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Volumn 248, Issue 11, 2001, Pages 979-986

Axonal metabolic recovery in multiple sclerosis patients treated with interferon β-1b

Author keywords

Axons; Interferon beta; Magnetic resonance spectroscopy; Multiple sclerosis; N acetylaspartate

Indexed keywords

BIOLOGICAL MARKER; CREATINE; INTERFERON BETA SERINE; N ACETYLASPARTIC ACID;

EID: 0035788425     PISSN: 03405354     EISSN: None     Source Type: Journal    
DOI: 10.1007/s004150170052     Document Type: Article
Times cited : (161)

References (61)
  • 1
    • 0018394631 scopus 로고
    • A histological, histochemical and biochemical study of the macroscopically normal white matter in multiple sclerosis
    • Allen IV, McKeown SR. A histological, histochemical and biochemical study of the macroscopically normal white matter in multiple sclerosis. J Neurol Sci 1979; 41(1):81-91
    • (1979) J Neurol Sci , vol.41 , Issue.1 , pp. 81-91
    • Allen, I.V.1    McKeown, S.R.2
  • 2
    • 0043073943 scopus 로고
    • Reversible reduction of N-acetylaspartate after acute central nervous system damage
    • Arnold DL. Reversible reduction of N-acetylaspartate after acute central nervous system damage. In: Society of Magnetic Resonance in Medicine; 1992; 1992. p. 643
    • (1992) Society of Magnetic Resonance in Medicine , vol.1992 , pp. 643
    • Arnold, D.L.1
  • 3
    • 0025295740 scopus 로고
    • Proton magnetic resonance spectroscopy of human brain in vivo in the evaluation of multiple sclerosis: Assessment of the load of disease
    • Arnold DL, Matthews PM, Francis G, Antel J. Proton magnetic resonance spectroscopy of human brain in vivo in the evaluation of multiple sclerosis: assessment of the load of disease. Magn Res Med 1990; 14:154-159
    • (1990) Magn Res Med , vol.14 , pp. 154-159
    • Arnold, D.L.1    Matthews, P.M.2    Francis, G.3    Antel, J.4
  • 4
    • 0029767436 scopus 로고    scopus 로고
    • Inhibition of N-acetylaspartate production: Implications for 1H MRS studies in vivo
    • Bates TE, Strangward M, Keelan J, Davey GP, Munro PM, Clark JB. Inhibition of N-acetylaspartate production: implications for 1H MRS studies in vivo. Neuroreport 1996; 7(8):1397-1400
    • (1996) Neuroreport , vol.7 , Issue.8 , pp. 1397-1400
    • Bates, T.E.1    Strangward, M.2    Keelan, J.3    Davey, G.P.4    Munro, P.M.5    Clark, J.B.6
  • 5
    • 0032966258 scopus 로고    scopus 로고
    • Interferon-gamma secretion by peripheral blood T-cell subsets in multiple sclerosis: Correlation with disease phase and interferon-beta therapy
    • Becher B, Giacomini PS, Pelletier D, McCrea E, Prat A, Antel JP. Interferon-gamma secretion by peripheral blood T-cell subsets in multiple sclerosis: correlation with disease phase and interferon-beta therapy. Ann Neurol 1999; 45(2):247-250
    • (1999) Ann Neurol , vol.45 , Issue.2 , pp. 247-250
    • Becher, B.1    Giacomini, P.S.2    Pelletier, D.3    McCrea, E.4    Prat, A.5    Antel, J.P.6
  • 6
    • 0033961818 scopus 로고    scopus 로고
    • In vitro expression of N-acetyl aspartate by oligodendrocytes: Implications for proton magnetic resonance spectroscopy signal in vivo
