In vitro effects of enamel matrix proteins on rat bone marrow cells and gingival fibroblasts

Journal of Dental Research

Volumn 83, Issue 2, 2004, Pages 134-138

  Keila, S ^a   Nemcovsky, C E ^a   Moses, O ^a   Artzi, Z ^a   Weinreb, M ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

Bone marrow; Enamel proteins; Gingival fibroblasts; in vitro; Rat; Stromal cells

Indexed keywords

ALKALINE PHOSPHATASE; ENAMEL MATRIX PROTEINS; ENAMEL PROTEIN;

ANIMAL; ARTICLE; BONE DEVELOPMENT; BONE MARROW CELL; BONE MATRIX; BONE MINERALIZATION; CELL ADHESION; CELL COUNT; CYTOLOGY; DRUG EFFECT; FIBROBLAST; GINGIVA; MALE; RAT; REGENERATION; SPRAGUE DAWLEY RAT; TIME;

ALKALINE PHOSPHATASE; ANIMALS; BONE MARROW CELLS; BONE MATRIX; CALCIFICATION, PHYSIOLOGIC; CELL ADHESION; CELL COUNT; DENTAL ENAMEL PROTEINS; FIBROBLASTS; GINGIVA; MALE; OSTEOGENESIS; RATS; RATS, SPRAGUE-DAWLEY; REGENERATION; TIME FACTORS;

EID: 4143123164     PISSN: 00220345     EISSN: None     Source Type: Journal    
DOI: 10.1177/154405910408300210     Document Type: Article

References (31)

