Animal models and medical countermeasures development for radiation-induced lung damage: Report from an NIAID workshop

Radiation Research

Volumn 177, Issue 5, 2012, Pages 25-39

  Williams, Jacqueline P ^a   Jackson, Isabel L ^b   Shah, Jui R ^c   Czarniecki, Christine W ^c   Maidment, Bert W ^c   Dicarlo, Andrea L ^c  

^a UNIVERSITY OF ROCHESTER MEDICAL CENTER   (United States)

^b DUKE UNIVERSITY MEDICAL CENTER   (United States)

^c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AEOL 10150; AMIFOSTINE; ANTIOXIDANT; CAPTOPRIL; CATALASE; CISPLATIN; ENALAPRIL; EUK 189; EUK 207; EUK 400; FOSINOPRIL; GENISTEIN; GLUTATHIONE DISULFIDE; GLUTATHIONE PLUS CISPLATIN; KERATINOCYTE GROWTH FACTOR; MNTE 2 PYP(5+); MNTNHEX 2 PYP (5+); NOV 205; P 552; PORPHYRIN DERIVATIVE; SIMVASTATIN; SODIUM CHANNEL BLOCKING AGENT; SUBSTANCE P; TRIPTOLIDE; UNCLASSIFIED DRUG; BIOLOGICAL MARKER; RADIOPROTECTIVE AGENT;

ACUTE RADIATION SYNDROME; BLOOD TOXICITY; CELL THERAPY; CYSTIC FIBROSIS; DISEASE MODEL; DRUG DELIVERY SYSTEM; DRUG HALF LIFE; DRUG MECHANISM; HEPATITIS C; HUMAN; LUNG DISEASE; LUNG FIBROSIS; LUNG FUNCTION; LUNG INJURY; MULTIPLE ORGAN FAILURE; NONHUMAN; PARTIAL BODY RADIATION; PNEUMONIA; PRIORITY JOURNAL; RADIATION DOSE; RADIATION EXPOSURE; RADIATION INJURY; RADIATION SAFETY; REVIEW; WHOLE BODY RADIATION; XEROSTOMIA; ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ATOMIC WARFARE; CLASSIFICATION; CONFERENCE PAPER; DRUG DEVELOPMENT; DRUG SCREENING; FINANCIAL MANAGEMENT; FOOD AND DRUG ADMINISTRATION; LUNG; METHODOLOGY; MULTIMODALITY CANCER THERAPY; NATIONAL HEALTH ORGANIZATION; NUCLEAR ACCIDENT; ORGANIZATION AND MANAGEMENT; STANDARD; STEM CELL TRANSPLANTATION; TERRORISM; UNITED STATES; VULNERABLE POPULATION;

ANIMALIA;

ANIMAL EXPERIMENTATION; ANIMALS; BIOLOGICAL MARKERS; COMBINED MODALITY THERAPY; DRUG DISCOVERY; DRUG EVALUATION, PRECLINICAL; HUMANS; LUNG; LUNG DISEASES; MODELS, ANIMAL; NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (U.S.); NUCLEAR WARFARE; RADIATION INJURIES, EXPERIMENTAL; RADIATION TOLERANCE; RADIATION-PROTECTIVE AGENTS; RADIOACTIVE HAZARD RELEASE; RESEARCH DESIGN; RESEARCH SUPPORT AS TOPIC; STEM CELL TRANSPLANTATION; TERRORISM; UNITED STATES; UNITED STATES FOOD AND DRUG ADMINISTRATION; VULNERABLE POPULATIONS;

EID: 84861364136     PISSN: 00337587     EISSN: 19385404     Source Type: Journal    
DOI: 10.1667/RROL04.1     Document Type: Review

References (118)

1. Pellmar TC, Rockwell S. Priority list of research areas for radiological nuclear threat countermeasures. Radiat Res. 2005;163(1):115-23. (Pubitemid 40039952)
2. Endo A, Yamaguchi Y. Analysis of dose distribution for heavily exposed workers in the first criticality accident in Japan. Radiat Res. 2003; 159(4):535-42. (Pubitemid 36397775)
3. Food and Drug Administration. New drug and biological drug products: evidence needed to demonstrate effectiveness of new drugs when human efficacy studies are not ethical or feasible. Fed Regist. 2002; 67:37988-98.
