A mutation of the H-loop selectively affects rhodamine transport by the yeast multidrug ABC transporter Pdr5

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 13, 2008, Pages 5069-5074

  Ernst, Robert ^a   Kueppers, Petra ^a   Klein, Cornelia M ^b   Schwarzmueller, Tobias ^b   Kuchler, Karl ^b   Schmitt, Lutz ^a  

^a HEINRICH HEINE UNIVERSITY   (Germany)

^b MEDICAL UNIVERSITY OF VIENNA   (Austria)

Author keywords

ATPase activity; Multidrug resistance; Substrate recognition

Indexed keywords

ABC TRANSPORTER; ADENOSINE TRIPHOSPHATASE; ADENOSINE TRIPHOSPHATE; AMINO ACID; CYCLOHEXIMIDE; FLUCONAZOLE; GLUTAMIC ACID; GLYCOPROTEIN P; HISTIDINE; KETOCONAZOLE; PROTEIN PDR5; RHODAMINE; PDR5 PROTEIN, S CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEIN; UNCLASSIFIED DRUG;

ANTIFUNGAL RESISTANCE; ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG TRANSPORT; ENZYME ACTIVITY; ENZYME SUBSTRATE COMPLEX; HYDROLYSIS; MULTIDRUG RESISTANCE; MUTATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; SACCHAROMYCES CEREVISIAE; CELL MEMBRANE; CHEMISTRY; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NUCLEOTIDE SEQUENCE; PHENOTYPE; PROTEIN MOTIF; SEQUENCE ALIGNMENT;

MAMMALIA;

ADENOSINE TRIPHOSPHATASES; AMINO ACID MOTIFS; ATP-BINDING CASSETTE TRANSPORTERS; CELL MEMBRANE; CONSERVED SEQUENCE; GENE EXPRESSION REGULATION, FUNGAL; HYDROLYSIS; MUTATION; PHENOTYPE; RHODAMINES; SACCHAROMYCES CEREVISIAE; SACCHAROMYCES CEREVISIAE PROTEINS; SEQUENCE ALIGNMENT;

EID: 42449109037     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0800191105     Document Type: Article

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