Age-Related lesions in the cerebrum in middle-aged female cynomolgus monkeys

Toxicologic Pathology

Volumn 38, Issue 2, 2010, Pages 303-311

  Kodama, Rinya ^a   Yang, Xiuying ^a   Saski, Yuji ^a   Iwashige, Shuichiro ^a   Tanigawa, Yohei ^a   Yoshikawa, Tsuyoshi ^a   Nagaoka, Takaharu ^a   Kamimura, Yasuhiro ^a   Maeda, Horishi ^a  

^a SHIN NIPPON BIOMEDICAL LABORATORIES LTD   (Japan)

Author keywords

Age related lesions; Alzheimer's disease; Cerebrum; Cynomolgus monkey; Hippocampus; Senile plaque

Indexed keywords

AMYLOID BETA PROTEIN;

AGE; AGING; ALZHEIMER DISEASE; ANIMAL TISSUE; ARTICLE; ASTROCYTE; BODY WEIGHT; BRAIN DAMAGE; BRAIN REGION; BRAIN WEIGHT; CELL COUNT; CELL LOSS; CONTROLLED STUDY; FEMALE; HISTOPATHOLOGY; MICROGLIA; MONKEY; NERVE CELL; NERVE CELL DEGENERATION; NEUROFIBRILLARY TANGLE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; SENILE PLAQUE; VASCULAR AMYLOIDOSIS;

AGE FACTORS; AGING; ANIMALS; ASTROCYTES; CELL COUNT; CEREBRAL AMYLOID ANGIOPATHY; CEREBRUM; FEMALE; HIPPOCAMPUS; MACACA FASCICULARIS; MICROGLIA; NEUROFIBRILLARY TANGLES; NEURONS; SENILE PLAQUES;

MACACA FASCICULARIS;

EID: 77952472697     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623309358904     Document Type: Article

References (19)

1. Anderton, B. H. (1997). Changes in the ageing brain in health and disease. Phil Trans R Soc Lond B 352, 1781-1792
2. Cork, L. C., and Walker, L. C. (1988). Age-related lesions, nervous system. In Non-Human Primates II (T. C. Jones, U. Mohr, and R. E. Hunt, eds.), pp. 173-183. Springer-Verlag, New York.
3. Fukuda, T., Shimizu, J., Furuhata, H., Abe, T., Shimizu, K., Oishi, T., Ogihara, M., Kubota, J., Sasaki, A., Sasaki, K., Azuma, T., and Umemura S. (2005). Overexpression of heat shock proteins in pallido-nigral axonal spheroids of nonhuman aged primates. Acta Neuropathol 110, 145-150
4. Hardy, J., Duff, K., Hardy, K. G., Perez-Tur, J., and Hutton, M. (1998). Genetic dissection of Alzheimer's disease and related dementias: amyloid and its relationship to tau. Nat Neurosci 1, 355-358
5. Hardy J., and Selkoe, D. J. (2002). The amyloidhypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297, 353-356
6. Kimberly, W. T., LaVoie, M. J., Ostaszewski, B. L., Ye, W., Wolfe, M. S., and Selkoe, D. J. (2003). γ-Secretase is a membrane protein complex comprised of presenilin, nicastrin, aph-1, and pen-2. Proc Natl Acad Sci USA 100, 6382-6387
7. Kimura, N., Nakamura, S., Honda, T., Takashima, A., Nakayama, H., Ono, F., Sakakibara, I., Doi, K., Kawamura, S., and Yoshikawa, Y. (2001). Age-related changes in the localization of presenilin-1 in cynomolgus monkey brain. Brain Res 922, 30-41.
8. Kimura, N., Negishi, T., Ishi, Y., Kyuwa, S., and Yoshikawa, Y. (2004). Astroglial responses against Aβ initially occur in cerebral primary cortical cultures: species differences between rat and cynomolgus monkey. Neurosci Res 49, 339-346
9. Kimura, N., Tanemura, K., Nakamura, S., Takashima, A., Ono, F., Sakakibara, I., Ishi, Y., Kyuwa, S., and Yoshikawa, Y. (2003). Age-related changes in Alzheimer's disease-associated proteins in cynomolgus monkey brains. Biochem Biophys Res Comm 310, 303-311
10. Kimura, N., Yanagisawa, K., Terao, K., Ono, F., Sakakibara, I., Ishi, Y., Kyuwa, S., and Yoshikawa, Y. (2005). Age-related changes ofintracellular Aβ in cynomolgus monkey brains. Neuropatho and Appl Neurobio 31, 170-180
11. Nakamura, S., Kiatipattanasakul W., Nakayama, H., Ono, F., Sakakibara, I., Yoshikawa, Y., Goto, N., and Doi, K. (1996). Immunohistochemical characteristics of the constituents of senile plaques and amyloid angiopathy in aged cynomolgus monkeys. J Med Primatol 25, 294-300.
12. Nakamura, S., Nakayama, H., Goto, N., Ono, F., Sakakibara, I., and Yoshikawa, Y. (1995a). Histopathological findings on senile plaques and amyloid angiopathy in aged cynomolgus monkeys. Biom Gerontol 19(3), 46-55.
13. Nakamura, S., Nakayama, H., Goto, N., Ono, F., Sakakibara, I., and Yoshikawa, Y. (1995b). Histopathological studies on senile plaques and cerebral amyloid angiopathy in aged cynomolgus monkeys. Exp Anim 43(5), 711-718
14. Nakamura,S.,Nakayama,H.,Goto,N.,Ono,F.,Sakakibara,I.,and Yoshikawa, Y. (1998). Histopathological studies of senile plaques and cerebral amyloidosis in cynomolgus monkeys. J Med Primatol 27, 244-252
15. Selkoe, D. J. (2001). Alzheimer's disease: genes, proteins, and therapy. Physiol Rev 81, 741-766
16. Tanaka, S., Narita, H., Ohtoh, K., Yoshida, T., Cho, F., and Yoshikawa, Y. (1995). Obesity and emaciation infemale cynomolgus monkeys (Macaca fascicularis): their relation to hematological and serum biochemical properties. J Growth 34, 43-48 (in Japanese).
17. Tanzi, R. E., and Bertram, L. (2001). New frontiers in Alzheimer's disease genetics. Neuron 32, 181-184
18. Tomlinson, B. E., Blessed, G., and Roth, M. (1968). Observations on the brains of non-demented old people. J Neurol Sci 7, 331-356
19. Tomlinson, B. E., Blessed, G., and Roth, M. (1970). Observations on the brains of demented old people. J Neurol Sci 11, 205-242