Enamel matrix derivative stimulates core binding factor α1 /Runt-related transcription factor-2 expression via activation of Smad1 in C2C12 cells

Journal of Periodontology

Volumn 76, Issue 2, 2005, Pages 244-249

  Takayama, Tadahiro ^a   Suzuki, Naoto ^a   Narukawa, Masataka ^a   Tokunaga, Tsuyoshi ^a   Otsuka, Kichibee ^a   Ito, Koichi ^a  

^a NIHON UNIVERSITY   (Japan)

Author keywords

Enamel matrix derivative; Osteogenesis

Indexed keywords

BONE MORPHOGENETIC PROTEIN; ENAMEL MATRIX DERIVATIVE; ENAMEL PROTEIN; MESSENGER RNA; NOGGIN; SMAD1 PROTEIN; TRANSCRIPTION FACTOR RUNX2; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL CULTURE; CELL DIFFERENTIATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; CULTURE MEDIUM; DRUG ACTIVITY; DRUG MECHANISM; DRUG SPECIFICITY; ENAMEL; MOUSE; NONHUMAN; NORTHERN BLOTTING; PROTEIN ANALYSIS; PROTEIN EXPRESSION; PROTEIN PHOSPHORYLATION; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

ANIMALS; BLOTTING, NORTHERN; BLOTTING, WESTERN; BONE MORPHOGENETIC PROTEINS; CARRIER PROTEINS; CELL DIFFERENTIATION; CELL LINE; CORE BINDING FACTOR ALPHA 1 SUBUNIT; CORE BINDING FACTORS; DENTAL ENAMEL PROTEINS; DNA-BINDING PROTEINS; MESENCHYMAL STEM CELLS; MICE; MICE, INBRED C3H; NEOPLASM PROTEINS; OSTEOGENESIS; PHOSPHORYLATION; POLYMERASE CHAIN REACTION; SMAD PROTEINS; SMAD1 PROTEIN; TRANS-ACTIVATORS; TRANSCRIPTION FACTORS; TRANSFORMING GROWTH FACTOR BETA;

EID: 17444417863     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2005.76.2.244     Document Type: Article

References (36)

