MR Spectroscopic studies of the brain in psychiatric disorders

Current Topics in Behavioral Neurosciences

Volumn 11, Issue , 2012, Pages 199-251

  Maddock, Richard J ^a   Buonocore, Michael H ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Cortex; Frontal; Glial; Limbic; Metabolism; Neural

Indexed keywords

4 AMINOBUTYRATE AMINOTRANSFERASE; 4 AMINOBUTYRIC ACID A RECEPTOR; ACID SENSING ION CHANNEL; CREATINE KINASE; EXCITATORY AMINO ACID TRANSPORTER 1; EXCITATORY AMINO ACID TRANSPORTER 2; GLUTAMATE DECARBOXYLASE; GLUTAMATE DECARBOXYLASE 67; GLUTAMATE DEHYDROGENASE; GLYCEROPHOSPHORYLCHOLINE; GUANIDINOACETATE METHYLTRANSFERASE; INOSITOL TRISPHOSPHATE; MONOCARBOXYLATE TRANSPORTER; MONOCARBOXYLATE TRANSPORTER 1; N ACETYLASPARTIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; PHOSPHORYLCHOLINE; SEROTONIN UPTAKE INHIBITOR; VESICULAR GLUTAMATE TRANSPORTER; VESICULAR GLUTAMATE TRANSPORTER 1; ASPARTIC ACID; CREATINE; GLUTAMIC ACID; GLUTAMINE; N-ACETYLASPARTATE;

ANTERIOR CINGULATE; ANXIETY DISORDER; ARTICLE; BIPOLAR DISORDER; BRAIN FUNCTION; BRAIN METABOLISM; ECHO PLANAR IMAGING; ELECTROENCEPHALOGRAPHY; GLUTAMATERGIC SYNAPSE; HUMAN; INTRACELLULAR SIGNALING; MAJOR DEPRESSION; MENTAL DISEASE; NUCLEAR MAGNETIC RESONANCE IMAGING; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OBSESSIVE COMPULSIVE DISORDER; PANIC; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SCHIZOPHRENIA; VISUAL CORTEX; ANALOGS AND DERIVATIVES; BRAIN; METABOLISM; PATHOLOGY;

ASPARTIC ACID; BRAIN; CREATINE; GLUTAMIC ACID; GLUTAMINE; HUMANS; MAGNETIC RESONANCE SPECTROSCOPY; MENTAL DISORDERS;

EID: 84860351184     PISSN: 18663370     EISSN: 18663389     Source Type: Book Series    
DOI: 10.1007/7854_2011_197     Document Type: Article

References (243)

1. Abbott C, Bustillo J (2006) What have we learned from proton magnetic resonance spectroscopy about schizophrenia? A critical update. Curr Opin Psychiatry 19: 135-139
2. Ajilore O, Haroon E, Kumaran S et al (2007) Measurement of brain metabolites in patients with type 2 diabetes and major depression using proton magnetic resonance spectroscopy. Neuropsychopharmacology 32: 1224-1231
3. Albrecht J, Sonnewald U, Waagepetersen HS, Schousboe A (2007) Glutamine in the central nervous system: function and dysfunction. Front Biosci 12: 332-343
4. Almeida LS, Salomons GS, Hogenboom F, Jakobs C, Schoffelmeer AN (2006) Exocytotic release of creatine in rat brain. Synapse 60: 118-123
5. Andres RH, Ducray AD, Schlattner U, Wallimann T, Widmer HR (2008) Functions and effects of creatine in the central nervous system. Brain Res Bull 76: 329-343
6. Arckens L, Schweigart G, Qu Y et al (2000) Cooperative changes in GABA, glutamate and activity levels: the missing link in cortical plasticity. Eur J Neurosci 12: 4222-4232
7. Ariyannur PS, Moffett JR, Manickam P et al (2010) Methamphetamine-induced neuronal protein NAT8L is the NAA biosynthetic enzyme: implications for specialized acetyl coenzyme A metabolism in the CNS. Brain Res 1335: 1-13
8. Arnone D, Cavanagh J, Gerber D, Lawrie SM, Ebmeier KP, McIntosh AM (2009) Magnetic resonance imaging studies in bipolar disorder and schizophrenia: meta-analysis. Br J Psychiatry 195: 194-201
9. Atmaca M, Yildirim H, Ozdemir H, Ogur E, Tezcan E (2007) Hippocampal 1H MRS in patients with bipolar disorder taking valproate versus valproate plus quetiapine. Psychol Med 37: 121-129
10. Baslow MH (2007) N-acetylaspartate and N-acetylaspartylglutamate. In: Lajtha A, Oja S, Schousboe A, Saransaari P (eds) Handbook of neurochemistry and molecular neurobiology: amino acids and peptides in the nervous system. Springer, New York, pp 305-346
11. Bates TE, Strangward M, Keelan J, Davey GP, Munro PM, Clark JB (1996) Inhibition of N-acetylaspartate production: implications for 1HMRS studies in vivo. Neuroreport 7: 1397-1400
12. Beard E, Braissant O (2010) Synthesis and transport of creatine in the CNS: importance for cerebral functions. J Neurochem 115: 297-313
13. Bergersen LH (2007) Is lactate food for neurons? Comparison of monocarboxylate transporter subtypes in brain and muscle. Neuroscience 145: 11-19
14. Berridge MJ (1989) The Albert Lasker medical awards: inositol trisphosphate, calcium, lithium, and cell signaling. JAMA 262: 1834-1841
15. Bertolino A, Callicott JH, Mattay VS, Weidenhammer KM, Rakow R, Egan MF, Weinberger DR (2001) The effect of treatment with antipsychotic drugs on brain N-acetylaspartate measures in patients with schizophrenia. Biol Psychiatry 49: 39-46
16. Bertolino A, Frye M, Callicott JH et al (2003) Neuronal pathology in the hippocampal area of patients with bipolar disorder: a study with proton magnetic resonance spectroscopic imaging. Biol Psychiatry 53: 906-913
17. Bhagwagar Z, Wylezinska M, Taylor M, Jezzard P, Matthews PM, Cowen PJ (2004) Increased brain GABA concentrations following acute administration of a selective serotonin reuptake inhibitor. Am J Psychiatry 161: 368-370
18. Bhagwagar Z, Wylezinska M, Jezzard P et al (2007) Reduction in occipital cortex gammaaminobutyric acid concentrations in medication-free recovered unipolar depressed and bipolar subjects. Biol Psychiatry 61: 806-812
19. Bhakoo KK, Williams IT, Williams SR, Gadian DG, Noble MD (1996) Proton nuclear magnetic resonance spectroscopy of primary cells derived from nervous tissue. J Neurochem 66: 1254-1263
20. Binesh N, Kumar A, Hwang S, Mintz J, Thomas MA (2004) Neurochemistry of late-life major depression: a pilot two-dimensional MR spectroscopic study. J Magn Reson Imaging 20: 1039-1045
21. Bitsch A, Bruhn H, Vougioukas V, Stringaris A, Lassmann H, Frahm J, Bruck W (1999) Inflammatory CNS demyelination: histopathologic correlation with in vivo quantitative proton MR spectroscopy. Am J Neuroradiol 20: 1619-1627
22. Bitto E, Bingman CA, Wesenberg GE, McCoy JG, Phillips GN Jr (2007) Structure of aspartoacylase, the brain enzyme impaired in Canavan disease. Proc Natl Acad Sci U S A 104: 456-461
23. Bora E, Fornito A, Yucel M, Pantelis C (2010) Voxelwise meta-analysis of gray matter abnormalities in bipolar disorder. Biol Psychiatry 67: 1097-1105
