-
1
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: Progress and problems on the road to therapeutics
-
DOI 10.1126/science.1072994
-
Hardy, J., and D. J. Selkoe. 2002. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297: 353-356. (Pubitemid 34790756)
-
(2002)
Science
, vol.297
, Issue.5580
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
2
-
-
0242668337
-
Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis
-
DOI 10.1126/science.1079469
-
Kayed, R., E. Head, J. L. Thompson, T. M. McIntire, S. C. Milton, C. W. Cotman, and C. G. Glabe. 2003. Common structure of soluble amyloid oligomers implies common mechanism of pathogenesis. Science 300: 486-489. (Pubitemid 36444329)
-
(2003)
Science
, vol.300
, Issue.5618
, pp. 486-489
-
-
Kayed, R.1
Head, E.2
Thompson, J.L.3
McIntire, T.M.4
Milton, S.C.5
Cotman, C.W.6
Glabel, C.G.7
-
3
-
-
0037975676
-
Spherical aggregates of β-amyloid (amylospheroid) show high neurotoxicity and activate tau protein kinase I/glycogen synthase kinase-3β
-
DOI 10.1073/pnas.1237107100
-
Hoshi, M., M. Sato, S. Matsumoto, A. Noguchi, K. Yasutake, N. Yoshida, and K. Sato. 2003. Spherical aggregates of β-amyloid (amylospheroid) show high neurotoxicity and activate τ protein kinase I/glycogen synthase kinase-3β. Proc. Natl. Acad. Sci. USA 100: 6370-6375. (Pubitemid 36666588)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.11
, pp. 6370-6375
-
-
Hoshi, M.1
Sato, M.2
Matsumoto, S.3
Noguchi, A.4
Yasutake, K.5
Yoshida, N.6
Sato, K.7
-
4
-
-
0029610011
-
The inflammatory response system of brain: Implications for therapy of Alzheimer and other neurodegenerative diseases
-
McGeer, P. L., and E. G. McGeer. 1995. The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases. Brain Res. Brain Res. Rev. 21: 195-218.
-
(1995)
Brain Res. Brain Res. Rev.
, vol.21
, pp. 195-218
-
-
McGeer, P.L.1
McGeer, E.G.2
-
5
-
-
0032942060
-
Microglia as mediators of inflammatory and degenerative diseases
-
DOI 10.1146/annurev.neuro.22.1.219
-
Gonzalez-Scarano, F., and G. Baltuch. 1999. Microglia as mediators of inflammatory and degenerative diseases. Annu. Rev. Neurosci. 22: 219-240. (Pubitemid 29144887)
-
(1999)
Annual Review of Neuroscience
, vol.22
, pp. 219-240
-
-
Gonzalez-Scarano, F.1
Baltuch, G.2
-
6
-
-
0028953529
-
Activation of microglial cells by β-amyloid protein and interferon-γ
-
Meda, L., M. A. Cassatella, G. I. Szendrei, L. Otvos, Jr., P. Baron, M. Villalba, D. Ferrari, and F. Rossi. 1995. Activation of microglial cells by β-amyloid protein and interferon-γ. Nature 374: 647-650.
-
(1995)
Nature
, vol.374
, pp. 647-650
-
-
Meda, L.1
Cassatella, M.A.2
Szendrei, G.I.3
Otvos Jr., L.4
Baron, P.5
Villalba, M.6
Ferrari, D.7
Rossi, F.8
-
7
-
-
20444496481
-
Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers
-
DOI 10.1074/jbc.M500997200
-
Demuro, A., E. Mina, R. Kayed, S. C. Milton, I. Parker, and C. G. Glabe. 2005. Calcium dysregulation and membrane disruption as a ubiquitous neurotoxic mechanism of soluble amyloid oligomers. J. Biol. Chem. 280: 17294-17300. (Pubitemid 41389198)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.17
, pp. 17294-17300
-
-
Demuro, A.1
Mina, E.2
Kayed, R.3
Milton, S.C.4
Parker, I.5
Glabe, C.G.6
-
8
-
-
0013615899
-
RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease
-
DOI 10.1038/382685a0
-
Yan, S. D., X. Chen, J. Fu, M. Chen, H. Zhu, A. Roher, T. Slattery, L. Zhao, M. Nagashima, J. Morser, et al. 1996. RAGE and amyloid-β peptide neurotoxicity in Alzheimer's disease. Nature 382: 685-691. (Pubitemid 26282167)
-
(1996)
Nature
, vol.382
, Issue.6593
, pp. 685-691
-
-
Yan, S.D.1
Chen, X.2
Fu, J.3
Chen, M.4
Zhu, H.5
Roher, A.6
Slattery, T.7
Zhao, L.8
Nagashima, M.9
Morser, J.10
Migheli, A.11
Nawroth, P.12
Stern, D.13
Schmidt, A.M.14
-
9
-
-
0034840664
-
Involvement of microglial receptor for advanced glycation endproducts (RAGE) in Alzheimer's disease: Identification of a cellular activation mechanism
-
Lue, L. F., D. G. Walker, L. Brachova, T. G. Beach, J. Rogers, A. M. Schmidt, D. M. Stern, and S. D. Yan. 2001. Involvement of microglial receptor for advanced glycation endproducts (RAGE) in Alzheimer's disease: identification of a cellular activation mechanism. Exp. Neurol. 171: 29-45.
