Expression, structure, and function of enamel proteinases

Connective Tissue Research

Volumn 43, Issue 2-3, 2002, Pages 441-449

  Simmer, James P ^a   Hu, J C C ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

EMSP1; Enamel matrix serine proteinase 1; Enamelysin; Kallikrein 4; KLKA dental enamel; MMP 20

Indexed keywords

AMELOBLASTIN; ENAMEL PROTEIN; ENAMELYSIN; KALLIKREIN; MATRIX METALLOPROTEINASE; MATRIX METALLOPROTEINASE 20; PROTEINASE; SERINE PROTEINASE; UNCLASSIFIED DRUG;

AMELOBLAST; AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CARBOXY TERMINAL SEQUENCE; CONNECTIVE TISSUE; CONTROLLED STUDY; DENTIN; ENAMEL; ENZYME DEGRADATION; ENZYME MECHANISM; ENZYME RELEASE; ENZYME STRUCTURE; EXTRACELLULAR SPACE; HYDROLYSIS; IN VITRO STUDY; IN VIVO STUDY; NONHUMAN; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN INTERACTION; PROTEIN LOCALIZATION; PROTEIN MODIFICATION; PROTEIN PROCESSING; SWINE; TOOTH DEVELOPMENT; ANIMAL; CHEMISTRY; CRYSTALLIZATION; ENZYMOLOGY; PHYSIOLOGY; REVIEW; STRUCTURE ACTIVITY RELATION;

ANIMALIA; SUS SCROFA;

AMELOGENESIS; ANIMALS; CRYSTALLIZATION; DENTAL ENAMEL; ENDOPEPTIDASES; MATRIX METALLOPROTEINASE 20; MATRIX METALLOPROTEINASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0035996553     PISSN: 03008207     EISSN: None     Source Type: Journal    
DOI: 10.1080/03008200290001159     Document Type: Article

References (78)

