The strategic use of supramolecular pKa shifts to enhance the bioavailability of drugs

Advanced Drug Delivery Reviews

Volumn 64, Issue 9, 2012, Pages 764-783

  Ghosh, Indrajit ^a   Nau, Werner M ^a  

^a JACOBS UNIVERSITY BREMEN   (Germany)

Author keywords

Acid base properties; Activation; Calixarenes; Cucurbiturils; Cyclodextrins; Drug delivery; Drug stability; Formulation; Host guest complexes; Macrocycles; Toxicity

Indexed keywords

ACID-BASE PROPERTY; CALIXARENES; CUCURBITURILS; DRUG STABILITY; FORMULATION; HOST GUEST COMPLEXES; MACROCYCLES;

BIOCHEMISTRY; CHEMICAL ACTIVATION; CYCLODEXTRINS; DRUG DELIVERY; LIPOSOMES; MOLECULES; PHENOLS; TOXICITY;

SUPRAMOLECULAR CHEMISTRY;

4 SULFONATOCALIX[4]ARENE; ALBENDAZOLE; BENZIMIDAZOLE; BETA CYCLODEXTRIN; CALIXARENE; CARBENDAZIM; CARBOXIN; CUCURBITURIL; CYCLODEXTRIN; ELECTROPHILE; ISONIAZID; LANSOPRAZOLE; MACROCYCLIC COMPOUND; NUCLEOPHILE; OXALIPLATIN; POLYCYCLIC AROMATIC COMPOUND; PRODRUG; RANITIDINE; SANGUINARINE; TROPICAMIDE; UNCLASSIFIED DRUG;

ADVERSE OUTCOME; AQUEOUS SOLUTION; BINDING AFFINITY; BINDING SITE; BIOCATALYSIS; COMPLEX FORMATION; CONTROLLED DRUG RELEASE; DRUG BINDING; DRUG BIOAVAILABILITY; DRUG COATING; DRUG CYTOTOXICITY; DRUG DEGRADATION; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM COMPARISON; DRUG HALF LIFE; DRUG SOLUBILITY; DRUG STABILITY; DRUG STRUCTURE; ENCAPSULATION; HUMAN; HYDROPHOBICITY; IONIZATION; LD 50; MOLECULAR DYNAMICS; MOLECULAR RECOGNITION; NONHUMAN; NUCLEOPHILICITY; PH MEASUREMENT; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; REVIEW; SOLID STATE; SUPRAMOLECULAR CHEMISTRY; THERMOSTABILITY;

ANIMALS; BIOLOGICAL AVAILABILITY; CHEMISTRY, PHARMACEUTICAL; DRUG DELIVERY SYSTEMS; HUMANS; MACROMOLECULAR SUBSTANCES; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; SOLUBILITY;

EID: 84861229454     PISSN: 0169409X     EISSN: 18728294     Source Type: Journal    
DOI: 10.1016/j.addr.2012.01.015     Document Type: Review

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