Bispecific Designed Ankyrin Repeat Proteins (DARPins) targeting epidermal growth factor receptor inhibit A431 cell proliferation and receptor recycling

Journal of Biological Chemistry

Volumn 286, Issue 48, 2011, Pages 41273-41285

  Boersma, Ykelien L ^a   Chao, Ginger ^b,c   Steiner, Daniel ^a,d   Wittrup, K Dane ^b   Pluc̈kthun, Andreas ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c BRISTOL MYERS SQUIBB RESEARCH AND DEVELOPMENT   (United States)

^d MOLECULAR PARTNERS AG   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ANKYRIN; BIOLOGICAL EFFECTS; CELL VIABILITY; CETUXIMAB; CLINICAL EFFICACY; DIFFERENT DOMAINS; EPIDERMAL GROWTH FACTOR RECEPTORS; FLEXIBLE LINKERS; G1 ARREST; HOMODIMERS; INHIBITORY MECHANISM; LEUCINE ZIPPERS; NANOMOLAR AFFINITY; NEW MECHANISMS; RECEPTOR RECYCLING; SURFACE DISPLAYS; TARGETING MOLECULES; TUMOR TARGETING; TUMOR THERAPY;

AMINO ACIDS; ANTIGENS; BIOACTIVITY; CELL PROLIFERATION; CHEMOTHERAPY; MONOCLONAL ANTIBODIES; RECYCLING; TRANSCRIPTION FACTORS; TUMORS;

CELLS;

ANKYRIN; CETUXIMAB; DESIGNED ANKYRIN REPEAT PROTEIN; EPIDERMAL GROWTH FACTOR; EPIDERMAL GROWTH FACTOR RECEPTOR; HOMODIMER; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING SITE; CANCER CELL; CELL CYCLE ARREST; CELL CYCLE G1 PHASE; CELL PROLIFERATION; CELL STRAIN A431; CELL VIABILITY; CONTROLLED STUDY; EPITOPE MAPPING; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN EXPRESSION; PROTEIN METABOLISM; PROTEIN TARGETING; RECEPTOR RECYCLING; SURFACE PROPERTY;

ANKYRIN REPEAT; ANKYRINS; ANTIBODIES, MONOCLONAL; ANTINEOPLASTIC AGENTS; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; EPITOPE MAPPING; EPITOPES; G1 PHASE; HUMANS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SACCHAROMYCES CEREVISIAE; SIGNAL TRANSDUCTION; TWO-HYBRID SYSTEM TECHNIQUES;

EID: 82355164168     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M111.293266     Document Type: Article

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