24. Boulanger Y, Labelle M, Khiat A (2000) Role of phospholipase A(2) on the variations of the choline signal intensity observed by 1H magnetic resonance spectroscopy in brain diseases. Brain Res Brain Res Rev 33: 380-389
25. Braissant O, Beard E, Torrent C, Henry H (2010) Dissociation of AGAT, GAMT and SLC6A8 in CNS: relevance to creatine deficiency syndromes. Neurobiol Dis 37: 423-433
26. Brambilla P, Stanley JA, Sassi RB, Nicoletti MA, Mallinger AG, Keshavan MS, Soares JC (2004) 1H MRS study of dorsolateral prefrontal cortex in healthy individuals before and after lithium administration. Neuropsychopharmacology 29: 1918-1924
27. Brand A, Richter-Landsberg C, Leibfritz D (1993) Multinuclear NMR studies on the energy metabolism of glial and neuronal cells. Dev Neurosci 15: 289-298
28. Bremner JD (2006) Traumatic stress: effects on the brain. Dialogues Clin Neurosci 8: 445-461
29. Brenner E, Kondziella D, Haberg A, Sonnewald U (2005) Impaired glutamine metabolism in NMDA receptor hypofunction induced by MK801. J Neurochem 94: 1594-1603
30. Brooks GA (2002) Lactate shuttles in nature. Biochem Soc Trans 30: 258-264
31. Brown AM (2004) Brain glycogen re-awakened. J Neurochem 89: 537-552
32. Bustillo JR, Rowland LM, Jung R et al (2008) Proton magnetic resonance spectroscopy during initial treatment with antipsychotic medication in schizophrenia. Neuropsychopharmacology 33: 2456-2466
33. Bustillo JR, Rowland LM, Mullins P et al (2010) 1H-MRS at 4 Tesla in minimally treated early schizophrenia. Mol Psychiatry 15: 629-636
34. Capizzano AA, Jorge RE, Acion LC, Robinson RG (2007) In vivo proton magnetic resonance spectroscopy in patients with mood disorders: a technically oriented review. J Magn Reson Imaging 26: 1378-1389
35. Caramanos Z, Narayanan S, Arnold DL (2005) 1H-MRS quantification of tNA and tCr in patients with multiple sclerosis: a meta-analytic review. Brain 128: 2483-2506
36. Carder RK, Hendry SH (1994) Neuronal characterization, compartmental distribution, and activity-dependent regulation of glutamate immunoreactivity in adult monkey striate cortex. J Neurosci 14: 242-262
37. Cecil KM, DelBello MP, Morey R, Strakowski SM (2002) Frontal lobe differences in bipolar disorder as determined by proton MR spectroscopy. Bipolar Disord 4: 357-365
38. Chopra M, Yao Y, Blake TJ, Hampson DR, Johnson EC (2009) The neuroactive peptide Nacetylaspartylglutamate is not an agonist at the metabotropic glutamate receptor subtype 3 of metabotropic glutamate receptor. J Pharmacol Exp Ther 330: 212-219
39. Choudary PV, Molnar M, Evans SJ et al (2005) Altered cortical glutamatergic and GABAergic signal transmission with glial involvement in depression. Proc Natl Acad Sci U S A 102: 15653-15658
40. Clark JB (1998) N-acetyl aspartate: a marker for neuronal loss or mitochondrial dysfunction. Dev Neurosci 20: 271-276
41. Clark JF, Doepke A, Filosa JA, Wardle RL, Lu A, Meeker TJ, Pyne-Geithman GJ (2006) Nacetylaspartate as a reservoir for glutamate. Med Hypotheses 67: 506-512
42. Colla M, Schubert F, Bubner M et al (2009) Glutamate as a spectroscopic marker of hippocampal structural plasticity is elevated in long-term euthymic bipolar patients on chronic lithium therapy and correlates inversely with diurnal cortisol. Mol Psychiatry 14: 696-704, 647
43. Coplan JD, Lydiard RB (1998) Brain circuits in panic disorder. Biol Psychiatry 44: 1264-1276
44. Coryell MW, Ziemann AE, Westmoreland PJ et al (2007) Targeting ASIC1a reduces innate fear and alters neuronal activity in the fear circuit. Biol Psychiatry 62: 1140-1148
45. Dager SR, Strauss WL, Marro KI, Richards TL, Metzger GD, Artru AA (1995) Proton magnetic resonance spectroscopy investigation of hyperventilation in subjects with panic disorder and comparison subjects. Am J Psychiatry 152: 666-672
46. Dager SR, Richards T, Strauss W, Artru A (1997) Single-voxel 1H-MRS investigation of brain metabolic changes during lactate-induced panic. Psychiatry Res 30: 89-99
47. Dager SR, Friedman SD, Heide A et al (1999) Two-dimensional proton echo-planar spectroscopic imaging of brain metabolic changes during lactate-induced panic. Arch Gen Psychiatry 56: 70-77
48. Dager SR, Friedman SD, Parow A et al (2004) Brain metabolic alterations in medication-free patients with bipolar disorder. Arch Gen Psychiatry 61: 450-458
49. De Stefano N, Matthews PM, Arnold DL (1995) Reversible decreases in N-acetylaspartate after acute brain injury. Magn Reson Med 34: 721-727
50. Deicken RF, Johnson C, Pegues M (2000) Proton magnetic resonance spectroscopy of the human brain in schizophrenia. Rev Neurosci 11: 147-158
51. Delp MD, Armstrong RB, Godfrey DA, Laughlin MH, Ross CD, Wilkerson MK (2001) Exercise increases blood flow to locomotor, vestibular, cardiorespiratory and visual regions of the brain in miniature swine. J Physiol 533: 849-859
52. Demougeot C, Marie C, Giroud M, Beley A (2004) N-acetylaspartate: a literature review of animal research on brain ischaemia. J Neurochem 90: 776-783
53. Dericioglu N, Garganta CL, Petroff OA, Mendelsohn D, Williamson A (2008) Blockade of GABA synthesis only affects neural excitability under activated conditions in rat hippocampal slices. Neurochem Int 53: 22-32
54. Dickstein DP, Towbin KE, Van Der Veen JW et al (2009) Randomized double-blind placebocontrolled trial of lithium in youths with severe mood dysregulation. J Child Adolesc Psychopharmacol 19: 61-73
55. Dolder M, Walzel B, Speer O, Schlattner U, Wallimann T (2003) Inhibition of the mitochondrial permeability transition by creatine kinase substrates: requirement for microcompartmentation. J Biol Chem 278: 17760-17766
56. Eastwood SL, Harrison PJ (2010) Markers of glutamate synaptic transmission and plasticity are increased in the anterior cingulate cortex in bipolar disorder. Biol Psychiatry 67: 1010-1016
57. Edden RA, Pomper MG, Barker PB (2007) In vivo differentiation of N-acetyl aspartyl glutamate from N-acetyl aspartate at 3 Tesla. Magn Reson Med 57: 977-982
