메뉴 건너뛰기




Volumn 33, Issue 12, 2003, Pages 3232-3241

Generation and characterization of the humoral immune response to DNA immunization with a chimeric β-amyloid-interleukin-4 minigene

Author keywords

Antibodies; Antigens; DNA immunization; Epitopes; Mice

Indexed keywords

ALZHEIMER DISEASE VACCINE; AMYLOID BETA PROTEIN; CHIMERIC PROTEIN; DNA VACCINE; EPITOPE; HYBRID PROTEIN; IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2A; IMMUNOGLOBULIN G2B; IMMUNOGLOBULIN M; INTERLEUKIN 4; MUTANT PROTEIN; PEPTIDE; PLASMID VECTOR; PROTEIN PRECURSOR;

EID: 10744223260     PISSN: 00142980     EISSN: None     Source Type: Journal    
DOI: 10.1002/eji.200324000     Document Type: Article
Times cited : (60)

References (59)
  • 1
    • 0028243033 scopus 로고
    • Cellular and molecular biology of Alzheimer's disease and animal models
    • Price, D. L. and Sisodia, S. S., Cellular and molecular biology of Alzheimer's disease and animal models. Annu. Rev. Med. 1994. 45: 435-446.
    • (1994) Annu. Rev. Med. , vol.45 , pp. 435-446
    • Price, D.L.1    Sisodia, S.S.2
  • 2
    • 0026597063 scopus 로고
    • Alzheimer's disease: The amyloid cascade hypothesis
    • Hardy, J. A. and Higgins, G. A., Alzheimer's disease: the amyloid cascade hypothesis. Science 1992. 256: 184-185.
    • (1992) Science , vol.256 , pp. 184-185
    • Hardy, J.A.1    Higgins, G.A.2
  • 3
    • 0025753852 scopus 로고
    • The molecular pathology of Alzheimer's disease
    • Selkoe, D. J., The molecular pathology of Alzheimer's disease. Neuron 1991. 6: 487-498.
    • (1991) Neuron , vol.6 , pp. 487-498
    • Selkoe, D.J.1
  • 4
    • 0035943345 scopus 로고    scopus 로고
    • A Portrait of alzheimer secretases - New features and familiar faces
    • Esler, W. P. and Wolfe, M. S., A Portrait of alzheimer secretases - new features and familiar faces. Science 2001. 293: 1449-1454.
    • (2001) Science , vol.293 , pp. 1449-1454
    • Esler, W.P.1    Wolfe, M.S.2
  • 5
    • 0034730295 scopus 로고    scopus 로고
    • An accomplice for gamma-secretase brought into focus
    • Sisodia, S. S., An accomplice for gamma-secretase brought into focus. Science 2000. 289: 2296-2297.
    • (2000) Science , vol.289 , pp. 2296-2297
    • Sisodia, S.S.1
  • 6
    • 0035433962 scopus 로고    scopus 로고
    • Alzheimer's disease and Aβ-toxicity. From top to bottom
    • Small, D. H., Mok, S. S. and Bornstein, J. C., Alzheimer's disease and Aβ-toxicity. From top to bottom. Nat. Rev. Neurosci. 2001. 2: 595-598.
    • (2001) Nat. Rev. Neurosci. , vol.2 , pp. 595-598
    • Small, D.H.1    Mok, S.S.2    Bornstein, J.C.3
  • 12
    • 0035902619 scopus 로고    scopus 로고
    • Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease
    • DeMattos, R. B., Bales, K. R., Cummins, D. J., Dodart, J. C., Paul, S. M. and Holtzman, D. M., Peripheral anti-A beta antibody alters CNS and plasma A beta clearance and decreases brain A beta burden in a mouse model of Alzheimer's disease. Proc. Natl. Acad. Sci. USA 2001. 98: 8850-8855.
    • (2001) Proc. Natl. Acad. Sci. USA , vol.98 , pp. 8850-8855
    • DeMattos, R.B.1    Bales, K.R.2    Cummins, D.J.3    Dodart, J.C.4    Paul, S.M.5    Holtzman, D.M.6
  • 14
    • 0036780877 scopus 로고    scopus 로고
    • Amyloid-β immunotherapy for Alzheimer's disease: The end of the beginning
    • Schenk, D., Amyloid-β immunotherapy for Alzheimer's disease: the end of the beginning. Nat. Rev. Neurosci. 2002. 3: 824-828.
    • (2002) Nat. Rev. Neurosci. , vol.3 , pp. 824-828
