메뉴 건너뛰기




Volumn 15, Issue 4, 2010, Pages 350-359

Targeting the TGF-β1 pathway to prevent normal tissue injury after cancer therapy

Author keywords

Complications; Fibrosis; Lung cancer; Transforming growth factor

Indexed keywords

BLEOMYCIN; CYTOKINE; GEFITINIB; PROTEIN ANTIBODY; PROTEIN TYROSINE KINASE INHIBITOR; SUPEROXIDE DISMUTASE; TRANSFORMING GROWTH FACTOR BETA1; TRANSFORMING GROWTH FACTOR BETA1 ANTIBODY; UNCLASSIFIED DRUG;

EID: 77951709927     PISSN: 10837159     EISSN: 1549490X     Source Type: Journal    
DOI: 10.1634/theoncologist.2009-S101     Document Type: Article
Times cited : (119)

References (114)
  • 1
    • 0025939587 scopus 로고
    • Tolerance of normal tissue to therapeutic irradiation
    • Emami B, Lyman J, Brown A et al. Tolerance of normal tissue to therapeutic irradiation. Int J Radiat Oncol Biol Phys 1991;21:109-122.
    • (1991) Int J Radiat Oncol Biol Phys , vol.21 , pp. 109-122
    • Emami, B.1    Lyman, J.2    Brown, A.3
  • 2
    • 33947506252 scopus 로고    scopus 로고
    • Normal tissue tolerance dose metrics for radiation therapy of major organs
    • Milano MT, Constine LS, Okunieff P. Normal tissue tolerance dose metrics for radiation therapy of major organs. Semin Radiat Oncol 2007;17: 131-140.
    • (2007) Semin Radiat Oncol , vol.17 , pp. 131-140
    • Milano, M.T.1    Constine, L.S.2    Okunieff, P.3
  • 3
    • 26944449737 scopus 로고    scopus 로고
    • Radiation pneumonitis and pulmonary fibrosis in non-small-cell lung cancer: Pulmonary function, prediction, and prevention
    • Mehta V. Radiation pneumonitis and pulmonary fibrosis in non-small-cell lung cancer: Pulmonary function, prediction, and prevention. Int J Radiat Oncol Biol Phys 2005;63:5-24.
    • (2005) Int J Radiat Oncol Biol Phys , vol.63 , pp. 5-24
    • Mehta, V.1
  • 4
    • 33947502318 scopus 로고    scopus 로고
    • Physical models and simpler dosimetric descriptors of radiation late toxicity
    • Kong FM, Pan C, Eisbruch A et al. Physical models and simpler dosimetric descriptors of radiation late toxicity. Semin Radiat Oncol 2007;17: 108-120.
    • (2007) Semin Radiat Oncol , vol.17 , pp. 108-120
    • Kong, F.M.1    Pan, C.2    Eisbruch, A.3
  • 5
    • 33751185152 scopus 로고    scopus 로고
    • Radiation pneumonitis and fibrosis: Mechanisms underlying its pathogenesis and implications for future research
    • Tsoutsou PG, Koukourakis MI. Radiation pneumonitis and fibrosis: Mechanisms underlying its pathogenesis and implications for future research. Int J Radiat Oncol Biol Phys 2006;66:1281-1293.
    • (2006) Int J Radiat Oncol Biol Phys , vol.66 , pp. 1281-1293
    • Tsoutsou, P.G.1    Koukourakis, M.I.2
  • 6
    • 33947499592 scopus 로고    scopus 로고
    • Molecular mechanisms of late normal tissue injury
    • Brush J, Lipnick SL, Phillips T et al. Molecular mechanisms of late normal tissue injury. Semin Radiat Oncol 2007;17:121-130.
    • (2007) Semin Radiat Oncol , vol.17 , pp. 121-130
    • Brush, J.1    Lipnick, S.L.2    Phillips, T.3
  • 7
    • 33947536682 scopus 로고    scopus 로고
    • Responses of normal cells to ionizing radiation
    • Rodemann HP, Blaese MA. Responses of normal cells to ionizing radiation. Semin Radiat Oncol 2007;17:81-88.
    • (2007) Semin Radiat Oncol , vol.17 , pp. 81-88
    • Rodemann, H.P.1    Blaese, M.A.2
  • 8
    • 33947503734 scopus 로고    scopus 로고
    • Genetic susceptibility to late normal tissue injury
    • Travis EL. Genetic susceptibility to late normal tissue injury. Semin Radiat Oncol 2007;17:149-155.
    • (2007) Semin Radiat Oncol , vol.17 , pp. 149-155
    • Travis, E.L.1
  • 9
    • 20944439541 scopus 로고    scopus 로고
    • Recent progress in defining mechanisms and potential targets for prevention of normal tissue injury after radiation therapy
    • Anscher MS, Chen L, Rabbani Z et al. Recent progress in defining mechanisms and potential targets for prevention of normal tissue injury after radiation therapy. Int J Radiat Oncol Biol Phys 2005;62:255-259.
    • (2005) Int J Radiat Oncol Biol Phys , vol.62 , pp. 255-259
    • Anscher, M.S.1    Chen, L.2    Rabbani, Z.3
  • 10
    • 0026437136 scopus 로고
    • Transforming growth factors-beta as regulators of cellular growth and phenotype
    • Laiho M, Keski-Oja J. Transforming growth factors-beta as regulators of cellular growth and phenotype. Crit Rev Oncog 1992;3:1-26.
    • (1992) Crit Rev Oncog , vol.3 , pp. 1-26
    • Laiho, M.1    Keski-Oja, J.2
  • 12
    • 0034644472 scopus 로고    scopus 로고
    • TGF signaling in growth control, cancer, and heritable disorders
    • Massagué J, Blain SW, Lo RS. TGF signaling in growth control, cancer, and heritable disorders. Cell 2000;103:295-309.
    • (2000) Cell , vol.103 , pp. 295-309
    • Massagué, J.1    Blain, S.W.2    Lo, R.S.3
  • 13
    • 34547587877 scopus 로고    scopus 로고
    • Cell size and invasion in TGF--induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway
    • Lamouille S, Derynck R. Cell size and invasion in TGF--induced epithelial to mesenchymal transition is regulated by activation of the mTOR pathway. J Cell Biol 2007;178:437-451.
    • (2007) J Cell Biol , vol.178 , pp. 437-451
    • Lamouille, S.1    Derynck, R.2
  • 14
    • 34548329486 scopus 로고    scopus 로고
    • Differentiation plasticity regulated by TGF- family proteins in development and disease
    • Derynck R, Akhurst RJ. Differentiation plasticity regulated by TGF- family proteins in development and disease. Nat Cell Biol 2007;9:1000-1004.
