메뉴 건너뛰기




Volumn 9, Issue , 2012, Pages

Preventive immunization of aged and juvenile non-human primates to beta-amyloid

Author keywords

Active immunization; Alzheimer's disease; Beta amyloid; Classical and alternative activation; Immunosenescence; Microglia; Neuroinflammation; Oligomers; Preventive immunotherapy

Indexed keywords

AMYLOID BETA PROTEIN ANTIBODY; AMYLOID BETA PROTEIN[1-42]; BIOLOGICAL MARKER; CARBON 11; DIMER; IMMUNOGLOBULIN G; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; PHOSPHORYL LIPID A; TAU PROTEIN;

EID: 84860369530     PISSN: None     EISSN: 17422094     Source Type: Journal    
DOI: 10.1186/1742-2094-9-84     Document Type: Article
Times cited : (21)

References (87)
  • 1
    • 0035902619 scopus 로고    scopus 로고
    • Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease
    • 10.1073/pnas.151261398, 37524, 11438712
    • DeMattos RB, Bales KR, Cummins DJ, Dodart JC, Paul SM, Holtzman DM. Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease. Proc Natl Acad Sci USA 2001, 98:8850-8855. 10.1073/pnas.151261398, 37524, 11438712.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 8850-8855
    • DeMattos, R.B.1    Bales, K.R.2    Cummins, D.J.3    Dodart, J.C.4    Paul, S.M.5    Holtzman, D.M.6
  • 2
    • 0033536163 scopus 로고    scopus 로고
    • Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse
    • 10.1038/22124, 10408445
    • Schenk D, Barbour R, Dunn W, Gordon G, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wood K, Khan K, et al. Immunization with amyloid-beta attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 1999, 400:173-177. 10.1038/22124, 10408445.
    • (1999) Nature , vol.400 , pp. 173-177
    • Schenk, D.1    Barbour, R.2    Dunn, W.3    Gordon, G.4    Grajeda, H.5    Guido, T.6    Hu, K.7    Huang, J.8    Johnson-Wood, K.9    Khan, K.10
  • 3
    • 0033801852 scopus 로고    scopus 로고
    • Nasal administration of amyloid-beta peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease
    • 10.1002/1531-8249(200010)48:4<567::AID-ANA3>3.0.CO;2-W, 11026440
    • Weiner HL, Lemere CA, Maron R, Spooner ET, Grenfell TJ, Mori C, Issazadeh S, Hancock WW, Selkoe DJ. Nasal administration of amyloid-beta peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease. Ann Neurol 2000, 48:567-579. 10.1002/1531-8249(200010)48:4<567::AID-ANA3>3.0.CO;2-W, 11026440.
    • (2000) Ann Neurol , vol.48 , pp. 567-579
    • Weiner, H.L.1    Lemere, C.A.2    Maron, R.3    Spooner, E.T.4    Grenfell, T.J.5    Mori, C.6    Issazadeh, S.7    Hancock, W.W.8    Selkoe, D.J.9
  • 8
    • 33646938005 scopus 로고    scopus 로고
    • Short amyloid-beta (Abeta) immunogens reduce cerebral Abeta load and learning deficits in an Alzheimer's disease mouse model in the absence of an Abeta-specific cellular immune response
    • 10.1523/JNEUROSCI.0381-06.2006, 16672644
    • Maier M, Seabrook TJ, Lazo ND, Jiang L, Das P, Janus C, Lemere CA. Short amyloid-beta (Abeta) immunogens reduce cerebral Abeta load and learning deficits in an Alzheimer's disease mouse model in the absence of an Abeta-specific cellular immune response. J Neurosci 2006, 26:4717-4728. 10.1523/JNEUROSCI.0381-06.2006, 16672644.
    • (2006) J Neurosci , vol.26 , pp. 4717-4728
    • Maier, M.1    Seabrook, T.J.2    Lazo, N.D.3    Jiang, L.4    Das, P.5    Janus, C.6    Lemere, C.A.7
  • 13
    • 76849091134 scopus 로고    scopus 로고
    • Can Alzheimer disease be prevented by amyloid-beta immunotherapy?
    • 10.1038/nrneurol.2009.219, 2864089, 20140000
    • Lemere CA, Masliah E. Can Alzheimer disease be prevented by amyloid-beta immunotherapy?. Nat Rev Neurol 2010, 6:108-119. 10.1038/nrneurol.2009.219, 2864089, 20140000.
    • (2010) Nat Rev Neurol , vol.6 , pp. 108-119
    • Lemere, C.A.1    Masliah, E.2
  • 16
    • 67649635733 scopus 로고    scopus 로고
    • Critical issues for successful immunotherapy in Alzheimer's disease: development of biomarkers and methods for early detection and intervention
    • 10.2174/187152709787847324, 2812706, 19355934
    • Tarawneh R, Holtzman DM. Critical issues for successful immunotherapy in Alzheimer's disease: development of biomarkers and methods for early detection and intervention. CNS Neurol Disord Drug Targets 2009, 8:144-159. 10.2174/187152709787847324, 2812706, 19355934.