    • Schenk, D.1
  • 15
    • 0036127580 scopus 로고    scopus 로고
    • Set back Alzheimer vaccine studies
    • Birmingham, K. and Frantz, S., Set back Alzheimer vaccine studies. Nat. Med. 2002. 8: 199-200.
    • (2002) Nat. Med. , vol.8 , pp. 199-200
    • Birmingham, K.1    Frantz, S.2
  • 21
    • 0034897403 scopus 로고    scopus 로고
    • Combination of gene delivery and DNA vaccination to protect from and reverse Th1 autoimmune disease via deviation to the Th2 pathway
    • Garren, H., Ruiz, P. J., Watkins, T. A., Fontoura, P., Nguyen, L. T., Estline, E. R., Hirschberg, D. L. and Steinman, L., Combination of gene delivery and DNA vaccination to protect from and reverse Th1 autoimmune disease via deviation to the Th2 pathway. Immunity. 2001. 15: 15-22.
    • (2001) Immunity , vol.15 , pp. 15-22
    • Garren, H.1    Ruiz, P.J.2    Watkins, T.A.3    Fontoura, P.4    Nguyen, L.T.5    Estline, E.R.6    Hirschberg, D.L.7    Steinman, L.8
  • 22
    • 0035689690 scopus 로고    scopus 로고
    • Nasal vaccination with beta-amyloid peptide for the treatment of Alzheimer's disease
    • Lemere, C. A., Maron, R., Selkoe, D. J. and Weiner, H. L., Nasal vaccination with beta-amyloid peptide for the treatment of Alzheimer's disease. DNA Cell Biol. 2001. 20: 705-711.
    • (2001) DNA Cell Biol. , vol.20 , pp. 705-711
    • Lemere, C.A.1    Maron, R.2    Selkoe, D.J.3    Weiner, H.L.4
  • 26
  • 28
    • 0034252626 scopus 로고    scopus 로고
    • C3d enhancement of antibodies to hemagglutinin accelerates protection against influenza virus challenge
    • Ross, T. M., Xu, Y., Bright, R. A. and Robinson, H. L., C3d enhancement of antibodies to hemagglutinin accelerates protection against influenza virus challenge. Nat. Immunol. 2000. 1: 127-131.
    • (2000) Nat. Immunol. , vol.1 , pp. 127-131
    • Ross, T.M.1    Xu, Y.2    Bright, R.A.3    Robinson, H.L.4
  • 33
    • 0030811634 scopus 로고    scopus 로고
    • Nucleic acid vaccines: An overview
    • Robinson, H. L., Nucleic acid vaccines: an overview. Vaccine 1997. 15: 785-787.
    • (1997) Vaccine , vol.15 , pp. 785-787
    • Robinson, H.L.1
  • 34
    • 0026579897 scopus 로고
    • Genetic immunization is a simple method for eliciting an immune response
    • Tang, D. C., DeVit, M. and Johnston, S. A., Genetic immunization is a simple method for eliciting an immune response. Nature 1992. 356: 152-154.
    • (1992) Nature , vol.356 , pp. 152-154
    • Tang, D.C.1    DeVit, M.2    Johnston, S.A.3
  • 37
    • 0031953116 scopus 로고    scopus 로고
    • Development of Th1 and Th2 populations and the nature of immune responses to hepatitis B virus DNA vaccines can be modulated by codelivery of various cytokine genes
    • Chow, Y. H., Chiang, B. L., Lee, Y. L., Chi, W. K., Lin, W. C., Chen, Y. T. and Tho, M. H., Development of Th1 and Th2 populations and the nature of immune responses to hepatitis B virus DNA vaccines can be modulated by codelivery of various cytokine genes. J. Immunol. 1998. 160: 1320-1329.
    • (1998) J. Immunol. , vol.160 , pp. 1320-1329
    • Chow, Y.H.1    Chiang, B.L.2    Lee, Y.L.3    Chi, W.K.4    Lin, W.C.5    Chen, Y.T.6    Tho, M.H.7
  • 38
    • 0031066827 scopus 로고    scopus 로고
    • Enhancement of cellular and humoral immune responses to hepatitis C virus core protein using DNA-based vaccines augmented with cytokine-expressing plasmids
    • Geissler, M., Gesien, A., Tokushige, K. and Wands, J. R., Enhancement of cellular and humoral immune responses to hepatitis C virus core protein using DNA-based vaccines augmented with cytokine-expressing plasmids. J. Immunol. 1997. 158: 1231-1237.
