Tuning the drug efflux activity of an ABC transporter in vivo by in vitro selected DARPin binders

PLoS ONE

Volumn 7, Issue 6, 2012, Pages

  Seeger, Markus A ^a,b   Mittal, Anshumali ^b   Velamakanni, Saroj ^a   Hohl, Michael ^b   Schauer, Stefan ^b   Salaa, Ihsene ^a   Grütter, Markus G ^b   van Veen, Hendrik W ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

^b UNIVERSITY OF ZURICH   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ABC TRANSPORTER; DESIGNED ANKYRIN REPEAT PROTEIN; MEMBRANE PROTEIN; PROTEOLIPOSOME; UNCLASSIFIED DRUG; ADENOSINE TRIPHOSPHATASE; ANKYRIN; DAUNORUBICIN; DETERGENT; DRUG; EPITOPE; PROTEOLIPID; PROTEOLIPOSOMES; RECOMBINANT PROTEIN;

ARTICLE; CONTROLLED STUDY; DRUG TRANSPORT; ENZYME SPECIFICITY; GEL PERMEATION CHROMATOGRAPHY; HYDROLYSIS; IN VITRO STUDY; IN VIVO STUDY; LACTOCOCCUS LACTIS; MOLECULAR MECHANICS; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN PURIFICATION; STOICHIOMETRY; SURFACE PLASMON RESONANCE; BIOPHYSICS; CELL MEMBRANE; DRUG EFFECT; ENZYME LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; IMMUNOLOGY; METABOLISM; RIBOSOME; SOLUBILITY; TRANSPORT AT THE CELLULAR LEVEL;

LACTOCOCCUS LACTIS;

ADENOSINE TRIPHOSPHATASES; ANKYRIN REPEAT; ATP-BINDING CASSETTE TRANSPORTERS; BIOLOGICAL TRANSPORT; BIOPHYSICAL PHENOMENA; CELL MEMBRANE; DAUNORUBICIN; DETERGENTS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; EPITOPES; LACTOCOCCUS LACTIS; PHARMACEUTICAL PREPARATIONS; PROTEIN BINDING; PROTEOLIPIDS; RECOMBINANT PROTEINS; RIBOSOMES; SOLUBILITY; SURFACE PLASMON RESONANCE;

EID: 84861848310     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0037845     Document Type: Article

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