    • Bhakoo KK, Pearce D. In vitro expression of N-acetyl aspartate by oligodendrocytes: implications for proton magnetic resonance spectroscopy signal in vivo. J Neurochem 2000; 74(1):254-262
    • (2000) J Neurochem , vol.74 , Issue.1 , pp. 254-262
    • Bhakoo, K.K.1    Pearce, D.2
  • 8
    • 0026751712 scopus 로고
    • Multiple sclerosis in children, cerebral metabolic alterations monitored by localized proton magnetic resonance spectroscopy in vivo
    • Bruhn H, Frahm J, Merboldt KD, Hanicke W, Hanefeld F, Christen HJ, et al. Multiple sclerosis in children: cerebral metabolic alterations monitored by localized proton magnetic resonance spectroscopy in vivo. Ann Neurol 1992; 32(2):140-150
    • (1992) Ann Neurol , vol.32 , Issue.2 , pp. 140-150
    • Bruhn, H.1    Frahm, J.2    Merboldt, K.D.3    Hanicke, W.4    Hanefeld, F.5    Christen, H.J.6
  • 9
    • 0000361150 scopus 로고
    • Histologie de la sclerose en plaques
    • Charcot M. Histologie de la sclerose en plaques. Gaz Hosp 1868; 141:554-555, 557-558
    • (1868) Gaz Hosp , vol.141 , pp. 554-555
    • Charcot, M.1
  • 10
    • 0002109016 scopus 로고    scopus 로고
    • Relation of cerebral atrophy in multiple sclerosis to severity of disease and axonal injury. American Academy of Neurology, 52nd Annual Meeting, San Diego CA
    • Collins DL, Narayanan S, Caramanos Z, De Stefano N, Tartaglia MC, Arnold DL. Relation of cerebral atrophy in multiple sclerosis to severity of disease and axonal injury. American Academy of Neurology, 52nd Annual Meeting, San Diego, CA. Neurology 2000; 54 Supp. 3:A17
    • (2000) Neurology , vol.54 , Issue.SUPP. 3
    • Collins, D.L.1    Narayanan, S.2    Caramanos, Z.3    De Stefano, N.4    Tartaglia, M.C.5    Arnold, D.L.6
  • 11
    • 0034068954 scopus 로고    scopus 로고
    • Early N-acetylaspartate depletion is a marker of neuronal dysfunction in rats and primates chronically treated with the mitochondrial toxin 3- nitropropionic acid
    • Dautry C,Vaufrey F, Brouillet E, Bizat N, Henry PG, Conde F, et al. Early N-acetylaspartate depletion is a marker of neuronal dysfunction in rats and primates chronically treated with the mitochondrial toxin 3- nitropropionic acid. J Cereb Blood Flow Metab 2000; 20(5):789-799
    • (2000) J Cereb Blood Flow Metab , vol.20 , Issue.5 , pp. 789-799
    • Dautry, C.1    Vaufrey, F.2    Brouillet, E.3    Bizat, N.4    Henry, P.G.5    Conde, F.6
  • 12
    • 0028265609 scopus 로고
    • Serial proton magnetic resonance spectroscopy in acute multiple sclerosis lesions
    • Davie CA, Hawkins CP, Barker GJ, Brennan A, Tofts PS, Miller DH, et al. Serial proton magnetic resonance spectroscopy in acute multiple sclerosis lesions. Brain 1994; 117:49-58
    • (1994) Brain , vol.117 , pp. 49-58
    • Davie, C.A.1    Hawkins, C.P.2    Barker, G.J.3    Brennan, A.4    Tofts, P.S.5    Miller, D.H.6
  • 14
    • 0000475729 scopus 로고
    • Analysis of NMR data using time domain fitting procedures
    • Berlin: Springer-Verlag
    • de Beer R, van Ormondt D. Analysis of NMR data using time domain fitting procedures. In: NMR Basic Principles and Progress. Berlin: Springer-Verlag; 1992. p. 204-248
    • (1992) NMR Basic Principles and Progress , pp. 204-248
    • De Beer, R.1    Van Ormondt, D.2
  • 15
    • 0028792005 scopus 로고
    • Reversible decreases in N-acetylaspartate after acute brain injury
