Cellular stresses profoundly inhibit protein synthesis and modulate the states of phosphorylation of multiple translation factors

European Journal of Biochemistry

Volumn 269, Issue 12, 2002, Pages 3076-3085

  Patel, Jashmin ^a   McLeod, Laura E ^b   Vries, Robert G J ^a   Flynn, Andrea ^a   Wang, Xuemin ^a,b   Proud, Christopher G ^a,b  

^a UNIVERSITY OF KENT   (United Kingdom)

^b UNIVERSITY OF DUNDEE   (United Kingdom)

Author keywords

Elongation factor; Initiation; mRNA translation; S6 kinase; Stress

Indexed keywords

ARSENIC TRIOXIDE; BINDING PROTEIN; ELONGATION FACTOR TU; HYDROGEN PEROXIDE; INITIATION FACTOR 4E; RAPAMYCIN; REPRESSOR PROTEIN; S6 KINASE; SORBITOL;

ANIMAL CELL; ARTICLE; CHO CELL; CONTROLLED STUDY; DEPHOSPHORYLATION; EUKARYOTIC CELL; MAMMAL CELL; NONHUMAN; OXIDATIVE STRESS; PHOSPHORYLATION; PRIORITY JOURNAL; PROTEIN SYNTHESIS; PROTEIN SYNTHESIS INHIBITION; STRESS; TRANSLATION REGULATION;

ANIMALS; ARSENITES; CARRIER PROTEINS; CHO CELLS; CRICETINAE; HYDROGEN PEROXIDE; MITOGEN-ACTIVATED PROTEIN KINASES; OSMOLAR CONCENTRATION; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PEPTIDE ELONGATION FACTOR 2; PEPTIDE INITIATION FACTORS; PHOSPHOPROTEINS; PHOSPHORYLATION; PROTEIN BINDING; PROTEIN BIOSYNTHESIS; PROTEIN SYNTHESIS INHIBITORS; RIBOSOMAL PROTEIN S6 KINASES;

ANIMALIA; EUKARYOTA; MAMMALIA;

EID: 0036314780     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1432-1033.2002.02992.x     Document Type: Article

References (68)

