Activation and stabilization of drugs by supramolecular pKa shifts: Drug-delivery applications tailored for cucurbiturils

Angewandte Chemie - International Edition

Volumn 47, Issue 29, 2008, Pages 5398-5401

  Saleh, Na'il ^a   Koner, Apurba L ^b   Nau, Werner M ^b  

^a YARMOUK UNIVERSITY   (Jordan)

^b JACOBS UNIVERSITY BREMEN   (Germany)

Author keywords

Cucurbiturils; Host guest systems; Prodrugs; Proton pump inhibitors; Protonation

Indexed keywords

ACIDS; HYDROCHLORIC ACID; NUCLEAR MAGNETIC RESONANCE; SPECTROSCOPIC ANALYSIS;

CUCURBITURILS; HOST-GUEST SYSTEMS; PRODRUGS; PROTON-PUMP INHIBITORS; PROTONATION;

SUPRAMOLECULAR CHEMISTRY;

2 [[(2 PYRIDYL)METHYL]SULFINYL]BENZIMIDAZOLE DERIVATIVE; CUCURBITURIL; LANSOPRAZOLE; MACROCYCLIC COMPOUND; OMEPRAZOLE; PRODRUG; PROTON PUMP;

ARTICLE; CHEMISTRY; DRUG ANTAGONISM; DRUG DELIVERY SYSTEM; DRUG STABILITY; METHODOLOGY; PH;

2-PYRIDINYLMETHYLSULFINYLBENZIMIDAZOLES; DRUG DELIVERY SYSTEMS; DRUG STABILITY; HYDROGEN-ION CONCENTRATION; MACROCYCLIC COMPOUNDS; OMEPRAZOLE; PRODRUGS; PROTON PUMPS;

EID: 49149093365     PISSN: 14337851     EISSN: None     Source Type: Journal    
DOI: 10.1002/anie.200801054     Document Type: Article

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