Suppression of ribosomal function triggers innate immune signaling through activation of the NLRP3 inflammasome

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Vyleta, Meghan L ^a,b   Wong, John ^a   Magun, Bruce E ^a  

^a OREGON HEALTH AND SCIENCE UNIVERSITY   (United States)

^b INSTITUTE OF SCIENCE AND TECHNOLOGY AUSTRIA   (Austria)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; ANISOMYCIN; CRYOPYRIN; CYCLOHEXIMIDE; DOUBLE STRANDED RNA; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; NIGERICIN; PACTAMYCIN; POLYINOSINIC POLYCYTIDYLIC ACID; POTASSIUM; PUROMYCIN; RICIN; URATE; BENZYLOXYCARBONYLLEUCYL LEUCYL LEUCINE ALDEHYDE; BENZYLOXYCARBONYLLEUCYL-LEUCYL-LEUCINE ALDEHYDE; CARRIER PROTEIN; CIAS1 PROTEIN, MOUSE; LEUPEPTIN; PROTEASOME; URIC ACID;

ANIMAL CELL; ARTICLE; CELLULAR PARAMETERS; CONTROLLED STUDY; CYTOKINE PRODUCTION; CYTOKINE RELEASE; CYTOKINE RESPONSE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME REPRESSION; EXTRACELLULAR POTASSIUM; IMMUNOBLOTTING; IMMUNOSTIMULATION; INNATE IMMUNITY; INTRACELLULAR SIGNALING; MALE; MASS SPECTROMETRY; MOUSE; NONHUMAN; POTASSIUM CELL LEVEL; POTASSIUM DEPLETION; POTASSIUM TRANSPORT; PROTEIN FUNCTION; PROTEIN PROCESSING; PROTEIN SYNTHESIS INHIBITION; RIBOSOME; ANIMAL; BIOLOGICAL MODEL; C57BL MOUSE; DRUG ANTAGONISM; DRUG EFFECT; GENETICS; IMMUNOLOGY; IN VITRO STUDY; ION TRANSPORT; MACROPHAGE; METABOLISM; MOUSE MUTANT; PROTEIN SYNTHESIS; SIGNAL TRANSDUCTION;

MURINAE;

ANIMALS; CARRIER PROTEINS; IMMUNITY, INNATE; INFLAMMASOMES; INTERLEUKIN-1BETA; ION TRANSPORT; LEUPEPTINS; MACROPHAGES; MALE; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MODELS, BIOLOGICAL; POTASSIUM; PROTEASOME ENDOPEPTIDASE COMPLEX; PROTEIN BIOSYNTHESIS; RIBOSOMES; RNA, DOUBLE-STRANDED; SIGNAL TRANSDUCTION; URIC ACID;

EID: 84861010060     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0036044     Document Type: Article

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