    • De Stefano N, Matthews PM, Arnold DL. Reversible decreases in N-acetylas-partate after acute brain injury. Magn Reson Med 1995; 34(5):721-727
    • (1995) Magn Reson Med , vol.34 , Issue.5 , pp. 721-727
    • De Stefano, N.1    Matthews, P.M.2    Arnold, D.L.3
  • 17
    • 0032852674 scopus 로고    scopus 로고
    • In vivo evidence for axonal dysfunction remote from focal cerebral demyelination of the type seen in multiple sclerosis
    • De Stefano N, Narayanan S, Matthews PM, Francis GS, Antel JP, Arnold DL. In vivo evidence for axonal dysfunction remote from focal cerebral demyelination of the type seen in multiple sclerosis. Brain 1999; 122(Pt 10):1933-1939
    • (1999) Brain , vol.122 , Issue.PART 10 , pp. 1933-1939
    • De Stefano, N.1    Narayanan, S.2    Matthews, P.M.3    Francis, G.S.4    Antel, J.P.5    Arnold, D.L.6
  • 19
    • 0031002545 scopus 로고    scopus 로고
    • Axonal damage in acute multiple sclerosis lesions
    • Ferguson B, Matyszak MK, Esiri MM, Perry VH. Axonal damage in acute multiple sclerosis lesions. Brain 1997; 120(Pt 3):393-399
    • (1997) Brain , vol.120 , Issue.PART 3 , pp. 393-399
    • Ferguson, B.1    Matyszak, M.K.2    Esiri, M.M.3    Perry, V.H.4
  • 20
    • 0031839220 scopus 로고    scopus 로고
    • Magnetization transfer changes in the normal appearing white matter precede the appearance of enhancing lesions in patients with multiple sclerosis
    • Filippi M, Rocca MA, Martino G, Horsfield MA, Comi G. Magnetization transfer changes in the normal appearing white matter precede the appearance of enhancing lesions in patients with multiple sclerosis. Ann Neurol 1998; 43(6):809-814
    • (1998) Ann Neurol , vol.43 , Issue.6 , pp. 809-814
    • Filippi, M.1    Rocca, M.A.2    Martino, G.3    Horsfield, M.A.4    Comi, G.5
  • 21
    • 0029075525 scopus 로고
    • A magnetization transfer imaging study of normal-appearing white matter in multiple sclerosis
    • Filippi M, Campi A, Dousset V, Baratti C, Martinelli V, Canal N, et al. A magnetization transfer imaging study of normal-appearing white matter in multiple sclerosis. Neurology 1995; 45(3 Pt 1):478-482
    • (1995) Neurology , vol.45 , Issue.3 PART 1 , pp. 478-482
    • Filippi, M.1    Campi, A.2    Dousset, V.3    Baratti, C.4    Martinelli, V.5    Canal, N.6
  • 22
    • 0034700989 scopus 로고    scopus 로고
    • Progressive cerebral atrophy in MS: A serial study using registered, volumetric MRI
    • Fox NC, Jenkins R, Leary SM, Stevenson VL, Losseff NA, Crum WR, et al. Progressive cerebral atrophy in MS: a serial study using registered, volumetric MRI [see comments]. Neurology 2000; 54(4):807-812
    • (2000) Neurology , vol.54 , Issue.4 , pp. 807-812
    • Fox, N.C.1    Jenkins, R.2    Leary, S.M.3    Stevenson, V.L.4    Losseff, N.A.5    Crum, W.R.6
  • 23
    • 0031962941 scopus 로고    scopus 로고
    • Imaging axonal damage of normal-appearing white matter in multiple sclerosis
    • Fu L, Matthews PM, De Stefano N, Worsley KJ, Narayanan S, Francis GS, et al. Imaging axonal damage of normal-appearing white matter in multiple sclerosis. Brain 1998; 121(Pt 1):103-113
    • (1998) Brain , vol.121 , Issue.PART 1 , pp. 103-113
    • Fu, L.1    Matthews, P.M.2    De Stefano, N.3    Worsley, K.J.4    Narayanan, S.5    Francis, G.S.6
