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Volumn 18, Issue 3, 2012, Pages 181-202

Enamel matrix derivative: A review of cellular effects in vitro and a model of molecular arrangement and functioning

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVE COMPONENTS; AMELOGENIN; AMELOGENIN PROTEINS; ANGIOGENESIS; CELL TYPES; CELLULAR EFFECTS; CYTOSTATIC; ENAMEL MATRIX DERIVATIVES; EPITHELIAL CELLS; IN-VITRO; IN-VIVO; MATRIX PROTEINS; MOLECULAR ARRANGEMENTS; MOLECULAR COMPOSITIONS; OSTEOBLASTIC CELLS; OSTEOGENIC EFFECTS; PERIODONTAL DISEASE; PERIODONTAL LIGAMENT; PERIODONTAL TISSUE; PROTEIN COMPLEXES; PROTEIN PRODUCTION; SYNERGISTIC EFFECT; TEMPORAL EFFECTS; UNDERLYING MECHANISM;

EID: 84861801847     PISSN: 19373368     EISSN: 19373376     Source Type: Journal    
DOI: 10.1089/ten.teb.2011.0365     Document Type: Review
Times cited : (94)

References (188)
  • 1
    • 18344401835 scopus 로고    scopus 로고
    • Enamel matrix derivative (Emdogain (R)) for periodontal tissue regeneration in intrabony defects
    • Esposito, M., et al. Enamel matrix derivative (Emdogain (R)) for periodontal tissue regeneration in intrabony defects. Cochrane Database Syst Rev CD003875, 2009.
    • (2009) Cochrane Database Syst Rev CD003875
    • Esposito, M.1
  • 2
    • 0035512814 scopus 로고    scopus 로고
    • Effect of an enamel matrix protein (Emdogain (R)) on ex vivo dental plaque vitality
    • Sculean, A., et al. Effect of an enamel matrix protein (Emdogain (R)) on ex vivo dental plaque vitality. J Clin Periodontol 28, 1074, 2001.
    • (2001) J Clin Periodontol , vol.28 , pp. 1074
    • Sculean, A.1
  • 3
    • 49749108573 scopus 로고    scopus 로고
    • Ten-year results following treatment of intra-bony defects with enamel matrix proteins and guided tissue regeneration
    • Sculean, A., et al. Ten-year results following treatment of intra-bony defects with enamel matrix proteins and guided tissue regeneration. J Clin Periodontol 35, 817, 2008.
    • (2008) J Clin Periodontol , vol.35 , pp. 817
    • Sculean, A.1
  • 4
    • 50249088828 scopus 로고    scopus 로고
    • Clinical outcomes with bioactive agents alone or in combination with grafting or guided tissue regeneration
    • Trombelli, L., and Farina, R. Clinical outcomes with bioactive agents alone or in combination with grafting or guided tissue regeneration. J Clin Periodontol 35, 117, 2008.
    • (2008) J Clin Periodontol , vol.35 , pp. 117
    • Trombelli, L.1    Farina, R.2
  • 5
    • 50249129693 scopus 로고    scopus 로고
    • Biological mediators and periodontal regeneration: A review of enamel matrix proteins at the cellular and molecular levels
    • Bosshardt, D.D. Biological mediators and periodontal regeneration: a review of enamel matrix proteins at the cellular and molecular levels. J Clin Periodontol 35, 87, 2008.
    • (2008) J Clin Periodontol , vol.35 , pp. 87
    • Bosshardt, D.D.1
  • 7
    • 0031229903 scopus 로고    scopus 로고
    • Enamel matrix, cementum development and regeneration
    • Hammarström, L. Enamel matrix, cementum development and regeneration. J Clin Periodontol 24, 658, 1997.
    • (1997) J Clin Periodontol , vol.24 , pp. 658
    • Hammarström, L.1
  • 8
    • 0031230219 scopus 로고    scopus 로고
    • Periodontal regeneration in a buccal dehiscence model in monkeys after application of enamel matrix proteins
    • Hammarström, L., Heijl, L., and Gestrelius, S. Periodontal regeneration in a buccal dehiscence model in monkeys after application of enamel matrix proteins. J Clin Periodontol 24, 669, 1997.
    • (1997) J Clin Periodontol , vol.24 , pp. 669
    • Hammarström, L.1    Heijl, L.2    Gestrelius, S.3
  • 9
    • 0033253637 scopus 로고    scopus 로고
    • Periodontal tissue alterations following Emdogain (R) treatment of periodontal sites with angular bone defects-a series of case reports
    • Heden, G., Wennstrom, J., and Lindhe, J. Periodontal tissue alterations following Emdogain (R) treatment of periodontal sites with angular bone defects-a series of case reports. J Clin Periodontol 26, 855, 1999.
    • (1999) J Clin Periodontol , vol.26 , pp. 855
    • Heden, G.1    Wennstrom, J.2    Lindhe, J.3
  • 10
    • 0031225440 scopus 로고    scopus 로고
    • Periodontal regeneration with enamel matrix derivative in one human experimental defect-a case report
    • Heijl, L. Periodontal regeneration with enamel matrix derivative in one human experimental defect-a case report. J Clin Periodontol 24, 693, 1997.
    • (1997) J Clin Periodontol , vol.24 , pp. 693
    • Heijl, L.1
  • 11
    • 34147172213 scopus 로고    scopus 로고
    • The application of an enamel matrix protein derivative (Emdogain (R)) in regenerative periodontal therapy: A review
    • Sculean, A., et al. The application of an enamel matrix protein derivative (Emdogain (R)) in regenerative periodontal therapy: a review. Med Princ Pract 16, 167, 2007.
    • (2007) Med Princ Pract , vol.16 , pp. 167
    • Sculean, A.1
  • 12
    • 17444365971 scopus 로고    scopus 로고
    • The use of enamel matrix derivative in the treatment of periodontal defects: A literature review and meta-analysis
    • Venezia, E., et al. The use of enamel matrix derivative in the treatment of periodontal defects: a literature review and meta-analysis. Crit Rev Oral Biol Med 15, 382, 2004.
    • (2004) Crit Rev Oral Biol Med , vol.15 , pp. 382
    • Venezia, E.1
  • 13
    • 0029136920 scopus 로고
    • Biochemistry and molecular-biology of amelogenin proteins of developing dental enamel
    • Brookes, S.J., et al. Biochemistry and molecular-biology of amelogenin proteins of developing dental enamel. Arch Oral Biol 40, 1, 1995.
    • (1995) Arch Oral Biol , vol.40 , pp. 1
    • Brookes, S.J.1
  • 14
    • 0022694208 scopus 로고
    • Effects of different extraction media on the electrophoretic pattern of proteins from partly mineralized bovine enamel
    • Salling, E., Moe, D., and Kirkeby, S. Effects of different extraction media on the electrophoretic pattern of proteins from partly mineralized bovine enamel. Acta Odontol Scand 44, 91, 1986.
    • (1986) Acta Odontol Scand , vol.44 , pp. 91
    • Salling, E.1    Moe, D.2    Kirkeby, S.3
  • 16
    • 0029079604 scopus 로고
    • Molecular mechanisms of dental enamel formation
    • Simmer, J.P., and Fincham, A.G. Molecular mechanisms of dental enamel formation. Crit Rev Oral Biol Med 6, 84, 1995.
    • (1995) Crit Rev Oral Biol Med , vol.6 , pp. 84
    • Simmer, J.P.1    Fincham, A.G.2
  • 17
    • 0019205616 scopus 로고
    • Properties of dissociatively extracted fetal tooth matrix proteins.1. Principal molecular-species in developing bovine enamel
    • Termine, J.D., et al. Properties of dissociatively extracted fetal tooth matrix proteins.1. Principal molecular-species in developing bovine enamel. J Biol Chem 255, 9760, 1980.
    • (1980) J Biol Chem , vol.255 , pp. 9760
    • Termine, J.D.1
  • 18
    • 0020744748 scopus 로고
    • Amelogenins-sequence homologies in enamel-matrix proteins from 3 mammalian-species
    • Fincham, A.G., et al. Amelogenins-sequence homologies in enamel-matrix proteins from 3 mammalian-species. Biochem J 211, 149, 1983.
    • (1983) Biochem J , vol.211 , pp. 149
    • Fincham, A.G.1
  • 19
    • 0035321491 scopus 로고    scopus 로고
    • A comparison of enamelin and amelogenin expression in developing mouse molars
    • Hu, J.C.C., et al. A comparison of enamelin and amelogenin expression in developing mouse molars. Eur J Oral Sci 109, 125, 2001.
    • (2001) Eur J Oral Sci , vol.109 , pp. 125
    • Hu, J.C.C.1
  • 20
    • 0031613859 scopus 로고    scopus 로고
    • The developing enamel matrix: Nature and function
    • Robinson, C., et al. The developing enamel matrix: nature and function. Eur J Oral Sci 106, 282, 1998.
    • (1998) Eur J Oral Sci , vol.106 , pp. 282
    • Robinson, C.1
  • 21
    • 0031227846 scopus 로고    scopus 로고
    • Formulation of enamel matrix derivative for surface coating-kinetics and cell colonization
    • Gestrelius, S., et al. Formulation of enamel matrix derivative for surface coating-kinetics and cell colonization. J Clin Periodontol 24, 678, 1997.
    • (1997) J Clin Periodontol , vol.24 , pp. 678
    • Gestrelius, S.1
  • 22
    • 0027451541 scopus 로고
    • Amelogenin posttranslational modifications-carboxy-terminal processing and the phosphorylation of bovine and porcine trap and lrap amelogenins
    • Fincham, A.G., and Moradianoldak, J. Amelogenin posttranslational modifications-carboxy-terminal processing and the phosphorylation of bovine and porcine trap and lrap amelogenins. Biochem Biophys Res Commun 197, 248, 1993.
    • (1993) Biochem Biophys Res Commun , vol.197 , pp. 248
    • Fincham, A.G.1    Moradianoldak, J.2
  • 23
    • 0028019289 scopus 로고
    • Massspectrographic analysis of a porcine amelogenin identifies a single phosphorylated locus
    • Fincham, A.G., Moradianoldak, J., and Sarte, P.E. Massspectrographic analysis of a porcine amelogenin identifies a single phosphorylated locus. Calcif Tissue Int 55, 398, 1994.