1. Hammarström L, Heijil L, Gestrelius S. Periodontal regeneration in a buccal dehiscence model in monkeys after application of enamel matrix proteins. J Clin Periodontol 1997;24:669-677.
2. Heiji L. Periodontal regeneration with enamel matrix derivative in one human experimental defect. A case report. J Clin Periodontol 1997;24:693-696.
3. Gestrelius S, Anderson C, Johansson AC. Formation of enamel matrix derivative for surface coating. Kinetics and cell colonization. J Clin Periodontol 1997;24:678-684.
4. Hammarström L. Enamel matrix, cementum development and regeneration. J Clin Periodontol 1997;24:658-668.
5. Venezia E, Goldstein M, Boyan BD, Schwartz Z. The use of enamel matrix derivative in the treatment of periodontal defects: A literature review and meta-analysis. Crit Rev Oral Biol Med 2004;15:382-402.
6. Gestrelius S, Andersson C, Lidstrom D, Hammarström L, Somerman M. In vitro studies on periodontal ligament cells and enamel matrix derivative. J Clin Periodontol 1997;24:685-692.
7. Schwartz Z, Carnes DL Jr, Pulliam R, et al. Porcine fetal enamel matrix derivative stimulates proliferation but not differentiation of pre-osteoblastic 2T9 cells, inhibits proliferation and stimulates differentiation of osteoblast-like MG63 cells, and increased proliferation and differentiation of normal human osteoblast NHOst cells. J Periodontol 2000;71:1287-1296.
8. Jiang J, Fouad AF, Safavi KE, Spangberg LS, Zhu Q. Effects of enamel matrix derivative on gene expression of primary osteoblasts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2001;91:95-100.
9. He J, Jiang J, Safavi KE, Spangberg LS, Zhu Q. Emdogain promotes osteoblast proliferation and differentiation and stimulates osteoprotegerin expression. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2004;97:239-245.
10. Kelia S, Nemcovsky CE, Moses O, Artzi Z, Weinreb M. In vitro effects of enamel matrix proteins on rat bone marrow cells and gingival fibroblasts. J Dent Res 2004; 83:134-138.
11. Oyama M, Suzuki N, Yamaguchi Y, Maeno M, Otsuka K, Ito K. Effect of enamel matrix derivative on the differentiation of C2C12 cells. J Periodontol 2002;73:543-550.
12. Suzuki N, Oyama M, Maeno M, Ito K, Otsuka K. Attachment of human periodontal ligament cells to enamel matrix-derived protein is mediated via interaction between BSP-like molecules and integrin avb3. J Periodontol 2001;72:1520-1526.
13. WAF1/cip1 and prevents its inhibition of human oral epithelial cell proliferation. J Periodontal Res 2002;37:255-262.
14. Iwata T, Morotome Y, Tanabe T, Fukae M, Ishikawa I, Oida S. Noggin blocks osteoinductive activity of porcine enamel extracts. J Dent Res 2002;81:387-391.
15. Yaffe D, Saxel O. Serial passaging and differentiation of myogenic cells isolated from dystrophic mouse muscle. Nature 1977;270:725-727.
16. Blau HM, Chiu CP, Webster C. Cytoplasmic activation of human nuclear genes in stable heterocaryons. Cell 1983; 32:1171-1180.
17. Laemmli UK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970; 227:680-685.
18. 2 zinc finger transcription factor involved in bone development. J Biol Chem 2001; 276:18282-18289.
19. Komori K, Yagi H, Nomura S, et al. Targeted disruption of Cbfa1 results in a complete lack of bone formation owing to maturational arrest of osteoblast. Cell 1997;89: 755-764.
20. Yamaguchi A, Komori T, Suda T. Regulation of osteoblast differentiation mediated by bone morphogenetic proteins, hedgehogs, and Cbfa1. Endocrine Rev 2000;21:393-411.
21. de Crombrugghe B, Lefebvre V, Nakashima K. Regulatory mechanisms in pathways of cartilage and bone formation. Curr Opin Cell Biol 2001;12:721-727.
22. Nakashima K, Crombrugghe B. Transcriptional mechanisms in osteoblast deferentiation and bone formation. Trend Genet 2003;19:458-466.
23. Ghosh-Choudhury N, Harris MA, Feng JQ, Mundy GR, Harris SE. Expression of the BMP-2 gene during bone differentiation. Crit Rev Eukatyot Gene Expr 1994;4:345-355.
24. Luo G, Hofmann C, Bronckers AL, Sohocki M, Bradley A, Karsenty G. BMP-7 is an inducer of nephogenesis, and also required for eye development and skeletal patterning. Genes Dev 1995;9:2808-2820.
25. Pereira RC, Rydziel S, Canals E. Bone morphogenetic protein-4 regulates its own expression in cultured osteoblast. J Cell Physiol 2000;182:239-246.
26. Yamamoto N, Furuya K, Hanada K. Progressive development of the osteoblast phenotype during differentiation of osteoprogenitor cells derived from fetal rat calvaria: Model for in vitro bone formation. Biol Pharm Bull 2002;25:509-515.
27. Katagiri T, Yamaguchi, Komaki M, et al. Bone morphogenetic protein-2 converts the differentiation pathway C2C12 myoblasts into osteoblast lineage. J Cell Biol 1994; 127:1755-1766.
28. Gori F, Thomas T, Hicok KC, Spelsberg TC, Riggs BL. Differentiation of human marrow stromal precursor cells: Bone morphogenetic protein-2 increases OSF2/CBFA1, enhances osteoblast commitment, and inhibits late adipocyte maturation. J Bone Miner Res 1999;14:1522-1535.
29. Chen D, Ji X, Harris MA, et al. Differentiation roles for bone morphogenetic protein (BMP) receptors type IB and IA in differentiation and specification of mesenchymal precursor cells to osteoblast and adipocyte lineage. J Biol Chem 1998;142:295-305.
30. Ducy P, Zhang R, Geoffroy V, Ridall AL, Karsenty G. Osf2/Cbfa1: A transcriptional activator of osteoblast differentiation. Cell 1997;89:747-754.
31. Nishimura R, Hata K, Harris SE, Ikeda F, Yoneda T. Core-binding factor α1 (Cbfa1) induced osteoblastic differentiation of C2C12 cells without interactions with Smad1 and Smad5. Bone 2002;31:303-312.
32. Lee MH, Javed A, Kim HJ, et al. Transient upregulation of CBFA1 in response to bone morphogenetic protein-2 and transforming growth factor b1 in C2C12 myogenic cells coincides with suppression of the myogenic phenotype but is not sufficient for osteoblast differentiation. J Cell Biolchem 1999;73:114-125.
33. Hanai J, Chen LF, Kanno T, et al. Interaction and functional cooperation of PEBP2/CBF with Smad. Synergistic induction of the immunoglobulin germline C α promoter. J Biol Chem 1999;274:31577-31582.
34. Zhang YW, Yasui N, Ito K. A RUNX"/PEBP2alphaA/CBFA1 mutation displaying impaired transactivation and Smad interaction in cleidocranial dysplasis. Proc Natl Acad Sci (USA) 2000;97:10549-10554.
35. Miyazono K. Positive and negative regulation of TGF-β signaling. J Cell Sci 2000;113:1101-1109.
36. Iemura S, Yamamoto TS, Takagi C, Kobayashi H, Ueno N. Isolation and characterization of bone morphogenetic protein-binding proteins from the early Xenopus embryo. J Biol Chem 1999;274:26834-26849.