  • 24
    • 0000256414 scopus 로고
    • Multiple chemical shift selective NMR imaging using stimulated echoes
    • Haase A, Frahm J. Multiple chemical shift selective NMR imaging using stimulated echoes. J. Magn. Reson. 1985(64):94-102
    • (1985) J Magn Reson , Issue.64 , pp. 94-102
    • Haase, A.1    Frahm, J.2
  • 25
    • 0028147810 scopus 로고
    • Biochemical alterations in multiple sclerosis lesions and normal-appearing white matter detected by in vivo 31p and 1H spectroscopic imaging
    • Husted CA, Goodin DS, Hugg JW, Maudsley AA, Tsuruda JS, de Bie SH, et al. Biochemical alterations in multiple sclerosis lesions and normal-appearing white matter detected by in vivo 31P and 1H spectroscopic imaging. Ann Neurol 1994; 36:157-165
    • (1994) Ann Neurol , vol.36 , pp. 157-165
    • Husted, C.A.1    Goodin, D.S.2    Hugg, J.W.3    Maudsley, A.A.4    Tsuruda, J.S.5    De Bie, S.H.6
  • 27
    • 0033615575 scopus 로고    scopus 로고
    • The pathology of multiple sclerosis and its evolution
    • Lassmann H. The pathology of multiple sclerosis and its evolution. Philos Trans R Soc Lond B Biol Sci 1999; 354(1390):1635-1640
    • (1999) Philos Trans R Soc Lond B Biol Sci , vol.354 , Issue.1390 , pp. 1635-1640
    • Lassmann, H.1
  • 28
    • 0025800033 scopus 로고
    • Proton magnetic resonance spectroscopy for metabolic characterization of plaques in multiple sclerosis
    • Matthews PM, Francis G, Antel J, Arnold DL. Proton magnetic resonance spectroscopy for metabolic characterization of plaques in multiplesclerosis. Neurology 1991; 41:1251-1256
    • (1991) Neurology , vol.41 , pp. 1251-1256
    • Matthews, P.M.1    Francis, G.2    Antel, J.3    Arnold, D.L.4
  • 29
    • 0000764437 scopus 로고
    • Demonstration of reversible decreases in N-Acetylaspartate (NAA) in a neuronal cell line: NAA decreases as a marker of sublethal neuronal dysfunction
    • Matthews PM, Cianfaglia L, McLaurin J, Cashman N, Sherwin D, Arnold D, et al. Demonstration of reversible decreases in N-Acetylaspartate (NAA) in a neuronal cell line: NAA decreases as a marker of sublethal neuronal dysfunction [abstract]. Proc Soc Magn Reson Med 1995; 1:147
    • (1995) Proc Soc Magn Reson Med , vol.1 , pp. 147
    • Matthews, P.M.1    Cianfaglia, L.2    McLaurin, J.3    Cashman, N.4    Sherwin, D.5    Arnold, D.6
  • 30
    • 0031769822 scopus 로고    scopus 로고
    • Putting magnetic resonance spectroscopy studies in context: Axonal damage and disability in multiple sclerosis
    • Matthews PM, De Stefano N, Narayanan S, Francis GS, Wolinsky JS, Antel JP, et al. Putting magnetic resonance spectroscopy studies in context: axonal damage and disability in multiple sclerosis. Semin Neurol 1998; 18(3):327-336
    • (1998) Semin Neurol , vol.18 , Issue.3 , pp. 327-336
    • Matthews, P.M.1    De Stefano, N.2    Narayanan, S.3    Francis, G.S.4    Wolinsky, J.S.5    Antel, J.P.6
  • 31
    • 0028291556 scopus 로고
    • Rachelle Fishman-Matthew Moore Lecture. The pathological and clinical dynamics of multiple sclerosis
    • McDonald WI. Rachelle Fishman-Matthew Moore Lecture. The pathological and clinical dynamics of multiple sclerosis. [Review]. J Neuropathol Exp Neurol 1994; 53:338-343
