Mitigation of lung injury after accidental exposure to radiation

Radiation Research

Volumn 176, Issue 6, 2011, Pages 770-780

  Mahmood, J ^a,b   Jelveh, S ^a   Calveley, V ^a   Zaidi, A ^a   Doctrow, S R ^c   Hill, R P ^a,d  

^a PRINCESS MARGARET HOSPITAL   (Canada)

^b UNIVERSITI TEKNOLOGI MARA   (Malaysia)

^c BOSTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d UNIVERSITY OF TORONTO   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; GENISTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BREATHING RATE; CONTROLLED STUDY; FEMALE; LUNG FIBROSIS; LUNG INJURY; MACROPHAGE; NONHUMAN; OXIDATIVE STRESS; PNEUMONIA; PRIORITY JOURNAL; RADIATION ACCIDENT; RADIATION DOSE; RADIATION EXPOSURE; RAT; SURVIVAL RATE;

ANIMALS; CYTOKINES; DIETARY SUPPLEMENTS; FEMALE; GENISTEIN; LUNG INJURY; MACROPHAGES; OXIDATIVE STRESS; PULMONARY FIBROSIS; RADIATION INJURIES, EXPERIMENTAL; RADIATION-PROTECTIVE AGENTS; RADIOACTIVE HAZARD RELEASE; RATS; RATS, INBRED F344; RESPIRATION; SURVIVAL ANALYSIS;

EID: 82955239897     PISSN: 00337587     EISSN: 19385404     Source Type: Journal    
DOI: 10.1667/RR2562.1     Document Type: Article

References (68)