4. Stone HB, Moulder JE, Coleman CN, Ang KK, Anscher MS, Barcellos-Hoff MH, et al. Models for evaluating agents intended for the prophylaxis, mitigation and treatment of radiation injuries. Report of an NCI Workshop, December 3-4, 2003. Radiat Res. 2004; 162(6):711-28. (Pubitemid 39552901)
5. Movsas B, Raffin TA, Epstein AH, Link CJ, Jr. Pulmonary radiation injury. Chest. 1997; 111(4):1061-76. (Pubitemid 27171481)
6. Oya N, Sasai K, Tachiiri S, Sakamoto T, Nagata Y, Okada T, et al. Influence of radiation dose rate and lung dose on interstitial pneumonitis after fractionated total body irradiation: acute parotitis may predict interstitial pneumonitis. Int J Hematol. 2006; 83(1):86-91. (Pubitemid 43172749)
7. Schneider RA, Schultze J, Jensen JM, Hebbinghaus D, Galalae RM. Long-term outcome after static intensity-modulated total body radiotherapy using compensators stratified by pediatric and adult cohorts. Int J Radiat Oncol Biol Phys. 2008; 70(1):194-202. (Pubitemid 350251020)
8. United Nations Scientific Committee on the Effects of Atomic Radiation (UNSCEAR). Report to the General Assembly, Annex J: Exposure and Effects of the Chernobyl Accident. Sources, Effects and Risks of Ionizing Radiation. 2000.
9. Uozaki H, Fukayama M, Nakagawa K, Ishikawa T, Misawa S, Doi M, et al. The pathology of multi-organ involvement: two autopsy cases from the Tokai-mura criticality accident. BJR Suppl. 2005; 27:13-6.
10. Changlin Y, Genyao Y. Multi-organ failure in a radiation accident: the Chinese experience of 1990. BJR Suppl. 2005; 27:47-54.
11. Mettler FA, Ortiz-Lopez P. Accidents in radiation therapy. Gusev IA, Guskova AK, Mettler FA, editors. Washington, DC: CRC Press; 2001.
12. Vlasov PA, Kvacheva Iu E. [The pathomorphology of the pulmonary infectious complications in acute radiation sickness (based on the autopsy data from persons who died as a result of the accident at the Chernobyl Atomic Electric Power Station]. Ter Arkh. 1996; 68(3):23-6. Patomorfologiia legochnykh infektsionnykh oslozhnenii ostroi luchevoi bolezni (po materialam autopsii lits, pogibshikh v rezul'tate avarii na Chernobyl'skoi AES.
13. Baranov AE, Selidovkin GD, Butturini A, Gale RP. Hematopoi-etic recovery after 10-Gy acute total body radiation. Blood. 1994; 83(2):596-9. (Pubitemid 24030590)
14. Moulder JE, Cohen EP. Future strategies for mitigation and treatment of chronic radiation-induced normal tissue injury. Semin Radiat Oncol. 2007; 17(2):141-8. (Pubitemid 46467384)
15. Travis EL, Down JD, Holmes SJ, Hobson B. Radiation pneumonitis and fibrosis in mouse lung assayed by respiratory frequency and histology. Radiat Res. 1980; 84(1):133-43. (Pubitemid 10030372)
16. Rubin P, Finkelstein JN, Siemann DW, Shapiro DL, Van Houtte P, Penney DP. Predictive biochemical assays for late radiation effects. Int J Radiat Oncol Biol Phys. 1986; 12(4):469-76. (Pubitemid 16081607)
17. Rubin P, Johnston CJ, Williams JP, McDonald S, Finkelstein JN. A perpetual cascade of cytokines postirradiation leads to pulmonary fibrosis. Int J Radiat Oncol Biol Phys. 1995; 33(1): 99-109.
18. Fleckenstein K, Zgonjanin L, Chen L, Rabbani Z, Jackson IL, Thrasher B, et al. Temporal onset of hypoxia and oxidative stress after pulmonary irradiation. Int J Radiat Oncol Biol Phys. 2007; 68(1):196-204. (Pubitemid 46589856)
19. Szabo S, Ghosh SN, Fish BL, Bodiga S, Tomic R, Kumar G, et al. Cellular inflammatory infiltrate in pneumonitis induced by a single moderate dose of thoracic x radiation in rats. Radiat Res. 2010; 173(4):545-56.