    • (2009) CNS Neurol Disord Drug Targets , vol.8 , pp. 144-159
    • Tarawneh, R.1    Holtzman, D.M.2
  • 17
    • 58149129243 scopus 로고    scopus 로고
    • Consequence of Abeta immunization on the vasculature of human Alzheimer's disease brain
    • 10.1093/brain/awn261, 18953056
    • Boche D, Zotova E, Weller RO, Love S, Neal JW, Pickering RM, Wilkinson D, Holmes C, Nicoll JA. Consequence of Abeta immunization on the vasculature of human Alzheimer's disease brain. Brain 2008, 131:3299-3310. 10.1093/brain/awn261, 18953056.
    • (2008) Brain , vol.131 , pp. 3299-3310
    • Boche, D.1    Zotova, E.2    Weller, R.O.3    Love, S.4    Neal, J.W.5    Pickering, R.M.6    Wilkinson, D.7    Holmes, C.8    Nicoll, J.A.9
  • 18
  • 19
    • 80955137862 scopus 로고    scopus 로고
    • Amyloid imaging as a biomarker for cerebral beta-amyloidosis and risk prediction for Alzheimer dementia
    • Klunk WE. Amyloid imaging as a biomarker for cerebral beta-amyloidosis and risk prediction for Alzheimer dementia. Neurobiol Aging 2011, 32:S20-S36.
    • (2011) Neurobiol Aging , vol.32
    • Klunk, W.E.1
  • 20
    • 33947223454 scopus 로고    scopus 로고
    • Cerebrospinal fluid tau/beta-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults
    • 10.1001/archneur.64.3.noc60123, 17210801
    • Fagan AM, Roe CM, Xiong C, Mintun MA, Morris JC, Holtzman DM. Cerebrospinal fluid tau/beta-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults. Arch Neurol 2007, 64:343-349. 10.1001/archneur.64.3.noc60123, 17210801.
    • (2007) Arch Neurol , vol.64 , pp. 343-349
    • Fagan, A.M.1    Roe, C.M.2    Xiong, C.3    Mintun, M.A.4    Morris, J.C.5    Holtzman, D.M.6
  • 22
    • 77953298690 scopus 로고    scopus 로고
    • In vivo CHI3L1 (YKL-40) expression in astrocytes in acute and chronic neurological diseases
    • 10.1186/1742-2094-7-34, 2892443, 20540736
    • Bonneh-Barkay D, Wang G, Starkey A, Hamilton RL, Wiley CA. In vivo CHI3L1 (YKL-40) expression in astrocytes in acute and chronic neurological diseases. J Neuroinflammation 2010, 7:34. 10.1186/1742-2094-7-34, 2892443, 20540736.
    • (2010) J Neuroinflammation , vol.7 , pp. 34
    • Bonneh-Barkay, D.1    Wang, G.2    Starkey, A.3    Hamilton, R.L.4    Wiley, C.A.5
  • 24
    • 44849116945 scopus 로고    scopus 로고
    • Longitudinal in vivo positron emission tomography imaging of infected and activated brain macrophages in a macaque model of human immunodeficiency virus encephalitis correlates with central and peripheral markers of encephalitis and areas of synaptic degeneration
    • 10.2353/ajpath.2008.070967, 2408420, 18467697
    • Venneti S, Bonneh-Barkay D, Lopresti BJ, Bissel SJ, Wang G, Mathis CA, Piatak M, Lifson JD, Nyaundi JO, Murphey-Corb M, Wiley CA. Longitudinal in vivo positron emission tomography imaging of infected and activated brain macrophages in a macaque model of human immunodeficiency virus encephalitis correlates with central and peripheral markers of encephalitis and areas of synaptic degeneration. Am J Pathol 2008, 172:1603-1616. 10.2353/ajpath.2008.070967, 2408420, 18467697.
    • (2008) Am J Pathol , vol.172 , pp. 1603-1616
    • Venneti, S.1    Bonneh-Barkay, D.2    Lopresti, B.J.3    Bissel, S.J.4    Wang, G.5    Mathis, C.A.6    Piatak, M.7    Lifson, J.D.8    Nyaundi, J.O.9    Murphey-Corb, M.10    Wiley, C.A.11
  • 25
    • 0034913087 scopus 로고    scopus 로고
    • Performance evaluation of the microPET P4: a PET system dedicated to animal imaging
    • 10.1088/0031-9155/46/7/308, 11474929
    • Tai C, Chatziioannou A, Siegel S, Young J, Newport D, Goble RN, Nutt RE, Cherry SR. Performance evaluation of the microPET P4: a PET system dedicated to animal imaging. Phys Med Biol 2001, 46:1845-1862. 10.1088/0031-9155/46/7/308, 11474929.
