Substrate-selective supramolecular tandem assays: Monitoring enzyme inhibition of arginase and diamine oxidase by fluorescent dye displacement from calixarene and cucurbituril macrocycles

Journal of the American Chemical Society

Volumn 131, Issue 32, 2009, Pages 11558-11570

  Nau, Werner M ^a   Ghale, Garima ^a   Hennig, Andreas ^a   Bakirci, Hüseyin ^a   Bailey, David M ^a  

^a JACOBS UNIVERSITY BREMEN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ACRIDINE ORANGE; BINDING CONSTANT; BIOCHEMICAL PATHWAY; CALIXARENES; CUCURBIT[7]URIL; CUCURBITURILS; DECARBOXYLASES; DIAMINE OXIDASE; DYNAMIC BINDING; ENZYMATIC OXIDATIONS; ENZYMATIC REACTION; ENZYMATIC TRANSFORMATION; ENZYME ASSAYS; FLUORESCENT DYES; HOMOGENEOUS SOLUTIONS; HOST-GUESTS; INHIBITION CONSTANTS; L-CYSTEINE; MACROCYCLES; MACROCYCLICS; MULTI-STEP; POTASSIUM CYANIDES; REAL TIME MONITORING; SEQUENTIAL COUPLING; SWITCH-ON; THERMALLY UNSTABLE;

AMINES; AMINO ACIDS; ARCTIC ENGINEERING; ASSAYS; CARBOXYLATION; CYANIDES; ENZYMES; FLUORESCENCE; OXIDATION; POTASSIUM; SUBSTRATES; SUPRAMOLECULAR CHEMISTRY;

ENZYME INHIBITION;

(2 BORONOETHYL) LEVO CYSTEINE; 1 AMINOMETHYL 2,3 DIAZABICYCLO[2.2.2]OCT 2 ENE; 5 AMINOVALERIC ACID; AMINE OXIDASE (COPPER CONTAINING); AMINO 6 BORONOHEXANOIC ACID; ARGINASE; CADAVERINE; CALIXARENE; ENZYME INHIBITOR; FLUORESCENT DYE; MACROCYCLIC COMPOUND; ORNITHINE; PENTYLAMINE; POTASSIUM CYANIDE; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; CHEMICAL BINDING; DECARBOXYLATION; ENZYME ASSAY; ENZYME DEGRADATION; ENZYME INHIBITION; ENZYME MECHANISM; ENZYME METABOLISM; HYDROLYSIS; SUPRAMOLECULAR CHEMISTRY; TANDEM MASS SPECTROMETRY;

AMINE OXIDASE (COPPER-CONTAINING); ANIMALS; ARGINASE; BINDING, COMPETITIVE; CALIXARENES; CATTLE; FLUORESCENT DYES; MACROCYCLIC COMPOUNDS; PROTEIN BINDING; SPECTROMETRY, FLUORESCENCE; SUBSTRATE SPECIFICITY; SWINE;

EID: 68849087539     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja904165c     Document Type: Article

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