 308:560-565.
42. Lambert J.D., Sang S., Yang C.S. Possible controversy over dietary polyphenols: benefits vs risks. Chem. Res. Toxicol. 2007, 20:583-585.
43. Yoshino M., Haneda M., Naruse M., Murakami K. Prooxidant activitiy of flavonoids: copper-dependent strand breaks and the formation of 8-hydroxy-2'-deoxyguanosine in DNA. Mol. Genet. Metab. 1999, 68:468-472.
44. Ogura R., Ikeda N., Yuki K., Morita O., Saigo K., Blackstock C., Nishiyama N., Kasamatsu T. Genotoxicity studies on green tea catechin. Food Chem. Toxicol. 2008, 46:2190-2200.
45. Chang P.Y., Mirsalis J., Riccio E.S., Bakke J.P., Lee P.S., Shimon J., Phillips S., Fairchild D., Hara Y., Crowell J.A. Genotoxicity and toxicity of the potential cancer-preventive agent Polyphenon E. Environ. Mol. Mutagen. 2003, 41:43-54.
46. Isbrucker R.A., Bausch J., Edwards J.A., Wolz E. Safety studies on epigallocatechin gallate (EGCG) preparations. Part 1: genotoxicity. Food Chem. Toxicol. 2006, 44:626-635.
47. Wada K., Matsumoto K. Mutagenic activity of tea flavonoid (-)-Epigallocatechin in bacterial and mammalian cells. Genes Environ. 2009, 31:37-42.
48. Utesch D., Feige K., Dasenbrock J., Broschard T.H., Harwood M., Danielewska-Nikiel B., Lines T.C. Evaluation of the potential in vivo genotoxicity of quercetin. Mutat. Res. 2008, 654:38-44.
49. Laughton M.J., Halliwell B., Evans P.J., Hoult J.R.S. Antioxidant and pro-oxidant actions of the plant phenolics quercetin, gossypol and myricetin. Biochem. Pharmacol. 1989, 38:2859-2865.
50. Matsuoka A., Furuta A., Ozaki M., Fukuhara K., Miyata N. Resveratrol, a naturally occurring polyphenol, induces sister chromatid exchanges in a Chinese hamster lung (CHL) cell line. Mutat. Res. 2001, 494:107-113.
51. Matsuoka A., Takeshita K., Furuta A., Ozaki M., Fukuhara K., Miyata N. The 4'-hydroxy group is responsible for the in vitro cytogenetic activity of resveratrol. Mutat. Res. 2002, 521:29-35.
52. Ullah Z., Lee C.Y., Lilly M.A., DePamphilis M.L. Developmentally programmed endoreduplication in animals. Cell Cycle 2009, 8:1501-1509.
53. Sutou S. The mechanisms of endoreduplication. Cancer Genet. Cytogenet. 1981, 3:317-325.
54. Neukam K., Pastor N., Cortés F. Tea flavanols inhibit cell growth and DNA topoisomerase II activity and induce endoreduplication in cultured Chinese hamster cells. Mutat. Res. 2008, 654:8-12.
55. Anderson D., Yu T.W., McGregor D.B. Comet assay responses as indicators of carcinogen exposure. Mutagenesis 1998, 13:539-555.
56. Kirkland D., Speit G. Evaluation of the ability of a battery of three in vitro genotoxicity tests to discriminate rodent carcinogens and non-carcinogens III. Appropriate follow-up testing in vivo. Mutat. Res. 2008, 654:114-132.
57. Peñalvo J.L., Heinonen S., Aura A., Adlercreutz H. Dietary is converted to enterolactone in humans. J. Nutr. 2005, 135:1056-1062.