    • (2001) Phys Med Biol , vol.46 , pp. 1845-1862
    • Tai, C.1    Chatziioannou, A.2    Siegel, S.3    Young, J.4    Newport, D.5    Goble, R.N.6    Nutt, R.E.7    Cherry, S.R.8
  • 27
    • 58449115240 scopus 로고    scopus 로고
    • Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease
    • 10.1001/archneurol.2008.511, 2666881, 19139300
    • Wiley CA, Lopresti BJ, Venneti S, Price J, Klunk WE, DeKosky ST, Mathis CA. Carbon 11-labeled Pittsburgh Compound B and carbon 11-labeled (R)-PK11195 positron emission tomographic imaging in Alzheimer disease. Arch Neurol 2009, 66:60-67. 10.1001/archneurol.2008.511, 2666881, 19139300.
    • (2009) Arch Neurol , vol.66 , pp. 60-67
    • Wiley, C.A.1    Lopresti, B.J.2    Venneti, S.3    Price, J.4    Klunk, W.E.5    DeKosky, S.T.6    Mathis, C.A.7
  • 31
    • 33747512494 scopus 로고    scopus 로고
    • Low avidity and level of serum anti-Abeta antibodies in Alzheimer disease
    • 10.1097/00002093-200607000-00001, 16917180
    • Jianping L, Zhibing Y, Wei Q, Zhikai C, Jie X, Jinbiao L. Low avidity and level of serum anti-Abeta antibodies in Alzheimer disease. Alzheimer Dis Assoc Disord 2006, 20:127-132. 10.1097/00002093-200607000-00001, 16917180.
    • (2006) Alzheimer Dis Assoc Disord , vol.20 , pp. 127-132
    • Jianping, L.1    Zhibing, Y.2    Wei, Q.3    Zhikai, C.4    Jie, X.5    Jinbiao, L.6
  • 32
    • 3042692322 scopus 로고    scopus 로고
    • Alzheimer's disease abeta vaccine reduces central nervous system abeta levels in a non-human primate, the Caribbean vervet
    • 10.1016/S0002-9440(10)63296-8, 1618542, 15215183
    • Lemere CA, Beierschmitt A, Iglesias M, Spooner ET, Bloom JK, Leverone JF, Zheng JB, Seabrook TJ, Louard D, Li D, et al. Alzheimer's disease abeta vaccine reduces central nervous system abeta levels in a non-human primate, the Caribbean vervet. Am J Pathol 2004, 165:283-297. 10.1016/S0002-9440(10)63296-8, 1618542, 15215183.
    • (2004) Am J Pathol , vol.165 , pp. 283-297
    • Lemere, C.A.1    Beierschmitt, A.2    Iglesias, M.3    Spooner, E.T.4    Bloom, J.K.5    Leverone, J.F.6    Zheng, J.B.7    Seabrook, T.J.8    Louard, D.9    Li, D.10
  • 33
    • 77954358003 scopus 로고    scopus 로고
    • Progressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins
    • 10.1111/j.1742-4658.2010.07719.x, 2933033, 20573181
    • Pham E, Crews L, Ubhi K, Hansen L, Adame A, Cartier A, Salmon D, Galasko D, Michael S, Savas JN, et al. Progressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins. FEBS J 2010, 277:3051-3067. 10.1111/j.1742-4658.2010.07719.x, 2933033, 20573181.
    • (2010) FEBS J , vol.277 , pp. 3051-3067
    • Pham, E.1    Crews, L.2    Ubhi, K.3    Hansen, L.4    Adame, A.5    Cartier, A.6    Salmon, D.7    Galasko, D.8    Michael, S.9    Savas, J.N.10
  • 34
    • 43249129990 scopus 로고    scopus 로고
    • Systemic and brain macrophage infections in relation to the development of simian immunodeficiency virus encephalitis
    • 10.1128/JVI.02069-07, 2346725, 18337567
    • Bissel SJ, Wang G, Bonneh-Barkay D, Starkey A, Trichel AM, Murphey-Corb M, Wiley CA. Systemic and brain macrophage infections in relation to the development of simian immunodeficiency virus encephalitis. J Virol 2008, 82:5031-5042. 10.1128/JVI.02069-07, 2346725, 18337567.
    • (2008) J Virol , vol.82 , pp. 5031-5042
    • Bissel, S.J.1    Wang, G.2    Bonneh-Barkay, D.3    Starkey, A.4    Trichel, A.M.5    Murphey-Corb, M.6    Wiley, C.A.7
  • 35
    • 0025908356 scopus 로고
    • The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease
    • 10.1212/WNL.41.4.479, 2011243
    • Mirra SS, Heyman A, McKeel D, Sumi SM, Crain BJ, Brownlee LM, Vogel FS, Hughes JP, van Belle G, Berg L. The Consortium to Establish a Registry for Alzheimer's Disease (CERAD). Part II. Standardization of the neuropathologic assessment of Alzheimer's disease. Neurology 1991, 41:479-486. 10.1212/WNL.41.4.479, 2011243.
