Proanthocyanidins and other flavonoids in relation to pancreatic cancer: A case-control study in Italy

Annals of Oncology

Volumn 23, Issue 6, 2012, Pages 1488-1493

  Rossi, M ^a,b   Lugo, A ^a   Lagiou, P ^c,d   Zucchetto, A ^e   Polesel, J ^e   Serraino, D ^e   Negri, E ^a   Trichopoulos, D ^c,f   La vecchia, C ^a,b,g  

^a MARIO NEGRI INSTITUTE FOR PHARMACOLOGICAL RESEARCH   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d UNIVERSITY OF ATHENS MEDICAL SCHOOL   (Greece)

^e CENTRO DI RIFERIMENTO ONCOLOGICO   (Italy)

^f BIOMEDICAL RESEARCH FOUNDATION   (Greece)

^g INTERNATIONAL PREVENTION RESEARCH INSTITUTE   (France)

Author keywords

Diet; Flavonoids; Pancreatic cancer; Proanthocyanidins; Risk

Indexed keywords

ANTHOCYANIDIN DERIVATIVE; ASCORBIC ACID; FLAVANOL DERIVATIVE; FLAVANONE DERIVATIVE; FLAVONE DERIVATIVE; FLAVONOID; FLAVONOL DERIVATIVE; FOLIC ACID; ISOFLAVONE DERIVATIVE; PROANTHOCYANIDIN; UNCLASSIFIED DRUG;

ADULT; AGE DISTRIBUTION; AGED; ALCOHOL CONSUMPTION; APPLE; ARTICLE; CALORIC INTAKE; CANCER RISK; CASE CONTROL STUDY; CONTROLLED STUDY; DIABETES MELLITUS; DISEASE ASSOCIATION; EDUCATIONAL STATUS; FEMALE; FOOD FREQUENCY QUESTIONNAIRE; FOOD INTAKE; FRUIT; HUMAN; ITALY; MAJOR CLINICAL STUDY; MALE; MEDICAL HISTORY; PANCREAS CANCER; PEAR; PRIORITY JOURNAL; PROTECTION; REPRODUCIBILITY; RISK REDUCTION; SEX DIFFERENCE; SMOKING; VEGETABLE; VITAMIN INTAKE;

EID: 84861730634     PISSN: 09237534     EISSN: 15698041     Source Type: Journal    
DOI: 10.1093/annonc/mdr475     Document Type: Article

References (50)

