Cellular effects of enamel matrix derivative are associated with different molecular weight fractions following separation by size-exclusion chomatography

Journal of Periodontology

Volumn 80, Issue 4, 2009, Pages 648-656

  Johnson, Dwight L ^a   Carnes, David ^b   Steffensen, Bjorn ^b   Cochran, David L ^b  

^a WILFORD HALL MEDICAL CENTER   (United States)

^b UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Angiogenesis; Bone morphogenetic protein; Cell differentiation; Cell proliferation

Indexed keywords

ALKALINE PHOSPHATASE; AMELOGENIN; BONE MORPHOGENETIC PROTEIN; ENAMEL MATRIX PROTEINS; ENAMEL PROTEIN;

ANGIOGENESIS; ANIMAL; ARTICLE; BIOSYNTHESIS; BONE DEVELOPMENT; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; CHEMISTRY; CHROMATOGRAPHY; DRUG EFFECT; ENDOTHELIUM CELL; FRACTIONATION; HUMAN; METHODOLOGY; MOLECULAR WEIGHT; MOUSE; OSTEOBLAST; PHYSIOLOGY; POLYACRYLAMIDE GEL ELECTROPHORESIS; REGENERATION; STEM CELL; SWINE;

ALKALINE PHOSPHATASE; AMELOGENIN; ANIMALS; BONE MORPHOGENETIC PROTEINS; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; CHEMICAL FRACTIONATION; CHROMATOGRAPHY; DENTAL ENAMEL PROTEINS; ELECTROPHORESIS, POLYACRYLAMIDE GEL; ENDOTHELIAL CELLS; HUMANS; MICE; MOLECULAR WEIGHT; NEOVASCULARIZATION, PHYSIOLOGIC; OSTEOBLASTS; OSTEOGENESIS; REGENERATION; STEM CELLS; SWINE;

EID: 63849140088     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2009.070420     Document Type: Article

References (35)