    • (2007) Nat Cell Biol , vol.9 , pp. 1000-1004
    • Derynck, R.1    Akhurst, R.J.2
  • 16
    • 41949103636 scopus 로고    scopus 로고
    • SnapShot: The TGF pathway interactome
    • 378.e1
    • Taylor IW, Wrana JL. SnapShot: The TGF pathway interactome. Cell 2008;133:378.e1.
    • (2008) Cell , vol.133
    • Taylor, I.W.1    Wrana, J.L.2
  • 17
    • 15744372725 scopus 로고    scopus 로고
    • Role of transforming growth factor beta in human cancer
    • Elliott RL, Blobe GC. Role of transforming growth factor beta in human cancer. J Clin Oncol 2005;23:2078-2093.
    • (2005) J Clin Oncol , vol.23 , pp. 2078-2093
    • Elliott, R.L.1    Blobe, G.C.2
  • 18
    • 0030977137 scopus 로고    scopus 로고
    • Expression of transforming growth factor beta (TGF) type III receptor restores autocrine TGF 1 activity in human breast cancer MCF-7 cells
    • Chen C, Wang XF, Sun L. Expression of transforming growth factor beta (TGF) type III receptor restores autocrine TGF 1 activity in human breast cancer MCF-7 cells. J Biol Chem 1997;272:12862-12867.
    • (1997) J Biol Chem , vol.272 , pp. 12862-12867
    • Chen, C.1    Wang, X.F.2    Sun, L.3
  • 19
    • 0033555627 scopus 로고    scopus 로고
    • Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers
    • Grady WM, Myeroff LL, Swinler SE et al. Mutational inactivation of transforming growth factor beta receptor type II in microsatellite stable colon cancers. Cancer Res 1999;59:320-324.
    • (1999) Cancer Res , vol.59 , pp. 320-324
    • Grady, W.M.1    Myeroff, L.L.2    Swinler, S.E.3
  • 20
    • 7844240481 scopus 로고    scopus 로고
    • Disruption of the antiproliferative TGF- signaling pathways in human pancreatic cancer cells
    • Villanueva A, Garcia C, Paules AB et al. Disruption of the antiproliferative TGF- signaling pathways in human pancreatic cancer cells. Oncogene 1998;17:1969-1978.
    • (1998) Oncogene , vol.17 , pp. 1969-1978
    • Villanueva, A.1    Garcia, C.2    Paules, A.B.3
  • 21
    • 0035847018 scopus 로고    scopus 로고
    • Oncogenic Ki-ras confers a more aggressive colon cancer phenotype through modification of transforming growth factor-beta receptor III
    • Yan Z, Deng X, Friedman E. Oncogenic Ki-ras confers a more aggressive colon cancer phenotype through modification of transforming growth factor-beta receptor III. J Biol Chem 2001;276:1555-1563.
    • (2001) J Biol Chem , vol.276 , pp. 1555-1563
    • Yan, Z.1    Deng, X.2    Friedman, E.3
  • 22
    • 0034785348 scopus 로고    scopus 로고
    • TGF- signaling in tumor suppression and cancer progression
    • Derynck R, Akhurst RJ, Balmain A. TGF- signaling in tumor suppression and cancer progression. Nat Genet 2001;29:117-129.
    • (2001) Nat Genet , vol.29 , pp. 117-129
    • Derynck, R.1    Akhurst, R.J.2    Balmain, A.3
  • 24
    • 0028187918 scopus 로고
    • Transforming growth factor-beta and extracellular matrix deposition in the kidney
    • Border WA, Brees D, Noble NA. Transforming growth factor-beta and extracellular matrix deposition in the kidney. Contrib Nephrol 1994;107: 140-145.
    • (1994) Contrib Nephrol , vol.107 , pp. 140-145
    • Border, W.A.1    Brees, D.2    Noble, N.A.3
  • 25
    • 0033524949 scopus 로고    scopus 로고
    • The integrin vß6 binds and activates latent TGF 1: A mechanism for regulating pulmonary inflammation and fibrosis
    • Munger J, Huang X, Kawakatsu H et al. The integrin vß6 binds and activates latent TGF 1: A mechanism for regulating pulmonary inflammation and fibrosis. Cell 1999;96:319-328.
    • (1999) Cell , vol.96 , pp. 319-328
    • Munger, J.1    Huang, X.2    Kawakatsu, H.3
  • 26
    • 0025993494 scopus 로고
    • Identification and activation of latent transforming growth factor
    • Lawrence D. Identification and activation of latent transforming growth factor. Methods Enzymol 1991;198:327-336.
    • (1991) Methods Enzymol , vol.198 , pp. 327-336
    • Lawrence, D.1
  • 27
    • 0035865279 scopus 로고    scopus 로고
    • Latency, activation, and binding proteins of TGF-
    • Koli K, Saharinen J, Hyytiäinen M et al. Latency, activation, and binding proteins of TGF-. Microsc Res Tech 2001;52:354-362.
    • (2001) Microsc Res Tech , vol.52 , pp. 354-362
    • Koli, K.1    Saharinen, J.2    Hyytiäinen, M.3
  • 28
    • 0344026339 scopus 로고    scopus 로고
    • M6P/IGFII-receptor complexes urokinase receptor and plasminogen for activation of transforming growth factor-ß1
    • Godár S, Horejsi V, Weidle UH et al. M6P/IGFII-receptor complexes urokinase receptor and plasminogen for activation of transforming growth factor-ß1. Eur J Immunol 1999;29:1004-1013.
    • (1999) Eur J Immunol , vol.29 , pp. 1004-1013
    • Godár, S.1    Horejsi, V.2    Weidle, U.H.3
  • 30
    • 0029736871 scopus 로고    scopus 로고
    • Redox-mediated activation of latent transforming growth factor-1
    • Barcellos-Hoff MH, Dix TA. Redox-mediated activation of latent transforming growth factor-1. Mol Endocrinol 1996;10:1077-1083.
    • (1996) Mol Endocrinol , vol.10 , pp. 1077-1083
    • Barcellos-Hoff, M.H.1    Dix, T.A.2
  • 31
  • 32
    • 0033399104 scopus 로고    scopus 로고
    • Bidirectional regulation of macrophage function by TGF-β
    • Ashcroft GS. Bidirectional regulation of macrophage function by TGF-β. Microbes Infect 1999;1:1275-1282.
    • (1999) Microbes Infect , vol.1 , pp. 1275-1282
    • Ashcroft, G.S.1
  • 33
    • 0024538265 scopus 로고
    • Transforming growth factor-inhibition of epithelial cell proliferation linked to the expression of a 53-kDa membrane receptor
    • Boyd F, Massagué J. Transforming growth factor-inhibition of epithelial cell proliferation linked to the expression of a 53-kDa membrane receptor. J Biol Chem 1989;264:2272-2278.