    • (1991) Neurology , vol.41 , pp. 479-486
    • Mirra, S.S.1    Heyman, A.2    McKeel, D.3    Sumi, S.M.4    Crain, B.J.5    Brownlee, L.M.6    Vogel, F.S.7    Hughes, J.P.8    van Belle, G.9    Berg, L.10
  • 37
    • 67649101348 scopus 로고    scopus 로고
    • Imaging microglial activation during neuroinflammation and Alzheimer's disease
    • 10.1007/s11481-008-9142-2, 2682630, 19052878
    • Venneti S, Wiley CA, Kofler J. Imaging microglial activation during neuroinflammation and Alzheimer's disease. J Neuroimmune Pharmacol 2009, 4:227-243. 10.1007/s11481-008-9142-2, 2682630, 19052878.
    • (2009) J Neuroimmune Pharmacol , vol.4 , pp. 227-243
    • Venneti, S.1    Wiley, C.A.2    Kofler, J.3
  • 39
    • 0035105538 scopus 로고    scopus 로고
    • Local distribution of microglia in the normal adult human central nervous system differs by up to one order of magnitude
    • Mittelbronn M, Dietz K, Schluesener HJ, Meyermann R. Local distribution of microglia in the normal adult human central nervous system differs by up to one order of magnitude. Acta Neuropathol 2001, 101:249-255.
    • (2001) Acta Neuropathol , vol.101 , pp. 249-255
    • Mittelbronn, M.1    Dietz, K.2    Schluesener, H.J.3    Meyermann, R.4
  • 40
    • 67650485985 scopus 로고    scopus 로고
    • Alternative activation of macrophages: an immunologic functional perspective
    • 10.1146/annurev.immunol.021908.132532, 19105661
    • Martinez FO, Helming L, Gordon S. Alternative activation of macrophages: an immunologic functional perspective. Annu Rev Immunol 2009, 27:451-483. 10.1146/annurev.immunol.021908.132532, 19105661.
    • (2009) Annu Rev Immunol , vol.27 , pp. 451-483
    • Martinez, F.O.1    Helming, L.2    Gordon, S.3
  • 41
    • 31044433933 scopus 로고    scopus 로고
    • Anti-Abeta42- and anti-Abeta40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model
    • 1307561, 16341263
    • Levites Y, Das P, Price RW, Rochette MJ, Kostura LA, McGowan EM, Murphy MP, Golde TE. Anti-Abeta42- and anti-Abeta40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model. J Clin Invest 2006, 116:193-201. 1307561, 16341263.
    • (2006) J Clin Invest , vol.116 , pp. 193-201
    • Levites, Y.1    Das, P.2    Price, R.W.3    Rochette, M.J.4    Kostura, L.A.5    McGowan, E.M.6    Murphy, M.P.7    Golde, T.E.8
  • 43
    • 78649846020 scopus 로고    scopus 로고
    • PIB binding in aged primate brain: Enrichment of high-affinity sites in humans with Alzheimer's disease
    • 10.1016/j.neurobiolaging.2009.02.011, 2891164, 19329226
    • Rosen RF, Walker LC, Levine H. PIB binding in aged primate brain: Enrichment of high-affinity sites in humans with Alzheimer's disease. Neurobiol Aging 2011, 32:223-234. 10.1016/j.neurobiolaging.2009.02.011, 2891164, 19329226.
    • (2011) Neurobiol Aging , vol.32 , pp. 223-234
    • Rosen, R.F.1    Walker, L.C.2    Levine, H.3
  • 44
    • 0025695087 scopus 로고
    • Development of senile plaques. Relationships of neuronal abnormalities and amyloid deposits
    • 1877724, 1701963
    • Cork LC, Masters C, Beyreuther K, Price DL. Development of senile plaques. Relationships of neuronal abnormalities and amyloid deposits. Am J Pathol 1990, 137:1383-1392. 1877724, 1701963.
    • (1990) Am J Pathol , vol.137 , pp. 1383-1392
    • Cork, L.C.1    Masters, C.2    Beyreuther, K.3    Price, D.L.4
  • 45
    • 0030276575 scopus 로고    scopus 로고
    • A beta40 is a major form of beta-amyloid in nonhuman primates
    • 10.1016/S0197-4580(96)00164-9, 9363802
    • Gearing M, Tigges J, Mori H, Mirra SS. A beta40 is a major form of beta-amyloid in nonhuman primates. Neurobiol Aging 1996, 17:903-908. 10.1016/S0197-4580(96)00164-9, 9363802.
    • (1996) Neurobiol Aging , vol.17 , pp. 903-908
    • Gearing, M.1    Tigges, J.2    Mori, H.3    Mirra, S.S.4
  • 48
    • 77951928742 scopus 로고    scopus 로고
    • The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia
    • 10.1093/brain/awq065, 2859152, 20403962
    • Mc Donald JM, Savva GM, Brayne C, Welzel AT, Forster G, Shankar GM, Selkoe DJ, Ince PG, Walsh DM. The presence of sodium dodecyl sulphate-stable Abeta dimers is strongly associated with Alzheimer-type dementia. Brain 2010, 133:1328-1341. 10.1093/brain/awq065, 2859152, 20403962.