1. Drouet M, Herodin F. Radiation victim management and the haematologist in the future: time to revisit therapeutic guidelines? Int J Radiat Biol 2010; 86:636-48.
2. Vlasov PA, Kvacheva Iu E. [The pathomorphology of the pulmonary infectious complications in acute radiation sickness based on the autopsy data from persons who died as a result of the accident at the Chernobyl Atomic Electric Power Station]. Ter Arkh 1996; 68:23-6.
3. Goans RE, Wald N. Radiation accidents with multi-organ failure in the United States. BJR Suppl 2005; 27:41-6.
4. Hirama T, Akashi M. Multi-organ involvement in the patient who survived the Tokai-mura criticality accident. BJR Suppl 2005; 27:17-20.
5. Svendsen ER, Kolpakov IE, Stepanova YI, Vdovenko VY, Naboka MV, Mousseau TA, et al. 137Cesium exposure and spirometry measures in Ukrainian children affected by the Chernobyl nuclear incident. Environ Health Perspect 2010; 118:720-5.
6. Uozaki H, Fukayama M, Nakagawa K, Ishikawa T, Misawa S, Doi M, et al. The pathology of multi-organ involvement: two autopsy cases from the Tokai-mura criticality accident. BJR Suppl 2005; 27:13-6.
7. Densow D. Are there 'common denominators' in different radiation exposure scenarios as a target for predictive assessment? Stem Cells 1995; 13 Suppl 1:307-17.
8. Densow D, Kindler H, Baranov AE, Tibken B, Hofer EP, Fliedner TM. Criteria for the selection of radiation accident victims for stem cell transplantation. Stem Cells 1997; 15 Suppl 2:287-97. (Pubitemid 27494863)
9. Fliedner TM, Meineke V. Multi-organ involvement as a pathogenetic principle of the radiation syndromes: a study involving 110 case histories documented in SEARCH and classified as the bases of haematopoietic indicators of effect. BJR Suppl 2005; 27:1-8.
10. Williams JP, McBride WH. After the bomb drops: A new look at radiation-induced multiple organ dysfunction syndrome (MODS). Int J Radiat Biol 2011; 87:851-68.
11. Kim K, Pollard JM, Norris AJ, McDonald JT, Sun Y, Micewicz E, et al. High-throughput screening identifies two classes of antibiotics as radioprotectors: tetracyclines and fluoroquinolones. Clin Cancer Res 2009; 15:7238-45.
12. Moulder JE, Cohen EP. Future strategies for mitigation and treatment of chronic radiation-induced normal tissue injury. Semin Radiat Oncol 2007; 17:141-8. (Pubitemid 46467384)
13. Williams JP, Johnston CJ, Finkelstein JN. Treatment for radiationinduced pulmonary late effects: spoiled for choice or looking in the wrong direction? Curr Drug Targets 2010; 11:1386-94.
14. Xiao M, Whitnall MH. Pharmacological countermeasures for the acute radiation syndrome. Curr Mol Pharmacol 2009; 2:122-33.
15. Zhao W, Robbins ME. Inflammation and chronic oxidative stress in radiation-induced late normal tissue injury: therapeutic implications. Curr Med Chem 2009; 16:130-43.
16. Michael McClain R, Wolz E, Davidovich A, Pfannkuch F, Edwards JA, Bausch J. Acute, subchronic and chronic safety studies with genistein in rats. Food Chem Toxicol 2006; 44:56-80. (Pubitemid 41773804)
17. Akiyama T, Ishida J, Nakagawa S, Ogawara H, Watanabe S, Itoh N, et al. Genistein, a specific inhibitor of tyrosine-specific protein kinases. J Biol Chem 1987; 262:5592-5.
18. Choi C, Cho H, Park J, Cho C, Song Y. Suppressive effects of genistein on oxidative stress and NFkappaB activation in RAW 264.7 macrophages. Biosci Biotechnol Biochem 2003; 67:1916-22. (Pubitemid 39251712)
19. Kang JL, Lee HW, Lee HS, Pack IS, Chong Y, Castranova V, et al. Genistein prevents nuclear factor-kappa B activation and acute lung injury induced by lipopolysaccharide. Am J Respir Crit Care Med 2001; 164:2206-12. (Pubitemid 34032937)
20. Landauer MR, Srinivasan V, Seed TM. Genistein treatment protects mice from ionizing radiation injury. J Appl Toxicol 2003; 23:379-85. (Pubitemid 37461713)
21. Day RM, Barshishat-Kupper M, Mog SR, McCart EA, Prasanna PG, Davis TA, et al. Genistein protects against biomarkers of delayed lung sequelae in mice surviving high-dose total body irradiation. J Radiat Res (Tokyo) 2008; 49:361-72. (Pubitemid 352030600)
22. Calveley VL, Jelveh S, Langan A, Mahmood J, Yeung IW, Van Dyk J, et al. Genistein can mitigate the effect of radiation on rat lung tissue. Radiat Res 2010; 173:602-11.
23. Para AE, Bezjak A, Yeung IW, Van Dyk J, Hill RP. Effects of genistein following fractionated lung irradiation in mice. Radiother Oncol 2009; 92:500-10.
24. Hill RP, Zaidi A, Mahmood J, Jelveh S. Investigations into the role of inflammation in normal tissue response to irradiation. Radiother Oncol. 2011. (doi: 10.1016/j.radonc.2011 06.017)