    • (1994) Calcif Tissue Int , vol.55 , pp. 398
    • Fincham, A.G.1    Moradianoldak, J.2    Sarte, P.E.3
  • 24
    • 0025152497 scopus 로고
    • Biochemical-characterization of stable high-molecular-weight aggregates of amelogenins formed during porcine enamel development
    • Limeback, H., and Simic, A. Biochemical-characterization of stable high-molecular-weight aggregates of amelogenins formed during porcine enamel development. Arch Oral Biol 35, 459, 1990.
    • (1990) Arch Oral Biol , vol.35 , pp. 459
    • Limeback, H.1    Simic, A.2
  • 25
    • 0035996557 scopus 로고    scopus 로고
    • Characterization of a porcine amelogenin preparation, EMDOGAIN, a biological treatment for periodontal disease
    • Maycock, J., et al. Characterization of a porcine amelogenin preparation, EMDOGAIN, a biological treatment for periodontal disease. Connect Tissue Res 43, 472, 2002.
    • (2002) Connect Tissue Res , vol.43 , pp. 472
    • Maycock, J.1
  • 26
    • 34548834437 scopus 로고    scopus 로고
    • Purification and analysis of a 5 kDa component of enamel matrix derivative
    • Mumulidu, A., et al. Purification and analysis of a 5 kDa component of enamel matrix derivative. J Chromatogr BAnalyt Technol Biomed Life Sci 857, 210, 2007.
    • (2007) J Chromatogr BAnalyt Technol Biomed Life Sci , vol.857 , pp. 210
    • Mumulidu, A.1
  • 27
    • 0035996553 scopus 로고    scopus 로고
    • Expression, structure, and function of enamel proteinases
    • Simmer, J.P., and Hu, J.C.C. Expression, structure, and function of enamel proteinases. Connect Tissue Res 43, 441, 2002.
    • (2002) Connect Tissue Res , vol.43 , pp. 441
    • Simmer, J.P.1    Hu, J.C.C.2
  • 28
    • 78650873426 scopus 로고    scopus 로고
    • Proteomic identification of proteinase inhibitors in the porcine enamel matrix derivative, EMD((R))
    • Zilm, P.S., and Bartold, P.M. Proteomic identification of proteinase inhibitors in the porcine enamel matrix derivative, EMD((R)). J Periodontal Res 46, 111, 2011.
    • (2011) J Periodontal Res , vol.46 , pp. 111
    • Zilm, P.S.1    Bartold, P.M.2
  • 29
    • 33646521688 scopus 로고    scopus 로고
    • Porcine sheath proteins show periodontal ligament regeneration activity
    • discussion 254 381
    • Fukae, M., et al. Porcine sheath proteins show periodontal ligament regeneration activity. Eur J Oral Sci 114 Suppl 1, 212; discussion 254, 381, 2006.
    • (2006) Eur J Oral Sci , vol.114 , Issue.SUPPL. 1 , pp. 212
    • Fukae, M.1
  • 30
    • 33646520608 scopus 로고    scopus 로고
    • The 17-kDa sheath protein in enamel proteins induces cementum regeneration in experimental cavities created in a buccal dehiscence model of dogs
    • Kanazashi, M., et al. The 17-kDa sheath protein in enamel proteins induces cementum regeneration in experimental cavities created in a buccal dehiscence model of dogs. J Periodontal Res 41, 193, 2006.
    • (2006) J Periodontal Res , vol.41 , pp. 193
    • Kanazashi, M.1
  • 31
    • 0031602513 scopus 로고    scopus 로고
    • Sheath proteins: Synthesis, secretion, degradation and fate in forming enamel
    • Uchida, T., et al. Sheath proteins: synthesis, secretion, degradation and fate in forming enamel. Eur J Oral Sci 106 Suppl 1, 308, 1998.
    • (1998) Eur J Oral Sci 106 Suppl , vol.1 , pp. 308
    • Uchida, T.1
  • 32
    • 0033617953 scopus 로고    scopus 로고
    • The structural biology of the developing dental enamel matrix
    • Fincham, A.G., Moradian-Oldak, J., and Simmer, J.P. The structural biology of the developing dental enamel matrix. J Struct Biol 126, 270, 1999.
    • (1999) J Struct Biol , vol.126 , pp. 270
    • Fincham, A.G.1    Moradian-Oldak, J.2    Simmer, J.P.3
  • 33
    • 0034852854 scopus 로고    scopus 로고
    • Is there more to enamel matrix proteins than biomineralization?
    • Zeichner-David, M. Is there more to enamel matrix proteins than biomineralization? Matrix Biol 20, 307, 2001.
    • (2001) Matrix Biol , vol.20 , pp. 307
    • Zeichner-David, M.1
  • 34
    • 0031227586 scopus 로고    scopus 로고
    • In vitro studies on periodontal ligament cells and enamel matrix derivative
    • Gestrelius, S., et al. In vitro studies on periodontal ligament cells and enamel matrix derivative. J Clin Periodontol 24, 685, 1997.
    • (1997) J Clin Periodontol , vol.24 , pp. 685
    • Gestrelius, S.1
  • 35
    • 63849140088 scopus 로고    scopus 로고
    • Cellular effects of enamel matrix derivative are associated with different molecular weight fractions following separation by size-exclusion chromatography
    • Johnson, D.L., et al. Cellular effects of enamel matrix derivative are associated with different molecular weight fractions following separation by size-exclusion chromatography. J Periodontol 80, 648, 2009.
    • (2009) J Periodontol , vol.80 , pp. 648
    • Johnson, D.L.1
  • 36
    • 0035656437 scopus 로고    scopus 로고
    • Enamel matrix derivative (EMDOGAIN(( R))) rapidly stimulates phosphorylation of the MAP kinase family and nuclear accumulation of smad2 in both oral epithelial and fibroblastic human cells
    • Kawase, T., et al. Enamel matrix derivative (EMDOGAIN(( R))) rapidly stimulates phosphorylation of the MAP kinase family and nuclear accumulation of smad2 in both oral epithelial and fibroblastic human cells. J Periodontal Res 36, 367, 2001.
    • (2001) J Periodontal Res , vol.36 , pp. 367
    • Kawase, T.1
  • 37
    • 33750581946 scopus 로고    scopus 로고
    • Porcine enamel protein fractions contain transforming growth factor-beta 1
    • Nagano, T., et al. Porcine enamel protein fractions contain transforming growth factor-beta 1. J Periodontol 77, 1688, 2006.
    • (2006) J Periodontol , vol.77 , pp. 1688
    • Nagano, T.1
  • 38
    • 52449130044 scopus 로고    scopus 로고
    • Amelogenin binds to both heparan sulfate and bone morphogenetic protein 2 and pharmacologically suppresses the effect of noggin
    • Saito, K., et al. Amelogenin binds to both heparan sulfate and bone morphogenetic protein 2 and pharmacologically suppresses the effect of noggin. Bone 43, 371, 2008.
    • (2008) Bone , vol.43 , pp. 371
    • Saito, K.1
  • 39
    • 22844439122 scopus 로고    scopus 로고
    • Enamel matrix derivative gel stimulates signal transduction of BMP and TGF-beta
    • Suzuki, S., et al. Enamel matrix derivative gel stimulates signal transduction of BMP and TGF-beta. J Dent Res 84, 510, 2005.
    • (2005) J Dent Res , vol.84 , pp. 510
    • Suzuki, S.1
  • 40
    • 34250012853 scopus 로고    scopus 로고
    • Gene profile in periodontal ligament cells and clones with enamel matrix proteins derivative
    • Barkana, I., et al. Gene profile in periodontal ligament cells and clones with enamel matrix proteins derivative. J Clin Periodontol 34, 599, 2007.
    • (2007) J Clin Periodontol , vol.34 , pp. 599
    • Barkana, I.1
  • 41
    • 32144445748 scopus 로고    scopus 로고
    • The effect of the amelogenin fraction of enamel matrix proteins on fibroblast-mediated collagen matrix reorganization
    • Grayson, R.E., et al., The effect of the amelogenin fraction of enamel matrix proteins on fibroblast-mediated collagen matrix reorganization. Biomaterials 27, 2926, 2006.
    • (2006) Biomaterials , vol.27 , pp. 2926
    • Grayson, R.E.1
  • 42
    • 0035256148 scopus 로고    scopus 로고
    • Autocrine growth factors in human periodontal ligament cells cultured on enamel matrix derivative
    • Lyngstadaas, S.P., et al. Autocrine growth factors in human periodontal ligament cells cultured on enamel matrix derivative. J Clin Periodontol 28, 181, 2001.
    • (2001) J Clin Periodontol , vol.28 , pp. 181
    • Lyngstadaas, S.P.1
  • 43
    • 0037608966 scopus 로고    scopus 로고
    • Participation of endogenous IGF-I and TGF-beta 1 with enamel matrix derivative-stimulated cell growth in human periodontal ligament cells
    • Okubo, K., et al. Participation of endogenous IGF-I and TGF-beta 1 with enamel matrix derivative-stimulated cell growth in human periodontal ligament cells. J Periodontal Res 38, 1, 2003.
    • (2003) J Periodontal Res , vol.38 , pp. 1
    • Okubo, K.1
  • 44
    • 0034731511 scopus 로고    scopus 로고
    • Specific amelogenin gene splice products have signaling effects on cells in culture and in implants in vivo
    • Veis, A., et al. Specific amelogenin gene splice products have signaling effects on cells in culture and in implants in vivo. J Biol Chem 275, 41263, 2000.
    • (2000) J Biol Chem , vol.275 , pp. 41263
    • Veis, A.1
  • 45
    • 70350324893 scopus 로고    scopus 로고
    • Enamel matrix proteins; Old molecules for new applications
    • Lyngstadaas, S.P., et al. Enamel matrix proteins; old molecules for new applications. Orthod Craniofac Res 12, 243, 2009.
    • (2009) Orthod Craniofac Res , vol.12 , pp. 243
    • Lyngstadaas, S.P.1
  • 47
    • 0028825987 scopus 로고
    • Evidence for amelogenin nanospheres as functional components of secretory-stage enamel matrix
    • Fincham, A.G., et al. Evidence for amelogenin nanospheres as functional components of secretory-stage enamel matrix. J Struct Biol 115, 50, 1995.