    • (1994) J Neuropathol Exp Neurol , vol.53 , pp. 338-343
    • McDonald, W.I.1
  • 33
    • 0029869119 scopus 로고    scopus 로고
    • Transient increase in symptoms associated with cytokine release in patients with multiple sclerosis
    • Moreau T, Coles A, Wing M, Isaacs J, Hale G, Waldmann H, et al. Transient increase in symptoms associated with cytokine release in patients with multiple sclerosis. Brain 1996; 119(Pt1):225-237
    • (1996) Brain , vol.119 , Issue.PART 1 , pp. 225-237
    • Moreau, T.1    Coles, A.2    Wing, M.3    Isaacs, J.4    Hale, G.5    Waldmann, H.6
  • 34
    • 0028346432 scopus 로고
    • Preliminary evidence from magnetic resonance imaging for reduction in disease activity after lymphocyte depletion in multiple sclerosis
    • published erratum appears in Lancet 1994 Aug 13; 344(8920):486
    • Moreau T, Thorpe J, Miller D, Moseley I, Hale G, Waldmann H, et al. Preliminary evidence from magnetic resonance imaging for reduction in disease activity after lymphocyte depletion in multiple sclerosis [published erratum appears in Lancet 1994 Aug 13; 344(8920):486]. Lancet 1994; 344(8918):298-301
    • (1994) Lancet , vol.344 , Issue.8918 , pp. 298-301
    • Moreau, T.1    Thorpe, J.2    Miller, D.3    Moseley, I.4    Hale, G.5    Waldmann, H.6
  • 35
    • 0031891884 scopus 로고    scopus 로고
    • Serial proton magnetic resonance spectroscopic imaging, contrast-enhanced magnetic resonance imaging, and quantitative lesion volumetry in multiple sclerosis
    • Narayana PA, Doyle TJ, Lai D, Wolinsky JS. Serial proton magnetic resonance spectroscopic imaging, contrast-enhanced magnetic resonance imaging, and quantitative lesion volumetry in multiple sclerosis. Ann Neurol 1998; 3(1):56-71
    • (1998) Ann Neurol , vol.3 , Issue.1 , pp. 56-71
    • Narayana, P.A.1    Doyle, T.J.2    Lai, D.3    Wolinsky, J.S.4
  • 36
    • 0031048695 scopus 로고    scopus 로고
    • Imaging of axonal damage in multiple sclerosis, spatial distribution of magnetic resonance imaging lesions
    • Narayanan S, Fu L, Pioro E, De Stefano N, Collins DL, Francis GS, et al. Imaging of axonal damage in multiple sclerosis: spatial distribution of magnetic resonance imaging lesions. Ann Neurol 1997; 41(3):385-391
    • (1997) Ann Neurol , vol.41 , Issue.3 , pp. 385-391
    • Narayanan, S.1    Fu, L.2    Pioro, E.3    De Stefano, N.4    Collins, D.L.5    Francis, G.S.6
  • 39
    • 0018622817 scopus 로고
    • Synthesis of N-acetyl-L-aspartate by rat brain mitochondria and its involvement in mitochondrial/cytosolic carbon transport
    • Patel TB, Clark JB. Synthesis of N-acetyl-L-aspartate by rat brain mitochondria and its involvement in mitochondrial/cytosolic carbon transport. Biochem J 1979; 184(3):539-546
    • (1979) Biochem J , vol.184 , Issue.3 , pp. 539-546
    • Patel, T.B.1    Clark, J.B.2
  • 40
    • 0027521002 scopus 로고
    • Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial
    • UBC MS/MRI Study Group and the IFNB Multiple Sclerosis Study Group
    • Paty DW, Li DK. Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. II. MRI analysis results of a multicenter, randomized, double-blind, placebo-controlled trial. UBC MS/MRI Study Group and the IFNB Multiple Sclerosis Study Group [see comments]. Neurology 1993; 43:662-667
