Polyene macrolide antifungal drugs trigger interleukin-1β secretion by activating the NLRP3 inflammasome

PLoS ONE

Volumn 6, Issue 5, 2011, Pages

  Darisipudi, Murthy Narayana ^a   Allam, Ramanjaneyulu ^b   Rupanagudi, Khader Valli ^a   Anders, Hans Joachim ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF LAUSANNE   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCYSTEINE; ADENOSINE TRIPHOSPHATE; AMPHOTERICIN B; CATHEPSIN; CRYOPYRIN; INFLAMMASOME; INTERLEUKIN 1BETA; INTERLEUKIN 1BETA CONVERTING ENZYME; NATAMYCIN; NYSTATIN; PURINERGIC P2X7 RECEPTOR; QUINIDINE; ANTIFUNGAL AGENT; CARRIER PROTEIN; CIAS1 PROTEIN, MOUSE; CYTOSKELETON PROTEIN; MACROLIDE; POTASSIUM; PYCARD PROTEIN, MOUSE; TOLL LIKE RECEPTOR;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOKINE RELEASE; DENDRITIC CELL; ENZYME ACTIVATION; ENZYME INDUCTION; ENZYME RELEASE; FUNGUS GROWTH; IN VITRO STUDY; INNATE IMMUNITY; MOUSE; NONHUMAN; PHAGOCYTOSIS; POTASSIUM TRANSPORT; PROTEIN CLEAVAGE; ANIMAL; C57BL MOUSE; CYTOLOGY; DRUG EFFECT; IMMUNOBLOTTING; MACROPHAGE; METABOLISM; MONOCYTE; MOUSE MUTANT; SECRETION; SIGNAL TRANSDUCTION;

AMPHOTERICIN B; ANIMALS; ANTIFUNGAL AGENTS; CARRIER PROTEINS; CASPASE 1; CYTOSKELETAL PROTEINS; DENDRITIC CELLS; IMMUNITY, INNATE; IMMUNOBLOTTING; INFLAMMASOMES; INTERLEUKIN-1BETA; MACROLIDES; MACROPHAGES; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MONOCYTES; NATAMYCIN; NYSTATIN; PHAGOCYTOSIS; POTASSIUM; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

EID: 79956358982     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0019588     Document Type: Article

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