An ABC transporter with a secondary-active multidrug translocator domain

Nature

Volumn 426, Issue 6968, 2003, Pages 866-870

  Venter, Henrietta ^a   Shilling, Richard A ^a   Velamakanni, Saroj ^a   Balakrishnan, Lekshmy ^a   Van Veen, Hendrik W ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINETRIPHOSPHATE; CELL MEMBRANES; ELECTROCHEMISTRY; EXTRUSION; HYDROLYSIS; PROTEINS; SUBSTRATES;

MULTIDRUG RESISTANCE;

DRUG PRODUCTS;

ABC TRANSPORTER; CARRIER PROTEIN; ETHIDIUM; GLYCOPROTEIN P; PROTEIN LMRA; UNCLASSIFIED DRUG;

BIOLOGY;

ARTICLE; CROSS LINKING; CYTOTOXICITY; DRUG TRANSPORT; ELECTROCHEMICAL ANALYSIS; ENERGY TRANSFER; LACTOCOCCUS LACTIS; MULTIDRUG RESISTANCE; PHOTOAFFINITY LABELING; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN HYDROLYSIS; PROTON MOTIVE FORCE; PROTON TRANSPORT;

ADENOSINE TRIPHOSPHATE; ATP-BINDING CASSETTE TRANSPORTERS; BACTERIAL PROTEINS; BINDING SITES; BIOLOGICAL TRANSPORT, ACTIVE; DRUG RESISTANCE, MULTIPLE; ETHIDIUM; HUMANS; HYDROGEN-ION CONCENTRATION; LACTOCOCCUS LACTIS; MEMBRANE POTENTIALS; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; PROTEIN STRUCTURE, TERTIARY; PROTON-MOTIVE FORCE; PROTONS; SEQUENCE DELETION;

LACTOCOCCUS; LACTOCOCCUS LACTIS; POSIBACTERIA; STREPTOCOCCUS;

EID: 0346096509     PISSN: 00280836     EISSN: None     Source Type: Journal    
DOI: 10.1038/nature02173     Document Type: Article

References (26)

1. Ambudkar, S. V. et al. Biochemical, cellular and pharmacological aspects of the multidrug transporter. Annu. Rev. Pharmacol. Toxicol. 39, 361-398 (1999).
2. Higgins, C. F. ABC transporters: from microorganisms to man. Annu. Rev. Cell Biol. 8, 67-113 (1992).
3. Paulsen, I. T., Brown, M. H. & Skurray, R. A. Proton-dependent multidrug efflux systems. Microbiol. Rev. 60, 575-608 (1996).
4. Van Veen, H. W. et al. Multidrug resistance mediated by a bacterial homolog of the human drug transporter MDR1. Proc. Natl Acad. Sci. USA 93, 10668-10672 (1996).
5. Van Veen, H. W. et al. A bacterial antibiotic-resistance gene that complements the human multidrug-resistance P-glycoprotein gene. Nature 391, 291-295 (1998).
6. Van Veen, H. W. et al. The homodimeric ATP-binding cassette transporter LmrA mediates multidrug transport by an alternating two-site (two-cylinder engine) mechanism. EMBO J. 19, 2503-2514 (2000).
7. Chang, G. & Roth, C. B. The structure of MsbA from E. coli: a homolog of the multidrug resistance ATP binding cassette (ABC) transporters. Science 293, 1793-1800 (2001).
8. Chang, G. Structure of MsbA from Vibrio cholera: a multidrug resistance ABC transporter homolog in a closed conformation. J. Mol. Biol. 330, 419-430 (2003).
9. Putman, M., Van Veen, H. W., Degener, J. E. & Konings, W. N. Antibiotic resistance: era of the multidrug pump. Mol. Microbiol. 36, 772-774 (2000).
10. Kaback, H. R. in The Bacteria Vol. 12 (Bacterial Energetics) (ed. Krulwich, T. A.) 151-193 (Academic, London, 1990).
11. Sharom, F. J., Yu, X. & Doige, C. A. Functional reconstitution of drug transport and ATPase activity in proteoliposomes containing partially purified P-glycoprotein. J. Biol. Chem. 268, 24197-24202 (1993).
12. Eytan, G. D., Regev, R. & Assaraf, Y. G. Functional reconstitution of P-glycoprotein reveals an apparent near stoichiometric drug transport to ATP hydrolysis. J. Biol. Chem. 271, 3172-3178 (1996).
13. Booth, I. R. Regulation of cytoplasmic pH in bacteria. Microbiol. Rev. 49, 359-378 (1985).
14. Kroll, R. G. & Booth, I. R. The relationship between intracellular pH, the pH gradient and potassium-transport in Escherichia coli. Biochem. J. 216, 709-716 (1983).
15. Bakker, E. P. Alkali Cation Transport Systems in Prokaryotes (CRC Press, Florida, 1993).
16. Thiebaut, F. et al. Activity of the multidrug transporter results in alkalinization of the cytosol: measurement of cytosolic pH by microinjection of a pH-sensitive dye. J. Histochem. Cytochem. 38, 685-690 (1990).
17. Landwojtowicz, E., Nervi, P. & Seelig, A. Real-time monitoring of P-glycoprotein activation in living cells. Biochemistry 41, 8050-8057 (2002).
18. +transport mediated by human MDR1 protein. Biochemistry 38, 4227-4234 (1999).
19. Howard, E. M. & Roepe, P. D. Purified human MDR1 modulates membrane potential in reconstituted proteoliposomes. Biochemistry 42, 3544-3555 (2003).
20. Kuroda, M., Dey, S., Sanders, O. I. & Rosen, B. P. Alternate energy coupling of ArsB, the membrane subunit of the Ars anion-translocating ATPase. J. Biol. Chem. 272, 326-331 (1997).
21. Margolles, A., Putman, M., Van Veen, H. W. & Konings, W. N. The purified and functionally reconstituted multidrug transporter LmrA of Lactococcus lactis mediates the transbilayer movement of specific fluorescent phospholipids. Biochemistry 38, 16298-16306 (1999).
22. Reuter, G. et al. The ATP-binding cassette multidrug transporter LmrA and lipid transporter MsbA have overlapping substrate specificities. J. Biol. Chem. 278, 35193-35198 (2003).
23. Janvilisri, T. et al. Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis. J. Biol. Chem. 278, 20645-20651 (2003).
24. Breeuwer, P., Drocourt, J., Rombouts, F. M. & Abee, T. A novel method for continuous determination of the intracellular pH in bacteria with the internally conjugated fluorescent probe 5 (and 6-)-carboxyfluorescein succinimidyl ester. Appl. Environ. Microbiol. 62, 178-183 (1996).
25. Novo, D., Perlmutter, N. G., Hunt, R. H. & Shapiro, H. M. Accurate flow cytometric membrane potential measurement in bacteria using diethyloxacarbocyanine and a ratiometric technique. Cytometry 35, 55-63 (1999).
26. Van Veen, H. W., Abee, T., Kortstee, G. J. J., Konings, W. N. & Zehnder, A. J. B. Mechanism and energetics of the secondary phosphate transport system of Acinetobacter johnsonii 210A. J. Biol. Chem. 268, 19377-19383 (1993).