    • (2010) Brain , vol.133 , pp. 1328-1341
    • Mc Donald, J.M.1    Savva, G.M.2    Brayne, C.3    Welzel, A.T.4    Forster, G.5    Shankar, G.M.6    Selkoe, D.J.7    Ince, P.G.8    Walsh, D.M.9
  • 49
    • 44549087765 scopus 로고    scopus 로고
    • Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior
    • 10.1016/j.bbr.2008.02.016, 2601528, 18359102
    • Selkoe DJ. Soluble oligomers of the amyloid beta-protein impair synaptic plasticity and behavior. Behav Brain Res 2008, 192:106-113. 10.1016/j.bbr.2008.02.016, 2601528, 18359102.
    • (2008) Behav Brain Res , vol.192 , pp. 106-113
    • Selkoe, D.J.1
  • 51
    • 68149162581 scopus 로고    scopus 로고
    • Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction
    • 10.1016/j.nbd.2009.05.024, 2725199, 19523517
    • Tomic JL, Pensalfini A, Head E, Glabe CG. Soluble fibrillar oligomer levels are elevated in Alzheimer's disease brain and correlate with cognitive dysfunction. Neurobiol Dis 2009, 35:352-358. 10.1016/j.nbd.2009.05.024, 2725199, 19523517.
    • (2009) Neurobiol Dis , vol.35 , pp. 352-358
    • Tomic, J.L.1    Pensalfini, A.2    Head, E.3    Glabe, C.G.4
  • 52
    • 75949101330 scopus 로고    scopus 로고
    • Oligomeric Abeta in Alzheimer's disease: relationship to plaque and tangle pathology, APOE genotype and cerebral amyloid angiopathy
    • 10.1111/j.1750-3639.2009.00321.x, 19725829
    • van Helmond Z, Miners JS, Kehoe PG, Love S. Oligomeric Abeta in Alzheimer's disease: relationship to plaque and tangle pathology, APOE genotype and cerebral amyloid angiopathy. Brain Pathol 2010, 20:468-480. 10.1111/j.1750-3639.2009.00321.x, 19725829.
    • (2010) Brain Pathol , vol.20 , pp. 468-480
    • van Helmond, Z.1    Miners, J.S.2    Kehoe, P.G.3    Love, S.4
  • 53
    • 33645038471 scopus 로고    scopus 로고
    • A specific amyloid-beta protein assembly in the brain impairs memory
    • 10.1038/nature04533, 16541076
    • Lesne S, Koh MT, Kotilinek L, Kayed R, Glabe CG, Yang A, Gallagher M, Ashe KH. A specific amyloid-beta protein assembly in the brain impairs memory. Nature 2006, 440:352-357. 10.1038/nature04533, 16541076.
    • (2006) Nature , vol.440 , pp. 352-357
    • Lesne, S.1    Koh, M.T.2    Kotilinek, L.3    Kayed, R.4    Glabe, C.G.5    Yang, A.6    Gallagher, M.7    Ashe, K.H.8
  • 54
    • 33645505550 scopus 로고    scopus 로고
    • Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers
    • 10.1113/jphysiol.2005.103754, 1779683, 16469784
    • Townsend M, Shankar GM, Mehta T, Walsh DM, Selkoe DJ. Effects of secreted oligomers of amyloid beta-protein on hippocampal synaptic plasticity: a potent role for trimers. J Physiol 2006, 572:477-492. 10.1113/jphysiol.2005.103754, 1779683, 16469784.
    • (2006) J Physiol , vol.572 , pp. 477-492
    • Townsend, M.1    Shankar, G.M.2    Mehta, T.3    Walsh, D.M.4    Selkoe, D.J.5
  • 59
    • 33846861744 scopus 로고    scopus 로고
    • Intracerebroventricular passive immunization with anti-oligoAbeta antibody in TgCRND8
    • 10.1002/jnr.21110, 17086547
    • Chauhan NB. Intracerebroventricular passive immunization with anti-oligoAbeta antibody in TgCRND8. J Neurosci Res 2007, 85:451-463. 10.1002/jnr.21110, 17086547.
    • (2007) J Neurosci Res , vol.85 , pp. 451-463
    • Chauhan, N.B.1
  • 60
    • 42949155299 scopus 로고    scopus 로고
    • Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization
    • 10.1523/JNEUROSCI.5161-07.2008, 2685151, 18417702
    • Klyubin I, Betts V, Welzel AT, Blennow K, Zetterberg H, Wallin A, Lemere CA, Cullen WK, Peng Y, Wisniewski T, et al. Amyloid beta protein dimer-containing human CSF disrupts synaptic plasticity: prevention by systemic passive immunization. J Neurosci 2008, 28:4231-4237. 10.1523/JNEUROSCI.5161-07.2008, 2685151, 18417702.
