Differential distribution of NAA and NAAG in human brain as determined by quantitative localized proton MRS

NMR in Biomedicine

Volumn 10, Issue 2, 1997, Pages 73-78

  Pouwels, Petra J W ^a   Frahm, Jens ^a  

^a Biomedizinische NMR Forschungs GmbH   (Germany)

Author keywords

Human brain; N acetylaspartate; N acetylaspartylglutamate; Proton spectroscopy

Indexed keywords

N ACETYLASPARTIC ACID; N ACETYLASPARTYLGLUTAMIC ACID;

ADULT; ARTICLE; BRAIN SCINTISCANNING; HUMAN; HUMAN EXPERIMENT; IMAGE ENHANCEMENT; IMAGE QUALITY; NORMAL HUMAN; PRIORITY JOURNAL; PROTEIN LOCALIZATION; PROTON NUCLEAR MAGNETIC RESONANCE; TISSUE DISTRIBUTION;

ADOLESCENT; ADULT; ASPARTIC ACID; BRAIN; DIPEPTIDES; FEASIBILITY STUDIES; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE SPECTROSCOPY; PROTONS; TISSUE DISTRIBUTION;

EID: 0030846501     PISSN: 09523480     EISSN: None     Source Type: Journal    
DOI: 10.1002/(SICI)1099-1492(199704)10:2<73::AID-NBM448>3.0.CO;2-4     Document Type: Article

References (30)