58. Edden RA, Muthukumaraswamy SD, Freeman TC, Singh KD (2009) Orientation discrimination performance is predicted by GABA concentration and gamma oscillation frequency in human primary visual cortex. J Neurosci 29: 15721-15726
59. Ellison-Wright I, Glahn DC, Laird AR, Thelen SM, Bullmore E (2008) The anatomy of firstepisode and chronic schizophrenia: an anatomical likelihood estimation meta-analysis. Am J Psychiatry 165: 1015-1023
60. Emsell L, McDonald C (2009) The structural neuroimaging of bipolar disorder. Int Rev Psychiatry 21: 297-313
61. Epperson CN, Haga K, Mason GF et al (2002) Cortical gamma-aminobutyric acid levels across the menstrual cycle in healthy women and those with premenstrual dysphoric disorder: a proton magnetic resonance spectroscopy study. Arch Gen Psychiatry 59: 851-858
62. Erlichman JS, Hewitt A, Damon TL, Hart M, Kurascz J, Li A, Leiter JC (2008) Inhibition of monocarboxylate transporter 2 in the retrotrapezoid nucleus in rats: a test of the astrocyteneuron lactate-shuttle hypothesis. J Neurosci 28: 4888-4896
63. Esquivel G, Schruers KR, Maddock RJ, Colasanti A, Griez EJ (2010) Review: Acids in the brain: a factor in panic? J Psychopharmacol 24: 639-647
64. Etkin A, Wager TD (2007) Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. Am J Psychiatry 164: 1476-1488
65. Fan Q, Tan L, You C et al (2010) Increased N-Acetylaspartate/creatine ratio in the medial prefrontal cortex among unmedicated obsessive-compulsive disorder patients. Psychiatry Clin Neurosci 64: 483-490
66. Farrant M, Nusser Z (2005) Variations on an inhibitory theme: phasic and tonic activation of GABA(A) receptors. Nat Rev Neurosci 6: 215-229
67. Ferrari MC, Busatto GF, McGuire PK, Crippa JA (2008) Structural magnetic resonance imaging in anxiety disorders: an update of research findings. Rev Bras Psiquiatr 30: 251-264
68. Fisher SK, Novak JE, Agranoff BW (2002) Inositol and higher inositol phosphates in neural tissues: homeostasis, metabolism and functional significance. J Neurochem 82: 736-754
69. Friedman SD, Dager SR, Parow A et al (2004) Lithium and valproic acid treatment effects on brain chemistry in bipolar disorder. Biol Psychiatry 56: 340-348
70. Friedman SD, Mathis CM, Hayes C, Renshaw P, Dager SR (2006) Brain pH response to hyperventilation in panic disorder: preliminary evidence for altered acid-base regulation. Am J Psychiatry 163: 710-715
71. Frye MA, Watzl J, Banakar S et al (2007) Increased anterior cingulate/medial prefrontal cortical glutamate and creatine in bipolar depression. Neuropsychopharmacology 32: 2490-2499
72. Fukuyama H, Ouchi Y, Matsuzaki S et al (1997) Brain functional activity during gait in normal subjects: a SPECT study. Neurosci Lett 228: 183-186
73. Fukuzako H (2001) Neurochemical investigation of the schizophrenic brain by in vivo phosphorus magnetic resonance spectroscopy. World J Biol Psychiatry 2: 70-82
74. Gaetz W, Edgar JC, Wang DJ, Roberts TP (2011) Relating MEG measured motor cortical oscillations to resting gamma-aminobutyric acid (GABA) concentration. Neuroimage 55: 616-621. doi: 10. 1016/j. neuroimage. 2010. 12. 077
75. Gasparovic C, Arfai N, Smid N, Feeney DM (2001) Decrease and recovery of N-acetylaspartate/creatine in rat brain remote from focal injury. J Neurotrauma 18: 241-246
76. Geddes JW, Panchalingam K, Keller JN, Pettegrew JW (1997) Elevated phosphocholine and phosphatidylcholine following rat entorhinal cortex lesions. Neurobiol Aging 18: 305-308
77. Gladden LB (2004) Lactate metabolism: a new paradigm for the third millennium. J Physiol 558: 5-30
78. Goddard AW, Mason GF, Almai A et al (2001) Reductions in occipital cortex GABA levels in panic disorder detected with 1H-magnetic resonance spectroscopy. Arch Gen Psychiatry 58: 556-561
79. Goddard AW, Mason GF, Appel M, Rothman DL, Gueorguieva R, Behar KL, Krystal JH (2004) Impaired GABA neuronal response to acute benzodiazepine administration in panic disorder. Am J Psychiatry 161: 2186-2193
80. Gorman JM, Kent JM, Sullivan GM, Coplan JD (2000) Neuroanatomical hypothesis of panic disorder, revised. Am J Psychiatry 157: 493-505
81. Goto N, Yoshimura R, Moriya J et al (2009) Reduction of brain gamma-aminobutyric acid (GABA) concentrations in early-stage schizophrenia patients: 3T proton MRS study. Schizophr Res 112: 192-193
82. Govindaraju V, Young K, Maudsley AA (2000) Proton NMR chemical shifts and coupling constants for brain metabolites. NMR Biomed 13: 129-153
83. Griffin JL, Bollard M, Nicholson JK, Bhakoo K (2002) Spectral profiles of cultured neuronal and glial cells derived from HRMAS (1)H NMR spectroscopy. NMR Biomed 15: 375-384
84. Gussew A, Rzanny R, Erdtel M, Scholle HC, Kaiser WA, Mentzel HJ, Reichenbach JR (2010) Time-resolved functional 1H MR spectroscopic detection of glutamate concentration changes in the brain during acute heat pain stimulation. Neuroimage 49: 1895-1902
85. Hajek T, Kozeny J, Kopecek M, Alda M, Hoschl C (2008) Reduced subgenual cingulate volumes in mood disorders: a meta-analysis. J Psychiatry Neurosci 33: 91-99
86. Hallcher LM, Sherman WR (1980) The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain. J Biol Chem 255: 10896-10901
87. Hamakawa H, Kato T, Murashita J, Kato N (1998) Quantitative proton magnetic resonance spectroscopy of the basal ganglia in patients with affective disorders. Eur Arch Psychiatry Clin Neurosci 248: 53-58
88. Hancu I (2009) Optimized glutamate detection at 3T. J Magn Reson Imaging 30: 1155-1162
89. Harada M, Kubo H, Nose A, Nishitani H, Matsuda T (2010) Measurement of variation in the human cerebral GABA level by in vivo MEGA-editing proton MR spectroscopy using a clinical 3 T instrument and its dependence on brain region and the female menstrual cycle. Hum Brain Mapp 32: 828-833
90. Hashimoto K, Engberg G, Shimizu E, Nordin C, Lindstrom LH, Iyo M (2005) Elevated glutamine/glutamate ratio in cerebrospinal fluid of first episode and drug naive schizophrenic patients. BMC Psychiatry 5: 6
91. Hashimoto T, Hussien R, Cho HS, Kaufer D, Brooks GA (2008) Evidence for the mitochondrial lactate oxidation complex in rat neurons: demonstration of an essential component of brain lactate shuttles. PLoS ONE 3: e2915