20. Thomas O, Mahe M, Campion L, Bourdin S, Milpied N, Brunet G, et al. Long-term complications of total body irradiation in adults. Int J Radiat Oncol Biol Phys. 2001; 49(1):125-31. (Pubitemid 32041284)
21. Franko AJ, Sharplin J, Ghahary A, Barcellos-Hoff MH. Immunohistochemical localization of transforming growth factor beta and tumor necrosis factor alpha in the lungs of fibrosis-prone and "nonfibrosing" mice during the latent period and early phase after irradiation. Radiat Res. 1997; 147(2):245-56.
22. Hong JH, Chiang CS, Tsao CY, Lin PY, McBride WH, Wu CJ. Rapid induction of cytokine gene expression in the lung after single and fractionated doses of radiation. Int J Radiat Biol. 1999; 75(11):1421-7.
23. Anscher MS, Thrasher B, Rabbani Z, Teicher B, Vujaskovic Z. Antitransforming growth factor-beta antibody 1D11 ameliorates normal tissue damage caused by high-dose radiation. Int J Radiat Oncol Biol Phys. 2006; 65(3):876-81. (Pubitemid 43795819)
24. Yuhas JM. Radiotherapy of experimental lung tumors in the presence and absence of a radioprotective drug, S-2-(3-amino-propylamino)ethylphosphorothioic acid (WR-2721). J Natl Cancer Inst. 1973; 50(1):69-78.
25. Travis EL, Parkins CS, Holmes SJ, Down JD, Fowler JF. WR-2721 protection of pneumonitis and fibrosis in mouse lung after single doses of x rays. Int J Radiat Oncol Biol Phys. 1984; 10(2): 243-51. Epub 1984/02/01. (Pubitemid 14131627)
26. Vujaskovic Z, Feng QF, Rabbani ZN, Samulski TV, Anscher MS, Brizel DM. Assessment of the protective effect of amifostine on radiation-induced pulmonary toxicity. Exp Lung Res. 2002; 28(7):577-90.
27. Down JD, Laurent GJ, McAnulty RJ, Steel GG. Oxygen-dependent protection of radiation lung damage in mice by WR 2721. Int J Radiat Biol Relat Stud Phys Chem Med. 1984; 46(5): 597-607. Epub 1984/11/01. (Pubitemid 15154161)
28. Komaki R, Lee JS, Milas L, Lee HK, Fossella FV, Herbst RS, et al. Effects of amifostine on acute toxicity from concurrent chemotherapy and radiotherapy for inoperable nonsmall-cell lung cancer: report of a randomized comparative trial. Int J Radiat Oncol Biol Phys. 2004; 58(5):1369-77. Epub 2004/03/31. (Pubitemid 38438296)
29. Magana E, Crowell RE. Radiation pneumonitis successfully treated with inhaled corticosteroids. South Med J. 2003; 96(5): 521-4. (Pubitemid 38031145)
30. Sekine I, Sumi M, Ito Y, Nokihara H, Yamamoto N, Kunitoh H, et al. Retrospective analysis of steroid therapy for radiation-induced lung injury in lung cancer patients. Radiother Oncol. 2006; 80(1):93-7. (Pubitemid 44226433)
31. Molls M, Herrmann T, Steinberg F, Feldmann HJ. Radio-pathology of the lung: experimental and clinical observations. Recent Results Cancer Res. 1993; 130:109-21.
32. Williams JP, Hernady E, Johnston CJ, Reed CM, Fenton B, Okunieff P, et al. Effect of administration of lovastatin on the development of late pulmonary effects after whole-lung irradiation in a murine model. Radiat Res. 2004; 161(5):560-7. (Pubitemid 40754225)
33. Ghosh SN, Zhang R, Fish BL, Semenenko VA, Li XA, Moulder JE, et al. Renin-Angiotensin system suppression mitigates experimental radiation pneumonitis. Int J Radiat Oncol Biol Phys. 2009; 75(5):1528-36.
34. Zhao W, Robbins ME. Inflammation and chronic oxidative stress in radiation-induced late normal tissue injury: therapeutic implications. Curr Med Chem. 2009; 16(2):130-43.
