Enamel matrix derivative stimulates human gingival fibroblast proliferation via ERK

Journal of Dental Research

Volumn 86, Issue 1, 2007, Pages 41-46

  Zeldich, E ^a   Koren, R ^a   Nemcovsky, C ^a   Weinreb, M ^a  

^a TEL AVIV UNIVERSITY   (Israel)

Author keywords

Cell cycle; Enamel proteins; ERK; Gingival fibroblasts; In vitro

Indexed keywords

1,3 BUTADIENE DERIVATIVE; 1,4 DIAMINO 1,4 BIS(2 AMINOPHENYLTHIO) 2,3 DICYANOBUTADIENE; COLLAGEN; DNA; ENAMEL MATRIX PROTEINS; ENAMEL PROTEIN; ENZYME INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; NITRILE; UNCLASSIFIED DRUG;

ARTICLE; BIOSYNTHESIS; BLOOD; CELL COUNT; CELL CULTURE; CELL CYCLE; CELL CYCLE S PHASE; CULTURE MEDIUM; CYTOLOGY; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; FIBROBLAST; GINGIVA; HUMAN; MITOSIS; TIME;

BLOOD; BUTADIENES; CELL COUNT; CELL CYCLE; CELLS, CULTURED; COLLAGEN; CULTURE MEDIA; CULTURE MEDIA, SERUM-FREE; DENTAL ENAMEL PROTEINS; DNA; ENZYME ACTIVATION; ENZYME INHIBITORS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; FIBROBLASTS; GINGIVA; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; MITOSIS; NITRILES; S PHASE; TIME FACTORS;

EID: 33846552935     PISSN: 00220345     EISSN: None     Source Type: Journal    
DOI: 10.1177/154405910708600106     Document Type: Article

References (29)