92. Hasler G, Neumeister A, van der Veen JW et al (2005) Normal prefrontal gamma-aminobutyric acid levels in remitted depressed subjects determined by proton magnetic resonance spectroscopy. Biol Psychiatry 58: 969-973
93. Hasler G, van der Veen JW, Tumonis T, Meyers N, Shen J, Drevets WC (2007) Reduced prefrontal glutamate/glutamine and gamma-aminobutyric acid levels in major depression determined using proton magnetic resonance spectroscopy. Arch Gen Psychiatry 64: 193-200
94. Hasler G, Nugent AC, Carlson PJ, Carson RE, Geraci M, Drevets WC (2008) Altered cerebral gamma-aminobutyric acid type A-benzodiazepine receptor binding in panic disorder determined by [11C]flumazenil positron emission tomography. Arch Gen Psychiatry 65: 1166-1175
95. Hasler G, van der Veen JW, Geraci M, Shen J, Pine D, Drevets WC (2009) Prefrontal cortical gamma-aminobutyric acid levels in panic disorder determined by proton magnetic resonance spectroscopy. Biol Psychiatry 65: 273-275
96. Hercher C, Turecki G, Mechawar N (2009) Through the looking glass: examining neuroanatomical evidence for cellular alterations in major depression. J Psychiatr Res 43: 947-961
97. Hertz L (2004) Intercellular metabolic compartmentation in the brain: past, present and future. Neurochem Int 45: 285-296
98. Hertz L (2006) Glutamate, a neurotransmitter-and so much more: a synopsis of Wierzba III. Neurochem Int 48: 416-425
99. Hettema JM, Neale MC, Kendler KS (2001) A review and meta-analysis of the genetic epidemiology of anxiety disorders. Am J Psychiatry 158: 1568-1578
100. Horn DI, Yu C, Steiner J et al (2010) Glutamatergic and resting-state functional connectivity correlates of severity in major depression-the role of pregenual anterior cingulate cortex and anterior insula. Front Syst Neurosci 4: 33
101. Hu Y, Wilson GS (1997) A temporary local energy pool coupled to neuronal activity: fluctuations of extracellular lactate levels in rat brain monitored with rapid-response enzyme-based sensor. J Neurochem 69: 1484-1490
102. Huey ED, Zahn R, Krueger F, Moll J, Kapogiannis D, Wassermann EM, Grafman J (2008) A psychological and neuroanatomical model of obsessive-compulsive disorder. J Neuropsychiatry Clin Neurosci 20: 390-408
103. Iltis I, Koski DM, Eberly LE et al (2009) Neurochemical changes in the rat prefrontal cortex following acute phencyclidine treatment: an in vivo localized (1)H MRS study. NMR Biomed 22: 737-744
104. Iosifescu DV, Bolo NR, Nierenberg AA, Jensen JE, Fava M, Renshaw PF (2008) Brain bioenergetics and response to triiodothyronine augmentation in major depressive disorder. Biol Psychiatry 63: 1127-1134
105. Jaaro-Peled H, Ayhan Y, Pletnikov MV, Sawa A (2010) Review of pathological hallmarks of schizophrenia: comparison of genetic models with patients and nongenetic models. Schizophr Bull 36: 301-313
106. Janaky R, Cruz-Aguado R, Oja SS, Shaw CA (2007) Glutathione in the nervous system: roles in neural function and health and implications for neurological disease. In: Lajtha A, Oja S, Schousboe A, Saransaari P (eds) Handbook of neurochemistry and molecular neurobiology: amino acids and peptides in the nervous system. Springer, New York
107. Jang JH, Kwon JS, Jang DP et al (2006) A proton MRSI study of brain N-acetylaspartate level after 12 weeks of citalopram treatment in drug-naive patients with obsessive-compulsive disorder. Am J Psychiatry 163: 1202-1207
108. Jensen JE, Miller J, Williamson PC et al (2006) Grey and white matter differences in brain energy metabolism in first episode schizophrenia: 31P-MRS chemical shift imaging at 4 Tesla. Psychiatry Res 146: 127-135
109. Jensen JE, Licata SC, Ongur D, Friedman SD, Prescot AP, Henry ME, Renshaw PF (2009) Quantification of J-resolved proton spectra in two-dimensions with LCModel using GAMMA-simulated basis sets at 4 Tesla. NMR Biomed 22: 762-769
110. Kalra S, Cashman NR, Genge A, Arnold DL (1998) Recovery of N-acetylaspartate in corticomotor neurons of patients with ALS after riluzole therapy. Neuroreport 9: 1757-1761
111. Karl A, Schaefer M, Malta LS, Dorfel D, Rohleder N, Werner A (2006) A meta-analysis of structural brain abnormalities in PTSD. Neurosci Biobehav Rev 30: 1004-1031
112. Karolewicz B, Maciag D, O'Dwyer G, Stockmeier CA, Feyissa AM, Rajkowska G (2010) Reduced level of glutamic acid decarboxylase-67 kDa in the prefrontal cortex in major depression. Int J Neuropsychopharmacol 13: 411-420
113. Kato T, Hamakawa H, Shioiri T, Murashita J, Takahashi Y, Takahashi S, Inubushi T (1996) Choline-containing compounds detected by proton magnetic resonance spectroscopy in the basal ganglia in bipolar disorder. J Psychiatry Neurosci 21: 248-254
114. Kauppinen RA, Williams SR (1991) Nondestructive detection of glutamate by 1H nuclear magnetic resonance spectroscopy in cortical brain slices from the guinea pig: evidence for changes in detectability during severe anoxic insults. J Neurochem 57: 1136-1144
115. Kim H, McGrath BM, Silverstone PH (2005) A review of the possible relevance of inositol and the phosphatidylinositol second messenger system (PI-cycle) to psychiatric disorders-focus on magnetic resonance spectroscopy (MRS) studies. Hum Psychopharmacol 20: 309-326
116. Klein DF (1993) False suffocation alarms, spontaneous panics, and related conditions: an integrative hypothesis. Arch Gen Psychiatry 50: 306-317
117. Klempan TA, Sequeira A, Canetti L, Lalovic A, Ernst C, Ffrench-Mullen J, Turecki G (2009) Altered expression of genes involved in ATP biosynthesis and GABAergic neurotransmission in the ventral prefrontal cortex of suicides with and without major depression. Mol Psychiatry 14: 175-189
118. Knox D, Perrine SA, George SA, Galloway MP, Liberzon I (2010) Single prolonged stress decreases glutamate, glutamine, and creatine concentrations in the rat medial prefrontal cortex. Neurosci Lett 480: 16-20
119. Koenigs M, Huey ED, Raymont V, Cheon B, Solomon J, Wassermann EM, Grafman J (2008) Focal brain damage protects against post-traumatic stress disorder in combat veterans. Nat Neurosci 11: 232-237