    • (1989) J Biol Chem , vol.264 , pp. 2272-2278
    • Boyd, F.1    Massagué, J.2
  • 34
    • 0033625343 scopus 로고    scopus 로고
    • TGF-ß1-mediated alterations of rat lung fibroblast differentiation resulting in the radiation-induced fibrotic phenotype
    • Hakenjos L, Bamberg M, Rodemann H. TGF-ß1-mediated alterations of rat lung fibroblast differentiation resulting in the radiation-induced fibrotic phenotype. Int J Radiat Biol 2000;76:503-509.
    • (2000) Int J Radiat Biol , vol.76 , pp. 503-509
    • Hakenjos, L.1    Bamberg, M.2    Rodemann, H.3
  • 35
    • 0029883757 scopus 로고    scopus 로고
    • Transforming growth factor 1 induces angiogenesis in vivo with a threshold pattern
    • Fajardo LF, Prionas SD, Kwan HH et al. Transforming growth factor 1 induces angiogenesis in vivo with a threshold pattern. Lab Invest 1996; 74:600-608.
    • (1996) Lab Invest , vol.74 , pp. 600-608
    • Fajardo, L.F.1    Prionas, S.D.2    Kwan, H.H.3
  • 36
    • 0027582106 scopus 로고
    • Transforming growth factor beta (TGF-B) stimulation of angiogenesis: An electron microscopic study
    • Phillips GD, Whitehead RA, Stone AM et al. Transforming growth factor beta (TGF-B) stimulation of angiogenesis: An electron microscopic study. J Submicroscop Cytol Pathol 1993;25:149-155.
    • (1993) J Submicroscop Cytol Pathol , vol.25 , pp. 149-155
    • Phillips, G.D.1    Whitehead, R.A.2    Stone, A.M.3
  • 38
    • 0031727915 scopus 로고    scopus 로고
    • Targeting TGF-β overexpression in renal disease: Maximizing the antifibrotic action of angiotensin II blockade
    • Peters H, Border WA, Noble NA. Targeting TGF-β overexpression in renal disease: Maximizing the antifibrotic action of angiotensin II blockade. Kidney Int 1998;54:1570-1580.
    • (1998) Kidney Int , vol.54 , pp. 1570-1580
    • Peters, H.1    Border, W.A.2    Noble, N.A.3
  • 39
    • 0026778310 scopus 로고
    • Transforming growth factor-β in disease: The dark side of tissue repair
    • Border WA, Ruoslahti E. Transforming growth factor-β in disease: The dark side of tissue repair. J Clin Invest 1992;90:1-7.
    • (1992) J Clin Invest , vol.90 , pp. 1-7
    • Border, W.A.1    Ruoslahti, E.2
  • 40
    • 1242306647 scopus 로고    scopus 로고
    • The role of transforming growth factor beta in lung development and disease
    • Bartram U, Speer CP. The role of transforming growth factor beta in lung development and disease. Chest 2004;125:754-765.
    • (2004) Chest , vol.125 , pp. 754-765
    • Bartram, U.1    Speer, C.P.2
  • 41
    • 0031926223 scopus 로고    scopus 로고
    • The relevance of transforming growth factor beta 1 in pulmonary injury after radiation therapy
    • Anscher MS, Kong FM, Jirtle RL. The relevance of transforming growth factor beta 1 in pulmonary injury after radiation therapy. Lung Cancer 1998;19:109-120.
    • (1998) Lung Cancer , vol.19 , pp. 109-120
    • Anscher, M.S.1    Kong, F.M.2    Jirtle, R.L.3
  • 42
    • 0029905441 scopus 로고    scopus 로고
    • Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney
    • Isaka Y, Brees DK, Ikegaya K et al. Gene therapy by skeletal muscle expression of decorin prevents fibrotic disease in rat kidney. Nat Med 1996; 2:418-423.
    • (1996) Nat Med , vol.2 , pp. 418-423
    • Isaka, Y.1    Brees, D.K.2    Ikegaya, K.3
  • 43
    • 10144227768 scopus 로고    scopus 로고
    • Inhibition of TGF-β1 expression by antisense oligonucleotides suppressed extracellular matrix accumulation in experimental glomerulonephritis
    • Akagi Y, Isaka Y, Arai M et al. Inhibition of TGF-β1 expression by antisense oligonucleotides suppressed extracellular matrix accumulation in experimental glomerulonephritis. Kidney Int 1996;50:148-155.
    • (1996) Kidney Int , vol.50 , pp. 148-155
    • Akagi, Y.1    Isaka, Y.2    Arai, M.3
  • 44
    • 0032955814 scopus 로고    scopus 로고
    • Reduced plasma transforming growth factor-ß1 levels in patients with chronic hepatitis C after interfer-on-therapy: Association with regression of hepatic fibrosis
    • Tsushima H, Kawata S, Tamura S et al. Reduced plasma transforming growth factor-ß1 levels in patients with chronic hepatitis C after interfer-on-therapy: Association with regression of hepatic fibrosis. J Hepatol 1999;30:1-7.
    • (1999) J Hepatol , vol.30 , pp. 1-7
    • Tsushima, H.1    Kawata, S.2    Tamura, S.3
  • 45
    • 0025277164 scopus 로고
    • Suppression of experimental glomerulonephritis by antiserum against transforming growth factor beta 1
    • Border W, Okuda S, Languino LR et al. Suppression of experimental glomerulonephritis by antiserum against transforming growth factor beta 1. Nature 1990;346:371-374.
    • (1990) Nature , vol.346 , pp. 371-374
    • Border, W.1    Okuda, S.2    Languino, L.R.3
  • 46
    • 33846232210 scopus 로고    scopus 로고
    • Long-term administration of a small molecular weight catalytic metalloporphyrin antioxidant, AEOL 10150, protects lungs from radiation-induced injury
    • Rabbani ZN, Batinic-Haberle I, Anscher MS et al. Long-term administration of a small molecular weight catalytic metalloporphyrin antioxidant, AEOL 10150, protects lungs from radiation-induced injury. Int J Radiat Oncol Biol Phys 2007;67:573-580.
    • (2007) Int J Radiat Oncol Biol Phys , vol.67 , pp. 573-580
    • Rabbani, Z.N.1    Batinic-Haberle, I.2    Anscher, M.S.3
  • 47
    • 0041419545 scopus 로고    scopus 로고
    • Soluble TGF type II receptor gene therapy ameliorates acute radiation-induced pulmonary injury in rats
    • Rabbani ZN, Anscher MS, Zhang X et al. Soluble TGF type II receptor gene therapy ameliorates acute radiation-induced pulmonary injury in rats. Int J Radiat Oncol Biol Phys 2003;57:563-572.