1. Boyan BD, Weesner TC, Lohmann CH, Andreacchio D, Carnes DL, Dean DD, et al. (2000). Porcine fetal enamel matrix derivative enhances bone formation induced by demineralized freeze dried bone allograft in vivo. J Periodontol 71:1278-1286.
2. Davenport DR, Mailhot JM, Wataha JC, Billman MA, Sharawy MM, Shrout MK (2003). Effects of enamel matrix protein application on the viability, proliferation, and attachment of human periodontal ligament fibroblasts to diseased root surfaces in vitro. J Clin Periodontol 30:125-131.
3. Fincham G, Lau EC, Simmer J, Zeichner-David M (1992). Amelogenin biochemistry - form and function. In: Chemistry and biology of mineralized tissues. Slavkin HC, Price PE, editors. New York: Elsevier Science Publishers, pp. 187-201.
4. Gestrelius S, Andersson C, Lidström D, Hammarström L, Somerman M (1997). In vitro studies on periodontal ligament cells and enamel matrix derivative. J Clin Periodontol 24:685-692.
5. Gestrelius S, Lyngstadaas SP, Hammarström L (2000). Emdogain - periodontal regeneration based on biomimicry. Clin Oral Investig 4:120-125.
6. Haase HR, Bartold PM (2001). Enamel matrix derivative induces matrix synthesis by cultured human periodontal fibroblast cells. J Periodontol 72:341-348.
7. Hägewald S, Spahr A, Rompola E, Haller B, Heijl L, Bernimoulin JP (2002). Comparative study of Emdogain® and coronally advanced flap technique in the treatment of human gingival recessions. A prospective controlled clinical study. J Clin Periodontol 29:35-41.
8. Hammarström L (1997). Enamel matrix, cementum development and regeneration. J Clin Periodontol 24:658-668.
9. Hammarström L, Heijl L, Gestrelius S (1997). Periodontal regeneration in a buccal dehiscence model in monkeys after application of enamel matrix proteins. J Clin Periodontol 24:669-677.
10. Heijl L (1997). Periodontal regeneration with enamel matrix derivative in one human experimental defect: a case report. J Clin Periodontol 24:693-696.
11. Heritier M (1982). Experimental induction of cementogenesis on the enamel of transplanted mouse tooth germs. Arch Oral Biol 27:87-97.
12. Jiang J, Safavi KE, Spangberg LS, Zhu Q (2001). Enamel matrix derivative prolongs primary osteoblast growth. J Endod 27:110-112.
13. Kawana F, Sawae Y, Sahara T, Tanaka S, Debari K, Shimizu M, et al. (2001). Porcine enamel matrix derivative enhances trabecular bone regeneration during wound healing of injured rat femur. Anat Rec 264:438-446.
14. Kawase T, Okuda K, Momose M, Kato Y, Yoshie H, Burns DM (2001). Enamel matrix derivative (EMDOGAIN®) rapidly stimulates phosphorylation of the MAP kinase family and nuclear accumulation of smad2 in both oral epithelial and fibroblastic human cells. J Periodontal Res 36:367-376.
15. 2 increases cancellous bone formation and mass in aging rats and stimulates their bone marrow osteogenic capacity in vivo and in vitro. J Endocrinol 168:131-139.
16. Krebsbach PH, Gu K, Franceschi RT, Rutherford RB (2000). Gene therapy-directed osteogenesis: BMP-7-transduced human fibroblasts form bone in vivo. Hum Gene Ther 11:1201-1210.
17. Mellonig JT (1999). Enamel matrix derivative for periodontal reconstructive surgery: technique and clinical and histologic case report. Int J Periodontics Restorative Dent 19:8-19.
18. Ohyama M, Suzuki N, Yamaguchi Y, Maeno M, Otsuka K, Ito K (2002). Effect of enamel matrix derivative on the differentiation of C2C12 cells. J Periodontol 73:543-550.
19. Okubo K, Kobayashi M, Takiguchi T, Takada T, Ohazama A, Okamatsu Y, et al. (2003). Participation of endogenous IGF-1 and TGF-beta1 with enamel matrix derivative-stimulated cell growth in human periodontal ligament cells. J Periodontal Res 38:1-9.
20. Robinson C, Brookes SJ, Shore RC, Kirkham J (1998). The developing enamel matrix: nature and function. Eur J Oral Sci 106:282-291.
21. Schwartz Z, Carnes DL Jr, Pulliam R, Lohmann CH, Sylvia VL, Liu Y, et al. (2000). Porcine fetal enamel matrix derivative stimulates proliferation but not differentiation of pre-osteoblastic 2T9 cells, inhibits proliferation and stimulates differentiation of osteoblast-like MG63 cells, and increases proliferation and differentiation of normal human osteoblast NHOst cells. J Periodontol 71:1287-1296.
22. Sculean A, Chiantella GC, Windisch P, Donos N (2000). Clinical and histologic evaluation of human intrabony defects treated with an enamel matrix protein derivative (Emdogain). Int J Periodontics Restorative Dent 20:374-381.
23. Shimizu-Ishiura M, Tanaka S, Lee WS, Debari K, Sasaki T (2002). Effects of enamel matrix derivative to titanium implantation in rat femurs. J Biomed Mater Res 60:269-276.
24. Simmer JP, Fincham AG (1995). Molecular mechanisms of dental enamel formation. Crit Rev Oral Biol Med 6:84-108.
25. Ten Cate AR (1996). The role of epithelium in the development, structure and function of the tissues of tooth support. Oral Dis 2:55-62.
26. Tonetti MS, Lang NP, Cortellini P, Suvan JE, Adriaens P, Dubravec D, et al. (2002). Enamel matrix proteins in the regenerative therapy of deep intrabony defects. J Clin Periodontol 29:317-325.
27. Van der Pauw MT, Van den Bos T, Everts V, Beertsen W (2000). Enamel matrix-derived protein stimulates attachment of periodontal ligament fibroblasts and enhances alkaline phosphatase activity and transforming growth factor beta 1 release of periodontal ligament and gingival fibroblasts. J Periodontol 71:31-43.
28. 2 in young rats increases the osteogenic capacity of bone marrow. Bone 20:521-526.
29. 4 receptor subtype. Am J Physiol 276:E376-E383.
30. Wennström JL, Lindhe J (2002). Some effects of enamel matrix proteins on wound healing in the dento-gingival region. J Clin Periodontol 29:9-14.
31. Zeichner-David M (2001). Is there more to enamel matrix proteins than biomineralization? Matrix Biol 20:307-316.