Antihypertensive effects of sesamin in humans

Journal of Nutritional Science and Vitaminology

Volumn 55, Issue 1, 2009, Pages 87-91

  Miyawaki, Takashi ^a   Aono, Hideshi ^a   Toyoda Ono, Yoshiko ^b   Maeda, Hirofumi ^b   Kiso, Yoshinobu ^b   Moriyama, Kenji ^c  

^a 11 40 Hijiyamahonmachi   (Japan)

^b SUNTORY LTD   (Japan)

^c MUKOGAWA WOMEN'S UNIVERSITY   (Japan)

Author keywords

Antihypertensive effects; Cross over study; Double blind; Hypertension; Sesamin

Indexed keywords

PLACEBO; SESAMIN; 1,3 DIOXOLANE DERIVATIVE; ANTIHYPERTENSIVE AGENT; LIGNAN; PLANT EXTRACT;

ABSENCE OF SIDE EFFECTS; ADULT; AGE DISTRIBUTION; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BLOOD PRESSURE; BODY MASS; CARDIOVASCULAR DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIASTOLIC BLOOD PRESSURE; DOUBLE BLIND PROCEDURE; DRUG CAPSULE; DRUG STRUCTURE; FEMALE; HUMAN; HYPERTENSION; LOW DRUG DOSE; MALE; SYSTOLIC BLOOD PRESSURE; DRUG EFFECT; MIDDLE AGED; PHYTOTHERAPY; PLANT SEED; SESAME;

RATTUS; SESAMUM INDICUM;

ANTIHYPERTENSIVE AGENTS; BLOOD PRESSURE; DIOXOLES; DOUBLE-BLIND METHOD; FEMALE; HUMANS; HYPERTENSION; LIGNANS; MALE; MIDDLE AGED; PHYTOTHERAPY; PLANT EXTRACTS; SEEDS; SESAMUM;

EID: 66849140882     PISSN: 03014800     EISSN: 18817742     Source Type: Journal    
DOI: 10.3177/jnsv.55.87     Document Type: Article

References (32)