    • (1997) J. Immunol. , vol.158 , pp. 1231-1237
    • Geissler, M.1    Gesien, A.2    Tokushige, K.3    Wands, J.R.4
  • 39
    • 0032992275 scopus 로고    scopus 로고
    • Activity and safety of DNA plasmids encoding IL-4 and IFN gamma
    • Ishii, K. J., Weiss, W. R., Ichino, M., Verthelyi, D. and Klinman, D. M., Activity and safety of DNA plasmids encoding IL-4 and IFN gamma. Gene. Ther 1999. 6: 237-244.
    • (1999) Gene Ther. , vol.6 , pp. 237-244
    • Ishii, K.J.1    Weiss, W.R.2    Ichino, M.3    Verthelyi, D.4    Klinman, D.M.5
  • 40
    • 0026602231 scopus 로고
    • Glycosylation variants of murine interleukin-4: Evidence for different functional properties
    • Thor, G. and Brian, A. A., Glycosylation variants of murine interleukin-4: evidence for different functional properties. Immunol. 1992. 75: 143-149.
    • (1992) Immunol. , vol.75 , pp. 143-149
    • Thor, G.1    Brian, A.A.2
  • 41
    • 0025734549 scopus 로고
    • Human and rodent sequence analogs of Alzheimer's amyloid beta A4 share similar properties and can be solubilized in buffers of pH 7.4
    • Hilbich, C., Kisters-Woike, B., Reed, J., Masters, C. L. and Beyreuther, K., Human and rodent sequence analogs of Alzheimer's amyloid beta A4 share similar properties and can be solubilized in buffers of pH 7.4. Eur. J. Biochem. 1991. 201: 61-69.
    • (1991) Eur. J. Biochem. , vol.201 , pp. 61-69
    • Hilbich, C.1    Kisters-Woike, B.2    Reed, J.3    Masters, C.L.4    Beyreuther, K.5
  • 42
    • 0036752625 scopus 로고    scopus 로고
    • Amyloid immunotherapy-engendered CNS inflammation
    • Bowers, W. J. and Federoff, H. J., Amyloid immunotherapy-engendered CNS inflammation. Neurobiol. Aging 2002. 23: 663-674.
    • (2002) Neurobiol. Aging , vol.23 , pp. 663-674
    • Bowers, W.J.1    Federoff, H.J.2
  • 45
    • 0031568095 scopus 로고    scopus 로고
    • In vivo engineering of a cellular immune response by coadministration of IL-12 expression vector with a DNA immunogen
    • Kim, J. J., Ayyavoo, V., Bagarazzi, M. L., Chattergoon, M. A., Dang, K., Wang, B., Boyer, J. D. and Weiner, D. B., In vivo engineering of a cellular immune response by coadministration of IL-12 expression vector with a DNA immunogen. J. Immunol. 1997. 158: 816-826.
    • (1997) J. Immunol. , vol.158 , pp. 816-826
    • Kim, J.J.1    Ayyavoo, V.2    Bagarazzi, M.L.3    Chattergoon, M.A.4    Dang, K.5    Wang, B.6    Boyer, J.D.7    Weiner, D.B.8
  • 46
    • 0035751961 scopus 로고    scopus 로고
    • Strategies for designing and optimizing new generation vaccines
    • Berzofsky, J. A., Ahlers, J. D. and Belyakov, I. M., Strategies for designing and optimizing new generation vaccines. Nat. Rev. Immunol. 2001. 1: 209-219.
    • (2001) Nat. Rev. Immunol. , vol.1 , pp. 209-219
    • Berzofsky, J.A.1    Ahlers, J.D.2    Belyakov, I.M.3
  • 47
    • 0034662257 scopus 로고    scopus 로고
    • Cutting edge: DNA immunization with minigenes of carbohydrate mimotopes induces functional anticarbohydrate antibody response
    • Kieber-Emmons, T., Monzavi-Karbassi, B., Wang, B., Luo, P. and Weiner, D. B., Cutting edge: DNA immunization with minigenes of carbohydrate mimotopes induces functional anticarbohydrate antibody response. J. Immunol. 2000. 165; 623-627.
    • (2000) J. Immunol. , vol.165 , pp. 623-627
    • Kieber-Emmons, T.1    Monzavi-Karbassi, B.2    Wang, B.3    Luo, P.4    Weiner, D.B.5