    • (2003) Int J Radiat Oncol Biol Phys , vol.57 , pp. 563-572
    • Rabbani, Z.N.1    Anscher, M.S.2    Zhang, X.3
  • 48
    • 8444250143 scopus 로고    scopus 로고
    • Overexpression of extracellular superoxide dismutase reduces severity of radiation-induced lung toxicity through downregulation of the TGF- signal transduction pathway
    • Rabbani ZN, Anscher MS, Golson ML et al. Overexpression of extracellular superoxide dismutase reduces severity of radiation-induced lung toxicity through downregulation of the TGF- signal transduction pathway. Int J Radiat Oncol Biol Phys 2003;57:S158-S159.
    • (2003) Int J Radiat Oncol Biol Phys , vol.57
    • Rabbani, Z.N.1    Anscher, M.S.2    Golson, M.L.3
  • 49
    • 1542316342 scopus 로고    scopus 로고
    • Histopathologic amelioration of fibroproliferative change in rat irradiated lung using soluble transforming growth factor-beta (TGF-) receptor mediated by adenoviral vector
    • Nishioka A, Ogawa Y, Mima T et al. Histopathologic amelioration of fibroproliferative change in rat irradiated lung using soluble transforming growth factor-beta (TGF-) receptor mediated by adenoviral vector. Int J Radiat Oncol Biol Phys 2004;58:1235-1241.
    • (2004) Int J Radiat Oncol Biol Phys , vol.58 , pp. 1235-1241
    • Nishioka, A.1    Ogawa, Y.2    Mima, T.3
  • 50
    • 0032719815 scopus 로고    scopus 로고
    • Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice
    • Nakao A, Fujii M, Matsumura R et al. Transient gene transfer and expression of Smad7 prevents bleomycin-induced lung fibrosis in mice. J Clin Invest 1999;104:5-11.
    • (1999) J Clin Invest , vol.104 , pp. 5-11
    • Nakao, A.1    Fujii, M.2    Matsumura, R.3
  • 51
    • 0037725916 scopus 로고    scopus 로고
    • Overexpression of extracellular superoxide dismutase protects mice from radiation induced lung injury
    • Kang S, Rabbani Z, Folz R et al. Overexpression of extracellular superoxide dismutase protects mice from radiation induced lung injury. Int J Radiat Oncol Biol Phys 2002;54:78.
    • (2002) Int J Radiat Oncol Biol Phys , vol.54 , pp. 78
    • Kang, S.1    Rabbani, Z.2    Folz, R.3
  • 52
    • 0027425864 scopus 로고
    • Effect of antibody to transforming growth factor ß on bleomycin induced accumulation of lung collagen in mice
    • Giri SN, Hyde DM, Hollinger MA. Effect of antibody to transforming growth factor ß on bleomycin induced accumulation of lung collagen in mice. Thorax 1993;48:959-966.
    • (1993) Thorax , vol.48 , pp. 959-966
    • Giri, S.N.1    Hyde, D.M.2    Hollinger, M.A.3
  • 53
    • 15244339164 scopus 로고    scopus 로고
    • Imatinib mesylate inhibits the pro-fibrogenic activity of TGF- and prevents bleomycin-mediated lung fibrosis
    • Daniels CE, Wilkes MC, Edens M et al. Imatinib mesylate inhibits the pro-fibrogenic activity of TGF- and prevents bleomycin-mediated lung fibrosis. J Clin Invest 2004;114:1308-1316.
    • (2004) J Clin Invest , vol.114 , pp. 1308-1316
    • Daniels, C.E.1    Wilkes, M.C.2    Edens, M.3
  • 54
    • 0025342073 scopus 로고
    • Transforming growth factor-beta 1 expression in irradiated liver
    • Anscher MS, Crocker IR, Jirtle RL. Transforming growth factor-beta 1 expression in irradiated liver. Radiat Res 1990;122:77-85.
    • (1990) Radiat Res , vol.122 , pp. 77-85
    • Anscher, M.S.1    Crocker, I.R.2    Jirtle, R.L.3
  • 55
    • 0031049913 scopus 로고    scopus 로고
    • Immunohistochemical localization of transforming growth factor beta and tumor necrosis factor alpha in the lungs of fibrosis-prone and "non-fibrosing" mice during the latent period and early phase after irradiation
    • Franko AJ, Sharplin J, Ghahary A et al. Immunohistochemical localization of transforming growth factor beta and tumor necrosis factor alpha in the lungs of fibrosis-prone and "non-fibrosing" mice during the latent period and early phase after irradiation. Radiat Res 1997;147:245-256.
    • (1997) Radiat Res , vol.147 , pp. 245-256
    • Franko, A.J.1    Sharplin, J.2    Ghahary, A.3
  • 56
    • 17844408013 scopus 로고    scopus 로고
    • Assessment of the protective effect of keratinocyte growth factor on radiation-induced pulmonary toxicity in rats
    • Liguang C, Larrier N, Rabbani ZN et al. Assessment of the protective effect of keratinocyte growth factor on radiation-induced pulmonary toxicity in rats. Int J Radiat Oncol Biol Phys 2003;57:S162.
    • (2003) Int J Radiat Oncol Biol Phys , vol.57
    • Liguang, C.1    Larrier, N.2    Rabbani, Z.N.3
  • 57
    • 36849026669 scopus 로고    scopus 로고
    • New rationales for using TGF inhibitors in radiotherapy
    • Andarawewa KL, Paupert J, Pal A et al. New rationales for using TGF inhibitors in radiotherapy. Int J Radiat Biol 2007;83:803-811.
    • (2007) Int J Radiat Biol , vol.83 , pp. 803-811
    • Andarawewa, K.L.1    Paupert, J.2    Pal, A.3
  • 58
    • 33847065545 scopus 로고    scopus 로고
    • Low-dose irradiation of nontransformed cells stimulates the selective removal of precancerous cells via intercellular induction of apoptosis
    • Portess DI, Bauer G, Hill MA et al. Low-dose irradiation of nontransformed cells stimulates the selective removal of precancerous cells via intercellular induction of apoptosis. Cancer Res 2007;67:1246-1253.
    • (2007) Cancer Res , vol.67 , pp. 1246-1253
    • Portess, D.I.1    Bauer, G.2    Hill, M.A.3
  • 59
    • 0036124599 scopus 로고    scopus 로고
    • Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation
    • Flanders KC, Sullivan CD, Fujii M et al. Mice lacking Smad3 are protected against cutaneous injury induced by ionizing radiation. Am J Pathol 2002;160:1057-1068.
    • (2002) Am J Pathol , vol.160 , pp. 1057-1068
    • Flanders, K.C.1    Sullivan, C.D.2    Fujii, M.3
  • 60
    • 38849201802 scopus 로고    scopus 로고
    • TGFB1 single nucleotide polymorphisms are associated with adverse quality of life in prostate cancer patients treated with radiotherapy
    • Peters CA, Stock RG, Cesaretti JA et al. TGFB1 single nucleotide polymorphisms are associated with adverse quality of life in prostate cancer patients treated with radiotherapy. Int J Radiat Oncol Biol Phys 2008;70: 752-759.