1. Fukuda Y, Nagata M, Osawa T, Namiki M. 198 6. Contribution of lignan analogues to antioxidative activity of refined unroasted sesame seed oil. J Am Oil Chem Soc 63: 1027-1031.
2. Nakai M, Harada M, Nakahara K, Akimoto K, Shibata H, Miki W, Kiso Y. 2003. Novel antioxidative metabolites in rat liver with ingested sesamin. J Agric Food Chem 51: 1666-1670.
3. Ikeda T, Nishijima Y, Shibata H, Kiso Y, Ohnuki K, Fushiki T, Moritani T. 2003. Protective effect of sesamin administration on exercise induced lipid peroxidation. Int J Sports Med 24: 530-534.
4. Hirose N, Inoue T, Nishihara K, Sugano M, Akimoto K, Shimizu S, Yamada H. 1991. Inhibition of cholesterol absorption and synthesis in rats by sesamin. J Lipid Res 32: 629-638.
5. Hirata F, Fujita K, Ishikura Y, Hosoda K, Ishikawa T, Nakamura H. 1996. Hypocholesterolemic effect of sesame lignan in humans. Atherosclerosis 122: 135-136.
6. Nakabayashi A, Kitagawa Y, Suwa Y, Akimoto K, Asami S, Shimizu S, Hirose N, Sugano M, Yamada H. 1995. alpha-Tocopherol enhances the hypocholesterolemic action of sesamin in rats. Int J Vitam Nutr Res 65: 162-168.
7. Ogawa H. Sasagawa S, Murakami T, Yoshizumi H. 1995. Sesame lignans modulate cholesterol metabolism in the stroke-prone spontaneously hypertensive rat. Clin Exp Pharmacol Physiol 22: S310-312.
8. Kiso Y. 2004. Antioxidative roles of sesamin, a functional lignan in sesame seed, and its effect on lipid-and alcohol-metabolism in the liver: A DNA microarray study. Biofactors 21: 191-196.
9. Akimoto K, Kitabawa Y, Akamatsu T, Hirose N, Sugano M, Shimizu S, Yamada H. 1993. Protective effects of sesamin against liver damage caused by alcohol or carbon tetrachloride in rodents. Ann Nutr Metab 37: 218-224.
10. Kiso Y, Tsuruoka N, Kidokoro A, Matsumoto I, Abe K. 2005. Sesamin ingestion regulates the transcription levels of hepatic metabolizing enzymes for alcohol and lipids in rats. Alcohol Clin Exp Res 29: 116S-120S.
11. Yamashita K, Kagaya M, Higuchi N, Kiso Y. 2000. Sesamin and alfa-tocopherol synergistically suppress lipidperoxide in rats fed with a high docosahexaenoic acid diet. Biofactors 11: 11-13.
12. Kamal-Eldin A, Pettersson D, Appelqvist LA. 199 5. Sesamin (a compound from sesame oil) increases tocopherol levels in rats fed ad libitum. Lipids 30: 499-505.
13. Frank J, Kamal-Eldin A, Traber MG. 2004. Consumption of sesame oil muffins decreases the urinary excretion of gamma-tocopherol metabolities in humans. Ann NY Acad Sci 1031: 365-367.
14. Frank J, Lee S, Leonard SW, Atkinson JK, Kamal-Eldin A, Traber MG. 2008. Sex differences in the inhibition of gamma-tocopherol metabolism by a single dose of dietary sesame oil in healthy subjects. Am J Clin Nutr 87: 1723-1729.
15. Hirose N, Doi F, Ueki T, Akazawa K, Chijiiwa K, Sugano M, Akimoto K, Shimizu S, Yamada H. 1992. Suppressive effect of sesamin against 7,12-dimethylbenz[a]-anthracene induced rat mammary carcinogenesis. Anticancer Res 12: 1259-1265.
16. Miyahara Y, Komiya T, Katsuzaki H, Imai K, Nakagawa M, Ishii Y, Hibasami H. 2000. Sesamin and episesamin induce apoptosis in human lymphoid leukemia. Int J Mol Med 6: 43-46.
17. Peñalvo JL, Heinonen SM, Aura AM, Adlercreutz H. 2005. Dietary sesamin is converted to enterolactone in humans. J Nutr 135: 1056-1062.
18. Liu Z, Saarinen NM, Thompson LU. 2006. Sesamin is one of the major precursors of mammalian lignans in sesame seed (Sesamum indicum) as observed in vitro and in rats. J Nutr 136: 906-912.
19. Matsumura Y, Kita S, Morimoto S, Akimoto K, Furuya M, Oka N, Tanaka T. 1995. Antihypertensive effect of sesamin. I. Protection against deoxycorticosterone acetate-salt-induced hypertension and cardiovascular hypertrophy. Biol Pharm Bull 18: 1016-1019.
20. Kita S, Matsumura Y, Morimoto S, Akimoto K, Furuya M, Oka N, Tanaka T. 1995. Antihypertensive effect of sesamin. II. Protection against two-kidney, one-clip renal hypertension and cardiovascular hypertrophy. Biol Pharm Bull 18: 1283-1285.
21. Matsumura Y, Kita S, Tanida Y, Taguchi Y, Morimoto S, Akimoto K, Tanaka T. 1998. Antihypertensive effect of sesamin. III. Protection against development and maintenance of hypertension in stroke-prone spontaneously hypertensive rats. Biol Pharm Bull 21: 469-473.
22. Noguchi T, Ikeda K, Sasaki Y, Yamamoto J, Seki J, Yamagata K, Nara Y, Hara H, Kakuta H, Yamori Y. 2001. Effects of vitamin E and sesamin on hypertension and cerebral thrombogensis in stroke-prone spontaneously hypertensive rats. Hypertens Res 24: 735-742.
23. Nakano D, Itoh C, Takaoka M, Kiso Y, Tanaka T, Matsumura Y. 2002. Antihypertensive effect of sesamin. IV. Inhibition of vascular superoxide production by sesamin. Biol Pharm Bull 25: 1247-1249.
24. Nakano D, Itoh C, Ishii F, Kawanishi H, Takaoka M, Kiso Y, Tsuruoka N, Tanaka T, Matsumura Y. 2003. Effects of sesamin on aortic oxidative stress and endothelial dysfunction in deoxycorticosterone acetate-salt hypertensive rats. Biol Pharm Bull 26: 1701-1705.
25. Lee CC, Chen PR, Lin S, Tsai SC, Wang BW, Chen WW, Tsai CE, Shyu KG. 2004. Sesamin induces nitric oxide and decreases endothelin-1 production in HUVECs: possible implications for its antihypertensive effect. J Hypertens 22: 2329-2338.
26. Nakano D, Takaoka M, Kiso Y, Matsumura Y. 2004. Antihypertensive effect of sesamin. Vasc Dis Prev 1: 233-241.
27. Moritani T, Hamada T, Kimura T, Hayashi T, Kiso Y. 2003. Changes in cardiac autonomic activities and antioxidant effects of sesamin during smoking. Med Sci Sports Exerc 35: S269.
28. Stamler J, Rose G, Stamler R, Elliott P, Dyer A, Marmot M. 1989. INTERSALT study findings. Public health and medical care implications. Hypertension 14: 570-577.
29. Japanese Society of Hypertension. 2006. Epidemiology of hypertension. Japanese society of hypertension guidelines for the management of hypertension (JSH 2004). Hypertens Res 29 (Suppl): S1-S6.
30. Zalba G, Josè GS, Moreno MU, Fortuño MA, Fortuño A, Beaumont FJ, Díez J. 2001. Oxidative stress in arterial hypertension. Role of NAD(P)H oxidase. Hypertension 38: 1395-1399.
31. Nakano D, Kwak CJ, Fujii K, Ikemura K, Satake A, Ohkita M, Takaoka M, Ono Y, Nakai M, Tomimorí N, Kiso Y, Matsumura Y. 2006. Sesamin metabolites induce an endothelial nitric oxide-dependent vasorelaxation through their antioxidative property-independent mechanisms: Possible involvement of the metabolites in the antihypertensive effect of sesamin. J Pharm Exp Ther 318: 328-335.
32. Kushiro M, Masaoka T, Hageshita S, Takahashi Y, Ide T, Sugano M. 2002. Comparative effect of sesamin and episesamin on the activity and gene expression of enzymes in fatty acid oxidation and synthesis in rat liver. J Nutr Biochem 13: 289-295.