Immunohistochemical localization of transforming growth factor β and tumor necrosis factor α in the lungs of fibrosis-prone and 'non-fibrosing' mice during the latent period and early phase after irradiation

Radiation Research

Volumn 147, Issue 2, 1997, Pages 245-256

  Franko, Allan J ^a,b   Sharplin, Janet ^a   Ghahary, Aziz ^b   Barcellos Hoff, Mary Helen ^c  

^a CROSS CANCER INSTITUTE   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MESSENGER RNA; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CELLULAR DISTRIBUTION; IMMUNOHISTOCHEMISTRY; INFLAMMATION; IRRADIATION; LETHAL DOSE; LUNG FIBROSIS; MOUSE; MOUSE STRAIN; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RADIATION PNEUMONIA;

NON-PROGRAMMATIC;

ANIMALS; DISEASE PROGRESSION; FIBROSIS; GENE EXPRESSION REGULATION; IMMUNOHISTOCHEMISTRY; INFLAMMATION; LUNG; MICE; MICE, INBRED C3H; MICE, INBRED STRAINS; PULMONARY FIBROSIS; RADIATION INJURIES, EXPERIMENTAL; THORAX; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR-ALPHA;

EID: 0031049913     PISSN: 00337587     EISSN: None     Source Type: Journal    
DOI: 10.2307/3579426     Document Type: Article

References (40)