120. Koga Y, Takahashi H, Oikawa D, Tachibana T, Denbow DM, Furuse M (2005) Brain creatine functions to attenuate acute stress responses through GABAnergic system in chicks. Neuroscience 132: 65-71
121. Konarski JZ, McIntyre RS, Kennedy SH, Rafi-Tari S, Soczynska JK, Ketter TA (2008) Volumetric neuroimaging investigations in mood disorders: bipolar disorder versus major depressive disorder. Bipolar Disord 10: 1-37
122. Kondo DG, Hellem TL, Sung YH et al (2011) Review: magnetic resonance spectroscopy studies of pediatric major depressive disorder. Depress Res Treat 2011: 650450
123. Kosenko E, Llansola M, Montoliu C et al (2003) Glutamine synthetase activity and glutamine content in brain: modulation by NMDA receptors and nitric oxide. Neurochem Int 43: 493-499
124. Krishnan V, Nestler EJ (2008) The molecular neurobiology of depression. Nature 455: 894-902
125. Lan MJ, McLoughlin GA, Griffin JL et al (2009) Metabonomic analysis identifies molecular changes associated with the pathophysiology and drug treatment of bipolar disorder. Mol Psychiatry 14: 269-279
126. Layton ME, Friedman SD, Dager SR (2001) Brain metabolic changes during lactate-induced panic: effects of gabapentin treatment. Dep Anxiety 14: 251-254
127. Lei H, Berthet C, Hirt L, Gruetter R (2009) Evolution of the neurochemical profile after transient focal cerebral ischemia in the mouse brain. J Cereb Blood Flow Metab 29: 811-819
128. Liberzon I, Sripada CS (2008) The functional neuroanatomy of PTSD: a critical review. Prog Brain Res 167: 151-169
129. Lisman JE, Coyle JT, Green RW, Javitt DC, Benes FM, Heckers S, Grace AA (2008) Circuitbased framework for understanding neurotransmitter and risk gene interactions in schizophrenia. Trends Neurosci 31: 234-242
130. Maciag D, Hughes J, O'Dwyer G, Pride Y, Stockmeier CA, Sanacora G, Rajkowska G (2010) Reduced density of calbindin immunoreactive GABAergic neurons in the occipital cortex in major depression: relevance to neuroimaging studies. Biol Psychiatry 67: 465-470
131. Maciejewski PK, Rothman DL (2008) Proposed cycles for functional glutamate trafficking in synaptic neurotransmission. Neurochem Int 52: 809-825
132. MacMaster FP, Moore GJ, Russell A, Mirza Y, Taormina SP, Buhagiar C, Rosenberg DR (2008) Medial temporal N-acetyl-aspartate in pediatric major depression. Psychiatry Res 164: 86-89
133. Maddock RJ (2001) The lactic acid response to alkalosis in panic disorder: an integrative review. J Neuropsychiatry Clin Neurosci 13: 22-34
134. Maddock RJ, Buonocore MH (2008) Measuring brain lactate at rest and during visual stimulation. Psychiatry Res 162: 175-179
135. Maddock RJ, Buonocore MH (2010) Abnormal metabolic activation of fear and arousal responses as a model of vulnerability to panic disorder. In: Anxiety disorders association of America annual meeting, Baltimore, MA
136. Maddock RJ, BuonocoreMH, Lavoie SP, Copeland LE, Kile SJ, RichardsAL, Ryan JM (2006) Brain lactate responses during visual stimulation in fasting and hyperglycemic subjects: a proton magnetic resonance spectroscopy study at 1. 5 Tesla. Psychiatry Research: Neuroimaging 148: 47-54
137. Maddock RJ, Buonocore MH, Copeland LE, Richards AL (2009) Elevated brain lactate responses to neural activation in panic disorder: a dynamic 1H-MRS study. Mol Psychiatry 14: 537-545
138. Maddock RJ, Casazza GA, Buonocore MH, Tanase C (2011) Vigorous exercise increases brain lactate and Glx (glutamate + glutamine): a dynamic 1H-MRS study. Neuroimage. doi: 10. 1016/j. neuroimage. 2011. 05. 048
139. Mangia S, Tkac I, Gruetter R, Van de Moortele PF, Maraviglia B, Ugurbil K (2007) Sustained neuronal activation raises oxidative metabolism to a new steady-state level: evidence from 1H NMR spectroscopy in the human visual cortex. J Cereb Blood Flow Metab 27: 1055-1063
140. Manji HK, Moore GJ, Chen G (2000) Clinical and preclinical evidence for the neurotrophic effects of mood stabilizers: implications for the pathophysiology and treatment of manicdepressive illness. Biol Psychiatry 48: 740-754
141. Mann EO, Mody I (2010) Control of hippocampal gamma oscillation frequency by tonic inhibition and excitation of interneurons. Nat Neurosci 13: 205-212
142. Mescher M, Merkle H, Kirsch J, Garwood M, Gruetter R (1998) Simultaneous in vivo spectral editing and water suppression. NMR Biomed 11: 266-272
143. Meyer LE, Machado LB, Santiago AP et al (2006) Mitochondrial creatine kinase activity prevents reactive oxygen species generation: antioxidant role of mitochondrial kinasedependent ADP re-cycling activity. J Biol Chem 281: 37361-37371
144. Meyerhoff DJ, MacKay S, Bachman L, Poole N, Dillon WP, Weiner MW, Fein G (1993) Reduced brain N-acetylaspartate suggests neuronal loss in cognitively impaired human immunodeficiency virus-seropositive individuals: in vivo 1H magnetic resonance spectroscopic imaging. Neurology 43: 509-515
145. Meyer-Lindenberg A (2010) From maps to mechanisms through neuroimaging of schizophrenia. Nature 468: 194-202
146. Michael N, Erfurth A, Ohrmann P, Arolt V, Heindel W, Pfleiderer B (2003a) Neurotrophic effects of electroconvulsive therapy: a proton magnetic resonance study of the left amygdalar region in patients with treatment-resistant depression. Neuropsychopharmacology 28: 720-725
147. Michael N, Erfurth A, Ohrmann P, Gossling M, Arolt V, Heindel W, Pfleiderer B (2003b) Acute mania is accompanied by elevated glutamate/glutamine levels within the left dorsolateral prefrontal cortex. Psychopharmacology (Berl) 168: 344-346
148. Michael N, Erfurth A, Pfleiderer B (2009) Elevated metabolites within dorsolateral prefrontal cortex in rapid cycling bipolar disorder. Psychiatry Res 172: 78-81
149. Miguel-Hidalgo JJ, Waltzer R, Whittom AA, Austin MC, Rajkowska G, Stockmeier CA (2010) Glial and glutamatergic markers in depression, alcoholism, and their comorbidity. J Affect Disord 127: 230-240
150. Moffett JR, Ross B, Arun P, Madhavarao CN, Namboodiri AM (2007) N-Acetylaspartate in the CNS: from neurodiagnostics to neurobiology. Prog Neurobiol 81: 89-131