-
(2001)
Exp. Neurol.
, vol.171
, pp. 29-45
-
-
Lue, L.F.1
Walker, D.G.2
Brachova, L.3
Beach, T.G.4
Rogers, J.5
Schmidt, A.M.6
Stern, D.M.7
Yan, S.D.8
-
10
-
-
0032732224
-
Elimination of the class A scavenger receptor does not affect amyloid plaque formation or neurodegeneration in transgenic mice expressing human amyloid protein precursors
-
Huang, F., M. Buttini, T. Wyss-Coray, L. McConlogue, T. Kodama, R. E. Pitas, and L. Mucke. 1999. Elimination of the class A scavenger receptor does not affect amyloid plaque formation or neurodegeneration in transgenic mice expressing human amyloid protein precursors. Am. J. Pathol. 155: 1741-1747.
-
(1999)
Am. J. Pathol.
, vol.155
, pp. 1741-1747
-
-
Huang, F.1
Buttini, M.2
Wyss-Coray, T.3
McConlogue, L.4
Kodama, T.5
Pitas, R.E.6
Mucke, L.7
-
11
-
-
0033527637
-
Uptake, degradation, and release of fibrillar and soluble forms of Alzheimer's amyloid β-peptide by microglial cells
-
Chung, H., M. I. Brazil, T. T. Soe, and F. R. Maxfield. 1999. Uptake, degradation, and release of fibrillar and soluble forms of Alzheimer's amyloid β-peptide by microglial cells. J. Biol. Chem. 274: 32301-32308. (Pubitemid 129503830)
-
(1999)
Journal of Biological Chemistry
, vol.274
, Issue.45
, pp. 32301-32308
-
-
Chung, H.1
Brazil, M.I.2
Soe, T.T.3
Maxfield, F.R.4
-
12
-
-
0030764732
-
Amyloidogenic role of cytokine TGF-β1 in transgenic mice and in Alzheimer's disease
-
DOI 10.1038/39321
-
Wyss-Coray, T., E. Masliah, M. Mallory, L. McConlogue, K. Johnson-Wood, C. Lin, and L. Mucke. 1997. Amyloidogenic role of cytokine TGF-β1 in transgenic mice and in Alzheimer's disease. Nature 389: 603-606. (Pubitemid 27446177)
-
(1997)
Nature
, vol.389
, Issue.6651
, pp. 603-606
-
-
Wyss-Coray, T.1
Masliah, E.2
Mallory, M.3
McConlogue, L.4
Johnson-Wood, K.5
Lin, C.6
Mucke, L.7
-
13
-
-
33646384419
-
Immunology and immunotherapy of Alzheimer's disease
-
Weiner, H. L., and D. Frenkel. 2006. Immunology and immunotherapy of Alzheimer's disease. Nat. Rev. Immunol. 6: 404-416.
-
(2006)
Nat. Rev. Immunol.
, vol.6
, pp. 404-416
-
-
Weiner, H.L.1
Frenkel, D.2
-
14
-
-
0033536163
-
Immunization with amyloid-β attenuates Alzheimer disease-like pathology in the PDAPP mouse
-
DOI 10.1038/22124
-
Schenk, D., R. Barbour, W. Dunn, G. Gordon, H. Grajeda, T. Guido, K. Hu, J. Huang, K. Johnson-Wood, K. Khan, et al. 1999. Immunization with amyloid-β attenuates Alzheimer-disease-like pathology in the PDAPP mouse. Nature 400: 173-177. (Pubitemid 29327547)
-
(1999)
Nature
, vol.400
, Issue.6740
, pp. 173-177
-
-
Schenk, D.1
Barbour, R.2
Dunn, W.3
Gordon, G.4
Grajeda, H.5
Guldo, T.6
Hu, K.7
Huang, J.8
Johnson-Wood, K.9
Khan, K.10
Kholodenko, D.11
Lee, M.12
Liao, Z.13
Lieberburg, I.14
Motter, R.15
Mutter, L.16
Soriano, F.17
Shopp, G.18
Vasquez, N.19
Vandevert, C.20
Walker, S.21
Wogulis, M.22
Yednock, T.23
Games, D.24
Seubert, P.25
more..
-
15
-
-
0033835996
-
Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease
-
DOI 10.1038/78682
-
Bard, F., C. Cannon, R. Barbour, R. L. Burke, D. Games, H. Grajeda, T. Guido, K. Hu, J. Huang, K. Johnson-Wood, et al. 2000. Peripherally administered antibodies against amyloid β-peptide enter the central nervous system and reduce pathology in a mouse model of Alzheimer disease. Nat. Med. 6: 916-919. (Pubitemid 30644751)
-
(2000)
Nature Medicine
, vol.6
, Issue.8
, pp. 916-919
-
-
Bard, F.1
Cannon, C.2
Barbour, R.3
Burke, R.-L.4
Games, D.5
Grajeda, H.6
Guido, T.7
Hu, K.8
Huang, J.9
Johnson-Wood, K.10
Khan, K.11
Kholodenko, D.12
Lee, M.13
Lieberburg, I.14
Motter, R.15
Nguyen, M.16
Soriano, F.17
Vasquez, N.18
Weiss, K.19
Welch, B.20
Seubert, P.21
Schenk, D.22
Yednock, T.23
more..