    • (1995) J Struct Biol , vol.115 , pp. 50
    • Fincham, A.G.1
  • 48
    • 0037280016 scopus 로고    scopus 로고
    • Amelogenin gene splice products: Potential signaling molecules
    • Veis, A. Amelogenin gene splice products: potential signaling molecules. Cell Mol Life Sci 60, 38, 2003.
    • (2003) Cell Mol Life Sci , vol.60 , pp. 38
    • Veis, A.1
  • 49
    • 14644419564 scopus 로고    scopus 로고
    • Molecular evolution of amelogenin in mammals
    • Delgado, S., Girondot, M., and Sire, J.Y. Molecular evolution of amelogenin in mammals. J Mol Evol 60, 12, 2005.
    • (2005) J Mol Evol , vol.60 , pp. 12
    • Delgado, S.1    Girondot, M.2    Sire, J.Y.3
  • 50
    • 0026541083 scopus 로고
    • The human enamel protein gene amelogenin is expressed from both the X-chromosomes and the Y-chromosomes
    • Salido, E.C., et al. The human enamel protein gene amelogenin is expressed from both the X-chromosomes and the Y-chromosomes. Am J Hum Genet 50, 303, 1992.
    • (1992) Am J Hum Genet , vol.50 , pp. 303
    • Salido, E.C.1
  • 51
    • 0030307331 scopus 로고    scopus 로고
    • Cloning, cDNA sequence, and alternative splicing of porcine amelogenin mRNAs
    • Hu, C.C., et al. Cloning, cDNA sequence, and alternative splicing of porcine amelogenin mRNAs. J Dent Res 75, 1735, 1996.
    • (1996) J Dent Res , vol.75 , pp. 1735
    • Hu, C.C.1
  • 52
    • 15544386221 scopus 로고    scopus 로고
    • Porcine amelogenin is expressed from the X and y chromosomes
    • Ikawa, T., et al. Porcine amelogenin is expressed from the X and Y chromosomes. J Dent Res 84, 144, 2005.
    • (2005) J Dent Res , vol.84 , pp. 144
    • Ikawa, T.1
  • 53
    • 0028137553 scopus 로고
    • Porcine amelogenins
    • Yamakoshi, Y., et al. Porcine amelogenins. Calcif Tissue Int 54, 69, 1994.
    • (1994) Calcif Tissue Int , vol.54 , pp. 69
    • Yamakoshi, Y.1
  • 54
  • 55
    • 0027403490 scopus 로고
    • Molecular-conformation of porcine amelogenin in solution-3 folding units at the n-terminal, central, and c-terminal regions
    • Goto, Y., et al. Molecular-conformation of porcine amelogenin in solution-3 folding units at the n-terminal, central, and c-terminal regions. J Biochem 113, 55, 1993.
    • (1993) J Biochem , vol.113 , pp. 55
    • Goto, Y.1
  • 56
    • 0345240480 scopus 로고
    • Developing enamel matrix proteins-a conformation study of enamelins and amelogenins
    • Jodaikin, A., et al. Developing enamel matrix proteins-a conformation study of enamelins and amelogenins. Int J Biol Macromol 9, 166, 1987.
    • (1987) Int J Biol Macromol , vol.9 , pp. 166
    • Jodaikin, A.1
  • 57
    • 0022549306 scopus 로고
    • Studies of the secondary structures of amelogenin from bovine tooth enamel
    • Renugopalakrishnan, V., et al. Studies of the secondary structures of amelogenin from bovine tooth enamel. Biochemistry 25, 4879, 1986.
    • (1986) Biochemistry , vol.25 , pp. 4879
    • Renugopalakrishnan, V.1
  • 58
    • 64349115533 scopus 로고    scopus 로고
    • The tooth enamel protein, porcine amelogenin, is an intrinsically disordered protein with an extended molecular configuration in the monomeric form
    • Delak, K., et al. The tooth enamel protein, porcine amelogenin, is an intrinsically disordered protein with an extended molecular configuration in the monomeric form. Biochemistry 48, 2272, 2009.
    • (2009) Biochemistry , vol.48 , pp. 2272
    • Delak, K.1
  • 60
    • 36549013310 scopus 로고    scopus 로고
    • The role of secondary structure in the entropically driven amelogenin self-assembly
    • Lakshminarayanan, R., et al. The role of secondary structure in the entropically driven amelogenin self-assembly. Biophys J 93, 3664, 2007.
    • (2007) Biophys J , vol.93 , pp. 3664
    • Lakshminarayanan, R.1
  • 61
    • 33646908786 scopus 로고    scopus 로고
    • Conformation of the backbone in unfolded proteins
    • Shi, Z.S., et al. Conformation of the backbone in unfolded proteins. Chem Rev 106, 1877, 2006.
    • (2006) Chem Rev , vol.106 , pp. 1877
    • Shi, Z.S.1
  • 62
    • 68049128255 scopus 로고    scopus 로고
    • Analysis of secondary structure and self-assembly of amelogenin by variable temperature circular dichroism and isothermal titration calorimetry
    • Lakshminarayanan, R., et al. Analysis of secondary structure and self-assembly of amelogenin by variable temperature circular dichroism and isothermal titration calorimetry. Proteins-Struct Funct Bioinform 76, 560, 2009.
    • (2009) Proteins-Struct Funct Bioinform , vol.76 , pp. 560
    • Lakshminarayanan, R.1
  • 63
    • 0028360425 scopus 로고
    • Self-assembly of a recombinant amelogenin protein generates supramolecular structures
    • Fincham, A.G., et al. Self-assembly of a recombinant amelogenin protein generates supramolecular structures. J Struct Biol 112, 103, 1994.
    • (1994) J Struct Biol , vol.112 , pp. 103
    • Fincham, A.G.1
  • 64
    • 0028519190 scopus 로고
    • Detection of monodisperse aggregates of a recombinant amelogenin by dynamic lightscattering
    • Moradian-Oldak, J., et al. Detection of monodisperse aggregates of a recombinant amelogenin by dynamic lightscattering. Biopolymers 34, 1339, 1994.
    • (1994) Biopolymers , vol.34 , pp. 1339
    • Moradian-Oldak, J.1
  • 65
    • 0032223689 scopus 로고    scopus 로고
    • Quantitative analysis of amelogenin solubility
    • Tan, J., et al. Quantitative analysis of amelogenin solubility. J Dent Res 77, 1388, 1998.
    • (1998) J Dent Res , vol.77 , pp. 1388
    • Tan, J.1
  • 66
    • 33645964445 scopus 로고    scopus 로고
    • Intracellular nanosphere subunit assembly as revealed by amelogenin molecular cross-linking studies
    • Brookes, S.J., et al. Intracellular nanosphere subunit assembly as revealed by amelogenin molecular cross-linking studies. Eur J Oral Sci 114, 280, 2006.
    • (2006) Eur J Oral Sci , vol.114 , pp. 280
    • Brookes, S.J.1
  • 67
    • 0037237913 scopus 로고    scopus 로고
    • Amelogenin protein exhibits a modular design: Implications for form and function
    • Snead, M.L. Amelogenin protein exhibits a modular design: implications for form and function. Connect Tissue Res 44 Suppl 1, 47, 2003.
    • (2003) Connect Tissue Res , vol.44 , Issue.SUPPL. 1 , pp. 47
    • Snead, M.L.1
  • 68
    • 14644413519 scopus 로고    scopus 로고
    • Supramolecular assembly of amelogenin nanospheres into birefringent microribbons
    • Du, C., et al. Supramolecular assembly of amelogenin nanospheres into birefringent microribbons. Science 307, 1450, 2005.
    • (2005) Science , vol.307 , pp. 1450
    • Du, C.1
  • 69
    • 33645957322 scopus 로고    scopus 로고
    • Amelogenin supramolecular assembly in vitro compared with the architecture of the forming enamel matrix
    • Moradian-Oldak, J., and Goldberg, M. Amelogenin supramolecular assembly in vitro compared with the architecture of the forming enamel matrix. Cells Tissues Organs 181, 202, 2005.
    • (2005) Cells Tissues Organs , vol.181 , pp. 202
    • Moradian-Oldak, J.1    Goldberg, M.2
  • 70
    • 77649142033 scopus 로고    scopus 로고
    • How Amelogenin orchestrates the organization of hierarchical elongated microstructures of apatite
    • Yang, X.D., et al. How Amelogenin orchestrates the organization of hierarchical elongated microstructures of apatite. J Phys Chem B 114, 2293, 2010.
    • (2010) J Phys Chem B , vol.114 , pp. 2293
    • Yang, X.D.1
  • 71
    • 25144524137 scopus 로고    scopus 로고
    • The onset of amelogenin nanosphere aggregation studied by small-angle X-ray scattering and dynamic light scattering
    • Aichmayer, B., et al. The onset of amelogenin nanosphere aggregation studied by small-angle X-ray scattering and dynamic light scattering. J Struct Biol 151, 239, 2005.
    • (2005) J Struct Biol , vol.151 , pp. 239
    • Aichmayer, B.1
  • 72
    • 34547953382 scopus 로고    scopus 로고
    • Micelle structure of amelogenin in porcine secretory enamel
    • Fukae, M., et al. Micelle structure of amelogenin in porcine secretory enamel. J Dent Res 86, 758, 2007.
    • (2007) J Dent Res , vol.86 , pp. 758
    • Fukae, M.1
  • 73
    • 55649104516 scopus 로고    scopus 로고
    • The cooperative selfassembly of 25 and 23 kDa amelogenins
    • He, X.D., Li, W., and Habelitz, S. The cooperative selfassembly of 25 and 23 kDa amelogenins. J Struct Biol 164, 314, 2008.
    • (2008) J Struct Biol , vol.164 , pp. 314
    • He, X.D.1    Li, W.2    Habelitz, S.3
  • 74
    • 0033821661 scopus 로고    scopus 로고
    • Self-assembly properties of recombinant engineered amelogenin proteins analyzed by dynamic light scattering and atomic force microscopy
    • Moradian-Oldak, J., et al. Self-assembly properties of recombinant engineered amelogenin proteins analyzed by dynamic light scattering and atomic force microscopy. J Struct Biol 131, 27, 2000.
    • (2000) J Struct Biol , vol.131 , pp. 27
    • Moradian-Oldak, J.1
  • 75
    • 33646535253 scopus 로고    scopus 로고
    • Assembly and processing of an engineered amelogenin proteolytic product (rP148)
    • Sun, Z., et al. Assembly and processing of an engineered amelogenin proteolytic product (rP148). Eur J Oral Sci 114, 59, 2006.
