Porcine fetal enamel matrix derivative stimulates proliferation but not differentiation of pre-osteoblastic 219 cells, inhibits proliferation and stimulates differentiation of osteoblast-like MG63 cells, and increases proliferation and differentiation of normal human osteoblast NHOst cells

Journal of Periodontology

Volumn 71, Issue 8, 2000, Pages 1287-1296

  Schwartz, Z ^a,b   Carnes Jr , D L ^d   Pulliam, R ^d   Lohmann, C H ^a,c   Sylvia, V L ^a   Liu, Y ^a   Dean, D D ^a   Cochran, D L ^d   Boyan, Barbara D ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

^b HADASSAH HEBREW UNIVERSITY MEDICAL CENTER   (Israel)

^c UNIVERSITY OF GÖTTINGEN   (Germany)

^d Mail Code 7774 ^*

Author keywords

Dental cementum; Osteoblasts; Periodontal regeneration; Protein, enamel matrix

Indexed keywords

ALKALINE PHOSPHATASE; BMP2 PROTEIN, HUMAN; BONE MORPHOGENETIC PROTEIN; BONE MORPHOGENETIC PROTEIN 2; COLLAGEN; DIAGNOSTIC AGENT; ENAMEL MATRIX PROTEINS; ENAMEL PROTEIN; OSTEOCALCIN; PROSTAGLANDIN E2; RADIOPHARMACEUTICAL AGENT; SULFUR; THYMIDINE; TRANSFORMING GROWTH FACTOR BETA; TRITIUM;

ANIMAL; ARTICLE; BIOSYNTHESIS; BONE DEVELOPMENT; CELL COUNT; CELL CULTURE; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE; CELL LINEAGE; CULTURE MEDIUM; CYTOLOGY; DRUG EFFECT; HUMAN; METABOLISM; OSTEOBLAST; OSTEOSARCOMA; PATHOLOGY; PATHOPHYSIOLOGY; SWINE;

ALKALINE PHOSPHATASE; ANIMALS; BONE MORPHOGENETIC PROTEINS; CELL COUNT; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE; CELL LINEAGE; COLLAGEN; CULTURE MEDIA, CONDITIONED; DENTAL ENAMEL PROTEINS; DINOPROSTONE; HUMANS; OSTEOBLASTS; OSTEOCALCIN; OSTEOGENESIS; OSTEOSARCOMA; RADIOPHARMACEUTICALS; SULFUR RADIOISOTOPES; SWINE; THYMIDINE; TRANSFORMING GROWTH FACTOR BETA; TRITIUM; TUMOR CELLS, CULTURED;

EID: 0034243492     PISSN: 00223492     EISSN: None     Source Type: Journal    
DOI: 10.1902/jop.2000.71.8.1287     Document Type: Article

References (39)