1. Manach C, Scalbert A, Morand C et al. Polyphenols: food sources and bioavailability. Am J Clin Nutr 2004; 79: 727-747.
2. Nijveldt RJ, van Nood E, van Hoorn DE et al. Flavonoids: a review of probable mechanisms of action and potential applications. Am J Clin Nutr 2001; 74: 418-425.
3. Stoner GD, Mukhtar H. Polyphenols as cancer chemopreventive agents. J Cell Biochem Suppl 1995; 22: 169-180.
4. U.S. Department of Agriculture. USDA Database for the Flavonoid Content of Selected Foods. Beltsville, MD: USDA 2003.
5. U.S. Department of Agriculture. USDA Database for the Proanthocyanidin Content of Selected Foods. Beltsville, MD: USDA 2004.
6. De Stefani E, Ronco A, Mendilaharsu M, Deneo-Pellegrini H. Diet and risk of cancer of the upper aerodigestive tract-II. Nutrients. Oral Oncol 1999; 35: 22-26.
7. Garavello W, Rossi M, McLaughlin JK et al. Flavonoids and laryngeal cancer risk in Italy. Ann Oncol 2007; 18: 1104-1109.
8. Rossi M, Garavello W, Talamini R et al. Flavonoids and risk of squamous cell esophageal cancer. Int J Cancer 2007; 120: 1560-1564.
9. Rossi M, Garavello W, Talamini R et al. Flavonoids and the risk of oral and pharyngeal cancer: a case-control study from Italy. Cancer Epidemiol Biomarkers Prev 2007; 16: 1621-1625.
10. Cutler GJ, Nettleton JA, Ross JA et al. Dietary flavonoid intake and risk of cancer in postmenopausal women: the Iowa Women's Health Study. Int J Cancer 2008; 123: 664-671.
11. Lagiou P, Samoli E, Lagiou A et al. Flavonoids, vitamin C and adenocarcinoma of the stomach. Cancer Causes Control 2004; 15: 67-72.
12. Rossi M, Negri E, Talamini R et al. Flavonoids and colorectal cancer in Italy. Cancer Epidemiol Biomarkers Prev 2006; 15: 1555-1558.
13. Theodoratou E, Kyle J, Cetnarskyj R et al. Dietary flavonoids and the risk of colorectal cancer. Cancer Epidemiol Biomarkers Prev 2007; 16: 684-693.
14. Simons CC, Hughes LA, Arts IC et al. Dietary flavonol, flavone and catechin intake and risk of colorectal cancer in the Netherlands Cohort Study. Int J Cancer 2009; 125: 2945-2952.
15. Bosetti C, Rossi M, McLaughlin JK et al. Flavonoids and the risk of renal cell carcinoma. Cancer Epidemiol Biomarkers Prev 2007; 16: 98-101.
16. Gates MA, Tworoger SS, Hecht JL et al. A prospective study of dietary flavonoid intake and incidence of epithelial ovarian cancer. Int J Cancer 2007; 121: 2225-2232.
17. Rossi M, Negri E, Lagiou P et al. Flavonoids and ovarian cancer risk: a casecontrol study in Italy. Int J Cancer 2008; 123: 895-898.
18. Fink BN, Steck SE, Wolff MS et al. Dietary flavonoid intake and breast cancer risk among women on Long Island. Am J Epidemiol 2007; 165: 514-523.
19. Rossi M, Rosato V, Bosetti C et al. Flavonoids, proanthocyanidins, and the risk of stomach cancer. Cancer Causes Control 2010; 21: 1597-1604.
20. World Cancer Research Fund and American Institute for Cancer Research. Food, Nutrition, Physical Activity and the Prevention of Cancer: A Global Perspective. Washington, DC: American Institute for Cancer Research 2007.
21. Anderson KE, Mack TM, Silverman DT. Cancer of the pancreas. In Schottenfeld D, Fraumeni JF Jr (eds), Cancer Epidemiology and Prevention, 3rd edition. New York: Oxford University Press 2006; 721-762.
22. Zhang L, Angst E, Park JL et al. Quercetin aglycone is bioavailable in murine pancreas and pancreatic xenografts. J Agric Food Chem 2010; 58: 7252-7257.
23. Johnson J, de Mejia EG. Dietary factors and pancreatic cancer: the role of food bioactive compounds. Mol Nutr Food Res 2011; 55: 58-73.
24. Yamagishi M, Natsume M, Osakabe N et al. Effects of cacao liquor proanthocyanidins on PhIP-induced mutagenesis in vitro, and in vivo mammary and pancreatic tumorigenesis in female Sprague-Dawley rats. Cancer Lett 2002; 185: 123-130.
25. Borska S, Drag-Zalesinska M, Wysocka T et al. Antiproliferative and proapoptotic effects of quercetin on human pancreatic carcinoma cell lines EPP85-181P and EPP85-181RDB. Folia Histochem Cytobiol 2010; 48: 222-229.