1. Borenfreund E, Puerner JA (1985). A simple quantitative procedure using monolayer cultures for cytotoxicity assays (HTD/NR-90). J Tissue Cult Meth 9:7-9.
2. Buolamwini JK (2000). Cell cycle molecular targets in novel anticancer drug discovery. Curr Pharm Des 6:379-392.
3. Cattaneo V, Rota C, Silvestri M, Piacentini C, Fornilo A, Gallanti A, et al. (2003). Effect of enamel matrix derivative on human periodontal fibroblasts: proliferation, morphology and root surface colonization. An in vitro study. J Periodontal Res 38:568-574.
4. Fincham AG, Lau EC, Simmer J, Zeichner-David M (1992). Amelogenin biochemistry-form and function. In: Chemistry and biology of mineralized tissues. Slavkin HS, Price PE, editors. New York: Elsevier Science Publishers, pp. 187-201.
5. Gestrelius S, Andersson C, Lidström D, Hammarström L, Somerman M (1997). In vitro studies on periodontal ligament cells and enamel matrix derivative. J Clin Periodontol 24(9 Pt 2):685-692.
6. Giannobile WV, Somerman MJ (2003). Growth and amelogenin-like factors in periodontal wound healing. A systematic review. Ann Periodontol 8:193-204.
7. Granot I, Halevy O, Hurwitz S, Pines M (1993). Halofuginone: an inhibitor of collagen type I synthesis. Biochim Biophys Acta 1156:107-112.
8. Haase HR, Clarkson RW, Waters MJ, Bartold PM (1998). Growth factor modulation of mitogenic responses and proteoglycan synthesis by human periodontal fibroblasts. J Cell Physiol 174:353-361.
9. Hagewald S, Spahr A, Rompola E, Haller B, Heijl L, Bernimoulin JP (2002). Comparative study of Emdogain and coronally advanced flap technique in the treatment of human gingival recessions. A prospective controlled clinical study. J Clin Periodontol 29:35-41.
10. Hagewald S, Pischon N, Jawor P, Bernimoulin JP, Zimmermann B (2004). Effects of enamel matrix derivative on proliferation and differentiation of primary osteoblasts. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 98:243-249.
11. Hammarström L (1997). Enamel matrix, cementum development and regeneration. J Clin Periodontol 24(9 Pt 2):658-668.
12. Huang Z, Cheng SL, Slatopolsky E (2001). Sustained activation of the extracellular signal-regulated kinase pathway is required for extracellular calcium stimulation of human osteoblast proliferation. J Biol Chem 276(Pt 24):21351-21358.
13. Kawase K, Okuda H, Yoshie H, Burns DM (2000). Cytostatic action of enamel matrix derivative (EMDOGAIN®) on human oral squamous cell carcinoma-derived SCC25 epithelial cells. J Periodontal Res 35:291-300.
14. Kawase T, Okuda K, Momose M, Kato Y, Yoshie H, Burns DM (2001). Enamel matrix derivative (EMDOGAIN®) rapidly stimulates phosphorylation of the MAP kinase family and nuclear accumulation of smad2 in both oral epithelial and fibroblastic human cells. J Periodontal Res 36:367-376.
15. Keila S, Nemcovsky CE, Moses O, Artzi Z, Weinreb M (2004). In vitro effects of enamel matrix proteins on rat bone marrow cells and gingival fibroblasts. J Dent Res 83:134-138.
16. Koren R, Bercovitz H, Umezawa H, Muller WE (1981). The role of bestatin, a inhibitor of cell surface proteases, in the interaction of serum with untransformed cells in culture. J Antibiot (Tokyo) 34:90-94.
17. Marcopoulou CE, Vavouraki HN, Dereka XE, Vrotsos IA (2003). Proliferative effect of growth factors TGF-betal, PDGF-BB and rhBMP-2 on human gingival fibroblasts and periodontal ligament cells. J Int Acad Periodontol 5:63-70.
18. Matsuda N, Horikawa M, Watanabe M, Kitagawa S, Kudo Y, Takata T (2002). Possible involvement of extracellular signal-regulated kinases 1/2 in mitogenic response of periodontal ligament cells to enamel matrix derivative. Eur J Oral Sci 110:439-444.
19. Nemcovsky CE, Artzi Z, Tal H, Kozlovsky A, Moses O (2004). A multicenter comparative study of two root coverage procedures: coronally advanced flap with the addition of enamel matrix proteins and subpedicle connective tissue graft. J Periodontol 75:600-607.
20. Ohyama M, Suzuki N, Yamaguchi Y, Maeno M, Otsuka K, Ito K (2002). Effect of enamel matrix derivative on the differentiation of C2C12 cells. J Periodontol 73:543-550.
21. 3 increases the cellular content of the calcium-activated neutral protease mu-calpain in renal cell carcinoma. Endocrinology 135:2822-2825.
22. Rincon JC, Haase HR, Bartold PM (2003). Effect of Emdogain® on human periodontal fibroblasts in in vitro wound-healing model. J Periodontal Res 38:290-295.
23. Saati N, Ravid A, Liberman UA, Koren R (1997). 1,25-dihydroxyvitamin D3 and agents that increase intracellular adenosine 3′,5′-monophosphate synergistically inhibit fibroblast proliferation. In Vitro Cell Dev Biol Anim 33:310-314.
24. Sculean A, Chiantella GC, Windisch P, Donos N (2000). Clinical and histologic evaluation of human intrabony defects treated with an enamel matrix protein derivative (Emdogain). Int J Periodontics Restorative Dent 20:374-381.
25. Simmer JP, Fincham AG (1995). Molecular mechanisms of dental enamel formation. Crit Rev Oral Biol Med 6:84-108.
26. Slavkin HC, Boyd A (1975). Cementum: a epithelial secretory product? (abstract). J Dent Res 53:157.
27. Tonetti MS, Fourmousis I, Suva J, Cortellini P, Brägger U, Lang NP, et al. (2004). Healing, post-operative morbidity and patient perception of outcomes following regenerative therapy of deep intrabony defects. J Clin Periodontol 31:1092-1098.
28. Van der Pauw MT, Van den Bos T, Everts V, Beertsen W (2000). Enamel matrix-derived protein stimulates attachment of periodontal ligament fibroblasts and enhances alkaline phosphatase activity and transforming growth factor-beta 1 release of periodontal ligament and gingival fibroblasts. J Periodontol 71:31-43.
29. Vindelov LL, Christensen IJ, Nissen NI (1983). A detergent-trypsin method for the preparation of nuclei for flow cytometric DNA analysis. Cytometry 3:323-327.