1. Yukna RA, Mellonlg J, Histologic evaluation of periodontal healing in humans following regenerative therapy with enamel matrix derivative, A 10-case series, J Periodontal 2000;71:752-759.
2. Heijl L. Periodontal regeneration with enamel matrix derivative in one human experimental defect. A case report, J Clin Periodoniol 1997:24:693-896.
3. Hammarstrom L, Heijl L, Gestrelius S. Periodontal regeneration in a buccal dehiscence model in monkeys after application of enamel matrix proteins. J Clin Periodoniol 1997:24:669-677.
4. Froum SJ, Weinberg M, Rosenberg E, Tarnow D, A comparative study utilizing open lap debridement with and without enamel matrix derivative in the treatment of periodontal intrabony defects: A 12-month re-entry study. J Periodoniol 2001 ;72:25-34,
5. Kawase T, Okuda K, Yoshie H, Burns D. Cytostatic action of enamel matrix derivative (EMDOGAIN) on human oral squamous cell carcinoma-derived SCC25 epithelial cells. J Periodontal Res 2000;35:
6. Gestrelius S, Andersson C, Lidström D, Hammarstrom L, Somerman M. In vitro studies on periodontal ligament cells and enamel matrix derivative, J Clin Pert odontol 1997;24:685-692.
7. Schwartz Z, Carnes DL Jr., Pulliam R, et al. Porcine fetal enamel matrix derivative stimulates proliferation but not differentiation of pre-osteoblastic 2T9 cells, inhibits proliferation and stimulates differentiation of osteoblast-like MG63 cells, and increases proliferation and differentiation of normal human osteoblast NHOst cells, J Periodoniol 2000;71:1287-1296,
8. 1 release of periodontal ligament and gingival fibroblasts. J Periodoniol 2000;71:31-43,
9. Schlueter SR, Carnes DL, Cochran DL. in vitro effects of enamel matrix derivative on microvascular cells, J Periodontal 2007;78:141-151.
10. Spahr A, Lyngstadaas S, Boeckh C, Andersson C, Podbielski A, Haller B, Effect of the enamel matrix derivative Emdogain on the growth of periodontal pathogens in vitro. J Clin Periodontal 2002;29:62-72,
11. , Viswanathan HL, Berry JE, Foster BL, et al, Amelo-genin: A potential regulator of cementum-associated genes. J Periodoniol 2003;74:1423-1431.
12. Parkar MH, Tonetti M, dene expression profiles of periodontal ligament cells treated with enamel matrix proteins in vitro: Analysis using cDNA arrays. J Periodontal 2004;75:1539-1546.
13. , Lyngstadaas SP, Lundberg E, Ekdahl H, Andersson C, Gestrelius S. Autocrine growth factors in human periodontal ligament cells cultured on enamel matrix derivative. J Clin Periodontal 2001 ;28:181 -188,
14. Suzuki N, Ohyama M, Maeno M, Ito K, Otsuka K, Attachment of human periodontal ligament cells to enamel matrix-derived protein is mediated via interaction between BSP-like molecules and integrin avβ3. J Periodontal 2001 ;72:1520-1526,
15. Hoang AM, Kiebe RJ, Steffensen B, Ryu OH, Simmer JP, Cochran DL. Amelogenin is a cell adhesion protein, J Dent Res 2002;81:497-500,
16. Veis A, Tompkins K, Alvares K, et al. Specific amelogenin gene splice products have signaling effects on cells in culture and in implants in vivo. J Biol Chem 2000:275:41263-41272.
17. Tompkins K, Alvares K, George A, Veis A, Two related low molecular mass polypeptide isoforms of amelogenin have distinct activities in mouse tooth germ differentiation in vitro, J Bone Miner Res 2005;20: 341-349.
18. Takayama T, Suzuki N, Narukawa M, Tokunaga T, Otsuka K, Enamel matrix derivative stimulates core binding factor al/Runt-related transcription factor-2 expression via activation of Smadl in C2C12 cells, J Periodontal 2005;76:244-249.
19. Iwata T, Morotome Y, Tanabe T, Fukae M, Ishikawa I, Oida S. Noggin blocks osteoinductive activity of porcine enamel extracts. J Dent Res 2002;81:387-391.
20. Kawase T, Okuda K, Momose M, Kato Y, Yoshie H, Burns D. Enamel matrix derivative (Emdogain) rapidly stimulates phosphorylation of the MAP kinase family and nuclear accumulation of Smad2 in both oral epithelial and fibroblastic human cells. J Periodontal Res 2001;36:387-376.
21. Fisher LW, Termine JD, Noncollagenous proteins influencing the local mechanisms of calcification, J Orihop Relat Res 1985;(200):382-385.
22. Aoba T, Fukae M, Tanabe X, Shimizu M, Moreno EC. Selective adsorption of porcine amelogenlns onto hy-droxyapatite and their inhibitory activity on hydroxy-apatite growth in supersaturated solutions. Calcif Tissue Int 1987;41:281-289.
23. Ryu OH, Fincham A, Hu C, et al. Characterization of recombinant pig enamelysin activity and cleavage of recombinant pig and mouse amelogenins. J Dent Res 1999;78:743-750.
24. Malinda KM, Nomizu M, Chung M, et al. Identification of laminin alpha 1 and beta 1 chain peptides active for endothelial cell adhesion, tube formation, and aortic sprouting. FASEB J 1999;13:53-62.
25. Laemmii OK. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature 1970;227:680-888.
26. , Overall CM, Limeback H, Identification and characterization of enamel proteinases isolated from developing enamel. Amelogeninolytic serine proteinases are associated with maturation in pig. Biochem J 1988;258: 965-972.
27. Steffensen B, Bigg HF, Overall CM. The involvement of the fibroneetin type H-like modules of human gela-tinase A in cell surface localization and activation. J Biol Chem 1998;273:20622-20628.
28. Ohyama M, Suzuki N, Yamaguchi Y, Maeno M, Otsuka K, Ito K. Effect of enamel matrix derivative on the differentiation of C2C12 cells. J Periodontol 2002:73:543-550,
29. Nishimura R, Hata K, Harris S, Ikeda F, Yoneda T. Core-binding factor al (Cbfal) induced osteoblastic differentiation of C2C12 cells without interactions with Smadl and Smad5. Borie 2002;31:303-312.
30. Yuan K, Chen CL, Lin MT, Enamel matrix derivative exhibits angiogenic effect in vitro and in a murine model. J Clin Periodontol 2003;30:732-738.
31. Mirastschijski 0, Konrad D, Lundberg E, Lyngstadaas SP, Jorgensen LN, Agren MS. Effects of a topical enamel matrix derivative on skin wound healing. Wound Repair Regen 2004;12:100-108.
32. Steffensen B, Wallon OM, Overall CM. Extracellular matrix binding properties of recombinant fibroneetin type 11-like modules of 72-kDa gelatinase/type IV col-lagenase. High affinity binding to native type 1 collagen but not native type IV collagen. J Biol Chem 1995; 270:11555-11566.
33. Bartlett JD, Ryu OH, Xue J, Simmer JP, Margolis HC. Enamelysin mRNA displays a developmentally defined pattern of expression and encodes a protein which degrades amelogenin. Connect Tissue Res 1998;39:101-109.
34. Kjeldsen L, Johnsen AH, Sengeløv H, Borregaard N. Isolation and primary structure of NGAL, a novel protein associated with human neutrophil gelatinase. J Biol Chem 1993;268:10425-10432.
35. Westerlund Cl, Ingman T, Lukinmaa PL, et al. Human neutrophil gelatinase and associated lipocalin in adult and localized juvenile periodontitis. J Dent Res 1996; 75:1553-1563.