1. Regulation of translation initiation factors by signal transduction
2. Signal transduction pathways that regulate eukaryotic protein synthesis
3. eIF4 translation factors: Effectors of mRNA recruitment to ribosomes and regulators of translation
4. The role of eIF4 in cell proliferation
5. Serine 209, not serine 53, is the major site of phosphorylation in initiation factor eIF-4E in serum-treated Chinese hamster ovary cells
6. Phosphorylation of eukaryotic protein synthesis initiation factor eIF4E at serine 209
7. PHAS/4E-BPs as regulators of mRNA translation and cell proliferation
8. Regulation of ribosome recruitment in eukaryotes
9. Translational regulation of the heat shock response
10. Translational control during heat shock
11. Cap-independent translation of heat shock messenger RNAs
12. Translation of glucose-regulated protein-78-immunoglobulin heavy chain binding protein mRNA is increased in poliovirus infected cells at a time when cap-dependent translation of cellular mRNAs is inhibited
13. Insulin-dependent stimulation of protein synthesis by phosphorylation of a regulator of 5′-cap function
14. PHAS-I as a link between mitogen-activated protein kinase and translation initiation
15. Rapamycin blocks the phosphorylation of 4E-BP1 and inhibits cap-dependent translation
16. Repression of cap-dependent translation by 4E-binding protein 1: Competition with p220 for binding to eukaryotic initiation factor-4E
17. The translation initiation factor eIF-4E binds to a common motif shared by the translation factor eIF-4gamma and the translational repressors 4E-binding proteins
18. Control of the translational regulators PHAS-I and PHAS-II by insulin and cAMP in 3T3-L1 adipocytes
19. S6k
20. The p70, S6 kinase integrates nutrient and growth signals to control translational capacity
21. Translational control of TOP mRNAs
22. Regulation of protein synthesis at the elongation stage. New insights into the control of gene expression in eukaryotes
23. Control of the elongation phase of protein synthesis
24. Functional properties of phosphorylated elongation factor 2
25. Regulation of translation elongation factor-2 by insulin via a rapamycin-sensitive signalling pathway
26. Regulation of protein synthesis elongation factor-2 kinase by cAMP in adipocytes
27. RSK1 and p70, S6 kinase
28. Mechanism and regulation of methionyl-tRNA binding to ribosomes
29. Eukaryotic initiation factor 2B(eIF2B)
30. Protein kinases that phosphorylate eIF2 and eIF2B, and their role in eukaryotic cell translational control
31. Structure and regulation of eukaryotic initiation factor eIF-2. Sequence of the site in the alpha subunit phosphorylated by the haem-controlled repressor and by the double-stranded RNA- activated inhibitor
32. Insulin and phorbol ester stimulate eIF-4E phosphorylation by distinct pathways in Chinese hamster ovary cells overexpressing the insulin receptor
33. Both rapamycin-sensitive and -insensitive pathways are involved in the phosphorylation of the initiation factor 4E binding protein (4E-BP1) in response to insulin in rat epididymal fat cells
34. Eukaryotic initiation factors 4A (eIF4A) and 4G (eIF4G) mutually interact in a 1:1 ratio in vivo
35. β-Adrenergic agonists increase phosphorylation of elongation factor 2 in cardiomyocytes without eliciting calcium-independent eEF2 kinase activity
36. High-resolution one-dimensional polyacrylamide gel isoelectric focusing of various forms of elongation factor-2
37. Characterization of insulin-stimulated protein serine/threonine kinases in CHO cells expressing human insulin receptors with point and deletion mutations
38. Insulin stimulation of the phosphorylation of initiation factor 4E is mediated by the MAP kinase pathway
39. Use of monoclonal-antibodies to study the structure and function of eukaryotic protein synthesis initiation-factor-2B
40. Regulation of protein synthesis in Swiss 3T3 fibroblasts. Rapid activation of the guanine-nucleotide-exchange factor by insulin and growth factors
41. Multiple signalling pathways involved in the stimulation of fatty acid and glycogen synthesis by insulin in rat epididymal fat pads
42. Heat shock increases the association of binding protein-1 with initiation factor 4E
43. Anisomycin-activated protein kinases p45 and p55 but not mitogen-activated protein kinases ERK-1 and - 2 are implicated in the induction of c-fos and c-jun
44. Protein synthesis inhibitors reveal differential regulation of mitogen-activated protein kinase and stress-activated protein kinase pathways that converge on Elk-1
45. Cellular stresses differentially activate c-Jun N-terminal protein kinases and extracellular ligand regulated protein kinases in cultured ventricular myocytes
46. Participation of ATM in insulin signalling through phosphorylation of eIF-4E-binding protein 1
47. Insulin-stimulated kinase from rat fat cells that phosphorylates initiation factor 4E-binding protein 1 on the rapamycin-insensitive site (serine-111)
48. Multiple mechanisms control phosphorylation of PHAS-I in five (S/T)P sites that govern translational repression
49. Hierarchical phosphorylation of the translation inhibitor 4E-BP1
50. Amino acid availability regulates p70, S6 kinase and multiple translation factors
51. Nutrients differentially modulate multiple translation factors and their control by insulin
52. Regulation of the activity of eukaryotic initiation factors in stressed cells
53. p70, S6 kinase is activated by sodium arsenite in adult rat cardiomyocytes: Roles for phosphatidylinositol 3-kinase and p38 MAP kinase
54. Phosphorylation of elongation factor 2: A key mechanism regulating gene expression in vertebrates
55. SB-203580 is a specific inhibitor of a MAP kinase homolog which is activated by cellular stresses and interleukin-1
56. A novel method to identify protein kinase substrates: eEF2 kinase is phosphorylated and inhibited by SAPK4/p38delta
57. Osmotic stress inhibits p70/85, S6 kinase through activation of a protein phosphatase
58. Mammalian mitogen-activated protein kinase signal transduction pathways activated by stress and inflammation
59. Inactivation of eukaryotic initiation factor 2B in vitro by heat shock
60. The phosphorylation of eukaryotic initiation factor eIF4E in response to phorbol esters, cell stresses and cytokines is mediated by distinct MAP kinase pathways
61. Dynamic shuttling of TIA-1 accompanies the recruitment of mRNA to mammalian stress granules
62. RNA-binding proteins TIA-1 and TIAR link the phosphorylation of eIF-2 alpha to the assembly of mammalian stress granules
63. Cleavage of eukaryotic translation initiation factor 4G by exogenously added hybrid proteins containing poliovirus 2Apro in HeLa cells: Effects on gene expression
64. Molecular mechanisms of translation initiation in eukaryotes
65. Translational regulation of the immunoglobulin heavy-chain binding protein mRNA
66. Preferential translation of heat shock mRNAs in HeLa cells deficient in protein synthesis initiation factors eIF-4E and eIF- 4 gamma
67. An element within the 5′ untranslated region of human Hsp70 mRNA which acts as a general enhancer of mRNA translation