-
16
-
-
0035544150
-
+PS1 transgenic mice influences antibody titers, microglial activation, and congophilic plaque levels
-
+PS1 transgenic mice influences antibody titers, microglial activation, and congophilic plaque levels. DNA Cell Biol. 20: 731-736.
-
(2001)
DNA Cell Biol.
, vol.20
, pp. 731-736
-
-
Wilcock, D.M.1
Gordon, M.N.2
Ugen, K.E.3
Gottschall, P.E.4
DiCarlo, G.5
Dickey, C.6
Boyett, K.W.7
Jantzen, P.T.8
Connor, K.E.9
Melachrino, J.10
-
17
-
-
34147115541
-
Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease
-
DOI 10.1038/nm1555, PII NM1555
-
El Khoury, J., M. Toft, S. E. Hickman, T. K. Means, K. Terada, C. Geula, and A. D. Luster. 2007. Ccr2 deficiency impairs microglial accumulation and accelerates progression of Alzheimer-like disease. Nat. Med. 13: 432-438. (Pubitemid 46559828)
-
(2007)
Nature Medicine
, vol.13
, Issue.4
, pp. 432-438
-
-
El Khoury, J.1
Toft, M.2
Hickman, S.E.3
Means, T.K.4
Terada, K.5
Geula, C.6
Luster, A.D.7
-
18
-
-
32344440522
-
Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease
-
Simard, A. R., D. Soulet, G. Gowing, J. P. Julien, and S. Rivest. 2006. Bone marrow-derived microglia play a critical role in restricting senile plaque formation in Alzheimer's disease. Neuron 49: 489-502.
-
(2006)
Neuron
, vol.49
, pp. 489-502
-
-
Simard, A.R.1
Soulet, D.2
Gowing, G.3
Julien, J.P.4
Rivest, S.5
-
19
-
-
0142012147
-
Microglial overexpression of the M-CSF receptor augments phagocytosis of opsonized Aβ
-
Mitrasinovic, O. M., and G. M. Murphy, Jr. 2003. Microglial overexpression of the M-CSF receptor augments phagocytosis of opsonized Aβ. Neurobiol. Aging 24: 807-815.
-
(2003)
Neurobiol. Aging
, vol.24
, pp. 807-815
-
-
Mitrasinovic, O.M.1
Murphy Jr., G.M.2
-
20
-
-
26844507074
-
Low density lipoprotein receptor-related proteins (LRPs), Alzheimer's and cognition
-
DOI 10.2174/156800705774322102
-
Harris-White, M. E., and S. A. Frautschy. 2005. Low density lipoprotein receptor- related proteins (LRPs), Alzheimer's and cognition. Curr. Drug Targets CNS Neurol. Disord. 4: 469-480. (Pubitemid 41448375)
-
(2005)
Current Drug Targets: CNS and Neurological Disorders
, vol.4
, Issue.5
, pp. 469-480
-
-
Harris-White, M.E.1
Frautschy, S.A.2
-
21
-
-
0030753654
-
Interaction of apolipoprotein J-amyloid β-peptide complex with low density lipoprotein receptor-related protein-2/megalin: A mechanism to prevent pathological accumulation of amyloid β-peptide
-
Hammad, S. M., S. Ranganathan, E. Loukinova, W. O. Twal, and W. S. Argraves. 1997. Interaction of apolipoprotein J-amyloid β-peptide complex with low density lipoprotein receptor-related protein-2/megalin: a mechanism to prevent pathological accumulation of amyloid β-peptide. J. Biol. Chem. 272: 18644-18649.
-
(1997)
J. Biol. Chem.
, vol.272
, pp. 18644-18649
-
-
Hammad, S.M.1
Ranganathan, S.2
Loukinova, E.3
Twal, W.O.4
Argraves, W.S.5
-
22
-
-
0036917631
-
Serum insulin-like growth factor I regulates brain amyloid-β levels
-
DOI 10.1038/nm793
-
Carro, E., J. L. Trejo, T. Gomez-Isla, D. LeRoith, and I. Torres-Aleman. 2002. Serum insulin-like growth factor I regulates brain amyloid-β levels. Nat. Med. 8: 1390-1397. (Pubitemid 36019424)
-
(2002)
Nature Medicine
, vol.8
, Issue.12
, pp. 1390-1397
-
-
Carro, E.1
Trejo, J.L.2
Gomez-Isla, T.3
Leroith, D.4
Torres-Aleman, I.5
-
23
-
-
0035255055
-
1-42-induced cytokine and chemokine production in primary murine microglia and a human monocyte cell line
-
1-42-induced cytokine and chemokine production in primary murine microglia and a human monocyte cell line. J. Neuroimmunol. 113: 49-62.