1. Brookes SJ, Robinson C, Kirkham J, Bonass WA. Biochemistry and molecular biology of amelogenin proteins of developing dental enamel. Arch Oral Biol 1995;40:1-14.
2. Fischer LT. Noncollagenous proteins influencing the local mechanisms of calcification. J Clin Orthop 1985;20:362-385.
3. Gestrelius S, Andersson C, Johansson AC, et al. Formulation of enamel matrix derivative for surface coating. Kinetics and cell colonization. J Clin Periodontol 1997;24:678-684.
4. Hammarstrom L. Enamel matrix, cementum development and regeneration. J Clin Periodontol 1997;24:658-668.
5. Krebsbach PH, Lee SK, Matsuki Y, Kozak CA, Yamada KM, Yamada Y. Full-length sequence, localization, and chromosomal mapping of ameloblastin. J Biol Chem 1996;271:4431-4435.
6. Cerny R, Slaby I, Hammarstrom L, Wurtz T. A novel gene expressed in rat ameloblasts codes for proteins with cell binding domains. J Bone Miner Res 1995; 11:883-891.
7. Paynter KJP. A study of the structure, chemical nature and development of cementum in the rat. Anat Rec 1958;131:233-251.
8. Selvig KA. Electron microscopy of Hertwig's epithelial root sheath and of early dentin formation in the mouse incisor. Acta Odontol Scand 1963;21:175-186.
9. Formicola AJ, Krampf JI, Witte ET. Cementogenesis in developing rat molars. J Periodontol 1971;42:766-773.
10. Armitage GC. Cementum. In: Bhaskar SN, ed. Orban's Oral Histology and Embryology. Princeton, NJ: CV Mosby Company; 1986:175-197.
11. Cho MI, Garant PR. Ultrastructural evidence of directed cell migration during initial cementoblast differentiation in root formation. J Periodont Res 1988;23:268-276.
12. Bosshardt DD, Schroeder HE. Cementogenesis reviewed: A comparison between human premolars and rodent molars. Anat Rec 1996;245:267-292.
13. Slavkin HC, Boyd A. Cementum: An epithelial secretory product? J Dent Res 1974;53(Spec. Issue):157 (Abstr. 409).
14. Slavkin HC. Towards a cellular and molecular understanding of periodontics. Cementogenesis revisited. J Periodontol 1976;47:249-255.
15. Lindskog S. Formation of intermediate cementum. I: Early mineralization of aprismatic enamel and intermediate cementum in monkey. J Craniofac Genet Dev Biol 1982;2:147-160.
16. Lindskog S. Formation of intermediate cementum. II: A scanning electron microscopic study of the epithelial root sheath of Hertwig in monkey. J Craniofac Genet Dev Biol 1982;2:161-169.
17. 3H-proline uptake into the epithelial root sheath of Hertwig in vitro. J Craniofac Genet Dev Biol 1982;2:171-177.
18. Slavkin HC, Bringas P Jr., Bessem C, et al. Hertwig's epithelial root sheath differentiation and initial cementum and bone formation during long-term organ culture of mouse mandibular first molars using serumless, chemically-defined medium. J Periodont Res 1989;24:28-40.
19. Hammarstrom L, Heijl L, Gestrelius S. Periodontal regeneration in a buccal dehiscence model in monkeys after application of enamel matrix proteins. J Clin Periodontol 1997;24:669-677.
20. Zetterstrom O, Andersson C, Eriksson L, et al. Clinical safety of enamel matrix derivative (EMDOGAIN) in the treatment of periodontal defects. J Clin Periodontol 1997;24:697-704.
21. Heijl L. Periodontal regeneration with enamel matrix derivative in one human experimental defect. A case report. J Clin Periodontol 1997;24:693-696.
22. Ghosh-Choudhury N, Harris MA, Mundy GR, Harris SE. Transfection of bone morphogenetic protein 2 (BMP 2) expression plasmid induces osteoblastic differentiation in a BMP 2-dependent preosteoblast cell line. J Bone Miner Res 1994;9:S137(Abstr. 66).
23. Harris SE, Ghosh-Choudhury N, Fuqua SA, et al. Specific genes regulated by recombinant bone morphogenetic protein 2 (BMP 2) identified by differential display PCR. J Bone Miner Res 1994;9:S171(Abstr. A64).
24. Lian JB, Stein GS. Concepts of osteoblast growth and differentiation: Basis for modulation of bone cell development and tissue formation. Crit Rev Oral Biol Med 1992;3:269-305.
25. Harris SE, Bonewald LF, Harris MA, et al. Effects of transforming growth factor β on bone nodule formation and expression of bone morphogenetic protein 2, osteocalcin, osteopontin, alkaline phosphatase, and type I collagen mRNA in long term fetal rat calvarial osteoblasts. J Bone Miner Res 1994;9:855-863.
26. 3 specific regulation of growth, morphology, and fibronectin in a human osteosarcoma cell line. J Cell Physiol 1985;123:401-409.
27. 3 responsive alkaline phosphatase in osteoblast-like cells (ROS 17/2.8, MG63, and MC 3T3) and growth cartilage cells in culture. J Biol Chem 1989;264:11879-11886.
28. 3 on differentiation of a human osteosarcoma (MG-63). J Biol Chem 1992;267:8943-8949.
29. Schwartz Z, Schlader DL, Ramirez V, Kennedy MB, Boyan BD. Effects of vitamin D metabolites on collagen production and cell proliferation of growth zone and resting zone cartilage cells in vitro. J Bone Miner Res 1989; 4:199-207.
30. Bretaudiere JP, Spillman T. Alkaline phosphatases. In: Bergmeyer HU, ed. Methods of Enzymatic Analysis, 4th ed. Weinheim, Germany: Verlag Chemica; 1984:75-92.
31. 3. J Biomed Mater Res 1998;39:77-85.
32. Peterkofsky B, Diegelmann R. Use of a mixture of proteinase-free collagenases for the specific assay of radioactive collagen in the presence of other proteins. Biochemist 1971;10:988-994.
33. Beresford JN, Gallagher JA, Gowen M, et al. The effects of monocyte-conditioned medium and interleukin 1 on the synthesis of collagenous and non-collagenous proteins by mouse bone and human bone cells in vitro. Biochim Biophys Acta 1984;801:58-65.
34. Nasatzky E, Schwartz Z, Soskolne WA, et al. Sex steroid enhancement of matrix production by chondrocytes is sex and cell maturation specific. Endocrine J 1994; 2:207-215.
35. O'Keefe RJ, Puzas JE, Brand JS, Rosier RN. Effects of transforming growth factor-beta on matrix synthesis by chick growth plate chondrocytes. Endocrinol 1988;122: 2953-2961.
36. Kieswetter K, Schwartz Z, Hummert TW, et al. Surface roughness modulates the local production of growth factors and cytokines by osteoblast-like MG63 cells. J Biomed Mater Res 1996;32:55-63.
37. Reddi AH. Regulation of cartilage and bone differentiation by bone morphogenetic proteins. [Review]. Curr Opin Cell Biol 1992;4:850-855.
38. Bonewald LF, Dallas SL. Role of active and latent transforming growth factor β in bone formation. J Cell Biochem 1994;55:350-357.
39. Shalhoub V, Conlon D, Tassinari M, et al. Glucocorticoids promote development of the osteoblast phenotype by selectively modulating expression of cell growth and differentiation associated genes. J Cell Biochem 1992; 50:425-440.