1. The stages of amelogenesis as observed in molar teeth of young rats
2. Electron microscopy of the differentiating rat incisor ameloblast
3. A method for sampling the stages of amelogenesis on mandibular rat incisors using the molars as a reference for dissection
4. Immunochemical and immunohistochemical studies, using antisera against porcine 25 kDa amelogenin, 89 kDa enamelin and the 13-17 kDa nonamelogenins, on immature enamel of the pig and rat
5. Crystal growth in rat enamel
6. High-resolution electron microscope study of human enamel crystallites: Size, shape, and growth
7. Epitaxial overgrowth of apatite crystals on the thin-ribbon precursor at early stages of porcine enamel mineralization
8. Degradation and loss of matrix proteins from developing enamel
9. The structural biology of the developing dental enamel matrix
10. Dental enamel matrix: Sequences of two amelogenin polypeptides
11. Identification of the leucine-rich amelogenin peptide (LRAP) as the translation product of an alternatively spliced transcript
12. The human enamel protein gene amelogenin is expressed from both the X and Y chromosomes
13. Isolation and characterisation of an alternatively-spliced rat amelogenin cDNA: LRAP-a highly conserved, functional alternatively-spliced amelogenin?
14. Alternative splicing of the mouse amelogenin primary RNA transcript
15. Alternative splicing of amelogenin mRNA from rat incisor ameloblast
16. "Molecular biology of the amelogenin gene."
17. Cloning DNA sequence and alternative splicing of opossum amelogenin mRNAs
18. Analysis of amelogenin mRNA during bovine tooth development
19. Derived protein and cDNA sequences of hamster amelogenin
20. Sheathlin: Cloning, cDNA/polypeptide sequences, and immunolocalization of porcine enamel proteins concentrated in the sheath space
21. Partial amino acid sequences of two proteins in developing porcine enamel
22. Studies on porcine enamel proteins: A possible original enamel protein
23. Amino acid sequence of the main component of porcine enamel proteins
24. "Amino acid sequence of porcine 25kDa amelogenin."
25. Porcine amelogenins
26. Alternative splicing of amelogenins
27. Mass spectrometry of native rat amelogenins: Primary transcripts, secretory isoforms, and C-terminal degradation
28. Cloning and characterization of porcine enamelin mRNAs
29. Developmental changes in the pH of enamel fluid and its effects on matrix-resident proteinases
30. Molecular cloning and mRNA tissue distribution of a novel matrix metalloproteinase isolated from porcine enamel organ
31. Enamelysin mRNA displays a developmentally defined pattern of expression and encodes a protein which degrades amelogenin
32. Enamelysin (matrix metalloproteinase-20): Localization in the developing tooth and effects of pH and calcium on amelogenin hydrolysis
33. Purification, characterization and cloning of enamel matrix serine proteinase 1
34. Cloning of the murine EMSP1 cDNA and analysis of expression during tooth development
35. Identification and characterization of enamel proteinases isolated from developing enamel: Amelogeninolytic serine proteinases are associated with enamel maturation in pig
36. Enamelins in the newly formed bovine enamel
37. Amelogenins: Sequence homologies in enamel-matrix proteins from three mammalian species
38. Mass-spectrographic analysis of a porcine amelogenin identifies a single phosphorylated locus
39. Immunochemical and immunohistochemical study of 27 and 29 kDa calcium binding proteins and related proteins in the porcine tooth germ
40. Dentin sialoprotein, dentin phosphoprotein, enamelysin and ameloblastin: Tooth-specific molecules that are distinctively expressed during murine dental differentiations
41. Cloning, characterization, and expression analysis of mouse enamelysin
42. Characterization of recombinant enamelysin activity and cleavage of recombinant amelogenin
43. The amelogenesis of human teeth as revealed by electron microscopy: II The development of the enamel crystallites
44. The amelogenesis of human teeth as revealed by electron microscopy: I. The fine structure of the ameloblasts
45. Enamel maturation
46. Cellular and chemical events during enamel maturation
47. Control of crystal growth during enamel maturation
48. Molecular mechanisms of dental enamel formation
49. Biochemical characterization of recombinant mouse amelogenins: Proton absorption, and affinity for enamel crystals
50. Properties of phosphorylated 32 kd nonamelogenin proteins isolated from porcine secretory enamel
51. Growth tracks in dental enamel
52. Synthetic hammerhead ribozymes as tools in gene expression
53. Fine structure of rat incisor ameloblasts in transition between enamel secretion and maturation stages
54. Morphologic and functional correlations in the enamel organ of the rat incisor during amelogenesis
55. The ultrastructure of ameloblasts during matrix formation and the maturation of enamel
56. Cytochemical studies of ameloblasts and the surface layer of enamel of the rat incisor at the maturation stage
57. Extracellular processing of enamel matrix proteins and the control of crystal growth
58. Ameloblast modulation in the maturation zone of the rat incisor enamel organ: A light and electron microscopic study
59. Cyclical changes in pH in bovine developing enamel as sequential bands
60. MEROPS: The peptidase database
61. Identification and structural and functional characterization of human enamelysin (MMP-20)
62. Proteinases in developing dental enamel
63. Purification and sequencing of a 21 kDa and 25 kDa bovine enamel metalloproteinase
64. "The structure and function of enamelysin (MMP-20)."
65. Assignment of serine protease 17 (PRSS17) to human chromosome band(s) 19q13.3q13.4 by in situ hybridization
66. Characterization of the mouse and human PRSS17 genes, their relationship to other proteinases, and expression in developing incisors
67. Purification and characterization of proteolytic enzymes in porcine immature enamel
68. "Cloning and characterization of a cDNA encoding human EMSP1."
69. Molecular cloning and characterization of prostase an androgen-regulated serine protease with prostate-restricted expression
70. Localization of a new prostate-specific antigen-related serine protease gene, KLK4, is evidence for an expanded human kallikrein gene family cluster on chromosome 19q13.3-13.4
71. Enamel matrix serine proteinase 1: Stage-specific expression and molecular modeling
72. Identification of a novel proteinase ("ameloproteinase-I") responsible for complete degradation of amelogenin during enamel maturation
73. Immunocytochemical and immunochemical detection of a 32 kDa nonamelogenin and related proteins in porcine tooth germs
74. Structure of full-length porcine synovial collagenase reveals a C-terminal domain containing a calcium-linked, four-bladed beta-propeller
75. Stromelysin-1: Three-dimensional structure of the inhibited catalytic domain and of the C-truncated proenzyme