-
(2001)
J. Neuroimmunol.
, vol.113
, pp. 49-62
-
-
Szczepanik, A.M.1
Funes, S.2
Petko, W.3
Ringheim, G.E.4
-
24
-
-
0033082935
-
Other functions, other genes: Alternative activation of antigen- Presenting cells
-
Goerdt, S., and C. E. Orfanos. 1999. Other functions, other genes: alternative activation of antigen-presenting cells. Immunity 10: 137-142. (Pubitemid 29115619)
-
(1999)
Immunity
, vol.10
, Issue.2
, pp. 137-142
-
-
Goerdt, S.1
Orfanos, C.E.2
-
25
-
-
0036839143
-
Macrophage polarization: Tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes
-
DOI 10.1016/S1471-4906(02)02302-5, PII S1471490602023025
-
Mantovani, A., S. Sozzani, M. Locati, P. Allavena, and A. Sica. 2002. Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes. Trends Immunol. 23: 549-555. (Pubitemid 35223554)
-
(2002)
Trends in Immunology
, vol.23
, Issue.11
, pp. 549-555
-
-
Mantovani, A.1
Sozzani, S.2
Locati, M.3
Allavena, P.4
Sica, A.5
-
26
-
-
0037281863
-
The inflammatory macrophage: A story of Jekyll and Hyde
-
Duffield, J. S. 2003. The inflammatory macrophage: a story of Jekyll and Hyde. Clin. Sci. Lond. 104: 27-38.
-
(2003)
Clin. Sci. Lond.
, vol.104
, pp. 27-38
-
-
Duffield, J.S.1
-
27
-
-
24744467358
-
Microglial phagocytosis induced by fibrillar β-amyloid and IgGs are differentially regulated by proinflammatory cytokines
-
DOI 10.1523/JNEUROSCI.1808-05.2005
-
Koenigsknecht-Talboo, J., and G. E. Landreth. 2005. Microglial phagocytosis induced by fibrillar β-amyloid and IgGs are differentially regulated by proin- flammatory cytokines. J. Neurosci. 25: 8240-8249. (Pubitemid 41292118)
-
(2005)
Journal of Neuroscience
, vol.25
, Issue.36
, pp. 8240-8249
-
-
Koenigsknecht-Talboo, J.1
Landreth, G.E.2
-
28
-
-
0034332476
-
Differentiated regulation of allo-antigen presentation by different types of murine microglial cell lines
-
DOI 10.1002/1097-4547(20001101)62:3<383::AID-JNR8>3.0.CO;2-6
-
Kanzawa, T., M. Sawada, K. Kato, K. Yamamoto, H. Mori, and R. Tanaka. 2000. Differentiated regulation of allo-antigen presentation by different types of murine microglial cell lines. J. Neurosci. Res. 62: 383-388. (Pubitemid 30822720)
-
(2000)
Journal of Neuroscience Research
, vol.62
, Issue.3
, pp. 383-388
-
-
Kanzawa, T.1
Sawada, M.2
Kato, K.3
Yamamoto, K.4
Mori, H.5
Tanaka, R.6
-
29
-
-
18344377338
-
Production, characterization, and interspecies reactivities of monoclonal antibodies against human class a macrophage scavenger receptors
-
DOI 10.1016/S0021-9150(01)00624-4, PII S0021915001006244
-
Tomokiyo, R., K. Jinnouchi, M. Honda, Y. Wada, N. Hanada, T. Hiraoka, H. Suzuki, T. Kodama, K. Takahashi, and M. Takeya. 2002. Production, characterization, and interspecies reactivities of monoclonal antibodies against human class A macrophage scavenger receptors. Atherosclerosis 161: 123-132. (Pubitemid 34214828)
-
(2002)
Atherosclerosis
, vol.161
, Issue.1
, pp. 123-132
-
-
Tomokiyo, R.-I.1
Jinnouchi, K.2
Honda, M.3
Wada, Y.4
Hanada, N.5
Hiraoka, T.6
Suzuki, H.7
Kodama, T.8
Takahashi, K.9
Takeya, M.10
-
30
-
-
0037200117
-
Oligomeric and fibrillar species of amyloid-β peptides differentially affect neuronal viability
-
Dahlgren, K. N., A. M. Manelli, W. B. Stine, Jr., L. K. Baker, G. A. Krafft, and M. J. LaDu. 2002. Oligomeric and fibrillar species of amyloid-β peptides differentially affect neuronal viability. J. Biol. Chem. 277: 32046-32053.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 32046-32053
-
-
Dahlgren, K.N.1
Manelli, A.M.2
Stine Jr., W.B.3
Baker, L.K.4
Krafft, G.A.5
LaDu, M.J.6
-
31
-
-
0023252003
-
MHC antigen expression on bulk isolated macrophage-microglia from newborn mouse brain: Induction of Ia antigen expression by γ-interferon
-
DOI 10.1016/0165-5728(87)90121-4
-
Suzumura, A., S. G. Mezitis, N. K. Gonatas, and D. H. Silberberg. 1987. MHC antigen expression on bulk isolated macrophage-microglia from newborn mouse brain: induction of Ia antigen expression by γ-interferon. J. Neuroimmunol. 15: 263-278. (Pubitemid 17108036)
-
(1987)
Journal of Neuroimmunology
, vol.15