    • (1993) Neurology , vol.43 , pp. 662-667
    • Paty, D.W.1    Li, D.K.2
  • 41
    • 0032726280 scopus 로고    scopus 로고
    • Combined magnetization transfer and proton spectroscopic imaging in the assessment of pathologic brain lesions in multiple sclerosis
    • Pike GB, De Stefano N, Narayanan S, Francis GS, Antel JP, Arnold DL. Combined magnetization transfer and proton spectroscopic imaging in the assessment of pathologic brain lesions in multiple sclerosis. AJNR Am J Neuroradiol 1999; 20(5):829-837
    • (1999) AJNR Am J Neuroradiol , vol.20 , Issue.5 , pp. 829-837
    • Pike, G.B.1    De Stefano, N.2    Narayanan, S.3    Francis, G.S.4    Antel, J.P.5    Arnold, D.L.6
  • 42
    • 0033625549 scopus 로고    scopus 로고
    • Multiple sclerosis: Magnetization transfer MR imaging of white matter before lesion appearance on T2-weighted images
    • In Process Citation
    • Pike GB, De Stefano N, Narayanan S, Worsley KJ, Pelletier D, Francis GS, et al. Multiple sclerosis: magnetization transfer MR imaging of white matter before lesion appearance on T2-weighted images [In Process Citation]. Radiology 2000; 215(3):824-830
    • (2000) Radiology , vol.215 , Issue.3 , pp. 824-830
    • Pike, G.B.1    De Stefano, N.2    Narayanan, S.3    Worsley, K.J.4    Pelletier, D.5    Francis, G.S.6
  • 43
    • 0032471431 scopus 로고    scopus 로고
    • Serial whole-brain magnetization transfer imaging in patients with relapsing-remitting multiple sclerosis at baseline and during treatment with interferon beta-1b
    • Richert ND, Ostuni JL, Bash CN, Duyn JH, McFarland HF, Frank JA. Serial whole-brain magnetization transfer imaging in patients with relapsing-remitting multiple sclerosis at baseline and during treatment with interferon beta-1b. AJNR 1998; 19(9):1705-1713
    • (1998) AJNR , vol.19 , Issue.9 , pp. 1705-1713
    • Richert, N.D.1    Ostuni, J.L.2    Bash, C.N.3    Duyn, J.H.4    McFarland, H.F.5    Frank, J.A.6
  • 45
    • 0033544320 scopus 로고    scopus 로고
    • Use of the brain parenchymal fraction to measure whole brain atrophy in relapsing-remitting MS
    • Multiple Sclerosis Collaborative Research Group [In Process Citation]
    • Rudick RA, Fisher E, Lee JC, Simon J, Jacobs L. Use of the brain parenchymal fraction to measure whole brain atrophy in relapsing-remitting MS. Multiple Sclerosis Collaborative Research Group [In Process Citation]. Neurology 1999; 53(8):1698-1704
    • (1999) Neurology , vol.53 , Issue.8 , pp. 1698-1704
    • Rudick, R.A.1    Fisher, E.2    Lee, J.C.3    Simon, J.4    Jacobs, L.5
  • 46
    • 0031594381 scopus 로고    scopus 로고
    • 1H-MRS in patients with multiple sclerosis undergoing treatment with interferon beta-1a: Results of a preliminary study
    • Sarchielli P, Presciutti O, Tarducci R, Gobbi G, Alberti A, Pelliccioli GP, et al. 1H-MRS in patients with multiple sclerosis undergoing treatment with interferon beta-1a: results of a preliminary study. J Neurol Neurosurg Psychiatry 1998; 64(2):204-212
    • (1998) J Neurol Neurosurg Psychiatry , vol.64 , Issue.2 , pp. 204-212
    • Sarchielli, P.1    Presciutti, O.2    Tarducci, R.3    Gobbi, G.4    Alberti, A.5    Pelliccioli, G.P.6
  • 47
    • 0032985039 scopus 로고    scopus 로고