151. Mohamed MA, Smith MA, Schlund MW, Nestadt G, Barker PB, Hoehn-Saric R (2007) Proton magnetic resonance spectroscopy in obsessive-compulsive disorder: a pilot investigation comparing treatment responders and non-responders. Psychiatry Res 156: 175-179
152. Moore CM, Christensen JD, Lafer B, Fava M, Renshaw PF (1997) Lower levels of nucleoside triphosphate in the basal ganglia of depressed subjects: a phosphorous-31 magnetic resonance spectroscopy study. Am J Psychiatry 154: 116-118
153. Moore GJ, Bebchuk JM, Hasanat K et al (2000) Lithium increases N-acetyl-aspartate in the human brain: in vivo evidence in support of bcl-2's neurotrophic effects? Biol Psychiatry 48: 1-8
154. Mullins PG, Rowland LM, Jung RE, Sibbitt WL Jr (2005) A novel technique to study the brain's response to pain: proton magnetic resonance spectroscopy. Neuroimage 26: 642-646
155. Muthukumaraswamy SD, Edden RA, Jones DK, Swettenham JB, Singh KD (2009) Resting GABA concentration predicts peak gamma frequency and fMRI amplitude in response to visual stimulation in humans. Proc Natl Acad Sci U S A 106: 8356-8361
156. Narayanan S, De Stefano N, Francis GS et al (2001) Axonal metabolic recovery in multiple sclerosis patients treated with interferon beta-1b. J Neurol 248: 979-986
157. Neale JH, Bzdega T, Wroblewska B (2000) N-Acetylaspartylglutamate: the most abundant peptide neurotransmitter in the mammalian central nervous system. J Neurochem 75: 443-452
158. O'Donnell T, Rotzinger S, Ulrich M, Hanstock CC, Nakashima TT, Silverstone PH (2003) Effects of chronic lithium and sodium valproate on concentrations of brain amino acids. Eur Neuropsychopharmacol 13: 220-227
159. Ongur D, Jensen JE, Prescot AP, Stork C, Lundy M, Cohen BM, Renshaw PF (2008) Abnormal glutamatergic neurotransmission and neuronal-glial interactions in acute mania. Biol Psychiatry 64: 718-726
160. Ongur D, Prescot AP, McCarthy J, Cohen BM, Renshaw PF (2010) Elevated gammaaminobutyric acid levels in chronic schizophrenia. Biol Psychiatry 68: 667-670
161. Pae CU, Choe BY, Joo RH et al (2004) Neuronal dysfunction of the frontal lobe in schizophrenia. Neuropsychobiology 50: 211-215
162. Pajonk FG, Wobrock T, Gruber O et al (2010) Hippocampal plasticity in response to exercise in schizophrenia. Arch Gen Psychiatry 67: 133-143
163. Patel NC, DelBello MP, Cecil KM, Adler CM, Bryan HS, Stanford KE, Strakowski SM (2006) Lithium treatment effects on myo-inositol in adolescents with bipolar depression. Biol Psychiatry 60: 998-1004
164. Patel NC, DelBello MP, Cecil KM, Stanford KE, Adler CM, Strakowski SM (2008) Temporal change in N-acetyl-aspartate concentrations in adolescents with bipolar depression treated with lithium. J Child Adolesc Psychopharmacol 18: 132-139
165. Pauls DL (2010) The genetics of obsessive-compulsive disorder: a review. Dialogues Clin Neurosci 12: 149-163
166. Pellerin L, Bouzier-SoreAK, Aubert A, Serres S, MerleM, CostalatR, Magistretti PJ (2007)Activitydependent regulation of energy metabolism by astrocytes: an update. Glia 55: 1251-1262
167. Petroff OA, Prichard JW, Behar KL, Alger JR, den Hollander JA, Shulman RG (1985) Cerebral intracellular pH by 31P nuclear magnetic resonance spectroscopy. Neurology 35: 781-788
168. Petroff OA, Hyder F, Rothman DL, Mattson RH (2001) Topiramate rapidly raises brain GABA in epilepsy patients. Epilepsia 42: 543-548
169. Pierre K, Pellerin L (2005) Monocarboxylate transporters in the central nervous system: distribution, regulation and function. J Neurochem 94: 1-14
170. Port JD, Unal SS, Mrazek DA, Marcus SM (2008) Metabolic alterations in medication-free patients with bipolar disorder: a 3T CSF-corrected magnetic resonance spectroscopic imaging study. Psychiatry Res 162: 113-121
171. Pouwels PJ, Frahm J (1997) Differential distribution of NAA and NAAG in human brain as determined by quantitative localized proton MRS. NMR Biomed 10: 73-78
172. Premkumar P, Parbhakar VA, Fannon D, Lythgoe D, Williams SC, Kuipers E, Kumari V (2010) N-acetyl aspartate concentration in the anterior cingulate cortex in patients with schizophrenia: a study of clinical and neuropsychological correlates and preliminary exploration of cognitive behaviour therapy effects. Psychiatry Res 182: 251-260
173. Price RB, Shungu DC, Mao X et al (2009) Amino acid neurotransmitters assessed by proton magnetic resonance spectroscopy: relationship to treatment resistance in major depressive disorder. Biol Psychiatry 65: 792-800
174. Prichard J, Rothman D, Novotny E et al (1991) Lactate rise detected by 1H NMR in human visual cortex during physiologic stimulation. Proc Natl Acad Sci U S A 88: 5829-5831
175. Protopopescu X, Pan H, Tuescher O et al (2006) Increased brainstem volume in panic disorder: a voxel-based morphometric study. Neuroreport 17: 361-363
176. Qu Y, Massie A, Van der Gucht E et al (2003) Retinal lesions affect extracellular glutamate levels in sensory-deprived and remote non-deprived regions of cat area 17 as revealed by in vivo microdialysis. Brain Res 962: 199-206
177. Quiroz JA, Machado-Vieira R, Zarate CA Jr, Manji HK (2010) Novel insights into lithium's mechanism of action: neurotrophic and neuroprotective effects. Neuropsychobiology 62: 50-60
178. Radua J, Mataix-Cols D (2009) Voxel-wise meta-analysis of grey matter changes in obsessivecompulsive disorder. Br J Psychiatry 195: 393-402
179. Radua J, van den Heuvel OA, Surguladze S, Mataix-Cols D (2010) Meta-analytical comparison of voxel-based morphometry studies in obsessive-compulsive disorder vs other anxiety disorders. Arch Gen Psychiatry 67: 701-711
180. Rajkowska G, O'Dwyer G, Teleki Z, Stockmeier CA, Miguel-Hidalgo JJ (2007) GABAergic neurons immunoreactive for calcium binding proteins are reduced in the prefrontal cortex in major depression. Neuropsychopharmacology 32: 471-482
181. Reynolds LM, Reynolds GP (2011) Differential regional N-acetylaspartate deficits in postmortem brain in schizophrenia, bipolar disorder and major depressive disorder. J Psychiatr Res 45: 54-59
182. Rodrigo R, Felipo V (2007) Control of brain glutamine synthesis by NMDA receptors. Front Biosci 12: 883-890