, Issue.3
, pp. 263-278
-
-
Suzumura, A.1
Mezitis, S.G.E.2
Gonatas, N.K.3
Silberberg, D.H.4
-
32
-
-
0025176888
-
Activation and proliferation of the isolated microglia by colony stimulating factor-1 and possible involvement of protein kinase C
-
DOI 10.1016/0006-8993(90)90317-5
-
Sawada, M., A. Suzumura, H. Yamamoto, and T. Marunouchi. 1990. Activation and proliferation of the isolated microglia by colony stimulating factor-1 and possible involvement of protein kinase C. Brain Res. 509: 119-124. (Pubitemid 20043627)
-
(1990)
Brain Research
, vol.509
, Issue.1
, pp. 119-124
-
-
Sawada, M.1
Suzumura, A.2
Yamamoto, H.3
Marunouchi, T.4
-
33
-
-
0344013138
-
High-Yield Isolation of Murine Microglia by Mild Trypsinization
-
DOI 10.1002/glia.10274
-
Saura, J., J. M. Tusell, and J. Serratosa. 2003. High-yield isolation of murine microglia by mild trypsinization. Glia 44: 183-189. (Pubitemid 37484470)
-
(2003)
GLIA
, vol.44
, Issue.3
, pp. 183-189
-
-
Saura, J.1
Tusell, J.M.2
Serratosa, J.3
-
34
-
-
0035793602
-
CD36, a Member of the Class B Scavenger Receptor Family, as a Receptor for Advanced Glycation End Products
-
DOI 10.1074/jbc.M006545200
-
Ohgami, N., R. Nagai, M. Ikemoto, H. Arai, A. Kuniyasu, S. Horiuchi, and H. Nakayama. 2001. CD36, a member of the class B scavenger receptor family, as a receptor for advanced glycation end products. J. Biol. Chem. 276: 3195-3202. (Pubitemid 37411612)
-
(2001)
Journal of Biological Chemistry
, vol.276
, Issue.5
, pp. 3195-3202
-
-
Ohgami, N.1
Nagai, R.2
Ikemoto, M.3
Arai, H.4
Kuniyasu, A.5
Horiuchi, S.6
Nakayama, H.7
-
35
-
-
0026778656
-
Intracellular accumulation and resistance to degradation of the Alzheimer amyloid A4/β protein
-
Knauer, M. F., B. Soreghan, D. Burdick, J. Kosmoski, and C. G. Glabe. 1992. Intracellular accumulation and resistance to degradation of the Alzheimer amyloid A4/β protein. Proc. Natl. Acad. Sci. USA 89: 7437-7441.
-
(1992)
Proc. Natl. Acad. Sci. USA
, vol.89
, pp. 7437-7441
-
-
Knauer, M.F.1
Soreghan, B.2
Burdick, D.3
Kosmoski, J.4
Glabe, C.G.5
-
36
-
-
0038392455
-
Two populations of microglial cells isolated from rat primary mixed glial cultures
-
DOI 10.1002/jnr.10637
-
Kuwabara, Y., A. Yokoyama, L. Yang, K. Toku, K. Mori, I. Takeda, T. Shigekawa, B. Zhang, N. Maeda, M. Sakanaka, and J. Tanaka. 2003. Two populations of microglial cells isolated from rat primary mixed glial cultures. J. Neurosci. Res. 73: 22-30. (Pubitemid 36791367)
-
(2003)
Journal of Neuroscience Research
, vol.73
, Issue.1
, pp. 22-30
-
-
Kuwabara, Y.1
Yokoyama, A.2
Yang, L.3
Toku, K.4
Mori, K.5
Takeda, I.6
Shigekawa, T.7
Zhang, B.8
Maeda, N.9
Sakanaka, M.10
Tanaka, J.11
-
37
-
-
0036141148
-
CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to β-amyloid fibrils
-
Coraci, I. S., J. Husemann, J. W. Berman, C. Hulette, J. H. Dufour, G. K. Campanella, A. D. Luster, S. C. Silverstein, and J. B. El-Khoury. 2002. CD36, a class B scavenger receptor, is expressed on microglia in Alzheimer's disease brains and can mediate production of reactive oxygen species in response to β-amyloid fibrils. Am. J. Pathol. 160: 101-112.
-
(2002)
Am. J. Pathol.
, vol.160
, pp. 101-112
-
-
Coraci, I.S.1
Husemann, J.2
Berman, J.W.3
Hulette, C.4
Dufour, J.H.5
Campanella, G.K.6
Luster, A.D.7
Silverstein, S.C.8
El-Khoury, J.B.9
-
38
-
-
0037703255
-
RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain
-
DOI 10.1038/nm890
-
Deane, R., S. Du Yan, R. K. Submamaryan, B. LaRue, S. Jovanovic, E. Hogg, D. Welch, L. Manness, C. Lin, J. Yu, et al. 2003. RAGE mediates amyloid-β peptide transport across the blood-brain barrier and accumulation in brain. Nat. Med. 9: 907-913. (Pubitemid 36889934)
-
(2003)
Nature Medicine
, vol.9
, Issue.7
, pp. 907-913
-
-
Deane, R.1
Yan, S.D.2
Submamaryan, R.K.3
Larue, B.4
Jovanovic, S.5
Hogg, E.6
Welch, D.7
Manness, L.8
Lin, C.9
Yu, J.10
Zhu, H.11
Ghiso, J.12
Frangione, B.13
Stern, A.14
Schmidt, A.M.15
Armstrong, D.L.16
Arnold, B.17
Liliensiek, B.18
Nawroth, P.19
Hofman, F.20
Kindy, M.21
Stern, D.22
Zlokovic, B.23
more..