  • 48
    • 0034990655 scopus 로고    scopus 로고
    • DNA-based vaccines against malaria: Status and promise of the multi-stage malaria DNA vaccine operation
    • Doolan, D. L. and Hoffman, S. L., DNA-based vaccines against malaria: status and promise of the multi-stage malaria DNA vaccine operation. Int. J. Parasitol. 2001. 31: 753-762.
    • (2001) Int. J. Parasitol. , vol.31 , pp. 753-762
    • Doolan, D.L.1    Hoffman, S.L.2
  • 50
    • 0037302360 scopus 로고    scopus 로고
    • Enhancment of antibodies to the human immunodeficiency virus type I envelope by using the molecular adjuvant C3d
    • Green, T. D., Montefiori, D. C. and Ross, T. M., Enhancment of antibodies to the human immunodeficiency virus type I envelope by using the molecular adjuvant C3d. J. Virol. 2003. 77: 2046-2055.
    • (2003) J. Virol. , vol.77 , pp. 2046-2055
    • Green, T.D.1    Montefiori, D.C.2    Ross, T.M.3
  • 51
    • 0035694891 scopus 로고    scopus 로고
    • Duration and specificity of humoral immune responses in mice vaccinated with the Alzheimer's disease-associated beta-amyloid 1-42 peptide
    • Dickey, C. A., Morgan, D. G., Kudchodkar, S., Weiner, O. B., Bai, Y., Cao, C., Gordon, M. N. and Ugen, K. E., Duration and specificity of humoral immune responses in mice vaccinated with the Alzheimer's disease-associated beta-amyloid 1-42 peptide. DNA Cell Biol. 2001. 20: 723-729.
    • (2001) DNA Cell Biol. , vol.20 , pp. 723-729
    • Dickey, C.A.1    Morgan, D.G.2    Kudchodkar, S.3    Weiner, O.B.4    Bai, Y.5    Cao, C.6    Gordon, M.N.7    Ugen, K.E.8
  • 52
    • 0035854603 scopus 로고    scopus 로고
    • Characterization of murine immunoglobulin G antibodies against human amyloid-b 1-42
    • Town, T., Tan, J., Sansone, N., Obregon, D., Klein, T. and Mullan, M., Characterization of murine immunoglobulin G antibodies against human amyloid-b 1-42. Neurosci. Lett. 2001. 307: 101-104.
    • (2001) Neurosci. Lett. , vol.307 , pp. 101-104
    • Town, T.1    Tan, J.2    Sansone, N.3    Obregon, D.4    Klein, T.5    Mullan, M.6
  • 55
    • 0034222654 scopus 로고    scopus 로고
    • Gene therapy for T cell mediated autoimmunity: Teaching the immune system how to restrain its own harmful activities by targeted DNA vaccine
    • Karin, N., Gene therapy for T cell mediated autoimmunity: teaching the immune system how to restrain its own harmful activities by targeted DNA vaccine. Isr. Med. Assoc. J. 2000. 2. 63-68.
    • (2000) Isr. Med. Assoc. J. , vol.2 , pp. 63-68
    • Karin, N.1
  • 58
    • 0030058382 scopus 로고    scopus 로고
    • Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide
    • Solomon, B., Koppel, R., Hanan, E. and Katzav, T., Monoclonal antibodies inhibit in vitro fibrillar aggregation of the Alzheimer beta-amyloid peptide. Proc. Natl. Acad. Sci. USA 1996. 93: 452-455.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 452-455
    • Solomon, B.1    Koppel, R.2    Hanan, E.3    Katzav, T.4
  • 59
    • 0037393454 scopus 로고    scopus 로고
    • Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: A case report
    • Nicoll, J. A., Wilkinson, D., Holmes, C., Steart, P., Markham, H. and Weller, R. O., Neuropathology of human Alzheimer disease after immunization with amyloid-beta peptide: a case report. Nat. Med. 2003. 9: 448-452.
    • (2003) Nat. Med. , vol.9 , pp. 448-452
    • Nicoll, J.A.1    Wilkinson, D.2    Holmes, C.3    Steart, P.4    Markham, H.5    Weller, R.O.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.