    • (2008) J Neurosci , vol.28 , pp. 4231-4237
    • Klyubin, I.1    Betts, V.2    Welzel, A.T.3    Blennow, K.4    Zetterberg, H.5    Wallin, A.6    Lemere, C.A.7    Cullen, W.K.8    Peng, Y.9    Wisniewski, T.10
  • 61
    • 0035106780 scopus 로고    scopus 로고
    • Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy
    • 10.1038/85525, 11231639
    • Bacskai BJ, Kajdasz ST, Christie RH, Carter C, Games D, Seubert P, Schenk D, Hyman BT. Imaging of amyloid-beta deposits in brains of living mice permits direct observation of clearance of plaques with immunotherapy. Nat Med 2001, 7:369-372. 10.1038/85525, 11231639.
    • (2001) Nat Med , vol.7 , pp. 369-372
    • Bacskai, B.J.1    Kajdasz, S.T.2    Christie, R.H.3    Carter, C.4    Games, D.5    Seubert, P.6    Schenk, D.7    Hyman, B.T.8
  • 62
    • 0033835996 scopus 로고    scopus 로고
    • Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
    • 10.1038/78682, 10932230
    • Bard F, Cannon C, Barbour R, Burke RL, Games D, Grajeda H, Guido T, Hu K, Huang J, Johnson-Wood K, et al. Peripherally administered antibodies against amyloid beta-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat Med 2000, 6:916-919. 10.1038/78682, 10932230.
    • (2000) Nat Med , vol.6 , pp. 916-919
    • Bard, F.1    Cannon, C.2    Barbour, R.3    Burke, R.L.4    Games, D.5    Grajeda, H.6    Guido, T.7    Hu, K.8    Huang, J.9    Johnson-Wood, K.10
  • 63
    • 0141457897 scopus 로고    scopus 로고
    • Amyloid-beta immunization effectively reduces amyloid deposition in FcRgamma-/- knock-out mice
    • Das P, Howard V, Loosbrock N, Dickson D, Murphy MP, Golde TE. Amyloid-beta immunization effectively reduces amyloid deposition in FcRgamma-/- knock-out mice. J Neurosci 2003, 23:8532-8538.
    • (2003) J Neurosci , vol.23 , pp. 8532-8538
    • Das, P.1    Howard, V.2    Loosbrock, N.3    Dickson, D.4    Murphy, M.P.5    Golde, T.E.6
  • 64
    • 24644438615 scopus 로고    scopus 로고
    • Dynamic complexity of the microglial activation response in transgenic models of amyloid deposition: implications for Alzheimer therapeutics
    • 10.1097/01.jnen.0000178444.33972.e0, 16141783
    • Morgan D, Gordon MN, Tan J, Wilcock D, Rojiani AM. Dynamic complexity of the microglial activation response in transgenic models of amyloid deposition: implications for Alzheimer therapeutics. J Neuropathol Exp Neurol 2005, 64:743-753. 10.1097/01.jnen.0000178444.33972.e0, 16141783.
    • (2005) J Neuropathol Exp Neurol , vol.64 , pp. 743-753
    • Morgan, D.1    Gordon, M.N.2    Tan, J.3    Wilcock, D.4    Rojiani, A.M.5
  • 65
    • 1642497601 scopus 로고    scopus 로고
    • Microglial activation facilitates Abeta plaque removal following intracranial anti-Abeta antibody administration
    • 10.1016/j.nbd.2003.09.015, 14751766
    • Wilcock DM, Munireddy SK, Rosenthal A, Ugen KE, Gordon MN, Morgan D. Microglial activation facilitates Abeta plaque removal following intracranial anti-Abeta antibody administration. Neurobiol Dis 2004, 15:11-20. 10.1016/j.nbd.2003.09.015, 14751766.
    • (2004) Neurobiol Dis , vol.15 , pp. 11-20
    • Wilcock, D.M.1    Munireddy, S.K.2    Rosenthal, A.3    Ugen, K.E.4    Gordon, M.N.5    Morgan, D.6
  • 67
    • 19944429065 scopus 로고    scopus 로고
    • Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease
    • 10.1212/01.WNL.0000148590.39911.DF, 15642916
    • Masliah E, Hansen L, Adame A, Crews L, Bard F, Lee C, Seubert P, Games D, Kirby L, Schenk D. Abeta vaccination effects on plaque pathology in the absence of encephalitis in Alzheimer disease. Neurology 2005, 64:129-131. 10.1212/01.WNL.0000148590.39911.DF, 15642916.
    • (2005) Neurology , vol.64 , pp. 129-131
    • Masliah, E.1    Hansen, L.2    Adame, A.3    Crews, L.4    Bard, F.5    Lee, C.6    Seubert, P.7    Games, D.8    Kirby, L.9    Schenk, D.10
  • 69
    • 66949146836 scopus 로고    scopus 로고
    • Monocyte chemoattractant protein-1 plays a dominant role in the chronic inflammation observed in Alzheimer's disease
    • 10.1111/j.1750-3639.2008.00188.x, 18637012
    • Sokolova A, Hill MD, Rahimi F, Warden LA, Halliday GM, Shepherd CE. Monocyte chemoattractant protein-1 plays a dominant role in the chronic inflammation observed in Alzheimer's disease. Brain Pathol 2009, 19:392-398. 10.1111/j.1750-3639.2008.00188.x, 18637012.