35. Para AE, Bezjak A, Yeung IW, Van Dyk J, Hill RP. Effects of genistein following fractionated lung irradiation in mice. Radio-ther Oncol. 2009; 92(3):500-10.
36. Khan MA, Van Dyk J, Yeung IW, Hill RP. Partial volume rat lung irradiation; assessment of early DNA damage in different lung regions and effect of radical scavengers. Radiother Oncol. 2003; 66(1):95-102. (Pubitemid 36136009)
37. Epperly MW, Travis EL, Sikora C, Greenberger JS. Manganese superoxide dismutase (MnSOD) plasmid/liposome pulmonary radioprotective gene therapy: modulation of irradiation-induced mRNA for IL-I, TNF-alpha, and TGF-beta correlates with delay of organizing alveolitis/fibrosis. Biol Blood Marrow Transplant. 1999; 5(4):204-14.
38. Rabbani ZN, Anscher MS, Folz RJ, Archer E, Huang H, Chen L, et al. Overexpression of extracellular superoxide dismutase reduces acute radiation induced lung toxicity. BMC Cancer. 2005; 5:59.
39. Ward WF, Molteni A, Ts'ao CH. Radiation-induced endothelial dysfunction and fibrosis in rat lung: modification by the angiotensin converting enzyme inhibitor CL242817. Radiat Res. 1989; 117(2):342-50. (Pubitemid 19093104)
40. Molteni A, Moulder JE, Cohen EF, Ward WF, Fish BL, Taylor JM, et al. Control of radiation-induced pneumopathy and lung fibrosis by angiotensin-converting enzyme inhibitors and an angiotensin II type 1 receptor blocker. Int J Radiat Biol. 2000; 76(4):523-32. (Pubitemid 30232452)
41. Zhang R, Ghosh SN, Zhu D, North PE, Fish BL, Morrow NV, et al. Structural and functional alterations in the rat lung following whole thoracic irradiation with moderate doses: injury and recovery. Int J Radiat Biol. 2008; 84(6):487-97. (Pubitemid 351878832)
42. Ghosh SN, Wu Q, Mader M, Fish BL, Moulder JE, Jacobs ER, et al. Vascular injury after whole thoracic X-ray irradiation in the rat. Int J Radiat Oncol Biol Phys. 2009; 74(1):192-9.
43. Ward WF, Lin PJ, Wong PS, Behnia R, Jalali N. Radiation pneumonitis in rats and its modification by the angiotensin-converting enzyme inhibitor captopril evaluated by high-resolution computed tomography. Radiat Res. 1993; 135(1):81-7. (Pubitemid 23230669)
44. Heeneman S, Sluimer JC, Daemen MJ. Angiotensin-converting enzyme and vascular remodeling. Circ Res. 2007; 101(5):441-54. (Pubitemid 47347875)
45. Holecki M, Szewieczek J, Chudek J. Effects of angiotensin-converting enzyme inhibitors beyond lowering blood pressure-are they important for doctors? Pharmacol Rep. 2011; 63(3): 740-51.
46. Galderisi M, de Divitiis O. Risk factor-induced cardiovascular remodeling and the effects of angiotensin-converting enzyme inhibitors. J Cardiovasc Pharmacol. 2008; 51(6):523-31.
47. Food and Drug Administration. Guidance for Industry: Animal Models\Essential Elements to Address Efficacy Under the Animal Rule. In: Center for Drug Evaluation and Research (CDER) Center for Biologics Evaluation and Research (CBER), editor.: Office of Communications, Division of Drug Information, FDA; 2009
48. International Atomic Energy Agency. Accidental Overexposure of Radiotherapy Patients in Bialystok. Vienna. 2004.
49. Jackson IL, Vujaskovic Z, Down JD. Revisiting strain-related differences in radiation sensitivity of the mouse lung: recognizing and avoiding the confounding effects of pleural effusions. Radiat Res. 2010; 173(1):10-20.
