Transcription linked to recombination: A gene-internal promoter coincides with the recombination hot spot II of the human MLL gene

Oncogene

Volumn 26, Issue 10, 2007, Pages 1361-1371

  Scharf, S ^a   Zech, J ^a   Bursen, A ^a   Schraets, D ^a,e   Oliver, P L ^b   Kliem, S ^c   Pfitzner, E ^c,f   Gillert, E ^d   Dingermann, T ^a   Marschalek, R ^a,e  

^a GOETHE UNIVERSITY   (Germany)

^b UNIVERSITY OF OXFORD   (United Kingdom)

^c INSTITUTE FOR TUMOR BIOLOGY AND EXPERIMENTAL THERAPY   (Germany)

^d Procompliance Verlag GmbH   (Germany)

^e YES Pharmaceutical Development Services   (Germany)

^f FRIEDRICH SCHILLER UNIVERSITY JENA   (Germany)

Author keywords

Acute leukaemia; Gene internal promoter; MLL gene; Transcription

Indexed keywords

MESSENGER RNA; MIXED LINEAGE LEUKEMIA PROTEIN; RNA POLYMERASE II;

ACUTE LEUKEMIA; ARTICLE; BINDING SITE; CHROMOSOME TRANSLOCATION; CONTROLLED STUDY; DNA STRAND BREAKAGE; EMBRYO; GENETIC RECOMBINATION; GENETIC TRANSCRIPTION; GENOMIC INSTABILITY; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; TRANSCRIPTION INITIATION SITE;

ANIMALS; CHROMATIN; ETOPOSIDE; HUMANS; MICE; MYELOID-LYMPHOID LEUKEMIA PROTEIN; PROMOTER REGIONS (GENETICS); RECOMBINATION, GENETIC; RNA POLYMERASE II; TRANSCRIPTION, GENETIC;

EID: 33847400116     PISSN: 09509232     EISSN: 14765594     Source Type: Journal    
DOI: 10.1038/sj.onc.1209948     Document Type: Article

References (28)