-
39
-
-
0034521392
-
1-40 peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier
-
1-40 peptide from brain by LDL receptor-related protein-1 at the blood-brain barrier. J. Clin. Invest. 106: 1489-1499.
-
(2000)
J. Clin. Invest.
, vol.106
, pp. 1489-1499
-
-
Shibata, M.1
Yamada, S.2
Kumar, S.R.3
Calero, M.4
Bading, J.5
Frangione, B.6
Holtzman, D.M.7
Miller, C.A.8
Strickland, D.K.9
Ghiso, J.10
Zlokovic, B.V.11
-
40
-
-
0037119422
-
Accelerated phagocytosis of amyloid-β by mouse and human microglia overexpressing the macrophage colony-stimulating factor receptor
-
Mitrasinovic, O. M., and G. M. Murphy, Jr. 2002. Accelerated phagocytosis of amyloid-β by mouse and human microglia overexpressing the macrophage colony-stimulating factor receptor. J. Biol. Chem. 277: 29889-29896.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 29889-29896
-
-
Mitrasinovic, O.M.1
Murphy Jr., G.M.2
-
41
-
-
0035947207
-
Metabolic regulation of brain Aβ by neprilysin
-
Iwata, N., S. Tsubuki, Y. Takaki, K. Shirotani, B. Lu, N. P. Gerard, C. Gerard, E. Hama, H. J. Lee, and T. C. Saido. 2001. Metabolic regulation of brain Aβ by neprilysin. Science 292: 1550-1552.
-
(2001)
Science
, vol.292
, pp. 1550-1552
-
-
Iwata, N.1
Tsubuki, S.2
Takaki, Y.3
Shirotani, K.4
Lu, B.5
Gerard, N.P.6
Gerard, C.7
Hama, E.8
Lee, H.J.9
Saido, T.C.10
-
42
-
-
0000398342
-
Insulin-degrading enzyme regulates extracellular levels of amyloid β-protein by degradation
-
Qiu, W. Q., D. M. Walsh, Z. Ye, K. Vekrellis, J. Zhang, M. B. Podlisny, M. R. Rosner, A. Safavi, L. B. Hersh, and D. J. Selkoe. 1998. Insulin-degrading enzyme regulates extracellular levels of amyloid β-protein by degradation. J. Biol. Chem. 273: 32730-32738.
-
(1998)
J. Biol. Chem.
, vol.273
, pp. 32730-32738
-
-
Qiu, W.Q.1
Walsh, D.M.2
Ye, Z.3
Vekrellis, K.4
Zhang, J.5
Podlisny, M.B.6
Rosner, M.R.7
Safavi, A.8
Hersh, L.B.9
Selkoe, D.J.10
-
43
-
-
0042827324
-
Human neprilysin is capable of degrading amyloid β peptide not only in the monomeric form but also the pathological oligomeric form
-
DOI 10.1016/S0304-3940(03)00898-X
-
Kanemitsu, H., T. Tomiyama, and H. Mori. 2003. Human neprilysin is capable of degrading amyloid β peptide not only in the monomeric form but also the pathological oligomeric form. Neurosci. Lett. 350: 113-116. (Pubitemid 37101425)
-
(2003)
Neuroscience Letters
, vol.350
, Issue.2
, pp. 113-116
-
-
Kanemitsu, H.1
Tomiyama, T.2
Mori, H.3
-
44
-
-
0037390039
-
Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo
-
DOI 10.1073/pnas.0230450100
-
Farris, W., S. Mansourian, Y. Chang, L. Lindsley, E. A. Eckman, M. P. Frosch, C. B. Eckman, R. E. Tanzi, D. J. Selkoe, and S. Guenette. 2003. Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain in vivo. Proc. Natl. Acad. Sci. USA 100: 4162-4167. (Pubitemid 36418174)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.7
, pp. 4162-4167
-
-
Farris, W.1
Mansourian, S.2
Chang, Y.3
Lindsley, L.4
Eckman, E.A.5
Frosch, M.P.6
Eckman, C.B.7
Tanzi, R.E.8
Selkoe, D.J.9
Guenette, S.10
-
46
-
-
0028026864
-
Interleukin-4 induces proliferation and activation of microglia but suppresses their induction of class II major histocompatibility complex antigen expression
-
DOI 10.1016/0165-5728(94)90031-0
-
Suzumura, A., M. Sawada, Y. Itoh, and T. Marunouchi. 1994. Interleukin-4 induces proliferation and activation of microglia but suppresses their induction of class II major histocompatibility complex antigen expression. J. Neuroimmunol. 53: 209-218. (Pubitemid 24272012)
-
(1994)
Journal of Neuroimmunology
, vol.53
, Issue.2
, pp. 209-218
-
-
Suzumura, A.1
Sawada, M.2
Itoh, Y.3
Marunouchi, T.4
-
47
-
-
0027197996
-
Neuroprotective role of IL-4 against activated microglia
-
Chao, C. C., T. W. Molitor, and S. Hu. 1993. Neuroprotective role of IL-4 against activated microglia. J. Immunol. 151: 1473-1481.