    • (2006) Eur J Oral Sci , vol.114 , pp. 59
    • Sun, Z.1
  • 76
    • 34548613499 scopus 로고    scopus 로고
    • PH triggered self-assembly of native and recombinant amelogenins under physiological pH and temperature in vitro
    • Wiedemann-Bidlack, F.B., et al. pH triggered self-assembly of native and recombinant amelogenins under physiological pH and temperature in vitro. J Struct Biol 160, 57, 2007.
    • (2007) J Struct Biol , vol.160 , pp. 57
    • Wiedemann-Bidlack, F.B.1
  • 77
    • 33644905268 scopus 로고    scopus 로고
    • Selfassembly/aggregation behavior and adsorption of enamel matrix derivate protein to silica surfaces
    • Halthur, T.J., Bjorklund, A., and Elofsson, U.M. Selfassembly/aggregation behavior and adsorption of enamel matrix derivate protein to silica surfaces. Langmuir 22, 2227, 2006.
    • (2006) Langmuir , vol.22 , pp. 2227
    • Halthur, T.J.1    Bjorklund, A.2    Elofsson, U.M.3
  • 78
    • 33646534159 scopus 로고    scopus 로고
    • The effect of enamel matrix derivative on gene expression in osteoblasts
    • Reseland, J.E., et al. The effect of enamel matrix derivative on gene expression in osteoblasts. Eur J Oral Sci 114, 205, 2006.
    • (2006) Eur J Oral Sci , vol.114 , pp. 205
    • Reseland, J.E.1
  • 79
    • 0042659481 scopus 로고    scopus 로고
    • Analysis of hydroxyapatite surface coverage by amelogenin nanospheres following the Langmuir model for protein adsorption
    • Bouropoulos, N., and Moradian-Oldak, J. Analysis of hydroxyapatite surface coverage by amelogenin nanospheres following the Langmuir model for protein adsorption. Calcif Tissue Int 72, 599, 2003.
    • (2003) Calcif Tissue Int , vol.72 , pp. 599
    • Bouropoulos, N.1    Moradian-Oldak, J.2
  • 80
    • 59949100536 scopus 로고    scopus 로고
    • Rapid communication changes in the quaternary structure of amelogenin when adsorbed onto surfaces
    • Tarasevich, B.J., et al. Rapid communication changes in the quaternary structure of amelogenin when adsorbed onto surfaces. Biopolymers 91, 103, 2009.
    • (2009) Biopolymers , vol.91 , pp. 103
    • Tarasevich, B.J.1
  • 81
    • 76749149058 scopus 로고    scopus 로고
    • The leucine rich amelogenin protein (LRAP) adsorbs as monomers or dimers onto surfaces
    • Tarasevich, B.J., Lea, S., and Shaw, W.J. The leucine rich amelogenin protein (LRAP) adsorbs as monomers or dimers onto surfaces. J Struct Biol 169, 266, 2010.
    • (2010) J Struct Biol , vol.169 , pp. 266
    • Tarasevich, B.J.1    Lea, S.2    Shaw, W.J.3
  • 82
    • 0030275714 scopus 로고    scopus 로고
    • Developmental changes in the pH of enamel fluid and its effects on matrix-resident proteinases
    • Smith, C.E., et al. Developmental changes in the pH of enamel fluid and its effects on matrix-resident proteinases. Adv Dent Res 10, 159, 1996.
    • (1996) Adv Dent Res , vol.10 , pp. 159
    • Smith, C.E.1
  • 83
    • 0032223616 scopus 로고    scopus 로고
    • Enamelysin (Matrix metalloproteinase-20): Localization in the developing tooth and effects of pH and calcium on amelogenin hydrolysis
    • Fukae, M., et al. Enamelysin (Matrix metalloproteinase-20): localization in the developing tooth and effects of pH and calcium on amelogenin hydrolysis. J Dent Res 77, 1580, 1998.
    • (1998) J Dent Res , vol.77 , pp. 1580
    • Fukae, M.1
  • 84
    • 33645957485 scopus 로고    scopus 로고
    • On the formation of amelogenin microribbons
    • Moradian-Oldak, J., Du, C., and Falini, G. On the formation of amelogenin microribbons. Eur J Oral Sci 114, 289, 2006.
    • (2006) Eur J Oral Sci , vol.114 , pp. 289
    • Moradian-Oldak, J.1    Du, C.2    Falini, G.3
  • 85
    • 0033278065 scopus 로고    scopus 로고
    • Characterization of recombinant pig enamelysin activity and cleavage of recombinant pig and mouse amelogenins
    • Ryu, O.H., et al. Characterization of recombinant pig enamelysin activity and cleavage of recombinant pig and mouse amelogenins. J Dent Res 78, 743, 1999.
    • (1999) J Dent Res , vol.78 , pp. 743
    • Ryu, O.H.1
  • 86
    • 47549111347 scopus 로고    scopus 로고
    • Functions of KLK4 and MMP-20 in dental enamel formation
    • Lu, Y., et al. Functions of KLK4 and MMP-20 in dental enamel formation. Biol Chem 389, 695, 2008.
    • (2008) Biol Chem , vol.389 , pp. 695
    • Lu, Y.1
  • 87
    • 0038655332 scopus 로고    scopus 로고
    • Porcine kallikrein-4 activation, glycosylation, activity, and expression in prokaryotic and eukaryotic hosts
    • Ryu, O., et al. Porcine kallikrein-4 activation, glycosylation, activity, and expression in prokaryotic and eukaryotic hosts. Eur J Oral Sci 110, 358, 2002.
    • (2002) Eur J Oral Sci , vol.110 , pp. 358
    • Ryu, O.1
  • 88
    • 0034857932 scopus 로고    scopus 로고
    • Amelogenins: Assembly, processing and control of crystal morphology
    • Moradian-Oldak, J. Amelogenins: assembly, processing and control of crystal morphology. Matrix Biol 20, 293, 2001.
    • (2001) Matrix Biol , vol.20 , pp. 293
    • Moradian-Oldak, J.1
  • 89
    • 0019629246 scopus 로고
    • Dental enamel matrix-sequences of 2 amelogenin polypeptides
    • Fincham, A.G., et al. Dental enamel matrix-sequences of 2 amelogenin polypeptides. Biosci Rep 1, 771, 1981.
    • (1981) Biosci Rep , vol.1 , pp. 771
    • Fincham, A.G.1
  • 90
    • 0026029107 scopus 로고
    • Identification of the leucine-rich amelogenin peptide (LRAP) as the translation product of an alternatively spliced transcript
    • Gibson, C.W., et al. Identification of the leucine-rich amelogenin peptide (LRAP) as the translation product of an alternatively spliced transcript. Biochem Biophys Res Commun 174, 1306, 1991.
    • (1991) Biochem Biophys Res Commun , vol.174 , pp. 1306
    • Gibson, C.W.1
  • 91
    • 0030435714 scopus 로고    scopus 로고
    • Comparative mass spectrometric analyses of enamel matrix proteins from five species suggest a common pathway of post-secretory proteolytic processing
    • Fincham, A.G., and MoradianOldak, J. Comparative mass spectrometric analyses of enamel matrix proteins from five species suggest a common pathway of post-secretory proteolytic processing. Connect Tissue Res 35, 151, 1996.
    • (1996) Connect Tissue Res , vol.35 , pp. 151
    • Fincham, A.G.1    Moradianoldak, J.2
  • 92
    • 0027162297 scopus 로고
    • Enamelins in the newly formed bovine enamel
    • Fukae, M., et al. Enamelins in the newly formed bovine enamel. Calci Tissue Int 53, 257, 1993.
    • (1993) Calci Tissue Int , vol.53 , pp. 257
    • Fukae, M.1
  • 93
    • 0026800764 scopus 로고
    • The localization and characterization of proteinases for the initial cleavage of porcine amelogenin
    • Tanabe, T., et al. The localization and characterization of proteinases for the initial cleavage of porcine amelogenin. Calcif Tissue Int 51, 213, 1992.
    • (1992) Calcif Tissue Int , vol.51 , pp. 213
    • Tanabe, T.1
  • 94
    • 0025767907 scopus 로고
    • Immunochemical and immunohistochemical studies, using antisera against porcine 25kda amelogenin, 89kda enamelin and the 13-17kda nonamelogenins, on immature enamel of the pig and rat
    • Uchida, T., et al. Immunochemical and immunohistochemical studies, using antisera against porcine 25kda amelogenin, 89kda enamelin and the 13-17kda nonamelogenins, on immature enamel of the pig and rat. Histochemistry 96, 129, 1991.
    • (1991) Histochemistry , vol.96 , pp. 129
    • Uchida, T.1
  • 95
    • 0023624709 scopus 로고
    • Selective adsorption of porcine-amelogenins onto hydroxyapatite and their inhibitory activity on hydroxyapatite growth in supersaturated solutions
    • Aoba, T., et al. Selective adsorption of porcine-amelogenins onto hydroxyapatite and their inhibitory activity on hydroxyapatite growth in supersaturated solutions. Calcif Tissue Int 41, 281, 1987.
    • (1987) Calcif Tissue Int , vol.41 , pp. 281
    • Aoba, T.1
  • 96
    • 58149379900 scopus 로고    scopus 로고
    • Enamel proteases reduce amelogenin-apatite binding
    • Sun, Z., et al. Enamel proteases reduce amelogenin-apatite binding. J Dental Res 87, 1133, 2008.
    • (2008) J Dental Res , vol.87 , pp. 1133
    • Sun, Z.1
  • 97
    • 38049079976 scopus 로고    scopus 로고
    • Leucine-rich amelogenin peptide induces osteogenesis in mouse embryonic stem cells
    • Warotayanont, R., et al. Leucine-rich amelogenin peptide induces osteogenesis in mouse embryonic stem cells. Biochem Biophys Res Commun 367, 1, 2008.
    • (2008) Biochem Biophys Res Commun , vol.367 , pp. 1
    • Warotayanont, R.1
  • 98
    • 67651222568 scopus 로고    scopus 로고
    • Amelogenin in cranio-facial development: The tooth as a model to study the role of amelogenin during embryogenesis
    • Gruenbaum-Cohen, Y., et al. Amelogenin in cranio-facial development: the tooth as a model to study the role of amelogenin during embryogenesis. J Exp Zool B Mol Dev Evol 312B, 445, 2009.