1. Andersen MK, Christiansen DH, Jensen BA, Ernst P, Hauge G, Pedersen-Bjergaard J. (2001). Therapy-related acute lymphoblastic leukaemia with MLL rearrangements following DNA topoisomerase II inhibitors, an increasing problem: report on two new cases and review of the literature since 1992. Brit J Haematol 114: 539-543.
2. Aplan PD, Chervinsky DS, Stanulla M, Burhans WC. (1996). Site-specific DNA cleavage within the MLL breakpoint cluster region induced by topoisomerase II inhibitors. Blood 87: 2649-2658.
3. Betti CJ, Villalobos MJ, Diaz MO, Vaughan AT. (2001). Apoptotic triggers initiate translocations within the MLL gene involving the nonhomologous end joining repair system. Cancer Res 61: 4550-4555.
4. Betti CJ, Villalobos MJ, Jiang Q, Cline E, Diaz MO, Loredo G et al. (2005). Cleavage of the MLL gene by activators of apoptosis is independent of topoisomerase II activity. Leukemia 19: 2289-2295.
5. Blackwell TK, Moore MW, Yancopoulos GD, Suh H, Lutzker S, Selsing E et al. (1986). Recombination between immunoglobulin variable region gene segments is enhanced by transcription. Nature 324: 585-589.
6. Broeker PL, Super HG, Thirman MJ, Pomykala H, Yonebayashi Y, Tanabe S et al. (1996). Distribution of 11q23 breakpoints within the MLL breakpoint cluster region in de novo acute leukemia and in treatment-related acute myeloid leukemia: correlation with scaffold attachment regions and topoisomerase II consensus binding sites. Blood 87: 1912-1922.
7. Calin GA, Sevignani C, Dumitru CD, Hyslop T, Noch E, Yendamuri S et al. (2004). MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias. Proc Natl Acad Sci USA 101: 2999-3004.
8. Felix CA, Walker AH, Lange BJ, Williams TM, Winick NJ, Cheung NK et al. (1998). Association of CYP3A4 genotype with treatment-related leukemia. Proc Natl Acad Sci USA 95: 13176-13181.
9. Gillert E, Leis T, Repp R, Reichel M, Hösch A, Breitenlohner I et al. (1999). A DNA damage repair mechanism is involved in the origin of chromosomal translocations t(4;11) in primary leukemic cells. Oncogene 18: 4663-4671.
10. Goto H, Shimazaki C, Tatsumi T, Yamagata N, Inaba T, Fujita N et al. (1994). Acute myelomonocytic leukemia after treatment with chronic oral etoposide: are MLL and LTG9 genes targets for etoposide? Int J Hematol 60: 145-149.
11. Hsieh JJ, Cheng EH, Korsmeyer SJ. (2003). Taspase1: a threonine aspartase required for cleavage of MLL and proper HOX gene expression. Cell 115: 293-303.
12. Khobta A, Carlo-Stella C, Capranico G. (2004). Specific histone patterns and acetylase/deacetylase activity at the breakpoint-cluster region of the human MLL gene. Cancer Res 64: 2656-2662.
13. Libura J, Slater DJ, Felix CA, Richardson C. (2005). Therapy-related acute myeloid leukemia-like MLL rearrangements are induced by etoposide in primary human CD34+ cells and remain stable after clonal expansion. Blood 105: 2124-2131.
14. Margueron R, Trojer P, Reinberg D. (2005). The key to development: interpreting the histone code? Curr Opin Genet Dev 15: 163-176.
15. Mitterbauer-Hohendanner G, Mannhalter C. (2004). The biological and clinical significance of MLL abnormalities in haematological malignancies. Eur J Clin Invest 34: 12-24.
16. Nakamura T, Mori T, Tada S, Krajewski W, Rozovskaia T, Wassell R et al. (2002). ALL-1 is a histone methyltransferase that assembles a supercomplex of proteins involved in transcriptional regulation. Mol Cell 10: 1119-1128.
17. Nasr F, Macintyre E, Venuat AM, Bayle C, Carde P, Ribrag V. (1997). Translocation t(4;11)(q21;q23) and MLL gene rearrangement in acute lymphoblastic leukemia secondary to anti topoisomerase II anticancer agents. Leuk Lymphoma 25: 399-401.
18. Quandt K, Frech K, Karas H, Wingender E, Werner T. (1995). MatInd and MatInspector: new fast and versatile tools for detection of consensus matches in nucleotide sequence data. Nucl Acids Res 23: 4878-4884.
19. Rabbitts TH. (1994). Chromosomal translocations in human cancer. Nature 372: 143-149.
20. Reichel M, Gillert E, Angermüller S, Hensel JP, Heidel F, Lode M et al. (2001). Biased distribution of chromosomal breakpoints involving the MLL gene in infants versus children and adults with t(4;11) ALL. Oncogene 20: 2900-2907.
21. Reichel M, Gillert E, Nilson I, Siegler G, Greil J, Fey GH et al. (1998). Fine structure of translocation breakpoints in leukemic blasts with chromosomal translocation t(4;11): the DNA damage-repair model of translocation. Oncogene 17: 3035-3044.
22. Richardson C, Jasin M. (2000). Frequent chromosomal translocations induced by DNA double-strand breaks. Nature 405: 697-700.
23. Sim SP, Liu LF. (2001). Nucleolytic cleavage of the mixed lineage leukemia breakpoint cluster region during apoptosis. J Biol Chem 276: 31590-31595.
24. Stanulla M, Wang J, Chervinsky DS, Thandla S, Aplan PD. (1997). DNA cleavage within the MLL breakpoint cluster region is a specific event which occurs as part of higher-order chromatin fragmentation during the initial stages of apoptosis. Mol Cell Biol 17: 4070-4079.
25. Strissel PL, Strick R, Rowley JD, Zeleznik-Le NJ. (1998). An in vivo topoisomerase II cleavage site and a DNase I hypersensitive site colocalize near exon 9 in the MLL breakpoint cluster region. Blood 92: 3793-3803.
26. Uhl J, Klan N, Rose M, Entian KD, Werz O, Steinhilber D. (2002). The 5-lipoxygenase promoter is regulated by DNA methylation. J Biol Chem 277: 4374-4379.
27. Yokoyama A, Kitabayashi I, Ayton PM, Cleary ML, Ohki M. (2002). Leukemia proto-oncoprotein MLL is proteolytically processed into 2 fragments with opposite transcriptional properties. Blood 100: 3710-3718.
28. Yu BD, Hess JL, Horning SE, Brown GA, Korsmeyer SJ. (1995). Altered Hox expression and segmental identity in Mll-mutant mice. Nature 378: 505-508.