50. Sharplin J, Franko AJ. A quantitative histological study of strain-dependent differences in the effects of irradiation on mouse lung during the early phase. Radiat Res. 1989; 119(1):1-14. Epub 1989/07/01. (Pubitemid 19197732)
51. Travis EL, Tucker SL. The relationship between functional assays of radiation response in the lung and target cell depletion. The British Journal of Cancer Supplement. 1986; 7:304-19. Epub 1986/01/01. (Pubitemid 16076193)
52. Johnston CJ, Hernady E, Reed C, Thurston SW, Finkelstein JN, Williams JP. Early alterations in cytokine expression in adult compared to developing lung in mice after radiation exposure. Radiat Res. 2010; 173(4):522-35.
53. Fucic A, Gamulin M. Interaction between ionizing radiation and estrogen: What we are missing? Med Hypotheses. 2011.
54. Chen Q, Klein JS, Gamsu G, Webb WR. High-resolution computed tomography of the mammalian lung. Am J Vet Res. 1992; 53(7):1218-24.
55. Hopewell JW, Rezvani M, Moustafa HF. The pig as a model for the study of radiation effects on the lung. Int J Radiat Biol. 2000; 76(4):447-52. (Pubitemid 30232442)
56. Herrmann T, Baumann M, Voigtmann L, Knorr A. Effect of irradiated volume on lung damage in pigs. Radiother Oncol. 1997; 44(1):35-40. (Pubitemid 27303805)
57. Rezvani M, Heryet JC, Hopewell JW. Effects of single doses of gamma-radiation on pig lung. Radiother Oncol. 1989; 14(2): 133-42. (Pubitemid 19055820)
58. Rezvani M, Hopewell JW. The response of the pig lung to fractionated doses of X rays. Br J Radiol. 1990; 63(745):41-50. (Pubitemid 20040215)
59. Herrmann T, Voigtmann L, Knorr A, Lorenz J, Johanssen U. The time-dose relationship for radiation-induced lung damage in pigs. Radiother Oncol. 1986; 5(2):127-35. (Pubitemid 16159987)
60. Williams JP, Brown SL, Georges GE, Hauer-Jensen M, Hill RP, Huser AK, et al. Animal models for medical countermeasures to radiation exposure. Radiat Res. 2010; 173(4):557-78.
61. Kishi HS. Effects of the "special bomb": recollections of a neurosurgeon in Hiroshima, August 8-15, 1945. Neurosurgery. 2000; 47(2):441-5; discussion 5-6.
62. Palmer JL, Deburghgraeve CR, Bird MD, Hauer-Jensen M, Kovacs EJ. Development of a combined radiation and burn injury model. J Burn Care Res. 2011; 32(2):317-23.
63. Johnston CJ, Manning C, Hernady E, Reed C, Thurston SW, Finkelstein JN, et al. Effect of total body irradiation on late lung effects: Hidden dangers. Int J Radiat Biol. 2011.
64. Cappuccini F, Eldh T, Bruder D, Gereke M, Jastrow H, Schulze-Osthoff K, et al. New insights into the molecular pathology of radiation-induced pneumopathy. Radiother Oncol. 2011.
65. Anscher MS. Targeting the TGF-beta1 pathway to prevent normal tissue injury after cancer therapy. Oncologist. 2010; 15(4):350-9.
66. Kim JY, Kim YS, Kim YK, Park HJ, Kim SJ, Kang JH, et al. The TGF-beta1 dynamics during radiation therapy and its correlation to symptomatic radiation pneumonitis in lung cancer patients. Radiat Oncol. 2009; 4:59.
67. Sakai M, Iwakawa M, Iwakura Y, Ohta T, Tsujii H, Imai T. CD44 and Bak expression in IL-6 or TNF-alpha gene knockout mice after whole lung irradiation. J Radiat Res (Tokyo). 2008; 49(4):409-16. (Pubitemid 352030605)
68. Nozaki Y, Hasegawa Y, Takeuchi A, Fan ZH, Isobe KI, Nakashima I, et al. Nitric oxide as an inflammatory mediator of radiation pneumonitis in rats. Am J Physiol. 1997; 272(4 Pt 1): L651-8.
69. Graves PR, Siddiqui F, Anscher MS, Movsas B. Radiation pulmonary toxicity: from mechanisms to management. Semin Radiat Oncol. 2011; 20(3):201-7.