    • (2008) Int J Radiat Oncol Biol Phys , vol.70 , pp. 752-759
    • Peters, C.A.1    Stock, R.G.2    Cesaretti, J.A.3
  • 61
    • 0027193827 scopus 로고
    • Transforming growth factor beta as a predictor of liver and lung fibrosis after autologous bone marrow transplantation for advanced breast cancer
    • Anscher MS, Peters WP, Reisenbichler H et al. Transforming growth factor beta as a predictor of liver and lung fibrosis after autologous bone marrow transplantation for advanced breast cancer. N Engl J Med 1993;328: 1592-1598.
    • (1993) N Engl J Med , vol.328 , pp. 1592-1598
    • Anscher, M.S.1    Peters, W.P.2    Reisenbichler, H.3
  • 62
    • 0029133133 scopus 로고
    • Elevated plasma transforming growth factor beta 1 levels in breast cancer patients decrease after surgical removal of the tumor
    • Kong FM, Anscher MS, Murase T et al. Elevated plasma transforming growth factor beta 1 levels in breast cancer patients decrease after surgical removal of the tumor. Ann Surg 1995;222:155-162.
    • (1995) Ann Surg , vol.222 , pp. 155-162
    • Kong, F.M.1    Anscher, M.S.2    Murase, T.3
  • 63
    • 0007699416 scopus 로고
    • Elevated circulating transforming growth factor 1 levels decreased after radiotherapy in patients with lung cancer, cervical cancer and Hodgkin's disease: A possible tumor marker
    • Kong F-M, Anscher M, Xiong Z et al. Elevated circulating transforming growth factor 1 levels decreased after radiotherapy in patients with lung cancer, cervical cancer and Hodgkin's disease: A possible tumor marker. Int J Radiat Oncol Biol Phys 1995;32(suppl 1):239.
    • (1995) Int J Radiat Oncol Biol Phys , vol.32 , Issue.SUPPL. 1 , pp. 239
    • Kong, F.-M.1    Anscher, M.2    Xiong, Z.3
  • 64
    • 1942446138 scopus 로고    scopus 로고
    • Transforming growth factor-beta plasma dynamics and post-irradiation lung injury in lung cancer patients
    • Novakova-Jiresova A, Van Gameren MM, Coppes RP et al. Transforming growth factor-beta plasma dynamics and post-irradiation lung injury in lung cancer patients. Radiother Oncol 2004;71:183-189.
    • (2004) Radiother Oncol , vol.71 , pp. 183-189
    • Novakova-Jiresova, A.1    van Gameren, M.M.2    Coppes, R.P.3
  • 65
    • 1842581511 scopus 로고    scopus 로고
    • Significance of plasma transforming growth factor-beta levels in radiotherapy for non-small-cell lung cancer
    • De Jaeger K, Seppenwoolde Y, Kampinga HH et al. Significance of plasma transforming growth factor-beta levels in radiotherapy for non-small-cell lung cancer. Int J Radiat Oncol Biol Phys 2004;58:1378-1387.
    • (2004) Int J Radiat Oncol Biol Phys , vol.58 , pp. 1378-1387
    • de Jaeger, K.1    Seppenwoolde, Y.2    Kampinga, H.H.3
  • 66
    • 0032527651 scopus 로고    scopus 로고
    • Plasma transforming growth factor 1 as a predictor of radiation pneumonitis
    • Anscher MS, Kong FM, Andrews K et al. Plasma transforming growth factor 1 as a predictor of radiation pneumonitis. Int J Radiat Oncol Biol Phys 1998;41:1029-1035.
    • (1998) Int J Radiat Oncol Biol Phys , vol.41 , pp. 1029-1035
    • Anscher, M.S.1    Kong, F.M.2    Andrews, K.3
  • 67
    • 0030978490 scopus 로고    scopus 로고
    • Changes in plasma transforming growth factor beta during radiotherapy and the risk of symptomatic radiation-induced pneumonitis
    • Anscher MS, Kong FM, Marks LB et al. Changes in plasma transforming growth factor beta during radiotherapy and the risk of symptomatic radiation-induced pneumonitis. Int J Radiat Oncol Biol Phys 1997;37:253-258.
    • (1997) Int J Radiat Oncol Biol Phys , vol.37 , pp. 253-258
    • Anscher, M.S.1    Kong, F.M.2    Marks, L.B.3
  • 68
    • 0028168685 scopus 로고
    • Changes in plasma TGF beta levels during pulmonary radiotherapy as a predictor of the risk of developing radiation pneumonitis
    • Anscher MS, Murase T, Prescott DM et al. Changes in plasma TGF beta levels during pulmonary radiotherapy as a predictor of the risk of developing radiation pneumonitis. Int J Radiat Oncol Biol Phys 1994;30:671-676.
    • (1994) Int J Radiat Oncol Biol Phys , vol.30 , pp. 671-676
    • Anscher, M.S.1    Murase, T.2    Prescott, D.M.3
  • 69
    • 49649100905 scopus 로고    scopus 로고
    • The use of blood biomarkers to predict radiation lung toxicity: A potential strategy to individualize thoracic radiation therapy
    • Kong FM, Ao X, Wang L et al. The use of blood biomarkers to predict radiation lung toxicity: A potential strategy to individualize thoracic radiation therapy. Cancer Control 2008;15:140-150.
    • (2008) Cancer Control , vol.15 , pp. 140-150
    • Kong, F.M.1    Ao, X.2    Wang, L.3
  • 70
    • 0035879570 scopus 로고    scopus 로고
    • Predicting the risk of symptomatic radiation-induced lung injury using both the physical and biologic parameters V(30) and transforming growth factor beta
    • Fu XL, Huang H, Bentel G et al. Predicting the risk of symptomatic radiation-induced lung injury using both the physical and biologic parameters V(30) and transforming growth factor beta. Int J Radiat Oncol Biol Phys 2001;50:899-908.
    • (2001) Int J Radiat Oncol Biol Phys , vol.50 , pp. 899-908
    • Fu, X.L.1    Huang, H.2    Bentel, G.3
  • 71
    • 0035449431 scopus 로고    scopus 로고
    • Using plasma transforming growth factor beta-1 during radiotherapy to select patients for dose escalation
    • Anscher MS, Marks LB, Shafman TD et al. Using plasma transforming growth factor beta-1 during radiotherapy to select patients for dose escalation. J Clin Oncol 2001;19:3758-3765.
    • (2001) J Clin Oncol , vol.19 , pp. 3758-3765
    • Anscher, M.S.1    Marks, L.B.2    Shafman, T.D.3
  • 72
    • 0038048219 scopus 로고    scopus 로고
    • Risk of long-term complications after TGF-β1-guided very-high-dose thoracic radiotherapy
    • Anscher MS, Marks LB, Shafman TD et al. Risk of long-term complications after TGF-β1-guided very-high-dose thoracic radiotherapy. Int J Radiat Oncol Biol Phys 2003;56:988-995.