26. Murtaza I, Adhami VM, Hafeez BB et al. Fisetin, a natural flavonoid, targets chemoresistant human pancreatic cancer AsPC-1 cells through DR3-mediated inhibition of NF-kappaB. Int J Cancer 2009; 125: 2465-2473.
27. Bobe G, Weinstein SJ, Albanes D et al. Flavonoid intake and risk of pancreatic cancer in male smokers (Finland). Cancer Epidemiol Biomarkers Prev 2008; 17: 553-562.
28. Nothlings U, Murphy SP, Wilkens LR et al. Flavonols and pancreatic cancer risk: the multiethnic cohort study. Am J Epidemiol 2007; 166: 924-931.
29. Arts IC, Jacobs DR Jr, Gross M et al. Dietary catechins and cancer incidence among postmenopausal women: the Iowa Women's Health Study (United States). Cancer Causes Control 2002; 13: 373-382.
30. Knekt P, Jarvinen R, Seppanen R et al. Dietary flavonoids and the risk of lung cancer and other malignant neoplasms. Am J Epidemiol 1997; 146: 223-230.
31. Polesel J, Talamini R, Negri E et al. Dietary habits and risk of pancreatic cancer: an Italian case-control study. Cancer Causes Control 2010; 21: 493-500.
32. Talamini R, Polesel J, Gallus S et al. Tobacco smoking, alcohol consumption and pancreatic cancer risk: a case-control study in Italy. Eur J Cancer 2010; 46: 370-376.
33. Franceschi S, Negri E, Salvini S et al. Reproducibility of an Italian food frequency questionnaire for cancer studies: results for specific food items. Eur J Cancer 1993; 29A: 2298-2305.
34. Decarli A, Franceschi S, Ferraroni M et al. Validation of a food-frequency questionnaire to assess dietary intakes in cancer studies in Italy. Results for specific nutrients. Ann Epidemiol 1996; 6: 110-118.
35. U.S. Department of Agriculture. Database for the Flavonoid Content of Selected Foods. Release 2.1. Beltsville, MD: USDA 2007.
36. Liggins J, Bluck LJ, Runswick S et al. Daidzein and genistein contents of vegetables. Br J Nutr 2000; 84: 717-725.
37. Gnagnarella P, Parpinel M, Salvini S et al. The update of the Italian food composition database. J Food Comp Anal 2004; 17: 509-522.
38. Breslow NE, Day NE. Statistical Methods in Cancer Research. Volume I. The Analysis of Case-Control Studies. Lyon, France: IARC 1980.
39. Willett W, Stampfer MJ. Total energy intake: implications for epidemiologic analyses. Am J Epidemiol 1986; 124: 17-27.
40. Lin Y, Kikuchi S, Tamakoshi A et al. Green tea consumption and the risk of pancreatic cancer in Japanese adults. Pancreas 2008; 37: 25-30.
41. Luo J, Inoue M, Iwasaki M et al. Green tea and coffee intake and risk of pancreatic cancer in a large-scale, population-based cohort study in Japan (JPHC study). Eur J Cancer Prev 2007; 16: 542-548.
42. Bors W, Michel C. Antioxidant capacity of flavanols and gallate esters: pulse radiolysis studies. Free Radic Biol Med 1999; 27: 1413-1426.
43. Das N, Pereira T. Effects of flavonoids on thermal autoxidation of palm oil-structure activity-relationship. J Am Oil Chem Soc 1990; 67: 255-258.
44. Hayes R, Bookwalter Q, Bayley E. Antioxidant activity of soybean flour and derivatives-a review. J Food Sci 1977; 42: 1527-1532.
45. Chan JM, Wang F, Holly EA. Vegetable and fruit intake and pancreatic cancer in a population-based case-control study in the San Francisco bay area. Cancer Epidemiol Biomarkers Prev 2005; 14: 2093-2097.
46. Ji BT, Chow WH, Gridley G et al. Dietary factors and the risk of pancreatic cancer: a case-control study in Shanghai China. Cancer Epidemiol Biomarkers Prev 1995; 4: 885-893.
47. Miura T, Chiba M, Kasai K et al. Apple procyanidins induce tumor cell apoptosis through mitochondrial pathway activation of caspase-3. Carcinogenesis 2008; 29: 585-593.
48. Nothlings U, Murphy SP, Wilkens LR et al. A food pattern that is predictive of flavonol intake and risk of pancreatic cancer. Am J Clin Nutr 2008; 88: 1653-1662.
49. Chan JM, Wang F, Holly EA. Sweets, sweetened beverages, and risk of pancreatic cancer in a large population-based case-control study. Cancer Causes Control 2009; 20: 835-846.
50. D'Avanzo B, La Vecchia C, Katsouyanni K et al. An assessment, and reproducibility of food frequency data provided by hospital controls. Eur J Cancer Prev 1997; 6: 288-293.