70. Wilson MS, Wynn TA. Pulmonary fibrosis: pathogenesis, etiology and regulation. Mucosal Immunol. 2009; 2(2):103-21.
71. Brush J, Lipnick SL, Phillips T, Sitko J, McDonald JT, McBride WH. Molecular mechanisms of late normal tissue injury. Semin Radiat Oncol. 2007; 17(2):121-30. (Pubitemid 46467382)
72. Tsoutsou PG, Koukourakis MI. Radiation pneumonitis and fibrosis: mechanisms underlying its pathogenesis and implications for future research. Int J Radiat Oncol Biol Phys. 2006; 66(5):1281-93.
73. Anscher MS, Vujaskovic Z. Mechanisms and potential targets for prevention and treatment of normal tissue injury after radiation therapy. Semin Oncol. 2005; 32(2 Suppl 3):S86-91.
74. Rube CE, Wilfert F, Palm J, Konig J, Burdak-Rothkamm S, Liu L, et al. Irradiation induces a biphasic expression of pro-inflammatory cytokines in the lung. Strahlenther Onkol. 2004; 180(7):442-8. (Pubitemid 39207383)
75. Travis EL. Early indicators of radiation injury in the lung: are they useful predictors for late changes? Int J Radiat Oncol Biol Phys. 1980; 6(9):1267-9. (Pubitemid 10016484)
76. Yakovlev VA, Rabender CS, Sankala H, Gauter-Fleckenstein B, Fleckenstein K, Batinic-Haberle I, et al. Proteomic analysis of radiation-induced changes in rat lung: Modulation by the superoxide dismutase mimetic MnTE-2-PyP(5+). Int J Radiat Oncol Biol Phys. 2010; 78(2):547-54.
77. Gauter-Fleckenstein B, Fleckenstein K, Owzar K, Jiang C, Batinic-Haberle I, Vujaskovic Z. Comparison of two Mn porphyrin-based mimics of superoxide dismutase in pulmonary radioprotection. Free Radic Biol Med. 2008; 44(6):982-9.
78. Vujaskovic Z, Batinic-Haberle I, Rabbani ZN, Feng QF, Kang SK, Spasojevic I, et al. A small molecular weight catalytic metalloporphyrin antioxidant with superoxide dismutase (SOD) mimetic properties protects lungs from radiation-induced injury. Free Radic Biol Med. 2002; 33(6):857-63. (Pubitemid 35232320)
79. Rabbani ZN, Batinic-Haberle I, Anscher MS, Huang J, Day BJ, Alexander E, et al. Long-term administration of a small molecular weight catalytic metalloporphyrin antioxidant, AEOL 10150, protects lungs from radiation-induced injury. Int J Radiat Oncol Biol Phys. 2007; 67(2):573-80. (Pubitemid 46108330)
80. Day BJ, Shawen S, Liochev SI, Crapo JD. A metalloporphyrin superoxide dismutase mimetic protects against paraquat-induced endothelial cell injury, in vitro. J Pharmacol Exp Ther. 1995; 275(3):1227-32. (Pubitemid 26130633)
81. Szabo C, Day BJ, Salzman AL. Evaluation of the relative contribution of nitric oxide and peroxynitrite to the suppression of mitochondrial respiration in immunostimulated macrophages using a manganese mesoporphyrin superoxide dismutase mimetic and peroxynitrite scavenger. FEBS Lett. 1996; 381(1-2):82-6.
82. Day BJ, Fridovich I, Crapo JD. Manganic porphyrins possess catalase activity and protect endothelial cells against hydrogen peroxide-mediated injury. Arch Biochem Biophys. 1997; 347(2): 256-62. (Pubitemid 27492797)
83. Rabbani ZN, Salahuddin FK, Yarmolenko P, Batinic-Haberle I, Thrasher BA, Gauter-Fleckenstein B, et al. Low molecular weight catalytic metalloporphyrin antioxidant AEOL 10150 protects lungs from fractionated radiation. Free Radic Res. 2007; 41(11): 1273-82. (Pubitemid 350090780)
84. McGovern T, Day BJ, White CW, Powell WS, Martin JG. AEOL10150: A novel therapeutic for rescue treatment after toxic gas lung injury. Free Radic Biol Med. 2010.