    • (2009) J Exp Zool B Mol Dev Evol , vol.312 B , pp. 445
    • Gruenbaum-Cohen, Y.1
  • 100
    • 84861826032 scopus 로고    scopus 로고
    • Amelogenins: A review of formative and degradative aspects, and transgene expression in bone cells
    • Goldberg, M., ed Bentham Science Publishers
    • Wazen, R., Zalzal Francis, S., and Nanci, A. Amelogenins: a review of formative and degradative aspects, and transgene expression in bone cells. In: Goldberg, M., ed. Amelogenins: Multifaceted Proteins for Dental and Bone Formation and Repair. Bentham Science Publishers, 2010, pp. 32-41.
    • (2010) Amelogenins: Multifaceted Proteins for Dental and Bone Formation and Repair , pp. 32-41
    • Wazen, R.1    Zalzal Francis, S.2    Nanci, A.3
  • 101
    • 84872217428 scopus 로고    scopus 로고
    • Signaling effect of leucine-rich amelogenin peptide (LRAP) on bone regeneration
    • Goldberg, M., ed Bentham Science Publishers
    • Zhou, Y., et al. Signaling effect of leucine-rich amelogenin peptide (LRAP) on bone regeneration. In: Goldberg, M., ed. Amelogenins: Multifaceted Proteins for Dental and Bone Formation and Repair. Bentham Science Publishers, 2010, pp. 208-213.
    • (2010) Amelogenins: Multifaceted Proteins for Dental and Bone Formation and Repair , pp. 208-213
    • Zhou, Y.1
  • 102
    • 79251547685 scopus 로고    scopus 로고
    • Ameloblastin regulates osteogenic differentiation by inhibiting Src kinase via cross talk between integrin beta 1 and CD63
    • Iizuka, S., et al. Ameloblastin regulates osteogenic differentiation by inhibiting Src kinase via cross talk between integrin beta 1 and CD63. Mol Cell Biol 31, 783, 2011.
    • (2011) Mol Cell Biol , vol.31 , pp. 783
    • Iizuka, S.1
  • 103
    • 79952984503 scopus 로고    scopus 로고
    • Synthetic ameloblastin peptide stimulates differentiation of human periodontal ligament cells
    • Kitagawa, M., et al. Synthetic ameloblastin peptide stimulates differentiation of human periodontal ligament cells. Arch Oral Biol 56, 374, 2011.
    • (2011) Arch Oral Biol , vol.56 , pp. 374
    • Kitagawa, M.1
  • 104
    • 77956522555 scopus 로고    scopus 로고
    • Ameloblastin promotes bone growth by enhancing proliferation of progenitor cells and by stimulating immunoregulators
    • Tamburstuen, M.V., et al. Ameloblastin promotes bone growth by enhancing proliferation of progenitor cells and by stimulating immunoregulators. Eur J Oral Sci 118, 451, 2010.
    • (2010) Eur J Oral Sci , vol.118 , pp. 451
    • Tamburstuen, M.V.1
  • 105
    • 78650995037 scopus 로고    scopus 로고
    • Ameloblastin expression and putative autoregulation in mesenchymal cells suggest a role in early bone formation and repair
    • Tamburstuen, M.V., et al. Ameloblastin expression and putative autoregulation in mesenchymal cells suggest a role in early bone formation and repair. Bone 48, 406, 2011.
    • (2011) Bone , vol.48 , pp. 406
    • Tamburstuen, M.V.1
  • 106
    • 33646503873 scopus 로고    scopus 로고
    • Amelogenin and ameloblastin show growth-factor like activity in periodontal ligament cells
    • Zeichner-David, M., et al. Amelogenin and ameloblastin show growth-factor like activity in periodontal ligament cells. Eur J Oral Sci 114, 244, 2006.
    • (2006) Eur J Oral Sci , vol.114 , pp. 244
    • Zeichner-David, M.1
  • 107
    • 0029975483 scopus 로고    scopus 로고
    • A novel gene expressed in rat ameloblasts codes for proteins with cell binding domains
    • Cerny, R., et al. A novel gene expressed in rat ameloblasts codes for proteins with cell binding domains. J Bone Miner Res 11, 883, 1996.
    • (1996) J Bone Miner Res , vol.11 , pp. 883
    • Cerny, R.1
  • 108
    • 0242441731 scopus 로고    scopus 로고
    • Amelin: An enamel-related protein, transcribed in the cells of epithelial root sheath
    • Fong, C.D., Slaby, I., and Hammarstrom, L. Amelin: an enamel-related protein, transcribed in the cells of epithelial root sheath. J Bone Miner Res 11, 892, 1996.
    • (1996) J Bone Miner Res , vol.11 , pp. 892
    • Fong, C.D.1    Slaby, I.2    Hammarstrom, L.3
  • 109
    • 0031066027 scopus 로고    scopus 로고
    • Sheathlin: Cloning, cDNA/polypeptide sequences, and immunolocalization of porcine enamel sheath proteins
    • Hu, C.C., et al. Sheathlin: cloning, cDNA/polypeptide sequences, and immunolocalization of porcine enamel sheath proteins. J Dent Res 76, 648, 1997.
    • (1997) J Dent Res , vol.76 , pp. 648
    • Hu, C.C.1
  • 110
    • 0029965108 scopus 로고    scopus 로고
    • Full-length sequence, localization, and chromosomal mapping of ameloblastin. A novel toothspecific gene
    • Krebsbach, P.H., et al. Full-length sequence, localization, and chromosomal mapping of ameloblastin. A novel toothspecific gene. J Biol Chem 271, 4431, 1996.
    • (1996) J Biol Chem , vol.271 , pp. 4431
    • Krebsbach, P.H.1
  • 111
    • 0029026648 scopus 로고
    • Immunochemical and immunocytochemical study of a 15-kda non-amelogenin and related proteins in the porcine immature enamel-proposal of a new group of enamel proteins sheath proteins
    • Uchida, T., et al. Immunochemical and immunocytochemical study of a 15-kda non-amelogenin and related proteins in the porcine immature enamel-proposal of a new group of enamel proteins sheath proteins. Biomed Res-Tokyo 16, 131, 1995.
    • (1995) Biomed Res-Tokyo , vol.16 , pp. 131
    • Uchida, T.1
  • 112
    • 10344261517 scopus 로고    scopus 로고
    • Ameloblastin is a cell adhesion molecule required for maintaining the differentiation state of ameloblasts
    • Fukumoto, S., et al. Ameloblastin is a cell adhesion molecule required for maintaining the differentiation state of ameloblasts. J Cell Biol 167, 973, 2004.
    • (2004) J Cell Biol , vol.167 , pp. 973
    • Fukumoto, S.1
  • 113
    • 33847008368 scopus 로고    scopus 로고
    • Processing of ameloblastin by MMP-20
    • Iwata, T., et al. Processing of ameloblastin by MMP-20. J Dent Res 86, 153, 2007.
    • (2007) J Dent Res , vol.86 , pp. 153
    • Iwata, T.1
  • 114
    • 0035136054 scopus 로고    scopus 로고
    • Amelin extracellular processing and aggregation during rat incisor amelogenesis
    • Brookes, S.J., et al. Amelin extracellular processing and aggregation during rat incisor amelogenesis. Arch Oral Biol 46, 201, 2001.
    • (2001) Arch Oral Biol , vol.46 , pp. 201
    • Brookes, S.J.1
  • 115
    • 33845429482 scopus 로고    scopus 로고
    • Ameloblastin expression during craniofacial bone formation in rats
    • Spahr, A., et al. Ameloblastin expression during craniofacial bone formation in rats. Eur J Oral Sci 114, 504, 2006.
    • (2006) Eur J Oral Sci , vol.114 , pp. 504
    • Spahr, A.1
  • 116
    • 0345166875 scopus 로고    scopus 로고
    • Effect of enamel matrix derivative on human periodontal fibroblasts: Proliferation, morphology and root surface colonization. An in vitro study
    • Cattaneo, V., et al. Effect of enamel matrix derivative on human periodontal fibroblasts: proliferation, morphology and root surface colonization. An in vitro study. J Periodontal Res 38, 568, 2003.
    • (2003) J Periodontal Res , vol.38 , pp. 568
    • Cattaneo, V.1
  • 117
    • 0037977871 scopus 로고    scopus 로고
    • Effects of enamel matrix protein application on the viability, proliferation, and attachment of human periodontal ligament fibroblasts to diseased root surfaces in vitro
    • Davenport, D.R., et al. Effects of enamel matrix protein application on the viability, proliferation, and attachment of human periodontal ligament fibroblasts to diseased root surfaces in vitro. J Clin Periodontol 30, 125, 2003.
    • (2003) J Clin Periodontol , vol.30 , pp. 125
    • Davenport, D.R.1
  • 118
    • 0035345207 scopus 로고    scopus 로고
    • The effect of enamel matrix protein derivative on follicle cells in vitro
    • Hakki, S.S., Berry, J.E., and Somerman, M.J. The effect of enamel matrix protein derivative on follicle cells in vitro. J Periodontol 72, 679, 2001.
    • (2001) J Periodontol , vol.72 , pp. 679
    • Hakki, S.S.1    Berry, J.E.2    Somerman, M.J.3
  • 119
    • 35348889630 scopus 로고    scopus 로고
    • Enamel matrix derivative promotes human periodontal ligament cell differentiation and osteoprotegerin production in vitro
    • Lossdorfer, S., et al. Enamel matrix derivative promotes human periodontal ligament cell differentiation and osteoprotegerin production in vitro. J Dent Res 86, 980, 2007.
    • (2007) J Dent Res , vol.86 , pp. 980
    • Lossdorfer, S.1
  • 120
    • 2442430383 scopus 로고    scopus 로고
    • The influence of enamel matrix derivative associated with insulin-like growth factor-I on periodontal ligament fibroblasts
    • Palioto, D.B., et al. The influence of enamel matrix derivative associated with insulin-like growth factor-I on periodontal ligament fibroblasts. J Periodontol 75, 498, 2004.
    • (2004) J Periodontol , vol.75 , pp. 498
    • Palioto, D.B.1
  • 121
    • 0036886088 scopus 로고    scopus 로고
    • Possible involvement of extracellular signal-regulated kinases 1/2 in mitogenic response of periodontal ligament cells to enamel matrix derivative
    • Matsuda, N., et al. Possible involvement of extracellular signal-regulated kinases 1/2 in mitogenic response of periodontal ligament cells to enamel matrix derivative. Eur J Oral Sci 110, 439, 2002.