    • (2009) Brain Pathol , vol.19 , pp. 392-398
    • Sokolova, A.1    Hill, M.D.2    Rahimi, F.3    Warden, L.A.4    Halliday, G.M.5    Shepherd, C.E.6
  • 70
    • 0031848322 scopus 로고    scopus 로고
    • Immunohistochemical study of the beta-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer's disease brains
    • 10.1016/S0002-9440(10)65542-3, 1852933, 9665462
    • Xia MQ, Qin SX, Wu LJ, Mackay CR, Hyman BT. Immunohistochemical study of the beta-chemokine receptors CCR3 and CCR5 and their ligands in normal and Alzheimer's disease brains. Am J Pathol 1998, 153:31-37. 10.1016/S0002-9440(10)65542-3, 1852933, 9665462.
    • (1998) Am J Pathol , vol.153 , pp. 31-37
    • Xia, M.Q.1    Qin, S.X.2    Wu, L.J.3    Mackay, C.R.4    Hyman, B.T.5
  • 71
    • 77953268611 scopus 로고    scopus 로고
    • Alternative activation of macrophages: mechanism and functions
    • 10.1016/j.immuni.2010.05.007, 20510870
    • Gordon S, Martinez FO. Alternative activation of macrophages: mechanism and functions. Immunity 2010, 32:593-604. 10.1016/j.immuni.2010.05.007, 20510870.
    • (2010) Immunity , vol.32 , pp. 593-604
    • Gordon, S.1    Martinez, F.O.2
  • 72
    • 33750813483 scopus 로고    scopus 로고
    • Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression
    • Martinez FO, Gordon S, Locati M, Mantovani A. Transcriptional profiling of the human monocyte-to-macrophage differentiation and polarization: new molecules and patterns of gene expression. J Immunol 2006, 177:7303-7311.
    • (2006) J Immunol , vol.177 , pp. 7303-7311
    • Martinez, F.O.1    Gordon, S.2    Locati, M.3    Mantovani, A.4
  • 73
    • 56749174940 scopus 로고    scopus 로고
    • Exploring the full spectrum of macrophage activation
    • 10.1038/nri2448, 2724991, 19029990
    • Mosser DM, Edwards JP. Exploring the full spectrum of macrophage activation. Nat Rev Immunol 2008, 8:958-969. 10.1038/nri2448, 2724991, 19029990.
    • (2008) Nat Rev Immunol , vol.8 , pp. 958-969
    • Mosser, D.M.1    Edwards, J.P.2
  • 75
    • 0035696328 scopus 로고    scopus 로고
    • Intrahippocampal LPS injections reduce Abeta load in APP + PS1 transgenic mice
    • 10.1016/S0197-4580(01)00292-5, 11755009
    • DiCarlo G, Wilcock D, Henderson D, Gordon M, Morgan D. Intrahippocampal LPS injections reduce Abeta load in APP + PS1 transgenic mice. Neurobiol Aging 2001, 22:1007-1012. 10.1016/S0197-4580(01)00292-5, 11755009.
    • (2001) Neurobiol Aging , vol.22 , pp. 1007-1012
    • DiCarlo, G.1    Wilcock, D.2    Henderson, D.3    Gordon, M.4    Morgan, D.5
  • 76
    • 51149120624 scopus 로고    scopus 로고
    • El Khoury J: Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice
    • 10.1523/JNEUROSCI.0616-08.2008, 2597474, 18701698
    • Hickman SE, Allison EK. El Khoury J: Microglial dysfunction and defective beta-amyloid clearance pathways in aging Alzheimer's disease mice. J Neurosci 2008, 28:8354-8360. 10.1523/JNEUROSCI.0616-08.2008, 2597474, 18701698.
    • (2008) J Neurosci , vol.28 , pp. 8354-8360
    • Hickman, S.E.1    Allison, E.K.2
  • 77
    • 24744467358 scopus 로고    scopus 로고
    • Microglial phagocytosis induced by fibrillar beta-amyloid and IgGs are differentially regulated by proinflammatory cytokines
    • 10.1523/JNEUROSCI.1808-05.2005, 16148231
    • Koenigsknecht-Talboo J, Landreth GE. Microglial phagocytosis induced by fibrillar beta-amyloid and IgGs are differentially regulated by proinflammatory cytokines. J Neurosci 2005, 25:8240-8249. 10.1523/JNEUROSCI.1808-05.2005, 16148231.
    • (2005) J Neurosci , vol.25 , pp. 8240-8249
    • Koenigsknecht-Talboo, J.1    Landreth, G.E.2
  • 78
    • 58749093072 scopus 로고    scopus 로고
    • IL-4-induced selective clearance of oligomeric beta-amyloid peptide(1-42) by rat primary type 2 microglia
    • Shimizu E, Kawahara K, Kajizono M, Sawada M, Nakayama H. IL-4-induced selective clearance of oligomeric beta-amyloid peptide(1-42) by rat primary type 2 microglia. J Immunol 2008, 181:6503-6513.
