DARPins recognizing the tumor-associated antigen EpCAM selected by phage and ribosome display and engineered for multivalency

Journal of Molecular Biology

Volumn 413, Issue 4, 2011, Pages 826-843

  Stefan, Nikolas ^a   Martin Killias, Patricia ^a   Wyss Stoeckle, Sascha ^a   Honegger, Annemarie ^a   Zangemeister Wittke, Uwe ^a,b   Plückthun, Andreas ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b UNIVERSITY OF BERN   (Switzerland)

Author keywords

Designed Ankyrin Repeat Proteins (DARPins); epithelial cell adhesion molecule (EpCAM); phage display; ribosome display; tumor targeting

Indexed keywords

ANTINEOPLASTIC AGENT; BINDING PROTEIN; DESIGNED ANKYRIN REPEAT PROTEIN; EPITHELIAL CELL ADHESION MOLECULE; EPITOPE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL CELL; BINDING AFFINITY; COMBINATORIAL LIBRARY; CONTROLLED STUDY; CYTOPLASM; DRUG DELIVERY SYSTEM; ENDOCYTOSIS; ESCHERICHIA COLI; INTERNALIZATION; MUTAGENESIS; NONHUMAN; PHAGE DISPLAY; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FOLDING; PROTEIN FUNCTION; PROTEIN PURIFICATION; PROTEIN TARGETING; RIBOSOME; SOLID TUMOR; TUMOR CELL;

ESCHERICHIA COLI;

EID: 80054870896     PISSN: 00222836     EISSN: 10898638     Source Type: Journal    
DOI: 10.1016/j.jmb.2011.09.016     Document Type: Article

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