    • (2002) Eur J Oral Sci , vol.110 , pp. 439
    • Matsuda, N.1
  • 122
    • 84861796765 scopus 로고    scopus 로고
    • In vitro wound healing responses to enamel matrix derivative
    • Hoang, A.M., Oates, T.W., and Cochran, D.L. In vitro wound healing responses to enamel matrix derivative. J Dent Res 79, 1354, 2000.
    • (2000) J Dent Res , vol.79 , pp. 1354
    • Hoang, A.M.1    Oates, T.W.2    Cochran, D.L.3
  • 123
    • 0041758588 scopus 로고    scopus 로고
    • Effect of Emdogain(( R)) on human periodontal fibroblasts in an in vitro wound-healing model
    • Rincon, J.C., Haase, H.R., and Bartold, P.M. Effect of Emdogain(( R)) on human periodontal fibroblasts in an in vitro wound-healing model. J Periodontal Res 38, 290, 2003.
    • (2003) J Periodontal Res , vol.38 , pp. 290
    • Rincon, J.C.1    Haase, H.R.2    Bartold, P.M.3
  • 124
    • 0035203629 scopus 로고    scopus 로고
    • Attachment of human periodontal ligament cells to enamel matrix-derived protein is mediated via interaction between BSP-like molecules and integrin alpha v beta 3
    • Suzuki, N., et al. Attachment of human periodontal ligament cells to enamel matrix-derived protein is mediated via interaction between BSP-like molecules and integrin alpha v beta 3. J Periodontol 72, 1520, 2001.
    • (2001) J Periodontol , vol.72 , pp. 1520
    • Suzuki, N.1
  • 125
    • 0036828071 scopus 로고    scopus 로고
    • Expression profiling of periodontal ligament cells stimulated with enamel matrix proteins in vitro: A model for tissue regeneration
    • Brett, P.M., et al. Expression profiling of periodontal ligament cells stimulated with enamel matrix proteins in vitro: a model for tissue regeneration. J Dent Res 81, 776, 2002.
    • (2002) J Dent Res , vol.81 , pp. 776
    • Brett, P.M.1
  • 126
    • 0035287175 scopus 로고    scopus 로고
    • Enamel matrix derivative induces matrix synthesis by cultured human periodontal fibroblast cells
    • Haase, H.R., and Bartold, P.M. Enamel matrix derivative induces matrix synthesis by cultured human periodontal fibroblast cells. J Periodontol 72, 341, 2001.
    • (2001) J Periodontol , vol.72 , pp. 341
    • Haase, H.R.1    Bartold, P.M.2
  • 127
    • 10944243836 scopus 로고    scopus 로고
    • Gene expression profiles of periodontal ligament cells treated with enamel matrix proteins in vitro: Analysis using cDNA arrays
    • Parkar, M.H., and Tonetti, M. Gene expression profiles of periodontal ligament cells treated with enamel matrix proteins in vitro: analysis using cDNA arrays. J Periodontol 75, 1539, 2004.
    • (2004) J Periodontol , vol.75 , pp. 1539
    • Parkar, M.H.1    Tonetti, M.2
  • 128
    • 33746025298 scopus 로고    scopus 로고
    • Effects of enamel matrix derivative on bone-related mRNA expression in human periodontal ligament cells in vitro
    • Takayanagi, K., et al. Effects of enamel matrix derivative on bone-related mRNA expression in human periodontal ligament cells in vitro. J Periodontol 77, 891, 2006.
    • (2006) J Periodontol , vol.77 , pp. 891
    • Takayanagi, K.1
  • 129
    • 1642363405 scopus 로고    scopus 로고
    • Effect of enamel matrix proteins on the phenotype expression of periodontal ligament cells cultured on dental materials
    • Inoue, M., et al. Effect of enamel matrix proteins on the phenotype expression of periodontal ligament cells cultured on dental materials. J Biomed Mater Res Part A 69A, 172, 2004.
    • (2004) J Biomed Mater Res Part A , vol.69 A , pp. 172
    • Inoue, M.1
  • 130
    • 4143123164 scopus 로고    scopus 로고
    • In vitro effects of enamel matrix proteins on rat bone marrow cells and gingival fibroblasts
    • Keila, S., et al. In vitro effects of enamel matrix proteins on rat bone marrow cells and gingival fibroblasts. J Dent Res 83, 134, 2004.
    • (2004) J Dent Res , vol.83 , pp. 134
    • Keila, S.1
  • 131
    • 24344506072 scopus 로고    scopus 로고
    • Production of osteopontin by cultured porcine epithelial cell rests of Malassez
    • Rincon, J.C., et al. Production of osteopontin by cultured porcine epithelial cell rests of Malassez. J Periodontal Res 40, 417, 2005.
    • (2005) J Periodontal Res , vol.40 , pp. 417
    • Rincon, J.C.1
  • 132
    • 77958536825 scopus 로고    scopus 로고
    • Differential effects of prostaglandin E-2 and enamel matrix derivative on the proliferation of human gingival and dermal fibroblasts and gingival keratinocytes
    • Weinberg, E., et al. Differential effects of prostaglandin E-2 and enamel matrix derivative on the proliferation of human gingival and dermal fibroblasts and gingival keratinocytes. J Periodontal Res 45, 731, 2010.
    • (2010) J Periodontal Res , vol.45 , pp. 731
    • Weinberg, E.1
  • 133
    • 33846552935 scopus 로고    scopus 로고
    • Enamel matrix derivative stimulates human gingival fibroblast proliferation via ERK
    • Zeldich, E., et al. Enamel matrix derivative stimulates human gingival fibroblast proliferation via ERK. J Dent Res 86, 41, 2007.
    • (2007) J Dent Res , vol.86 , pp. 41
    • Zeldich, E.1
  • 134
    • 52649158109 scopus 로고    scopus 로고
    • EGFR in Enamel Matrix Derivativeinduced gingival fibroblast mitogenesis
    • Zeldich, E., et al. EGFR in Enamel Matrix Derivativeinduced gingival fibroblast mitogenesis. J Dent Res 87, 850, 2008.
    • (2008) J Dent Res , vol.87 , pp. 850
    • Zeldich, E.1
  • 135
    • 77950199317 scopus 로고    scopus 로고
    • Enamel matrix derivative induces the expression of tissue inhibitor of matrix metalloproteinase-3 in human gingival fibroblasts via extracellular signalregulated kinase
    • Zeldich, E., et al. Enamel matrix derivative induces the expression of tissue inhibitor of matrix metalloproteinase-3 in human gingival fibroblasts via extracellular signalregulated kinase. J Periodontal Res 45, 200, 2010.
    • (2010) J Periodontal Res , vol.45 , pp. 200
    • Zeldich, E.1
  • 136
    • 0034294730 scopus 로고    scopus 로고
    • Cytostatic action of enamel matrix derivative (EMDOGAIN (R)) on human oral squamous cell carcinoma-derived SCC25 epithelial cells
    • Kawase, T., et al. Cytostatic action of enamel matrix derivative (EMDOGAIN (R)) on human oral squamous cell carcinoma-derived SCC25 epithelial cells. J Periodontal Res 35, 291, 2000.
    • (2000) J Periodontal Res , vol.35 , pp. 291
    • Kawase, T.1
  • 137
    • 0036690146 scopus 로고    scopus 로고
    • Anti-TGF-beta antibody blocks enamel matrix derivative-induced upregulation of p21(WAF1/CiP1) and prevents its inhibition of human oral epithelial cell proliferation
    • Kawase, T., et al. Anti-TGF-beta antibody blocks enamel matrix derivative-induced upregulation of p21(WAF1/CiP1) and prevents its inhibition of human oral epithelial cell proliferation. J Periodontal Res 37, 255, 2002.
    • (2002) J Periodontal Res , vol.37 , pp. 255
    • Kawase, T.1
  • 138
    • 70349684851 scopus 로고    scopus 로고
    • Effects of enamel matrix derivative on proliferation/viability, migration, and expression of angiogenic factor and adhesion molecules in endothelial cells in vitro
    • Bertl, K., et al. Effects of enamel matrix derivative on proliferation/viability, migration, and expression of angiogenic factor and adhesion molecules in endothelial cells in vitro. J Periodontol 80, 1622, 2009.
    • (2009) J Periodontol , vol.80 , pp. 1622
    • Bertl, K.1
  • 139
    • 33846689957 scopus 로고    scopus 로고
    • In vitro effects of enamel matrix derivative on microvascular cells
    • Schlueter, S.R., Carnes, D.L., and Cochran, D.L. In vitro effects of enamel matrix derivative on microvascular cells. J Periodontol 78, 141, 2007.
    • (2007) J Periodontol , vol.78 , pp. 141
    • Schlueter, S.R.1    Carnes, D.L.2    Cochran, D.L.3
  • 140
    • 77649211800 scopus 로고    scopus 로고
    • Osteogenesis in an in vitro coculture of human periodontal ligament fibroblasts and human microvascular endothelial cells
    • Neeley, W.W., Carnes, D.L., and Cochran, D.L. Osteogenesis in an in vitro coculture of human periodontal ligament fibroblasts and human microvascular endothelial cells. J Periodontol 81, 139, 2010.
    • (2010) J Periodontol , vol.81 , pp. 139
    • Neeley, W.W.1    Carnes, D.L.2    Cochran, D.L.3
  • 141
    • 0034243492 scopus 로고    scopus 로고
    • Porcine fetal enamel matrix derivative stimulates proliferation but not differentiation of preosteoblastic 2T9 cells, inhibits proliferation and stimulates differentiation of osteoblast-like MG63 cells, and increases proliferation and differentiation of normal human osteoblast NHOst cells
    • Schwartz, Z., et al. Porcine fetal enamel matrix derivative stimulates proliferation but not differentiation of preosteoblastic 2T9 cells, inhibits proliferation and stimulates differentiation of osteoblast-like MG63 cells, and increases proliferation and differentiation of normal human osteoblast NHOst cells. J Periodontol 71, 1287, 2000.