1. 1H NMR spectroscopic studies of brain. Neurosci. Biobehav. Rev. 13, 23-31 (1989).
2. 1H NMR spectra of human brain in vivo. NMR Biomed. 4, 201-204 (1991).
3. 1H NMR properties of N-acetylaspartylglutamate in extracts of nervous tissue of the rat. NMR Biomed. 5, 43-47 (1992).
4. Tallan, H. H., Moore, S. and Stein, W. H. N-Acetyt-L-aspartic acid in brain. J. Biol. Chem. 219, 257-264 (1956).
5. Nadler, J. V. and Cooper, J. R. N-Acetyl-L-aspartic acid content of human neural tumours and bovine peripheral nervous tissues. J. Neurochem. 19, 313-319 (1972).
6. Blakely, R. D. and Coyle, J. T. The neurobiology of N-acetylaspartylglutamate. Int. Rev. Neurobiol. 30, 39-100 (1988).
7. Moffett, J. R., Namboodiri, M. A. A., Cangro, C. B. and Neale, J. H. Immuno-histochemical localization of N-acetylaspartate in rat brain. Neuroreport 2, 131-134 (1991).
8. Simmons, M. L., Frondoza, C. G. and Coyle, J. T. Immunocytochemical localization of N-acetylaspartate with monoclonal antibodies. Neurosci. 45, 37-45 (1991).
9. Urenjak, J., Williams, S. R., Gadian, D. G. and Noble, M. Specific expression of N-acetylaspartate in neurons, oligodendrocyte-type-2 astrocyte progenitors, and immature oligodendrocytes in vitro. J. Neurochem. 59, 55-61 (1992).
10. Moffett, J. R. and Namboodiri, M. A. A. Differential distribution of N-acetylaspartylglutamate and N-acetylaspartate immunoreactivities in rat forebrain. J. Neurocytol. 24, 409-433 (1995).
11. Mehta, V. and Namboodiri, M. A. A. N-Acetylaspartate as an acetyl source in the nervous system. Mol. Brain Res. 31, 151-157 (1995).
12. Taylor, D. L., Davies, S. E. C., Obrenovitch, T. P., Doheny, M. H., Patsalos, P. N., Clark, J. B. and Symon, L. Investigation into the role of N-acetylaspartate in cerebral osmoregulation. J. Neurochem. 65, 275-281 (1995).
13. 1H NMR spectroscopy of human brain. Water suppression, short echo times and 1 ml resolution. J. Magn. Reson. 90, 464-473 (1990).
14. Klose, U. In vivo proton spectroscopy in presence of eddy currents. Magn. Reson. Med. 14, 26-30 (1990).
15. Michaelis, T., Merboldt, K.-D., Bruhn, H., Hänicke, W. and Frahm, J. Absolute concentrations of metabolites in the adult human brain in vivo: quantification of localized proton MR spectra. Radiology 187, 219-227 (1993).
16. Provencher, S. W. Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magn. Reson. Med. 30, 672-679 (1993).
17. Ernst, T., Kreis, R. and Ross, B. D. Absolute quantitation of water and metabolites in the human brain. I. Compartments and water. J. Magn. Reson. B 102, 1-8 (1993).
18. Hennig, J., Pfister, H., Ernst, T. and Ott, D. Direct absolute quantification of metabolites in the human brain with in vivo localized proton spectroscopy. NMR Biomed. 5, 193-199 (1992).
19. Christiansen, P., Toft, P., Larsson, H. B. W., Stubgaard, M. and Henriksen, O. The concentration of N-acetylaspartate, creatine + phosphocreatine, and choline in different parts of the brain in adulthood and senium. Magn. Reson. Imag. 11, 799-606 (1993).
20. Kreis, R., Ernst, T. and Ross, B. D. Absolute quantitation of water and metabolites in the human brain. II. Metabolite concentrations. J. Magn. Reson. B 102, 9-19 (1993).
21. Tedeschi, G., Bertolino, A., Righini, A., Campbell, G., Raman, R., Duyn, J. H., Moonen, C. T. W., Alger, J. R. and Di Chiro, G. Brain regional distribution pattern of metabolite signal intensities in young adults by proton magnetic resonance spectroscopic imaging. Neurology 45, 1384-1391 (1995).
22. Soher, B. J., van Zijl, P. C. M., Duyn, J. H. and Barker, P. B. Quantitative proton MR spectroscopic imaging of the human brain. Magn. Reson. Med. 35, 356-363 (1996).
23. 1H spectroscopic imaging of human brain at 4.1 T using image segmentation. Magn. Reson. Med. 36, 21-29 (1996).
24. Rockel, A. J., Hiorns, R. W. and Powell, T. P. S. The basic uniformity in structure of the neocortex. Brain 103, 221-244 (1980).
25. Leuba, G., Garey, L. J. Comparison of neuronal and glial numerical density in primary and secondary visual cortex of man. Exp. Brain Res. 77, 31-38 (1989).
26. Moffett, J. R., Namboodiri, M. A. A. and Neale, J. H. Enhanced carbodiimide fixation for immunohistochemistry: application to the comparative distributions of N-acetylaspartylglutamate and N-acetylaspartate immunoreactivities in rat brain. J. Histochem. Cytochem. 41, 559-570 (1993).
27. Tsai, G., Slusher, B. S., Sim, L., Hedreen, J. C., Rothstein, J. D., Kuncl, R. and Coyle, J. T. Reductions in acidic amino acids and N-acetylaspartylglutamate in amyotropic lateral sclerosis CNS. Brain Res. 556, 151-156 (1991).
28. Plaitakis, A. and Constantakakis, E. Altered metabolism of excitatory amino acids, N-acetylaspartate and N-acetylaspartylglutamate in amyotrophic lateral sclerosis. Brain Res. Bull. 30, 381-386 (1993).
29. Jaarsma, D., Veenma-van der Duin, L. and Korf, J. N-Acetylaspartate and N-acetylaspartylglutamate levels in Alzheimer's disease post-mortem brain tissue. J. Neurol. Sci. 127, 230-233 (1994).
30. Tsai, G., Passani, L. A., Slusher, B. S., Carter, R., Baer, L., Kleinman, J. E. and Coyle, J. T. Abnormal excitatory neurotransmitter metabolism in schizophrenic brains. Arch. Gen. Psychiatry 52, 829-836 (1995).