    • Absolute quantification of brain metabolites by proton magnetic resonance spectroscopy in normal-appearing white matter of multiple sclerosis patients
    • In Process Citation
    • Sarchielli P, Presciutti O, Pelliccioli GP, Tarducci R, Gobbi G, Chiarini P, et al. Absolute quantification of brain metabolites by proton magnetic resonance spectroscopy in normal-appearing white matter of multiple sclerosis patients [In Process Citation]. Brain 1999; 122(Pt 3):513-521
    • (1999) Brain , vol.122 , Issue.PART 3 , pp. 513-521
    • Sarchielli, P.1    Presciutti, O.2    Pelliccioli, G.P.3    Tarducci, R.4    Gobbi, G.5    Chiarini, P.6
  • 48
    • 0031797815 scopus 로고    scopus 로고
    • Oligodendrocyte progenitors are present in the normal adult human CNS and in the lesions of multiple sclerosis
    • Scolding N, Franklin R, Stevens S, Heldin CH, Compston A, Newcombe J. Oligodendrocyte progenitors are present in the normal adult human CNS and in the lesions of multiple sclerosis [see comments]. Brain 1998; 121(Pt 12):2221-2228
    • (1998) Brain , vol.121 , Issue.PART 12 , pp. 2221-2228
    • Scolding, N.1    Franklin, R.2    Stevens, S.3    Heldin, C.H.4    Compston, A.5    Newcombe, J.6
  • 50
    • 0026000851 scopus 로고
    • Immunocytochemical localization of N-acetyl-aspartate with monoclonal antibodies
    • Simmons ML, Frondoza CG, Coyle JT. Immunocytochemical localization of N-acetyl-aspartate with monoclonal antibodies. Neuroscience 1991; 45:37-45
    • (1991) Neuroscience , vol.45 , pp. 37-45
    • Simmons, M.L.1    Frondoza, C.G.2    Coyle, J.T.3
  • 51
    • 0031972780 scopus 로고    scopus 로고
    • Pretreatment of astrocytes with interferon-alpha/beta prevents neuronal mitochondrial respiratory chain damage
    • Stewart VC, Land JM, Clark JB, Heales SJ. Pretreatment of astrocytes with in-terferon-alpha/beta prevents neuronal mitochondrial respiratory chain damage. J Neurochem 1998; 70(1):432-434
    • (1998) J Neurochem , vol.70 , Issue.1 , pp. 432-434
    • Stewart, V.C.1    Land, J.M.2    Clark, J.B.3    Heales, S.J.4
  • 52
    • 0030921516 scopus 로고    scopus 로고
    • Pre-treatment of astrocytes with interferon-alpha/beta impairs interferon-gamma induction of nitric oxide synthase
    • Stewart VC, Giovannoni G, Land JM, McDonald WI, Clark JB, Heales SJ. Pre-treatment of astrocytes with interferon-alpha/beta impairs interferon-gamma induction of nitric oxide synthase. J Neurochem 1997; 68(6):2547-2551
    • (1997) J Neurochem , vol.68 , Issue.6 , pp. 2547-2551
    • Stewart, V.C.1    Giovannoni, G.2    Land, J.M.3    McDonald, W.I.4    Clark, J.B.5    Heales, S.J.6
  • 53
    • 0028988737 scopus 로고
    • The effect of interferon-beta on blood-brain barrier disruptions demonstrated by contrast-enhanced magnetic resonance imaging in relapsing-remitting multiple sclerosis
    • Stone LA, Frank JA, Albert PS, Bash C, Smith ME, Maloni H, et al. The effect of interferon-beta on blood-brain barrier disruptions demonstrated by contrast-enhanced magnetic resonance imaging in relapsing-remitting multiple sclerosis. Ann Neurol 1995; 37(5):611-619
    • (1995) Ann Neurol , vol.37 , Issue.5 , pp. 611-619
    • Stone, L.A.1    Frank, J.A.2    Albert, P.S.3    Bash, C.4    Smith, M.E.5    Maloni, H.6