85. Melov S, Doctrow SR, Schneider JA, Haberson J, Patel M, Coskun PE, et al. Lifespan extension and rescue of spongiform encephalopathy in superoxide dismutase 2 nullizygous mice treated with superoxide dismutase-catalase mimetics. J Neurosci. 2001; 21(21):8348-53. (Pubitemid 33051432)
86. Doctrow S, Baudry M, Huffman K, Malfroy B, Melov S. Salen Manganese Complexes: Multifunctional Catalytic Antioxidants Protective in Models for Neurodegenerative Diseases of Aging. Medicinal Inorganic Chemistry: ACS Symposium Series: Oxford University Press; 2005.
87. Liesa M, Luptak I, Qin F, Hyde BB, Sahin E, Siwik DA, et al. Mitochondrial transporter ATP binding cassette mitochondrial erythroid is a novel gene required for cardiac recovery after ischemia/reperfusion. Circulation. 2011; 124(7):806-13.
88. Rosenthal RA, Fish B, Hill RP, Huffman KD, Lazarova Z, Mahmood J, et al. Salen Mn complexes mitigate radiation injury in normal tissues. Anticancer Agents Med Chem. 2011; 11(4): 359-72.
89. Srinivasan V, Doctrow S, Singh VK, Whitnall MH. Evaluation of EUK-189, a synthetic superoxide dismutase/catalase mimetic as a radiation countermeasure. Immunopharmacol Immunotoxicol. 2008; 30(2):271-90. (Pubitemid 351882925)
90. Langan AR, Khan MA, Yeung IW, Van Dyk J, Hill RP. Partial volume rat lung irradiation: the protective/mitigating effects of Eukarion-189, a superoxide dismutase-catalase mimetic. Radio-ther Oncol. 2006; 79(2):231-8. (Pubitemid 43884942)
91. Mahmood J, Jelveh S, Calveley V, Zaidi A, Doctrow SR, Hill RP. Mitigation of radiation-induced lung injury by genistein and EUK-207. Int J Radiat Biol. 2011; 87(8):889-901.
92. Rosenthal RA, Huffman KD, Fisette LW, Damphousse CA, Callaway WB, Malfroy B, et al. Orally available Mn porphyrins with superoxide dismutase and catalase activities. J Biol Inorg Chem. 2009; 14(6):979-91.
93. Vorotnikova E, Rosenthal RA, Tries M, Doctrow SR, Braunhut SJ. Novel synthetic SOD/catalase mimetics can mitigate capillary endothelial cell apoptosis caused by ionizing radiation. Radiat Res. 2010; 173(6):748-59.
94. Townsend DM, Pazoles CJ, Tew KD. NOV-002, a mimetic of glutathione disulfide. Expert Opin Investig Drugs. 2008; 17(7): 1075-83.
95. Jenderny S, Lin H, Garrett T, Tew KD, Townsend DM. Protective effects of a glutathione disulfide mimetic (NOV-002) against cisplatin induced kidney toxicity. Biomed Pharmacother. 2010; 64(1):73-6.
96. Mahmood J, Jelveh S, Calveley V, Zaidi A, Doctrow SR, Hill RP. Mitigation of Lung Injury after Accidental Exposure to Radiation. Radiat Res. 2011.
97. Su Y, Yang S, Xiao Z, Wang W, Okunieff P, Zhang L. Triptolide alters mitochondrial functions. Adv Exp Med Biol. 2007; 599:139-46.
98. Wang W, Yang S, Su Y, Xiao Z, Wang C, Li X, et al. Enhanced antitumor effect of combined triptolide and ionizing radiation. Clin Cancer Res. 2007; 13(16):4891-9. (Pubitemid 47294797)
99. Leuenroth SJ, Bencivenga N, Igarashi P, Somlo S, Crews CM. Triptolide reduces cystogenesis in a model of ADPKD. J Am Soc Nephrol. 2008; 19(9):1659-62.
100. Zhang J, Gong JF, Zhang W, Zhu WM, Li JS. Effects of transplanted bone marrow mesenchymal stem cells on the irradiated intestine of mice. J Biomed Sci. 2008; 15(5):585-94.
101. Semont A, Francois S, Mouiseddine M, Francois A, Sache A, Frick J, et al. Mesenchymal stem cells increase self-renewal of small intestinal epithelium and accelerate structural recovery after radiation injury. Adv Exp Med Biol. 2006; 585:19-30.