183. Roelants-Van Rijn AM, van der Grond J, de Vries LS, Groenendaal F (2001) Value of (1)H-MRS using different echo times in neonates with cerebral hypoxia-ischemia. Pediatr Res 49: 356-362
184. Rotge JY, Guehl D, Dilharreguy B et al (2009) Meta-analysis of brain volume changes in obsessive-compulsive disorder. Biol Psychiatry 65: 75-83
185. Rothman DL, Behar KL, Hyder F, Shulman RG (2003) In vivo NMR studies of the glutamate neurotransmitter flux and neuroenergetics: implications for brain function. Annu Rev Physiol 65: 401-427
186. Rowland LM, Bustillo JR, Mullins PG et al (2005) Effects of ketamine on anterior cingulate glutamate metabolism in healthy humans: a 4-T proton MRS study. Am J Psychiatry 162: 394-396
187. Royes LF, Fighera MR, Furian AF et al (2008) Neuromodulatory effect of creatine on extracellular action potentials in rat hippocampus: role of NMDA receptors. Neurochem Int 53: 33-37
188. Salo R, Buonocore MH, Leamon M et al (2011) Extended findings of brain metabolite normalization in MA-dependent subjects across sustained abstinence: a proton MRS study. Drug Alcohol Depend 113: 133-138
189. Sanacora G, Mason GF, Rothman DL et al (1999) Reduced cortical gamma-aminobutyric acid levels in depressed patients determined by proton magnetic resonance spectroscopy. Arch Gen Psychiatry 56: 1043-1047
190. Sanacora G, Mason GF, Rothman DL, Krystal JH (2002) Increased occipital cortex GABA concentrations in depressed patients after therapy with selective serotonin reuptake inhibitors. Am J Psychiatry 159: 663-665
191. Sanacora G, Mason GF, Rothman DL et al (2003) Increased cortical GABA concentrations in depressed patients receiving ECT. Am J Psychiatry 160: 577-579
192. Sanacora G, Gueorguieva R, Epperson CN et al (2004) Subtype-specific alterations of gammaaminobutyric acid and glutamate in patients with major depression. Arch Gen Psychiatry 61: 705-713
193. Sanacora G, Fenton LR, Fasula MK, Rothman DL, Levin Y, Krystal JH, Mason GF (2006) Cortical gamma-aminobutyric acid concentrations in depressed patients receiving cognitive behavioral therapy. Biol Psychiatry 59: 284-286
194. Sappey-Marinier D, Calabrese G, Fein G, Hugg JW, Biggins C, Weiner MW (1992) Effect of photic stimulation on human visual cortex lactate and phosphates using 1H and 31P magnetic resonance spectroscopy. J Cereb Blood Flow Metab 12: 584-592
195. Savitz J, Drevets WC (2009) Bipolar and major depressive disorder: neuroimaging the developmental-degenerative divide. Neurosci Biobehav Rev 33: 699-771
196. Schmidt H, Schwaller B, Eilers J (2005) Calbindin D28k targets myo-inositol monophosphatase in spines and dendrites of cerebellar Purkinje neurons. Proc Natl Acad Sci U S A 102: 5850-5855
197. Schuff N, Neylan TC, Fox-Bosetti S et al (2008) Abnormal N-acetylaspartate in hippocampus and anterior cingulate in posttraumatic stress disorder. Psychiatry Res 162: 147-157
198. Selemon LD, Goldman-Rakic PS (1999) The reduced neuropil hypothesis: a circuit based model of schizophrenia. Biol Psychiatry 45: 17-25
199. Senaratne R, Milne AM, MacQueen GM, Hall GB (2009) Increased choline-containing compounds in the orbitofrontal cortex and hippocampus in euthymic patients with bipolar disorder: a proton magnetic resonance spectroscopy study. Psychiatry Res 172: 205-209
200. Sequeira A, Mamdani F, Ernst C et al (2009) Global brain gene expression analysis links glutamatergic and GABAergic alterations to suicide and major depression. PLoS One 4: e6585
201. Shibuya-Tayoshi S, Tayoshi S, Sumitani S, Ueno S, Harada M, Ohmori T (2008) Lithium effects on brain glutamatergic and GABAergic systems of healthy volunteers as measured by proton magnetic resonance spectroscopy. Prog Neuropsychopharmacol Biol Psychiatry 32: 249-256
202. Shirayama Y, Obata T, Matsuzawa D et al (2010) Specific metabolites in the medial prefrontal cortex are associated with the neurocognitive deficits in schizophrenia: a preliminary study. Neuroimage 49: 2783-2790
203. Siegmund A, Kaltwasser SF, Holsboer F, Czisch M, Wotjak CT (2009) Hippocampal Nacetylaspartate levels before trauma predict the development of long-lasting posttraumatic stress disorder-like symptoms in mice. Biol Psychiatry 65: 258-262
204. Signoretti S, Di Pietro V, Vagnozzi R et al (2010) Transient alterations of creatine, creatine phosphate, N-acetylaspartate and high-energy phosphates after mild traumatic brain injury in the rat. Mol Cell Biochem 333: 269-277
205. Silverstone PH, McGrath BM (2009) Lithium and valproate and their possible effects on themyoinositol second messenger system in healthy volunteers and bipolar patients. Int Rev Psychiatry 21: 414-423
206. Smesny S, Rosburg T, Nenadic I et al (2007) Metabolic mapping using 2D 31P-MR spectroscopy reveals frontal and thalamic metabolic abnormalities in schizophrenia. Neuroimage 35: 729-737
207. Smith EA, Russell A, Lorch E et al (2003) Increased medial thalamic choline found in pediatric patients with obsessive-compulsive disorder versus major depression or healthy control subjects: a magnetic resonance spectroscopy study. Biol Psychiatry 54: 1399-1405
208. Star-Lack J, Spielman D, Adalsteinsson E, Kurhanewicz J, Terris DJ, Vigneron DB (1998) In vivo lactate editing with simultaneous detection of choline, creatine, NAA, and lipid singlets at 1. 5 T using PRESS excitation with applications to the study of brain and head and neck tumors. J Magn Reson 133: 243-254
209. Steen RG, Hamer RM, Lieberman JA (2005) Measurement of brain metabolites by 1H magnetic resonance spectroscopy in patients with schizophrenia: a systematic review and meta-analysis. Neuropsychopharmacology 30: 1949-1962
210. Stone JM (2009) Imaging the glutamate system in humans: relevance to drug discovery for schizophrenia. Curr Pharm Des 15: 2594-2602
211. Stork C, Renshaw PF (2005) Mitochondrial dysfunction in bipolar disorder: evidence from magnetic resonance spectroscopy research. Mol Psychiatry 10: 900-919
212. Taylor MJ, Selvaraj S, Norbury R, Jezzard P, Cowen PJ (2009) Normal glutamate but elevated myo-inositol in anterior cingulate cortex in recovered depressed patients. J Affect Disord 119: 186-189