    • (2003) Int J Radiat Oncol Biol Phys , vol.56 , pp. 988-995
    • Anscher, M.S.1    Marks, L.B.2    Shafman, T.D.3
  • 73
    • 0035689762 scopus 로고    scopus 로고
    • Malignant cells, directors of the malignant process: Role of transforming growth factor-beta
    • Teicher BA. Malignant cells, directors of the malignant process: Role of transforming growth factor-beta. Cancer Metastasis Rev 2001;20:133-143.
    • (2001) Cancer Metastasis Rev , vol.20 , pp. 133-143
    • Teicher, B.A.1
  • 74
    • 33745515023 scopus 로고    scopus 로고
    • Tumour microenvironment: TGF: The molecular Jekyll and Hyde of cancer
    • Bierie B, Moses HL. Tumour microenvironment: TGF: The molecular Jekyll and Hyde of cancer. Nat Rev Cancer 2006;6:506-520.
    • (2006) Nat Rev Cancer , vol.6 , pp. 506-520
    • Bierie, B.1    Moses, H.L.2
  • 75
    • 0035865146 scopus 로고    scopus 로고
    • Role of TGF- in immune-evasion of cancer
    • Beck C, Schreiber H, Rowley D. Role of TGF- in immune-evasion of cancer. Microsc Res Tech 2001;52:387-395.
    • (2001) Microsc Res Tech , vol.52 , pp. 387-395
    • Beck, C.1    Schreiber, H.2    Rowley, D.3
  • 76
    • 1642392553 scopus 로고    scopus 로고
    • Association of pre-and postoperative plasma levels of transforming growth factor beta(1) and interleukin 6 and its soluble receptor with prostate cancer progression
    • Shariat SF, Kattan MW, Traxel E et al. Association of pre-and postoperative plasma levels of transforming growth factor beta(1) and interleukin 6 and its soluble receptor with prostate cancer progression. Clin Cancer Res 2004;10:1992-1999.
    • (2004) Clin Cancer Res , vol.10 , pp. 1992-1999
    • Shariat, S.F.1    Kattan, M.W.2    Traxel, E.3
  • 77
    • 40849099826 scopus 로고    scopus 로고
    • Early postoperative plasma transforming growth factor-1 is a strong predictor of biochemical progression after radical prostatectomy
    • Shariat SF, Walz J, Roehrborn CG et al. Early postoperative plasma transforming growth factor-1 is a strong predictor of biochemical progression after radical prostatectomy. J Urol 2008;179:1593-1597.
    • (2008) J Urol , vol.179 , pp. 1593-1597
    • Shariat, S.F.1    Walz, J.2    Roehrborn, C.G.3
  • 78
    • 0035865274 scopus 로고    scopus 로고
    • Role of transforming growth factor-1 in prostate cancer
    • Wikström P, Damber J, Bergh A. Role of transforming growth factor-1 in prostate cancer. Microsc Res Tech 2001;52:411-419.
    • (2001) Microsc Res Tech , vol.52 , pp. 411-419
    • Wikström, P.1    Damber, J.2    Bergh, A.3
  • 79
    • 10844224603 scopus 로고    scopus 로고
    • Conditional overexpression of active transforming growth factor 1 in vivo accelerates metastases of transgenic mammary tumors
    • Muraoka-Cook RS, Kurokawa H, Koh Y et al. Conditional overexpression of active transforming growth factor 1 in vivo accelerates metastases of transgenic mammary tumors. Cancer Res 2004;64:9002-9011.
    • (2004) Cancer Res , vol.64 , pp. 9002-9011
    • Muraoka-Cook, R.S.1    Kurokawa, H.2    Koh, Y.3
  • 80
    • 0036086409 scopus 로고    scopus 로고
    • Blockade of TGF- inhibits mammary tumor cell viability, migration, and metastases
    • Muraoka RS, Dumont N, Ritter CA et al. Blockade of TGF- inhibits mammary tumor cell viability, migration, and metastases. J Clin Invest 2002;109:1551-1559.
    • (2002) J Clin Invest , vol.109 , pp. 1551-1559
    • Muraoka, R.S.1    Dumont, N.2    Ritter, C.A.3
  • 81
    • 33746145265 scopus 로고    scopus 로고
    • Inhibition of pulmonary and skeletal metastasis by a transforming growth factor-beta type I receptor kinase inhibitor
    • Bandyopadhyay A, Agyin JK, Wang L et al. Inhibition of pulmonary and skeletal metastasis by a transforming growth factor-beta type I receptor kinase inhibitor. Cancer Res 2006;66:6714-6721.
    • (2006) Cancer Res , vol.66 , pp. 6714-6721
    • Bandyopadhyay, A.1    Agyin, J.K.2    Wang, L.3
  • 82
    • 0031420122 scopus 로고    scopus 로고
    • Transforming growth factor-beta 1 overexpression produces drug resistance in vivo: Reversal by decorin
    • Teicher BA, Ikebe M, Ara G et al. Transforming growth factor-beta 1 overexpression produces drug resistance in vivo: Reversal by decorin. In Vivo 1997;11:463-472.
    • (1997) In Vivo , vol.11 , pp. 463-472
    • Teicher, B.A.1    Ikebe, M.2    Ara, G.3
  • 83
  • 85
    • 0026059613 scopus 로고
    • Cellular activation of latent transforming growth factor ß requires binding to the cation-independent mannose 6-phosphate/ insulin-like growth factor type II receptor
    • Dennis PA, Rifkin DB. Cellular activation of latent transforming growth factor ß requires binding to the cation-independent mannose 6-phosphate/ insulin-like growth factor type II receptor. Proc Natl Acad Sci U S A 1991; 88:580-584.
    • (1991) Proc Natl Acad Sci U S A , vol.88 , pp. 580-584
    • Dennis, P.A.1    Rifkin, D.B.2
  • 87
    • 0026496172 scopus 로고
    • TGF β signals through a heteromeric protein kinase receptor complex
    • Wrana JL, Attisano L, Cárcamo J et al. TGF β signals through a heteromeric protein kinase receptor complex. Cell 1992;71:1003-1014.
    • (1992) Cell , vol.71 , pp. 1003-1014
    • Wrana, J.L.1    Attisano, L.2    Cárcamo, J.3
  • 88
    • 0027250810 scopus 로고
    • Inactivation of the type II receptor reveals two receptor pathways for the diverse TGF- activities
    • Chen RH, Ebner R, Derynck R. Inactivation of the type II receptor reveals two receptor pathways for the diverse TGF- activities. Science 1993; 260:1335-1338.