    • (2000) J Periodontol , vol.71 , pp. 1287
    • Schwartz, Z.1
  • 142
    • 1242284114 scopus 로고    scopus 로고
    • Emdogain promotes osteoblast proliferation and differentiation and stimulates osteoprotegerin expression
    • He, J.N., et al. Emdogain promotes osteoblast proliferation and differentiation and stimulates osteoprotegerin expression. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 97, 239, 2004.
    • (2004) Oral Surg Oral Med Oral Pathol Oral Radiol Endod , vol.97 , pp. 239
    • He, J.N.1
  • 143
    • 4444273967 scopus 로고    scopus 로고
    • Direct contact between enamel matrix derivative (EMD) and osteoblasts is not required for EMDinduced cell proliferation
    • He, J.N., et al. Direct contact between enamel matrix derivative (EMD) and osteoblasts is not required for EMDinduced cell proliferation. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 98, 370, 2004.
    • (2004) Oral Surg Oral Med Oral Pathol Oral Radiol Endod , vol.98 , pp. 370
    • He, J.N.1
  • 144
    • 19344367983 scopus 로고    scopus 로고
    • Enamel matrix derivative inhibits TNF-alphainduced apoptosis in osteoblastic MC3T3-E1 cells
    • He, J.N., et al. Enamel matrix derivative inhibits TNF-alphainduced apoptosis in osteoblastic MC3T3-E1 cells. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 99, 761, 2005.
    • (2005) Oral Surg Oral Med Oral Pathol Oral Radiol Endod , vol.99 , pp. 761
    • He, J.N.1
  • 145
    • 45949098202 scopus 로고    scopus 로고
    • Stimulation of cytokines in osteoblasts cultured on enamel matrix derivative
    • Lee, A.Z., et al. Stimulation of cytokines in osteoblasts cultured on enamel matrix derivative. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106, 133, 2008.
    • (2008) Oral Surg Oral Med Oral Pathol Oral Radiol Endod , vol.106 , pp. 133
    • Lee, A.Z.1
  • 146
    • 70449127058 scopus 로고    scopus 로고
    • The effect of enamel matrix proteins on the spreading, proliferation and differentiation of osteoblasts cultured on titanium surfaces
    • Miron, R.J., et al. The effect of enamel matrix proteins on the spreading, proliferation and differentiation of osteoblasts cultured on titanium surfaces. Biomaterials 31, 449, 2010.
    • (2010) Biomaterials , vol.31 , pp. 449
    • Miron, R.J.1
  • 147
    • 0035258191 scopus 로고    scopus 로고
    • Enamel matrix derivative prolongs primary osteoblast growth
    • Jiang, J., et al. Enamel matrix derivative prolongs primary osteoblast growth. J Endod 27, 110, 2001.
    • (2001) J Endod , vol.27 , pp. 110
    • Jiang, J.1
  • 148
    • 33646691768 scopus 로고    scopus 로고
    • Effects of Emdogain on osteoblast gene expression
    • Carinci, F., et al. Effects of Emdogain on osteoblast gene expression. Oral Dis 12, 329, 2006.
    • (2006) Oral Dis , vol.12 , pp. 329
    • Carinci, F.1
  • 149
    • 0035220491 scopus 로고    scopus 로고
    • Effects of enamel matrix derivative on gene expression of primary osteoblasts
    • Jiang, J., et al. Effects of enamel matrix derivative on gene expression of primary osteoblasts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 91, 95, 2001.
    • (2001) Oral Surg Oral Med Oral Pathol Oral Radiol Endod , vol.91 , pp. 95
    • Jiang, J.1
  • 150
    • 47249087696 scopus 로고    scopus 로고
    • Stimulation of osteoblasts with Emdogain increases the expression of specific mineralization markers
    • Weishaupt, P., et al. Stimulation of osteoblasts with Emdogain increases the expression of specific mineralization markers. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 106, 304, 2008.
    • (2008) Oral Surg Oral Med Oral Pathol Oral Radiol Endod , vol.106 , pp. 304
    • Weishaupt, P.1
  • 151
    • 33748755521 scopus 로고    scopus 로고
    • Effects of an enamel matrix derivative on human osteoblasts and PDL cells grown in organoid cultures
    • Pischon, N., et al. Effects of an enamel matrix derivative on human osteoblasts and PDL cells grown in organoid cultures. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102, 551, 2006.
    • (2006) Oral Surg Oral Med Oral Pathol Oral Radiol Endod , vol.102 , pp. 551
    • Pischon, N.1
  • 152
    • 0037673945 scopus 로고    scopus 로고
    • Osteoclast differentiation and activation
    • Boyle, W.J., Simonet, W.S., and Lacey, D.L. Osteoclast differentiation and activation. Nature 423, 337, 2003.
    • (2003) Nature , vol.423 , pp. 337
    • Boyle, W.J.1    Simonet, W.S.2    Lacey, D.L.3
  • 153
    • 0042760453 scopus 로고    scopus 로고
    • The effects of enamel matrix derivative (EMD) on osteoblastic cells in culture and bone regeneration in a rat skull defect
    • Yoneda, S., et al. The effects of enamel matrix derivative (EMD) on osteoblastic cells in culture and bone regeneration in a rat skull defect. J Periodontal Res 38, 333, 2003.
    • (2003) J Periodontal Res , vol.38 , pp. 333
    • Yoneda, S.1
  • 154
    • 0036113996 scopus 로고    scopus 로고
    • Effect of enamel matrix derivative on the differentiation of C2C12 cells
    • Ohyama, M., et al. Effect of enamel matrix derivative on the differentiation of C2C12 cells. J Periodontol 73, 543, 2002.
    • (2002) J Periodontol , vol.73 , pp. 543
    • Ohyama, M.1
  • 155
    • 33847039171 scopus 로고    scopus 로고
    • Enamel matrix derivative stimulates chondrogenic differentiation of ATDC5 cells
    • Narukawa, M., et al. Enamel matrix derivative stimulates chondrogenic differentiation of ATDC5 cells. J Periodontal Res 42, 131, 2007.
    • (2007) J Periodontal Res , vol.42 , pp. 131
    • Narukawa, M.1
  • 156
    • 33846295910 scopus 로고    scopus 로고
    • Enamel matrix derivative stimulates osteogenesis-and chondrogenesis- related transcription factors in C3HI0T1/2 cells
    • Narukawa, M., et al. Enamel matrix derivative stimulates osteogenesis-and chondrogenesis-related transcription factors in C3HI0T1/2 cells. Acta Biochimica Et Biophysica Sinica 39, 1, 2007.
    • (2007) Acta Biochimica et Biophysica Sinica , vol.39 , pp. 1
    • Narukawa, M.1
  • 157
    • 17444417863 scopus 로고    scopus 로고
    • Enamel matrix derivative stimulates core binding factor alpha 1/runt-related transcription factor-2 expression via activation of Smad1 in C2C12 cells
    • Takayama, T., et al. Enamel matrix derivative stimulates core binding factor alpha 1/runt-related transcription factor-2 expression via activation of Smad1 in C2C12 cells. J Periodontol 76, 244, 2005.
    • (2005) J Periodontol , vol.76 , pp. 244
    • Takayama, T.1
  • 158
    • 33748520592 scopus 로고    scopus 로고
    • Mechanisms involved in the enhancement of osteoclast formation by enamel matrix derivative
    • Itoh, N., et al. Mechanisms involved in the enhancement of osteoclast formation by enamel matrix derivative. J Periodontal Res 41, 273, 2006.
    • (2006) J Periodontal Res , vol.41 , pp. 273
    • Itoh, N.1
  • 159
    • 26044482423 scopus 로고    scopus 로고
    • Enamel matrix derivative promotes osteoclast cell formation by RANKL production in mouse marrow cultures
    • Otsuka, T., et al. Enamel matrix derivative promotes osteoclast cell formation by RANKL production in mouse marrow cultures. J Dent 33, 749, 2005.
    • (2005) J Dent , vol.33 , pp. 749
    • Otsuka, T.1
  • 160
    • 0037237937 scopus 로고    scopus 로고
    • Exploring the origins of cementoblasts and their trigger factors
    • Berry, J.E., et al. Exploring the origins of cementoblasts and their trigger factors. Connect Tissue Res 44, 97, 2003.
    • (2003) Connect Tissue Res , vol.44 , pp. 97
    • Berry, J.E.1
  • 161
    • 0034567236 scopus 로고    scopus 로고
    • Enamel factors regulate expression of genes associated with cementoblasts
    • Tokiyasu, Y., et al. Enamel factors regulate expression of genes associated with cementoblasts. J Periodontol 71, 1829, 2000.
    • (2000) J Periodontol , vol.71 , pp. 1829
    • Tokiyasu, Y.1
  • 162
    • 0036020382 scopus 로고    scopus 로고
    • Effect of porcine fetal enamel matrix derivative on chondrocyte proliferation, differentiation, and local factor production is dependent on cell maturation state
    • Dean, D.D., et al. Effect of porcine fetal enamel matrix derivative on chondrocyte proliferation, differentiation, and local factor production is dependent on cell maturation state. Cells Tissues Organs 171, 117, 2002.
    • (2002) Cells Tissues Organs , vol.171 , pp. 117
    • Dean, D.D.1
  • 163
    • 33646523812 scopus 로고    scopus 로고
    • Anti-inflammatory properties of enamel matrix derivative in human blood
    • Myhre, A.E., et al. Anti-inflammatory properties of enamel matrix derivative in human blood. J Periodontal Res 41, 208, 2006.
    • (2006) J Periodontal Res , vol.41 , pp. 208
    • Myhre, A.E.1
  • 164
    • 0036885603 scopus 로고    scopus 로고
    • Antibacterial effect of an enamel matrix protein derivative on in vivo dental biofilm vitality
    • Arweiler, N.B., et al. Antibacterial effect of an enamel matrix protein derivative on in vivo dental biofilm vitality. Clin Oral Investig 6, 205, 2002.
    • (2002) Clin Oral Investig , vol.6 , pp. 205
    • Arweiler, N.B.1
  • 165
    • 0141854099 scopus 로고    scopus 로고
    • Effects of enamel matrix derivative on Porphyromonas gingivalis
    • Newman, S.A., et al. Effects of enamel matrix derivative on Porphyromonas gingivalis. J Periodontol 74, 1191, 2003.