    • (2008) J Immunol , vol.181 , pp. 6503-6513
    • Shimizu, E.1    Kawahara, K.2    Kajizono, M.3    Sawada, M.4    Nakayama, H.5
  • 79
    • 77954495173 scopus 로고    scopus 로고
    • IFN-gamma promotes complement expression and attenuates amyloid plaque deposition in amyloid beta precursor protein transgenic mice
    • 10.4049/jimmunol.0903382, 20368278
    • Chakrabarty P, Ceballos-Diaz C, Beccard A, Janus C, Dickson D, Golde TE, Das P. IFN-gamma promotes complement expression and attenuates amyloid plaque deposition in amyloid beta precursor protein transgenic mice. J Immunol 2010, 184:5333-5343. 10.4049/jimmunol.0903382, 20368278.
    • (2010) J Immunol , vol.184 , pp. 5333-5343
    • Chakrabarty, P.1    Ceballos-Diaz, C.2    Beccard, A.3    Janus, C.4    Dickson, D.5    Golde, T.E.6    Das, P.7
  • 82
    • 77956630701 scopus 로고    scopus 로고
    • Synthetic and natural TLR4 agonists as safe and effective vaccine adjuvants
    • 10.1007/978-90-481-9078-2_14, 20593273
    • Fox CB, Friede M, Reed SG, Ireton GC. Synthetic and natural TLR4 agonists as safe and effective vaccine adjuvants. Subcell Biochem 2010, 53:303-321. 10.1007/978-90-481-9078-2_14, 20593273.
    • (2010) Subcell Biochem , vol.53 , pp. 303-321
    • Fox, C.B.1    Friede, M.2    Reed, S.G.3    Ireton, G.C.4
  • 83
  • 85
    • 74549177126 scopus 로고    scopus 로고
    • Immunogenicity and safety of human papillomavirus-16/18 AS04-adjuvanted cervical cancer vaccine coadministered with combined diphtheria-tetanus-acellular pertussis-inactivated poliovirus vaccine to girls and young women
    • 10.1016/j.jadohealth.2009.11.205, 20113920
    • Garcia-Sicilia J, Schwarz TF, Carmona A, Peters K, Malkin JE, Tran PM, Behre U, Iturbe EB, Catteau G, Thomas F, et al. Immunogenicity and safety of human papillomavirus-16/18 AS04-adjuvanted cervical cancer vaccine coadministered with combined diphtheria-tetanus-acellular pertussis-inactivated poliovirus vaccine to girls and young women. J Adolesc Health 2010, 46:142-151. 10.1016/j.jadohealth.2009.11.205, 20113920.
    • (2010) J Adolesc Health , vol.46 , pp. 142-151
    • Garcia-Sicilia, J.1    Schwarz, T.F.2    Carmona, A.3    Peters, K.4    Malkin, J.E.5    Tran, P.M.6    Behre, U.7    Iturbe, E.B.8    Catteau, G.9    Thomas, F.10
  • 86
    • 79958026406 scopus 로고    scopus 로고
    • The evaluation of Tetanus-diphtheria (Td) vaccine impacts on immune response to hepatitis B (HB) vaccine in non-responder dialysis patients
    • 3214370, 22091281
    • Shahidi S, Ghareghani NN, Mortazavi M, Sadeghi S, Adeli R. The evaluation of Tetanus-diphtheria (Td) vaccine impacts on immune response to hepatitis B (HB) vaccine in non-responder dialysis patients. J Res Med Sci 2011, 16:598-604. 3214370, 22091281.
    • (2011) J Res Med Sci , vol.16 , pp. 598-604
    • Shahidi, S.1    Ghareghani, N.N.2    Mortazavi, M.3    Sadeghi, S.4    Adeli, R.5
  • 87
    • 33846012561 scopus 로고    scopus 로고
    • Immunogenicity and reactogenicity of primary immunization with a novel combined Haemophilus influenzae Type b and Neisseria meningitidis serogroup C-tetanus toxoid conjugate vaccine coadministered with a diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus vaccine at 2, 4 and 6 months
    • 10.1097/01.inf.0000247070.60063.09, 17195697
    • Tejedor JC, Moro M, Ruiz-Contreras J, Castro J, Gomez-Campdera JA, Navarro ML, Merino JM, Martin-Ancel A, Roca J, Garcia-Del-Ri M, et al. Immunogenicity and reactogenicity of primary immunization with a novel combined Haemophilus influenzae Type b and Neisseria meningitidis serogroup C-tetanus toxoid conjugate vaccine coadministered with a diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus vaccine at 2, 4 and 6 months. Pediatr Infect Dis J 2007, 26:1-7. 10.1097/01.inf.0000247070.60063.09, 17195697.
    • (2007) Pediatr Infect Dis J , vol.26 , pp. 1-7
    • Tejedor, J.C.1    Moro, M.2    Ruiz-Contreras, J.3    Castro, J.4    Gomez-Campdera, J.A.5    Navarro, M.L.6    Merino, J.M.7    Martin-Ancel, A.8    Roca, J.9    Garcia-Del-Ri, M.10


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.