213. Tayoshi S, Nakataki M, Sumitani S et al (2011) GABA concentration in schizophrenia patients and the effects of antipsychotic medication: a proton magnetic resonance spectroscopy study. Schizophr Res 117: 83-91
214. Theberge J, Bartha R, Drost DJ et al (2002) Glutamate and glutamine measured with 4. 0 T proton MRS in never-treated patients with schizophrenia and healthy volunteers. Am J Psychiatry 159: 1944-1946
215. Theberge J, Al-Semaan Y, Williamson PC et al (2003) Glutamate and glutamine in the anterior cingulate and thalamus of medicated patients with chronic schizophrenia and healthy comparison subjects measured with 4. 0-T proton MRS. Am J Psychiatry 160: 2231-2233
216. Trzesniak C, Araujo D, Crippa JAS (2008) Magnetic resonance spectroscopy in anxiety disorders. Acta Neuropsychiatr 20: 56-71
217. Uchida RR, Del-Ben CM, Busatto GF et al (2008) Regional gray matter abnormalities in panic disorder: a voxel-based morphometry study. Psychiatry Res 163: 21-29
218. Uhlhaas PJ, Singer W (2010) Abnormal neural oscillations and synchrony in schizophrenia. Nat Rev Neurosci 11: 100-113
219. Urenjak J, Williams SR, Gadian DG, Noble M (1993) Proton nuclear magnetic resonance spectroscopy unambiguously identifies different neural cell types. J Neurosci 13: 981-989
220. Valentine GW, Sanacora G (2009) Targeting glial physiology and glutamate cycling in the treatment of depression. Biochem Pharmacol 78: 431-439
221. van Tol MJ, van der Wee NJ, van den Heuvel OA et al (2010) Regional brain volume in depression and anxiety disorders. Arch Gen Psychiatry 67: 1002-1011
222. Volz HP, Rzanny R, Riehemann S et al (1998) 31P magnetic resonance spectroscopy in the frontal lobe of major depressed patients. Eur Arch Psychiatry Clin Neurosci 248: 289-295
223. Waagepetersen HS, Sonnewald U, Schousboe A (2007) Glutamine, Glutamate, and GABA: metabolic aspects. In: Lajtha A, Oja S, Schousboe A, Saransaari P (eds) Handbook of neurochemistry and molecular neurobiology: amino acids and peptides in the nervous system. Springer, New York, pp 1-21
224. Walter M, Henning A, Grimm S et al (2009) The relationship between aberrant neuronal activation in the pregenual anterior cingulate, altered glutamatergic metabolism, and anhedonia in major depression. Arch Gen Psychiatry 66: 478-486
225. Weber OM, Verhagen A, Duc CO, Meier D, Leenders KL, Boesiger P (1999) Effects of vigabatrin intake on brain GABA activity as monitored by spectrally edited magnetic resonance spectroscopy and positron emission tomography. Magn Reson Imaging 17: 417-425
226. Williams RS, Cheng L, Mudge AW, Harwood AJ (2002) A common mechanism of action for three mood-stabilizing drugs. Nature 417: 292-295
227. Winsberg ME, Sachs N, Tate DL, Adalsteinsson E, Spielman D, Ketter TA (2000) Decreased dorsolateral prefrontal N-acetyl aspartate in bipolar disorder. Biol Psychiatry 47: 475-481
228. Wright IC, Rabe-Hesketh S, Woodruff PW, David AS, Murray RM, Bullmore ET (2000) Metaanalysis of regional brain volumes in schizophrenia. Am J Psychiatry 157: 16-25
229. Wu Y, Wang W, Diez-Sampedro A, Richerson GB (2007) Nonvesicular inhibitory neurotransmission via reversal of the GABA transporter GAT-1. Neuron 56: 851-865
230. Yacubian J, de Castro CC, Ometto M et al (2002) 31P-spectroscopy of frontal lobe in schizophrenia: alterations in phospholipid and high-energy phosphate metabolism. Schizophr Res 58: 117-122
231. Yang D, Xie Z, Stephenson D et al (2011) Volumetric MRI and MRS provide sensitive measures of Alzheimer's disease neuropathology in inducible Tau transgenic mice (rTg4510). Neuroimage 54: 2652-2658
232. Yildiz A, Sachs GS, Dorer DJ, Renshaw PF (2001) 31P Nuclear magnetic resonance spectroscopy findings in bipolar illness: a meta-analysis. Psychiatry Res 106: 181-191
233. Yildiz-Yesiloglu A, Ankerst DP (2006a) Neurochemical alterations of the brain in bipolar disorder and their implications for pathophysiology: a systematic review of the in vivo proton magnetic resonance spectroscopy findings. Prog Neuropsychopharmacol Biol Psychiatry 30: 969-995
234. Yildiz-Yesiloglu A, Ankerst DP (2006b) Review of 1H magnetic resonance spectroscopy findings in major depressive disorder: a meta-analysis. Psychiatry Res 147: 1-25
235. Yoon JH, Rokem AS, Silver MA, Minzenberg MJ, Ursu S, Ragland JD, Carter CS (2009) Diminished orientation-specific surround suppression of visual processing in schizophrenia. Schizophr Bull 35: 1078-1084
236. Yoon JH, Maddock RJ, Rokem A, Silver MA, Minzenberg MJ, Ragland JD, Carter CS (2010a) GABA concentration is reduced in visual cortex in schizophrenia and correlates with orientation-specific surround suppression. J Neurosci 30: 3777-3781
237. Yoon SJ, Lyoo IK, Kim HJ et al (2010b) Neurochemical alterations in methamphetaminedependent patients treated with cytidine-50-diphosphate choline: a longitudinal proton magnetic resonance spectroscopy study. Neuropsychopharmacology 35: 1165-1173
238. Yucel M, Harrison BJ, Wood SJ et al (2007) Functional and biochemical alterations of the medial frontal cortex in obsessive-compulsive disorder. Arch Gen Psychiatry 64: 946-955
239. Yue Q, Shibata Y, Isobe T, Anno I, Kawamura H, Gong QY, Matsumura A (2009) Absolute choline concentration measured by quantitative proton MR spectroscopy correlates with cell density in meningioma. Neuroradiology 51: 61-67
240. Yuksel C, Ongur D (2010) Magnetic resonance spectroscopy studies of glutamate-related abnormalities in mood disorders. Biol Psychiatry 68: 785-794
241. Zarate CA Jr, Singh JB, Carlson PJ et al (2006) A randomized trial of an N-methyl-D-aspartate antagonist in treatment-resistant major depression. Arch Gen Psychiatry 63: 856-864
242. Ziemann AE, Allen JE, Dahdaleh NS et al (2009) The amygdala is a chemosensor that detects carbon dioxide and acidosis to elicit fear behavior. Cell 139: 1012-1021
243. Zink M, Vollmayr B, Gebicke-Haerter PJ, Henn FA (2010) Reduced expression of glutamate transporters vGluT1, EAAT2 and EAAT4 in learned helpless rats, an animal model of depression. Neuropharmacology 58: 465-473