1. F. L. Jennings and A. Arden, Development of experimental radiation pneumonitis. Arch. Pathol. 71, 437-446 (1961).
2. D. E. Bennett, R. R. Million and L. V. Ackerman, Bilateral radiation pneumonitis, a complication of the radiotherapy of bronchogenic carcinoma. Cancer 23, 1001-1018 (1969).
3. S. Warren and J. Spencer, Radiation reaction in the lung. Am. J. Roentgenol. 43, 682-701 (1940).
4. L. F. Fajardo and M. Berthrong, Radiation injury in surgical pathology. Am. J. Surg. Pathol 2, 159-199 (1978).
5. R. K. Kumar and A. W. J. Lykke, Messages and handshakes: Cellular interactions in pulmonary fibrosis. Pathology 27, 18-26 (1995).
6. C. L. Rochester and J. A. Elias, Cytokines and cytokine networking in the pathogenesis of interstitial and fibrotic lung disorders. Semin. Respir. Med. 14, 389-416 (1993).
7. E. L. Travis and J. D. Down, Repair in mouse lung after split doses of X rays. Radiat. Res. 87, 166-174 (1981).
8. E. L. Travis, M. L. Meistrich, M. V. Finch-Neimeyer, T. L. Watkins and I. Kiss, Late functional and biochemical changes in mouse lung after irradiation: Differential effects of WR-2721. Radiat. Res. 103, 219-231 (1985).
9. J. Sharplin and A. J. Franko, A quantitative histological study of strain-dependent differences in the effects of irradiation on mouse lung during the intermediate and late phases. Radiat. Res. 119, 15-31 (1989).
10. J. Sharplin and A. J. Franko, A quantitative histological study of strain-dependent differences in the effects of irradiation on mouse lung during the early phase. Radiat. Res. 119, 1-14 (1989).
11. A. J. Franko and J. Sharplin, Development of fibrosis after lung irradiation in relation to inflammation and lung function in a mouse strain prone to fibrosis. Radiat. Res. 140, 347-355 (1994).
12. A. J. Franko, J. Sharplin, W. F. Ward and J. M. Hinz, The genetic basis of strain-dependent differences in the early phase of radiation injury in mouse lung. Radiat. Res. 126, 349-356 (1991).
13. A. J. Franko, J. Sharplin, W. F. Ward and J. M. Taylor, Evidence for two patterns of inheritance of sensitivity to induction of lung fibrosis in mice by radiation, one of which involves two genes. Radiat. Res. 146, 68-74 (1996).
14. J. N. Finkelstein, C. J. Johnston, R. Baggs and P. Rubin, Early alterations in extracellular matrix and transforming growth factor β gene expression in mouse lung indicative of late radiation fibrosis. Int. J. Radiat. Oncol. Biol. Phys. 28, 621-631 (1994).
15. C. J. Johnston, B. Piedboeuf, R. Baggs, P. Rubin and J. N. Finkelstein, Differences in correlation of mRNA gene expression in mice sensitive and resistant to radiation-induced pulmonary fibrosis. Radiat. Res. 142, 197-203 (1995).
16. P. Rubin, C. J. Johnston, J. P. Williams, S. McDonald and J. N. Finkelstein, A perpetual cascade of cytokines postirradiation leads to pulmonary fibrosis. Int. J. Radiat. Oncol. Biol. Phys. 33, 99-109 (1995).
17. C. J. Johnston, B. Piedboeuf, P. Rubin, J. P. Williams, R. Baggs and J. N. Finkelstein, Early and persistent alterations in the expression of interleukin-1α, interleukin-1β and tumor necrosis factor α mRNA levels in fibrosis-resistant and sensitive mice after thoracic irradiation. Radiat. Res. 145, 762-767 (1996).
18. A. Magnan, I. Frachon, B. Rain, M. Peuchmaur, G. Monti, B. Lenot, M, Fattal, G. Simonneau, P. Galanaud and E. Dominique, Transforming growth factor β in normal human lung: Preferential location in bronchial epithelial cells. Thorax 49, 789-792 (1994).
19. 1 gene expression in human airways. Thorax 49, 225-232 (1994).
20. A. A. Colletta, L. M. Wakefield, F. V. Howell, K. E. P. Roozendaal, D. Danielpour, S. R. Ebbs, M. B. Sporn and M. Baum, Antioestrogens induce the secretion of active transforming growth factor beta from human fetal fibroblasts. Br. J. Cancer 62, 405-409 (1990).
21. E. L. Travis, C. S. Parkins, S. J. Holmes and J. D. Down, Effect of misonidazole on radiation injury to mouse spinal cord. Br. J. Cancer 45, 469-473 (1982).
22. A. J. Franko and J. Sharplin, Assessment of radiation-induced lung injury in mice using carbon monoxide uptake: Correlation with histologically visible damage. Radiat. Res. 133, 245-251 (1993).
23. G. W. Snedecor and W. G. Cochran, Statistical Methods, 7th ed. Iowa State University Press, Ames, 1980.
24. K. Zhang, K. C. Flanders and S. H. Phan, Cellular localization of transforming growth factor-β in bleomycin-induced pulmonary fibrosis. Am. J. Pathol. 147, 352-361 (1995).
25. S. H. Phan and S. L. Kunkel, Lung cytokine production in bleomycin-induced pulmonary fibrosis. Exp. Lung Res. 18, 29-43 (1992).
26. D. G. Hoyt and J. S. Lazo, Alterations in pulmonary mRNA encoding procollagens, fibronectin and transforming growth factor-β precede bleomycin-induced pulmonary fibrosis. J. Pharmacol. Exp. Ther. 246, 765-770 (1988).
27. N. Khalil, O. Bereznay, M. Sporn and A. H. Greenberg, Macrophage production of transforming growth factor β and fibroblast collagen synthesis in chronic pulmonary inflammation. J. Exp. Med. 170, 727-737 (1989).
28. D. G, Hoyt and J. S. Lazo, Early increases in pulmonary mRNA encoding procollagens and transforming growth factor-β in mice sensitive to cyclophosphamide-induced pulmonary fibrosis. J. Pharmacol. Exp. Ther. 249, 38-43 (1989).
29. M. S. Anscher, T. Murase, D. M. Prescott, L. B. Marks, H. Reisenbichler, G. C. Bentel, D. Spencer, G. Sherouse and R. L. Jirtle, Changes in plasma TGFβ levels during pulmonary radiotherapy as a predictor of the risk of developing radiation pneumonitis. Int. J. Radiat. Oncol. Biol. Phys. 30, 671-676 (1994).
30. S. N. Giri, D. M. Hyde and M. A. Hollinger, Effect of antibody to transforming growth factor β on bleomycin induced accumulation of lung collagen in mice. Thorax 48, 959-966 (1993).
31. R. Raghow, Role of transforming growth factor-β in repair and fibrosis. Chest 3, 61S-65S (1991).
32. L. M. Wakefield, D. M. Smith, K. C. Flanders and M. B. Sporn, Latent transforming growth factor-β from human platelets: a high molecular weight complex containing precursor sequences. J. Biol. Chem. 263, 7646-7654 (1988).
33. M. H. Barcellos-Hoff, R. Derynck, M. L-S. Tsang and J. A. Weatherbee, Transforming growth factor-β activation in irradiated murine mammary gland. J. Clin. Invest. 93, 892-899 (1994).
34. M. H. Barcellos-Hoff, E. J. Ehrhart, M. Kalia, R. Jirtle, K. Flanders and M. L-S. Tsang, Immunohistochemical detection of active TGF-β in situ using engineered tissue. Am. J. Pathol. 147, 1228-1237 (1995).
35. P. F. Piguet, M. A. Collart, G. E. Grau, Y. Kapanci and P. Vassalli, Tumor necrosis factor/cachectin plays a key role in bleomycin-induced pneumopathy and fibrosis. J. Exp. Med. 170, 655-663 (1989).
36. P. F. Piguet and C. Vesin, Treatment by human recombinant soluble TNF receptor of pulmonary fibrosis induced by bleomycin or silica in mice. Eur. Respir. J. 7, 515-518 (1994).
37. M. Denis, Y. Cormier, M. Fournier, J. Tardif and F. Laviolette, Tumor necrosis factor plays an essential role in determining hypersensitivity pneumonitis in a mouse model. Am. J. Respir. Cell Mol. Biol. 5, 477-483 (1991).
38. J. R. G. Nash, P. J. McLaughlin, D. Butcher and B. Corrin, Expression of tumour necrosis factor-α in cryptogenic fibrosing alveolitis. Histopathology 22, 343-347 (1993).
39. P. Maestrelli, A. Di Stefano, P. Occari, G. Turato, G. Milani, F. Pivirotto, C. Mapp, L. M. Fabbri and M. Saetta, Cytokines in the airway mucosa of subjects with asthma induced by toluene diisocyanate. Am. J. Respir. Crit. Care Med. 151, 607-612 (1995).
40. D. R. Branch and L. J. Guilbert, Differential expression of tumor necrosis factor-α isoforms from lipopolysaccharide- and cytokine-stimulated mouse macrophages. Int. J. Biochem. Cell Biol. 28, 949-955 (1996).