    • (1993) Science , vol.260 , pp. 1335-1338
    • Chen, R.H.1    Ebner, R.2    Derynck, R.3
  • 89
    • 0034477043 scopus 로고    scopus 로고
    • Activation of latent transforming growth factor-1 is induced by mannose 6-phosphate/insulin-like growth factor-II receptor
    • Yang L, Tredget EE, Ghahary A. Activation of latent transforming growth factor-1 is induced by mannose 6-phosphate/insulin-like growth factor-II receptor. Wound Repair Regen 2000;8:538-546.
    • (2000) Wound Repair Regen , vol.8 , pp. 538-546
    • Yang, L.1    Tredget, E.E.2    Ghahary, A.3
  • 90
    • 0029934868 scopus 로고    scopus 로고
    • M6P/IGF2 receptor: A candidate breast tumor suppressor gene
    • Hankins GR, De Souza AT, Bentley RC et al. M6P/IGF2 receptor: A candidate breast tumor suppressor gene. Oncogene 1996;12:2003-2009.
    • (1996) Oncogene , vol.12 , pp. 2003-2009
    • Hankins, G.R.1    de Souza, A.T.2    Bentley, R.C.3
  • 91
    • 0024364949 scopus 로고
    • Mannose-6 phosphate receptors and lysosomal enzyme targeting
    • Dahms NM, Lobel P, Kornfeld S. Mannose-6 phosphate receptors and lysosomal enzyme targeting. J Biol Chem 1989;264:12115-12118.
    • (1989) J Biol Chem , vol.264 , pp. 12115-12118
    • Dahms, N.M.1    Lobel, P.2    Kornfeld, S.3
  • 92
    • 0008330281 scopus 로고    scopus 로고
    • M6P/IGF2R tumor suppressor gene is mutated in lung cancer
    • Kong F, Pulford D, Bandera M, et al. M6P/IGF2R tumor suppressor gene is mutated in lung cancer. Proc Am Assoc Cancer Res 1999;40:733.
    • (1999) Proc Am Assoc Cancer Res , vol.40 , pp. 733
    • Kong, F.1    Pulford, D.2    Bandera, M.3
  • 93
    • 0035174298 scopus 로고    scopus 로고
    • Loss of heterozygosity at the mannose 6-phosphate insulin-like growth factor 2 receptor (M6P/IGF2R) locus predisposes patients to radiation-induced lung injury
    • Kong FM, Anscher MS, Sporn TA et al. Loss of heterozygosity at the mannose 6-phosphate insulin-like growth factor 2 receptor (M6P/IGF2R) locus predisposes patients to radiation-induced lung injury. Int J Radiat Oncol Biol Phys 2001;49:35-41.
    • (2001) Int J Radiat Oncol Biol Phys , vol.49 , pp. 35-41
    • Kong, F.M.1    Anscher, M.S.2    Sporn, T.A.3
  • 94
    • 0035870259 scopus 로고    scopus 로고
    • Hypoxia in radiation-induced blood-spinal cord barrier breakdown
    • Li Y-Q, Ballinger JR, Nordal RA et al. Hypoxia in radiation-induced blood-spinal cord barrier breakdown. Cancer Res 2001;61:3348-3354.
    • (2001) Cancer Res , vol.61 , pp. 3348-3354
    • Li, Y.-Q.1    Ballinger, J.R.2    Nordal, R.A.3
  • 95
  • 96
    • 33646919832 scopus 로고    scopus 로고
    • Antitransforming growth factor-beta antibody 1D11 ameliorates normal tissue damage caused by high-dose radiation
    • Anscher MS, Thrasher B, Rabbani Z et al. Antitransforming growth factor-beta antibody 1D11 ameliorates normal tissue damage caused by high-dose radiation. Int J Radiat Oncol Biol Phys 2006;65:876-881.
    • (2006) Int J Radiat Oncol Biol Phys , vol.65 , pp. 876-881
    • Anscher, M.S.1    Thrasher, B.2    Rabbani, Z.3
  • 97
    • 0036197408 scopus 로고    scopus 로고
    • Low oxygen tension stimulates collagen synthesis and COL1A1 transcription through the action of TGF-β1
    • Falanga V, Zhou L, Yufit T. Low oxygen tension stimulates collagen synthesis and COL1A1 transcription through the action of TGF-β1. J Cell Physiol 2002;191:42-50.
    • (2002) J Cell Physiol , vol.191 , pp. 42-50
    • Falanga, V.1    Zhou, L.2    Yufit, T.3
  • 98
    • 0033662026 scopus 로고    scopus 로고
    • Hypoxia promotes fibrogenesis in human renal fibroblasts
    • Norman JT, Clark IM, Garcia PL. Hypoxia promotes fibrogenesis in human renal fibroblasts. Kidney Int 2000;58:2351-2366.
    • (2000) Kidney Int , vol.58 , pp. 2351-2366
    • Norman, J.T.1    Clark, I.M.2    Garcia, P.L.3
  • 99
    • 36749103090 scopus 로고    scopus 로고
    • Hypoxia can be detected in irradiated normal human tissue: A study using the hypoxic marker pimonidazole hydrochloride
    • Westbury CB, Pearson A, Nerurkar A et al. Hypoxia can be detected in irradiated normal human tissue: A study using the hypoxic marker pimonidazole hydrochloride. Br J Radiol 2007;80:934-938.
    • (2007) Br J Radiol , vol.80 , pp. 934-938
    • Westbury, C.B.1    Pearson, A.2    Nerurkar, A.3
  • 100
    • 28444492266 scopus 로고    scopus 로고
    • Induction of CTGF by TGF-β1 in normal and radiation enteritis human smooth muscle cells: Smad/Rho balance and therapeutic perspectives
    • Haydont V, Mathe D, Bourgier C et al. Induction of CTGF by TGF-β1 in normal and radiation enteritis human smooth muscle cells: Smad/Rho balance and therapeutic perspectives. Radiother Oncol 2005;76:219-225.
    • (2005) Radiother Oncol , vol.76 , pp. 219-225
    • Haydont, V.1    Mathe, D.2    Bourgier, C.3
  • 101
    • 47249151503 scopus 로고    scopus 로고
    • Specific signals involved in the long-term maintenance of radiation-induced fibrogenic differentiation: A role for CCN2 and low concentration of TGF-β1
    • Haydont V, Riser BL, Aigueperse J et al. Specific signals involved in the long-term maintenance of radiation-induced fibrogenic differentiation: A role for CCN2 and low concentration of TGF-β1. Am J Physiol Cell Physiol 2008;294:C1332-C1341.
