Designed ankyrin repeat protein binders for the crystallization of AcrB: Plasticity of the dominant interface

Journal of Structural Biology

Volumn 174, Issue 2, 2011, Pages 269-281

  Monroe, Nicole ^a,b   Sennhauser, Gaby ^a   Seeger, Markus A ^a   Briand, Christophe ^a   Grütter, Markus G ^a  

^a UNIVERSITY OF ZURICH   (Switzerland)

^b MOLECULAR PARTNERS AG   (Switzerland)

Author keywords

AcrB; Crystallization chaperone; Designed ankyrin repeat protein (DARPin); Hot spot epitope; Membrane protein

Indexed keywords

ANKYRIN; BACTERIAL PROTEIN; PROTEIN ACRB; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CONTROLLED STUDY; CRYSTAL STRUCTURE; CRYSTALLIZATION; CRYSTALLOGRAPHY; DIFFRACTION; IN VITRO STUDY; NONHUMAN; PLASTICITY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BINDING; PROTEIN PROTEIN INTERACTION; RIBOSOME;

AMINO ACID SEQUENCE; ANKYRIN REPEAT; BINDING, COMPETITIVE; CRYSTALLIZATION; CRYSTALLOGRAPHY, X-RAY; DIRECTED MOLECULAR EVOLUTION; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPE MAPPING; ESCHERICHIA COLI PROTEINS; HYDROGEN BONDING; MACROMOLECULAR SUBSTANCES; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MULTIDRUG RESISTANCE-ASSOCIATED PROTEINS; PROTEIN BINDING; PROTEIN INTERACTION DOMAINS AND MOTIFS; PROTEIN STRUCTURE, SECONDARY; RECOMBINANT PROTEINS; SEQUENCE ALIGNMENT;

EID: 79954422505     PISSN: 10478477     EISSN: 10958657     Source Type: Journal    
DOI: 10.1016/j.jsb.2011.01.014     Document Type: Article

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