25. Kaneko T, Tahara S, Tanno M, Taguchi T. Effect of age on the induction of 8-oxo-20-deoxyguanosine-releasing enzyme in rat liver by gamma-ray irradiation. Arch Gerontol Geriatr 2003; 36:23-35. (Pubitemid 35175475)
26. Coldham NG, Zhang AQ, Key P, Sauer MJ. Absolute bioavailability of [14C] genistein in the rat; plasma pharmacokinetics of parent compound, genistein glucuronide and total radioactivity. Eur J Drug Metab Pharmacokinet 2002; 27:249-58. (Pubitemid 36205472)
27. Holder CL, Churchwell MI, Doerge DR. Quantification of soy isoflavones, genistein and daidzein, and conjugates in rat blood using LC/ES-MS. J Agric Food Chem 1999; 47:3764-70. (Pubitemid 29449503)
28. Soucy NV, Parkinson HD, Sochaski MA, Borghoff SJ. Kinetics of genistein and its conjugated metabolites in pregnant Sprague-Dawley rats following single and repeated genistein administration. Toxicol Sci 2006; 90:230-40. (Pubitemid 43264743)
29. Clarkson R, Lindsay PE, Ansell S, Wilson G, Jelveh S, Hill RP, et al. Characterization of image quality and image-guidance performance of a preclinical microirradiator. Med Phys 2011; 38:845-56.
30. Ma CM, Coffey CW, DeWerd LA, Liu C, Nath R, Seltzer SM, et al. AAPM protocol for 40-300 kV X-ray beam dosimetry in radiotherapy and radiobiology. Med Phys 2001; 28:868-93. (Pubitemid 32574672)
31. Marks LB, Yu X, Vujaskovic Z, Small W, Jr., Folz R, Anscher MS. Radiation-induced lung injury. Semin Radiat Oncol 2003; 13:333-45. (Pubitemid 36966158)
32. Finkelstein JN, Johnston CJ, Baggs R, Rubin P. Early alterations in extracellular matrix and transforming growth factor beta gene expression in mouse lung indicative of late radiation fibrosis. Int J Radiat Oncol Biol Phys 1994; 28:621-31. (Pubitemid 24072746)
33. Fleckenstein K, Gauter-Fleckenstein B, Jackson IL, Rabbani Z, Anscher M, Vujaskovic Z. Using biological markers to predict risk of radiation injury. Semin Radiat Oncol 2007; 17:89-98. (Pubitemid 46467379)
34. Haiping Z, Takayama K, Uchino J, Harada A, Adachi Y, Kura S, et al. Prevention of radiation-induced pneumonitis by recombinant adenovirus-mediated transferring of soluble TGF-beta type II receptor gene. Cancer Gene Ther 2006; 13:864-72.
35. Madani I, De Ruyck K, Goeminne H, De Neve W, Thierens H, Van Meerbeeck J. Predicting risk of radiation-induced lung injury. J Thorac Oncol 2007; 2:864-74. (Pubitemid 47361031)
36. Molteni A, Wolfe LF, Ward WF, Ts'ao CH, Molteni LB, Veno P, et al. Effect of an angiotensin II receptor blocker and two angiotensin converting enzyme inhibitors on transforming growth factor-beta (TGF-beta) and alpha-actomyosin (alpha SMA), important mediators of radiation-induced pneumopathy and lung fibrosis. Curr Pharm Des 2007; 13:1307-16. (Pubitemid 46746368)
37. Rabbani ZN, Mi J, Zhang Y, Delong M, Jackson IL, Fleckenstein K, et al. Hypoxia inducible factor 1alpha signaling in fractionated radiation-induced lung injury: role of oxidative stress and tissue hypoxia. Radiat Res 2010; 173:165-74.
38. Rodemann HP, Bamberg M. Cellular basis of radiation-induced fibrosis. Radiother Oncol 1995; 35:83-90.
39. Rube CE, Uthe D, Schmid KW, Richter KD, Wessel J, Schuck A, et al. Dose-dependent induction of transforming growth factor beta (TGF-beta) in the lung tissue of fibrosis-prone mice after thoracic irradiation. Int J Radiat Oncol Biol Phys 2000; 47:1033-42. (Pubitemid 30345604)
40. Xavier S, Piek E, Fujii M, Javelaud D, Mauviel A, Flanders KC, et al. Amelioration of radiation-induced fibrosis: inhibition of transforming growth factor-beta signaling by halofuginone. J Biol Chem 2004; 279:15167-76. (Pubitemid 38618912)
41. Robbins ME, Zhao W. Chronic oxidative stress and radiationinduced late normal tissue injury: a review. Int J Radiat Biol 2004; 80:251-9. (Pubitemid 38736754)
42. van Loon B, Markkanen E, Hubscher U. Oxygen as a friend and enemy: How to combat the mutational potential of 8-oxo-guanine. DNA Repair (Amst) 2010; 9:604-16.
43. Baxa DM, Yoshimura FK. Genistein reduces NF-kappa B in T lymphoma cells via a caspase-mediated cleavage of I kappa B alpha. Biochem Pharmacol 2003; 66:1009-18. (Pubitemid 37083596)
44. Chambers AF. Influence of diet on metastasis and tumor dormancy. Clin Exp Metastasis 2009; 26:61-6.
45. El Touny LH, Banerjee PP. Identification of a biphasic role for genistein in the regulation of prostate cancer growth and metastasis. Cancer Res 2009; 69:3695-703.
46. Farina HG, Pomies M, Alonso DF, Gomez DE. Antitumor and antiangiogenic activity of soy isoflavone genistein in mouse models of melanoma and breast cancer. Oncol Rep 2006; 16:885-91.
47. Lakshman M, Xu L, Ananthanarayanan V, Cooper J, Takimoto CH, Helenowski I, et al. Dietary genistein inhibits metastasis of human prostate cancer in mice. Cancer Res 2008; 68:2024-32. (Pubitemid 351416590)