    • (2008) Am J Physiol Cell Physiol , vol.294
    • Haydont, V.1    Riser, B.L.2    Aigueperse, J.3
  • 102
    • 44449179168 scopus 로고    scopus 로고
    • Small molecular inhibitor of transforming growth factor-beta protects against development of radiation-induced lung injury
    • Anscher MS, Thrasher B, Zgonjanin L et al. Small molecular inhibitor of transforming growth factor-beta protects against development of radiation-induced lung injury. Int J Radiat Oncol Biol Phys 2008;71:829-837.
    • (2008) Int J Radiat Oncol Biol Phys , vol.71 , pp. 829-837
    • Anscher, M.S.1    Thrasher, B.2    Zgonjanin, L.3
  • 103
    • 0027954494 scopus 로고
    • Free radicals in biology: Oxidative stress and the effects of ionizing radiation
    • Riley PA. Free radicals in biology: Oxidative stress and the effects of ionizing radiation. Int J Radiat Biol 1994;65:27-33.
    • (1994) Int J Radiat Biol , vol.65 , pp. 27-33
    • Riley, P.A.1
  • 104
    • 0142186658 scopus 로고    scopus 로고
    • Overexpression of extracellular superoxide dismutase protects mice from radiation-induced lung injury
    • Kang SK, Rabbani ZN, Folz RJ et al. Overexpression of extracellular superoxide dismutase protects mice from radiation-induced lung injury. Int J Radiat Oncol Biol Phys 2003;57:1056-1066.
    • (2003) Int J Radiat Oncol Biol Phys , vol.57 , pp. 1056-1066
    • Kang, S.K.1    Rabbani, Z.N.2    Folz, R.J.3
  • 105
    • 2942713709 scopus 로고    scopus 로고
    • A small molecular weight catalytic metalloporphyrin antioxidant with superoxide dismutase (SOD) mimetic properties protects lungs from radiation-induced injury
    • Vujaskovic Z, Batinic-Haberle I, Rabbani ZN et al. A small molecular weight catalytic metalloporphyrin antioxidant with superoxide dismutase (SOD) mimetic properties protects lungs from radiation-induced injury. Free Radic Biol Med 2002;33:857-863.
    • (2002) Free Radic Biol Med , vol.33 , pp. 857-863
    • Vujaskovic, Z.1    Batinic-Haberle, I.2    Rabbani, Z.N.3
  • 106
    • 2942571350 scopus 로고    scopus 로고
    • Acute lung injury as an adverse event of gefitinib
    • Inomata S, Takahashi H, Nagata M et al. Acute lung injury as an adverse event of gefitinib. Anticancer Drugs 2004;15:461-467.
    • (2004) Anticancer Drugs , vol.15 , pp. 461-467
    • Inomata, S.1    Takahashi, H.2    Nagata, M.3
  • 107
    • 0030724619 scopus 로고    scopus 로고
    • Murine susceptibility to radiation-induced pulmonary fibrosis is influenced by a genetic factor implicated in susceptibility to bleomycin-induced pulmonary fibrosis
    • Haston CK, Travis EL. Murine susceptibility to radiation-induced pulmonary fibrosis is influenced by a genetic factor implicated in susceptibility to bleomycin-induced pulmonary fibrosis. Cancer Res 1997;57:5286-5291.
    • (1997) Cancer Res , vol.57 , pp. 5286-5291
    • Haston, C.K.1    Travis, E.L.2
  • 108
    • 21644449683 scopus 로고    scopus 로고
    • Expression of mutant human epidermal receptor 3 attenuates lung fibrosis and improves survival in mice
    • Nethery DE, Moore BB, Minowada G et al. Expression of mutant human epidermal receptor 3 attenuates lung fibrosis and improves survival in mice. J Appl Physiol 2005;99:298-307.
    • (2005) J Appl Physiol , vol.99 , pp. 298-307
    • Nethery, D.E.1    Moore, B.B.2    Minowada, G.3
  • 109
    • 36849046661 scopus 로고    scopus 로고
    • Bleomycin-induced pulmonary fibrosis is attenuated by a monoclonal antibody targeting HER2
    • Faress JA, Nethery DE, Kern EF et al. Bleomycin-induced pulmonary fibrosis is attenuated by a monoclonal antibody targeting HER2. J Appl Physiol 2007;103:2077-2083.
    • (2007) J Appl Physiol , vol.103 , pp. 2077-2083
    • Faress, J.A.1    Nethery, D.E.2    Kern, E.F.3
  • 110
    • 66149118892 scopus 로고    scopus 로고
    • Suppression of PAI-1 expression through inhibition of the EGFR-mediated signaling cascade in rat kidney fibro-blast by ascofuranone
    • Cho HJ, Kang JH, Kim T et al. Suppression of PAI-1 expression through inhibition of the EGFR-mediated signaling cascade in rat kidney fibro-blast by ascofuranone. J Cell Biochem 2009;107:335-344.
    • (2009) J Cell Biochem , vol.107 , pp. 335-344
    • Cho, H.J.1    Kang, J.H.2    Kim, T.3
  • 111
    • 0032771311 scopus 로고    scopus 로고
    • Reduction of bleomycin induced lung fibrosis by transforming growth factor beta soluble receptor in hamsters
    • Wang Q, Wang Y, Hyde DM et al. Reduction of bleomycin induced lung fibrosis by transforming growth factor beta soluble receptor in hamsters. Thorax 1999;54:805-812.
    • (1999) Thorax , vol.54 , pp. 805-812
    • Wang, Q.1    Wang, Y.2    Hyde, D.M.3
  • 112
    • 0035083956 scopus 로고    scopus 로고
    • Transient transgene expression of decorin in the lung reduces the fibrotic response to bleomycin
    • Kolb M, Margetts PJ, Galt T et al. Transient transgene expression of decorin in the lung reduces the fibrotic response to bleomycin. Am J Respir Crit Care Med 2001;163:770-777.
    • (2001) Am J Respir Crit Care Med , vol.163 , pp. 770-777
    • Kolb, M.1    Margetts, P.J.2    Galt, T.3
  • 113
    • 0141653957 scopus 로고    scopus 로고
    • Effects of radiation on normal tissue: Consequences and mechanisms
    • Stone HB, Coleman CN, Anscher MS et al. Effects of radiation on normal tissue: Consequences and mechanisms. Lancet Oncol 2003;4:529-536.
    • (2003) Lancet Oncol , vol.4 , pp. 529-536
    • Stone, H.B.1    Coleman, C.N.2    Anscher, M.S.3
  • 114
    • 37549027570 scopus 로고    scopus 로고
    • Transforming growth factor-beta activation in the lung: Focus on fibrosis and reactive oxygen species
    • Koli K, Myllärniemi M, Keski-Oja J et al. Transforming growth factor-beta activation in the lung: Focus on fibrosis and reactive oxygen species. Antioxid Redox Signal 2008;10:333-342.
    • (2008) Antioxid Redox Signal , vol.10 , pp. 333-342
    • Koli, K.1    Myllärniemi, M.2    Keski-Oja, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.