    • (2003) J Periodontol , vol.74 , pp. 1191
    • Newman, S.A.1
  • 166
    • 32944474386 scopus 로고    scopus 로고
    • Moderate effect of enamel matrix derivative (Emdogain (R) Gel) on Porphyromonas gingivalis growth in vitro
    • Walter, C., et al. Moderate effect of enamel matrix derivative (Emdogain (R) Gel) on Porphyromonas gingivalis growth in vitro. Arch Oral Biol 51, 171, 2006.
    • (2006) Arch Oral Biol , vol.51 , pp. 171
    • Walter, C.1
  • 167
    • 0027930243 scopus 로고
    • Alternative splicing of the mouse amelogenin primary rna transcript
    • Simmer, J.P., et al. Alternative splicing of the mouse amelogenin primary rna transcript. Calcif Tissue Int 55, 302, 1994.
    • (1994) Calcif Tissue Int , vol.55 , pp. 302
    • Simmer, J.P.1
  • 168
    • 78649315601 scopus 로고    scopus 로고
    • Effects of human full-length amelogenin on the proliferation of human mesenchymal stem cells derived from bone marrow
    • Huang, Y.C., et al. Effects of human full-length amelogenin on the proliferation of human mesenchymal stem cells derived from bone marrow. Cell Tissue Res 342, 205, 2010.
    • (2010) Cell Tissue Res , vol.342 , pp. 205
    • Huang, Y.C.1
  • 169
    • 33846541352 scopus 로고    scopus 로고
    • Cellular uptake of amelogenin, and its localization to CD63, and Lamp1-positive vesicles
    • Shapiro, J.L., et al. Cellular uptake of amelogenin, and its localization to CD63, and Lamp1-positive vesicles. Cell Mol Life Sci 64, 244, 2007.
    • (2007) Cell Mol Life Sci , vol.64 , pp. 244
    • Shapiro, J.L.1
  • 170
    • 77955425764 scopus 로고    scopus 로고
    • Full length amelogenin binds to cell surface LAMP-1 on tooth root/periodontium associated cells
    • Zhang, H., et al. Full length amelogenin binds to cell surface LAMP-1 on tooth root/periodontium associated cells. Arch Oral Biol 55, 417, 2010.
    • (2010) Arch Oral Biol , vol.55 , pp. 417
    • Zhang, H.1
  • 171
    • 37549021878 scopus 로고    scopus 로고
    • Determination of protein regions responsible for interactions of amelogenin with CD63 and LAMP1
    • Zou, Y., et al. Determination of protein regions responsible for interactions of amelogenin with CD63 and LAMP1. Biochem J 408, 347, 2007.
    • (2007) Biochem J , vol.408 , pp. 347
    • Zou, Y.1
  • 172
    • 53549103556 scopus 로고    scopus 로고
    • The effects of LAMP1 and LAMP3 on M180 amelogenin uptake, localization and amelogenin mRNA induction by amelogenin protein
    • Xu, L., Harada, H., and Taniguchi, A. The effects of LAMP1 and LAMP3 on M180 amelogenin uptake, localization and amelogenin mRNA induction by amelogenin protein. J Biochem 144, 531, 2008.
    • (2008) J Biochem , vol.144 , pp. 531
    • Xu, L.1    Harada, H.2    Taniguchi, A.3
  • 173
    • 43149116535 scopus 로고    scopus 로고
    • Identification of the functional activity of the A-4 amelogenin gene splice product in newborn mouse ameloblasts
    • Iacob, S., and Veis, A. Identification of the functional activity of the A-4 amelogenin gene splice product in newborn mouse ameloblasts. Bone 42, 1072, 2008.
    • (2008) Bone , vol.42 , pp. 1072
    • Iacob, S.1    Veis, A.2
  • 174
    • 31544444139 scopus 로고    scopus 로고
    • Characterization of a mouse amelogenin A-4/M59 cell surface receptor
    • Tompkins, K., George, A., and Veis, A. Characterization of a mouse amelogenin A-4/M59 cell surface receptor. Bone 38, 172, 2006.
    • (2006) Bone , vol.38 , pp. 172
    • Tompkins, K.1    George, A.2    Veis, A.3
  • 175
    • 77951255195 scopus 로고    scopus 로고
    • Amelogenin is phagocytized and induces changes in integrin configuration, gene expression and proliferation of cultured normal human dermal fibroblasts
    • Almqvist, S., et al. Amelogenin is phagocytized and induces changes in integrin configuration, gene expression and proliferation of cultured normal human dermal fibroblasts. J Mater Sci-Mater Med 21, 947, 2010.
    • (2010) J Mater Sci-Mater Med , vol.21 , pp. 947
    • Almqvist, S.1
  • 176
    • 0036777080 scopus 로고    scopus 로고
    • Expression of integrins by human periodontal ligament and gingival fibroblasts and their involvement in fibroblast adhesion to enamel matrix-derived proteins
    • van der Pauw, M.T.M., Everts, V., and Beertsen, W. Expression of integrins by human periodontal ligament and gingival fibroblasts and their involvement in fibroblast adhesion to enamel matrix-derived proteins. J Periodontal Res 37, 317, 2002.
    • (2002) J Periodontal Res , vol.37 , pp. 317
    • Van Der Pauw, M.T.M.1    Everts, V.2    Beertsen, W.3
  • 177
    • 0032487612 scopus 로고    scopus 로고
    • Interaction of amelogenin with hydroxyapatite crystals: An adherence effect through amelogenin molecular self-association
    • Moradian-Oldak, J., Tan, J., and Fincham, A.G. Interaction of amelogenin with hydroxyapatite crystals: An adherence effect through amelogenin molecular self-association. Biopolymers 46, 225, 1998.
    • (1998) Biopolymers , vol.46 , pp. 225
    • Moradian-Oldak, J.1    Tan, J.2    Fincham, A.G.3
  • 178
    • 0035983867 scopus 로고    scopus 로고
    • Amelogenin is a cell adhesion protein
    • Hoang, A.M., et al. Amelogenin is a cell adhesion protein. J Dent Res 81, 497, 2002.
    • (2002) J Dent Res , vol.81 , pp. 497
    • Hoang, A.M.1
  • 179
    • 0344035373 scopus 로고    scopus 로고
    • Amelogenin: A potential regulator of cementum-associated genes
    • Viswanathan, H.L., et al. Amelogenin: a potential regulator of cementum-associated genes. J Periodontol 74, 1423, 2003.
    • (2003) J Periodontol , vol.74 , pp. 1423
    • Viswanathan, H.L.1
  • 180
    • 33744780170 scopus 로고    scopus 로고
    • Amelogenin-mediated regulation of osteoclastogenesis, and periodontal cell proliferation and migration
    • Hatakeyama, J., et al. Amelogenin-mediated regulation of osteoclastogenesis, and periodontal cell proliferation and migration. J Dent Res 85, 144, 2006.
    • (2006) J Dent Res , vol.85 , pp. 144
    • Hatakeyama, J.1
  • 181
    • 77950628649 scopus 로고    scopus 로고
    • Different effects of 25-kDa amelogenin on the proliferation, attachment and migration of various periodontal cells
    • Li, X.T., et al. Different effects of 25-kDa amelogenin on the proliferation, attachment and migration of various periodontal cells. Biochem Biophys Res Commun 394, 581, 2010.
    • (2010) Biochem Biophys Res Commun , vol.394 , pp. 581
    • Li, X.T.1
  • 182
    • 65349089448 scopus 로고    scopus 로고
    • Putative signaling action of amelogenin utilizes the Wnt/beta-catenin pathway
    • Matsuzawa, M., et al. Putative signaling action of amelogenin utilizes the Wnt/beta-catenin pathway. J Periodontal Res 44, 289, 2009.
    • (2009) J Periodontal Res , vol.44 , pp. 289
    • Matsuzawa, M.1
  • 183
    • 36549077834 scopus 로고    scopus 로고
    • The effect of LRAP on enamel organ epithelial cell differentiation
    • Le, T.Q., et al. The effect of LRAP on enamel organ epithelial cell differentiation. J Dent Res 86, 1095, 2007.
    • (2007) J Dent Res , vol.86 , pp. 1095
    • Le, T.Q.1
  • 184
    • 4644372595 scopus 로고    scopus 로고
    • Leucine-rich amelogenin peptide: A candidate signaling molecule during cementogenesis
    • Boabaid, F., et al. Leucine-rich amelogenin peptide: a candidate signaling molecule during cementogenesis. J Periodontol 75, 1126, 2004.
    • (2004) J Periodontol , vol.75 , pp. 1126
    • Boabaid, F.1
  • 185
    • 33646520304 scopus 로고    scopus 로고
    • Amelogenins regulate expression of genes associated with cementoblasts in vitro
    • Swanson, E.C., et al. Amelogenins regulate expression of genes associated with cementoblasts in vitro. Eur J Oral Sci 114, 239, 2006.
    • (2006) Eur J Oral Sci , vol.114 , pp. 239
    • Swanson, E.C.1
  • 186
    • 0033278141 scopus 로고    scopus 로고
    • Identification of the chondrogenicinducing activity from bovine dentin (bCIA) as a lowmolecular-mass amelogenin polypeptide
    • Nebgen, D.R., et al. Identification of the chondrogenicinducing activity from bovine dentin (bCIA) as a lowmolecular-mass amelogenin polypeptide. J Dent Res 78, 1484, 1999.
    • (1999) J Dent Res , vol.78 , pp. 1484
    • Nebgen, D.R.1
  • 187
    • 12544250599 scopus 로고    scopus 로고
    • Two related low molecular mass polypeptide isoforms of amelogenin have distinct activities in mouse tooth germ differentiation in vitro
    • Tompkins, K., et al. Two related low molecular mass polypeptide isoforms of amelogenin have distinct activities in mouse tooth germ differentiation in vitro. J Bone Miner Res 20, 341, 2005.
    • (2005) J Bone Miner Res , vol.20 , pp. 341
    • Tompkins, K.1
  • 188
    • 0035996484 scopus 로고    scopus 로고
    • Polypeptides translated from alternatively spliced transcripts of the amelogenin gene, devoid of the exon 6a, b, c region, have specific effects on tooth germ development in culture
    • Tompkins, K., and Veis, A. Polypeptides translated from alternatively spliced transcripts of the amelogenin gene, devoid of the exon 6a, b, c region, have specific effects on tooth germ development in culture. Connect Tissue Res 43, 224, 2002.
    • (2002) Connect Tissue Res , vol.43 , pp. 224
    • Tompkins, K.1    Veis, A.2


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