-
(1993)
J. Immunol.
, vol.151
, pp. 1473-1481
-
-
Chao, C.C.1
Molitor, T.W.2
Hu, S.3
-
48
-
-
20244364226
-
SWE transgenic mice
-
DOI 10.1016/S0165-5728(02)00050-4, PII S0165572802000504
-
Abbas, N., I. Bednar, E. Mix, S. Marie, D. Paterson, A. Ljungberg, C. Morris, B. Winblad, A. Nordberg, and J. Zhu. 2002. Up-regulation of the inflammatory cytokines IFN-γ and IL-12 and down-regulation of IL-4 in cerebral cortex regions of APPSWE transgenic mice. J. Neuroimmunol. 126: 50-55. (Pubitemid 34521731)
-
(2002)
Journal of Neuroimmunology
, vol.126
, Issue.1-2
, pp. 50-57
-
-
Abbas, N.1
Bednar, I.2
Mix, E.3
Marie, S.4
Paterson, D.5
Ljungberg, A.6
Morris, C.7
Winblad, B.8
Nordberg, A.9
Zhu, J.10
-
49
-
-
15744373610
-
Role of interleukin-4 in regulation of age-related inflammatory changes in the hippocampus
-
DOI 10.1074/jbc.M412170200
-
Nolan, Y., F. O. Maher, D. S. Martin, R. M. Clarke, M. T. Brady, A. E. Bolton, K. H. Mills, and M. A. Lynch. 2005. Role of interleukin-4 in regulation of age-related inflammatory changes in the hippocampus. J. Biol. Chem. 280: 9354-9362. (Pubitemid 40409629)
-
(2005)
Journal of Biological Chemistry
, vol.280
, Issue.10
, pp. 9354-9362
-
-
Nolan, Y.1
Maher, F.O.2
Martin, D.S.3
Clarke, R.M.4
Brady, M.T.5
Bolton, A.E.6
Mills, K.H.G.7
Lynch, M.A.8
-
50
-
-
0025981021
-
T-lymphocyte entry into the central nervous system
-
Hickey, W. F., B. L. Hsu, and H. Kimura. 1991. T-lymphocyte entry into the central nervous system. J. Neurosci. Res. 28: 254-260.
-
(1991)
J. Neurosci. Res.
, vol.28
, pp. 254-260
-
-
Hickey, W.F.1
Hsu, B.L.2
Kimura, H.3
-
51
-
-
0024157709
-
Expression of immune system-associated antigens by cells of the human central nervous system: Relationship to the pathology of Alzheimer's disease
-
Rogers, J., J. Luber-Narod, S. D. Styren, and W. H. Civin. 1988. Expression of immune system-associated antigens by cells of the human central nervous system: relationship to the pathology of Alzheimer's disease. Neurobiol. Aging 9: 339-349. (Pubitemid 19262065)
-
(1988)
Neurobiology of Aging
, vol.9
, Issue.4
, pp. 339-349
-
-
Rogers, J.1
Luber-Narod, J.2
Styren, S.D.3
Civin, W.H.4
-
52
-
-
0036200984
-
Occurrence of T cells in the brain of Alzheimer's disease and other neurological diseases
-
DOI 10.1016/S0165-5728(01)00496-9, PII S0165572801004969
-
Togo, T., H. Akiyama, E. Iseki, H. Kondo, K. Ikeda, M. Kato, T. Oda, K. Tsuchiya, and K. Kosaka. 2002. Occurrence of T cells in the brain of Alzheimer's disease and other neurological diseases. J. Neuroimmunol. 124: 83-92. (Pubitemid 34212013)
-
(2002)
Journal of Neuroimmunology
, vol.124
, Issue.1-2
, pp. 83-92
-
-
Togo, T.1
Akiyama, H.2
Iseki, E.3
Kondo, H.4
Ikeda, K.5
Kato, M.6
Oda, T.7
Tsuchiya, K.8
Kosaka, K.9
-
53
-
-
17444382009
-
Defining antigen-dependent stages of T cell migration from the blood to the central nervous system parenchyma
-
Archambault, A. S., J. Sim, M. A. Gimenez, and J. H. Russell. 2005. Defining antigen-dependent stages of T cell migration from the blood to the central nervous system parenchyma. Eur. J. Immunol. 35: 1076-1085.
-
(2005)
Eur. J. Immunol.
, vol.35
, pp. 1076-1085
-
-
Archambault, A.S.1
Sim, J.2
Gimenez, M.A.3
Russell, J.H.4
-
54
-
-
27144470749
-
T-cells in Alzheimer's disease
-
Town, T., J. Tan, R. A. Flavell, and M. Mullan. 2005. T-cells in Alzheimer's disease. Neuromolecular Med. 7: 255-264.
-
(2005)
Neuromolecular Med.