  • 54
    • 0027418515 scopus 로고
    • Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial
    • The IFNB multiple sclerosis study group. Interferon beta-1b is effective in relapsing-remitting multiple sclerosis. I. Clinical results of a multicenter, randomized, double-blind, placebo-controlled trial. Neurology 1993; 43:655-661
    • (1993) Neurology , vol.43 , pp. 655-661
  • 56
    • 0022196667 scopus 로고
    • N-Acetylation of L-aspartate in the nervous system: Differential distribution of a specific enzyme
    • Truckenmiller ME, Namboodiri MA, Brownstein MJ, Neale JH. N-Acetylation of L-aspartate in the nervous system: differential distribution of a specific enzyme. J Neurochem 1985; 45(5):1658-1662
    • (1985) J Neurochem , vol.45 , Issue.5 , pp. 1658-1662
    • Truckenmiller, M.E.1    Namboodiri, M.A.2    Brownstein, M.J.3    Neale, J.H.4
  • 57
    • 0026633564 scopus 로고
    • Specific expression of N-acetylaspartate in neurons, oligodendrocyte-type-2 astrocyte progenitors and immature oligodendrocytes in vitro
    • Urenjak J, Williams SR, Gadian DG, Noble M. Specific expression of N-acetylaspartate in neurons, oligodendrocyte-type-2 astrocyte progenitors, and immature oligodendrocytes in vitro. J Neurochem 1992; 59:55-61
    • (1992) J Neurochem , vol.59 , pp. 55-61
    • Urenjak, J.1    Williams, S.R.2    Gadian, D.G.3    Noble, M.4
  • 58
    • 0027450301 scopus 로고
    • Proton nuclear magnetic resonance spectroscopy unambiguously identifies different neural cell types
    • Urenjak J, Williams SR, Gadian DG, Noble M. Proton nuclear magnetic resonance spectroscopy unambiguously identifies different neural cell types. J Neurosci 1993; 13:981-989
    • (1993) J Neurosci , vol.13 , pp. 981-989
    • Urenjak, J.1    Williams, S.R.2    Gadian, D.G.3    Noble, M.4
  • 59
    • 0032971730 scopus 로고    scopus 로고
    • Neuronal damage in T1-hypointense multiple sclerosis lesions demonstrated in vivo using proton magnetic resonance spectroscopy
    • van Walderveen MA, Barkhof F, Pouwels PJ, van Schijndel RA, Polman CH, Castelijns JA. Neuronal damage in T1-hypointense multiple sclerosis lesions demonstrated in vivo using proton magnetic resonance spectroscopy. Ann Neurol 1999; 46(1):79-87
    • (1999) Ann Neurol , vol.46 , Issue.1 , pp. 79-87
    • Van Walderveen, M.A.1    Barkhof, F.2    Pouwels, P.J.3    Van Schijndel, R.A.4    Polman, C.H.5    Castelijns, J.A.6
  • 60
    • 0032576636 scopus 로고    scopus 로고
    • Demyelinating diseases-new pathological insights, new therapeutic targets
    • Waxman SG. Demyelinating diseases-new pathological insights, new therapeutic targets [editorial; comment]. N Engl J Med 1998; 338(5):323-325
    • (1998) N Engl J Med , vol.338 , Issue.5 , pp. 323-325
    • Waxman, S.G.1
  • 61
    • 0031962240 scopus 로고    scopus 로고
    • Chronic stage multiple sclerosis lesions contain a relatively quiescent population of oligodendrocyte precursor cells
    • Wolswijk G. Chronic stage multiple sclerosis lesions contain a relatively quiescent population of oligodendrocyte precursor cells. J Neurosci 1998; 18(2):601-609
    • (1998) J Neurosci , vol.18 , Issue.2 , pp. 601-609
    • Wolswijk, G.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.