48. Magee PJ, McGlynn H, Rowland IR. Differential effects of isoflavones and lignans on invasiveness of MDA-MB-231 breast cancer cells in vitro. Cancer Lett 2004; 208:35-41. (Pubitemid 38501781)
49. Martinez-Montemayor MM, Otero-Franqui E, Martinez J, De La Mota-Peynado A, Cubano LA, Dharmawardhane S. Individual and combined soy isoflavones exert differential effects on metastatic cancer progression. Clin Exp Metastasis 2010; 27:465-80.
50. Nakamura H, Wang Y, Kurita T, Adomat H, Cunha GR, Wang Y. Genistein increases epidermal growth factor receptor signaling and promotes tumor progression in advanced human prostate cancer. PLoS One 2011; 6:e20034.
51. Singh AV, Franke AA, Blackburn GL, Zhou JR. Soy phytochemicals prevent orthotopic growth and metastasis of bladder cancer in mice by alterations of cancer cell proliferation and apoptosis and tumor angiogenesis. Cancer Res 2006; 66:1851-8. (Pubitemid 43259972)
52. Vantyghem SA, Wilson SM, Postenka CO, Al-Katib W, Tuck AB, Chambers AF. Dietary genistein reduces metastasis in a postsurgical orthotopic breast cancer model. Cancer Res 2005; 65:3396-403. (Pubitemid 40524625)
53. van Eerde MR, Kampinga HH, Szabo BG, Vujaskovic Z. Comparison of three rat strains for development of radiationinduced lung injury after hemithoracic irradiation. Radiother Oncol 2001; 58:313-6. (Pubitemid 32181866)
54. Gauter-Fleckenstein B, Fleckenstein K, Owzar K, Jiang C, Batinic-Haberle I, Vujaskovic Z. Comparison of two Mn porphyrin-based mimics of superoxide dismutase in pulmonary radioprotection. Free Radic Biol Med 2008; 44:982-9.
55. Rabbani ZN, Anscher MS, Folz RJ, Archer E, Huang H, Chen L, et al. Overexpression of extracellular superoxide dismutase reduces acute radiation induced lung toxicity. BMC Cancer 2005; 5:59.
56. Rabbani ZN, Batinic-Haberle I, Anscher MS, Huang J, Day BJ, Alexander E, et al. Long-term administration of a small molecular weight catalytic metalloporphyrin antioxidant, AEOL 10150, protects lungs from radiation-induced injury. Int J Radiat Oncol Biol Phys 2007; 67:573-80. (Pubitemid 46108330)
57. Mahmood J, Jelveh S, Calveley V, Zaidi A, Doctrow SR, Hill RP. Mitigation of radiation-induced lung injury by genistein and EUK-207. Int J Radiat Biol. 2011; 87:889-901.
58. Khan MA, Hill RP, Van Dyk J. Partial volume rat lung irradiation: an evaluation of early DNA damage. Int J Radiat Oncol Biol Phys 1998; 40:467-76. (Pubitemid 28114396)
59. Khan MA, Van Dyk J, Yeung IW, Hill RP. Partial volume rat lung irradiation; assessment of early DNA damage in different lung regions and effect of radical scavengers. Radiother Oncol 2003; 66:95-102. (Pubitemid 36136009)
60. Langan AR, Khan MA, Yeung IW, Van Dyk J, Hill RP. Partial volume rat lung irradiation: the protective/mitigating effects of Eukarion-189, a superoxide dismutase-catalase mimetic. Radiother Oncol 2006; 79:231-8. (Pubitemid 43884942)
61. Singh VK, Grace MB, Parekh VI, Whitnall MH, Landauer MR. Effects of genistein administration on cytokine induction in wholebody gamma irradiated mice. Int Immunopharmacol 2009; 9:1401-10.
62. Vujaskovic Z, Feng QF, Rabbani ZN, Anscher MS, Samulski TV, Brizel DM. Radioprotection of lungs by amifostine is associated with reduction in profibrogenic cytokine activity. Radiat Res 2002; 157:656-60. (Pubitemid 34569133)
63. Antonadou D, Throuvalas N, Petridis A, Bolanos N, Sagriotis A, Synodinou M. Effect of amifostine on toxicities associated with radiochemotherapy in patients with locally advanced non-smallcell lung cancer. Int J Radiat Oncol Biol Phys 2003; 57:402-8. (Pubitemid 37040936)
64. Ozturk B, Egehan I, Atavci S, Kitapci M. Pentoxifylline in prevention of radiation-induced lung toxicity in patients with breast and lung cancer: a double-blind randomized trial. Int J Radiat Oncol Biol Phys 2004; 58:213-9. (Pubitemid 38010355)
65. Ghosh SN, Zhang R, Fish BL, Semenenko VA, Li XA, Moulder JE, et al. Renin-angiotensin system suppression mitigates experimental radiation pneumonitis. Int J Radiat Oncol Biol Phys 2009; 75:1528-36.
66. Gauter-Fleckenstein B, Fleckenstein K, Owzar K, Jiang C, Reboucas JS, Batinic-Haberle I, et al. Early and late administration of MnTE-2-PyP5\+ in mitigation and treatment of radiationinduced lung damage. Free Radic Biol Med 2010; 48:1034-43.
67. McBride WH, Chiang CS, Olson JL, Wang CC, Hong JH, Pajonk F, et al. A sense of danger from radiation. Radiat Res 2004; 162:1-19. (Pubitemid 39044714)
68. McBride WH, Vegesna V. The role of T-cells in radiation pneumonitis after bone marrow transplantation. Int J Radiat Biol 2000; 76:517-21. (Pubitemid 30232451)