, vol.7
, pp. 255-264
-
-
Town, T.1
Tan, J.2
Flavell, R.A.3
Mullan, M.4
-
55
-
-
0033962411
-
Inflammatory mediators and modulation of blood-brain barrier permeability
-
DOI 10.1023/A:1007074420772
-
Abbott, N. J. 2000. Inflammatory mediators and modulation of blood-brain barrier permeability. Cell. Mol. Neurobiol. 20: 131-147. (Pubitemid 30091452)
-
(2000)
Cellular and Molecular Neurobiology
, vol.20
, Issue.2
, pp. 131-147
-
-
Abbott, N.J.1
-
56
-
-
0034603407
-
Agrin and microvascular damage in Alzheimer's disease
-
DOI 10.1016/S0197-4580(00)00121-4, PII S0197458000001214
-
Berzin, T. M., B. D. Zipser, M. S. Rafii, V. Kuo-Leblanc, G. D. Yancopoulos, D. J. Glass, J. R. Fallon, and E. G. Stopa. 2000. Agrin and microvascular damage in Alzheimer's disease. Neurobiol. Aging 21: 349-355. (Pubitemid 30387094)
-
(2000)
Neurobiology of Aging
, vol.21
, Issue.2
, pp. 349-355
-
-
Berzin, T.M.1
Zipser, B.D.2
Rafii, M.S.3
Kuo - Leblanc, V.4
Yancopoulos, G.D.5
Glass, D.J.6
Fallon, J.R.7
Stopa, E.G.8
-
57
-
-
0041428141
-
Microglia-mediated nitric oxide cytotoxicity of T cells following amyloid β-peptide presentation to Th1 cells
-
Monsonego, A., J. Imitola, V. Zota, T. Oida, and H. L. Weiner. 2003. Microglia-mediated nitric oxide cytotoxicity of T cells following amyloid β-peptide presentation to Th1 cells. J. Immunol. 171: 2216-2224. (Pubitemid 37025526)
-
(2003)
Journal of Immunology
, vol.171
, Issue.5
, pp. 2216-2224
-
-
Monsonego, A.1
Imitola, J.2
Zota, V.3
Oida, T.4
Weiner, H.L.5
-
58
-
-
0037393454
-
Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: A case report
-
Nicoll, J. A., D. Wilkinson, C. Holmes, P. Steart, H. Markham, and R. O. Weller. 2003. Neuropathology of human Alzheimer disease after immunization with amyloid-β peptide: a case report. Nat. Med. 9: 448-452.
-
(2003)
Nat. Med.
, vol.9
, pp. 448-452
-
-
Nicoll, J.A.1
Wilkinson, D.2
Holmes, C.3
Steart, P.4
Markham, H.5
Weller, R.O.6
-
59
-
-
1942452266
-
Specificity of mechanisms for plaque removal after Aβ immunotherapy for Alzheimer disease
-
Akiyama, H., and P. L. McGeer. 2004. Specificity of mechanisms for plaque removal after Aβ immunotherapy for Alzheimer disease. Nat. Med. 10: 117-118.
-
(2004)
Nat. Med.
, vol.10
, pp. 117-118
-
-
Akiyama, H.1
McGeer, P.L.2
-
60
-
-
0035719975
-
Th2 cytokines and asthma: Interleukin-4: Its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists
-
Steinke, J. W., and L. Borish. 2001. Th2 cytokines and asthma: interleukin-4: its role in the pathogenesis of asthma, and targeting it for asthma treatment with interleukin-4 receptor antagonists. Respir. Res. 2: 66-70.
-
(2001)
Respir. Res.
, vol.2
, pp. 66-70
-
-
Steinke, J.W.1
Borish, L.2
-
61
-
-
0034047780
-
Intratumoral administration of recombinant circularly permuted interleukin-4-Pseudomonas exotoxin in patients with high-grade glioma
-
Rand, R. W., R. J. Kreitman, N. Patronas, F. Varricchio, I. Pastan, and R. K. Puri. 2000. Intratumoral administration of recombinant circularly permuted interleukin-4-Pseudomonas exotoxin in patients with high-grade glioma. Clin. Cancer Res. 6: 2157-2165.
-
(2000)
Clin. Cancer Res.
, vol.6
, pp. 2157-2165
-
-
Rand, R.W.1
Kreitman, R.J.2
Patronas, N.3
Varricchio, F.4
Pastan, I.5
Puri, R.K.6
-
62
-
-
0033801852
-
Nasal administration of amyloid-β peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease
-
Weiner, H. L., C. A. Lemere, R. Maron, E. T. Spooner, T. J. Grenfell, C. Mori, S. Issazadeh, W. W. Hancock, and D. J. Selkoe. 2000. Nasal administration of amyloid-β peptide decreases cerebral amyloid burden in a mouse model of Alzheimer's disease. Ann. Neurol. 48: 567-579.
-
(2000)
Ann. Neurol.
, vol.48
, pp. 567-579
-
-
Weiner, H.L.1
Lemere, C.A.2
Maron, R.3
Spooner, E.T.4
Grenfell, T.J.5
Mori, C.6
Issazadeh, S.7
Hancock, W.W.8
Selkoe, D.J.9
|