102. Agay D, Scherthan H, Forcheron F, Grenier N, Herodin F, Meineke V, et al. Multipotent mesenchymal stem cell grafting to treat cutaneous radiation syndrome: development of a new minipig model. Exp Hematol. 2010; 38(10):945-56.
103. Coppes RP, Stokman MA. Stem cells and the repair of radiation-induced salivary gland damage. Oral Dis. 2011; 17(2):143-53.
104. Lombaert IM, Wierenga PK, Kok T, Kampinga HH, deHaan G, Coppes RP. Mobilization of bone marrow stem cells by granulocyte colony-stimulating factor ameliorates radiation-induced damage to salivary glands. Clin Cancer Res. 2006; 12(6):1804-12.
105. Muggenburg BA, Boecker BB, Hahn FF, McClellan RO. Lung lavage therapy to lessen the biological effects of inhaled 144Ce in dogs. Radiat Res. 1990; 124(2):147-55.
106. Muggenburg BA, Mewhinney JA. Removal of inhaled 241Am oxide particles of various sizes from beagle dogs using lung lavage and chelation treatment. Health Phys. 1981; 41(1):123-33. (Pubitemid 11039938)
107. Voelz GL, Lawrence JN, Johnson ER. Fifty years of plutonium exposure to the Manhattan Project plutonium workers: an update. Health Phys. 1997; 73(4):611-9. (Pubitemid 27407324)
108. Hirsh AJ, Sabater JR, Zamurs A, Smith RT, Paradiso AM, Hopkins S, et al. Evaluation of second generation amiloride analogs as therapy for cystic fibrosis lung disease. J Pharmacol Exp Ther. 2004; 311(3):929-38. (Pubitemid 39612697)
109. Singh ML, Papas AS, Fox PC, Stevens AL, Boucher RC, Thelin BT. Development of P552-02 to treat xerostomia in Sjgrens Syndrome. Arthritis Rheum. 2009; 60(Suppl 10):494
110. An YS, Lee E, Kang MH, Hong HS, Kim MR, Jang WS, et al. Substance P stimulates the recovery of bone marrow after the irradiation. J Cell Physiol. 2011; 226(5):1204-13.
111. Centers for Disease Control. Emergency Preparedness and Response: Strategic National Stockpile. 2010.
112. Food and Drug Administration. Draft Guidance: Emergency Use Authorization of Medical Products. In: Office of Counterterror-ism Policy and Planning, editor.: Office of Counterterrorism Policy and Planning (HF-29), Office of the Commissioner, FDA; 2005.
113. DiCarlo AL, Poncz M, Cassatt DR, Shah JR, Czarniecki CW, Maidment BW. Medical countermeasures for platelet regeneration after radiation exposure. Report of a workshop and guided discussion sponsored by the National Institute of Allergy and Infectious Diseases, Bethesda, MD, March 22-23, 2010. Radiat Res. 2011; 176(1):e0001-15.
114. Azoulay E, Canet E, Raffoux E, Lengline E, Lemiale V, Vincent F, et al. Dexamethasone in patients with acute lung injury from acute monocytic leukemia. Eur Respir J. 2011.
115. Dik WA, McAnulty RJ, Versnel MA, Naber BA, Zimmermann LJ, Laurent GJ, et al. Short course dexamethasone treatment following injury inhibits bleomycin induced fibrosis in rats. Thorax. 2003; 58(9):765-71. (Pubitemid 37094052)
116. MacVittie TJ, Farese AM, Jackson W. Defining the full therapeutic potential of recombinant growth factors in the post radiation-accident environment: the effect of supportive care plus administration of G-CSF. Health Phys. 2005; 89(5):546-55. (Pubitemid 41463888)
117. Van Dyk J, Keane TJ, Kan S, Rider WD, Fryer CJ. Radiation pneumonitis following large single dose irradiation: a re-evaluation based on absolute dose to lung. Int J Radiat Oncol Biol Phys. 1981; 7(4):461-7. (Pubitemid 11112799)
118. Sampath S, Schultheiss TE, Wong J. Dose response and factors related to interstitial pneumonitis after bone marrow transplant. Int J Radiat Oncol Biol Phys. 2005; 63(3):876-84. Epub 2005/10/04. (Pubitemid 41400079)