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Volumn 14, Issue 7, 2009, Pages 696-704

Glutamate as a spectroscopic marker of hippocampal structural plasticity is elevated in long-term euthymic bipolar patients on chronic lithium therapy and correlates inversely with diurnal cortisol

Author keywords

Bipolar disorder; Cortisol; Glutamate; Lithium; Magnetic resonance spectroscopy

Indexed keywords

CHOLINE; CREATINE; GLUTAMIC ACID; HYDROCORTISONE; LITHIUM; N ACETYLASPARTIC ACID;

EID: 67649366651     PISSN: 13594184     EISSN: 14765578     Source Type: Journal    
DOI: 10.1038/mp.2008.26     Document Type: Article
Times cited : (62)

References (81)
  • 1
    • 20344374645 scopus 로고    scopus 로고
    • Prevalence, severity, and comorbidity of twelve-month DSM-IV disorders in the National Comorbidity Survey Replication (NCS-R)
    • Kessler RC, Chiu WT, Demler O, Merikangas KR, Walters E. Prevalence, severity, and comorbidity of twelve-month DSM-IV disorders in the National Comorbidity Survey Replication (NCS-R). Arch Gen Psychiatry 2005; 62: 617-627.
    • (2005) Arch Gen Psychiatry , vol.62 , pp. 617-627
    • Kessler, R.C.1    Chiu, W.T.2    Demler, O.3    Merikangas, K.R.4    Walters, E.5
  • 4
    • 0035034203 scopus 로고    scopus 로고
    • The cellular neurobiology of depression
    • Manji HK, Drevets WC, Charney DS. The cellular neurobiology of depression. Nat Med 2001; 7: 541-547.
    • (2001) Nat Med , vol.7 , pp. 541-547
    • Manji, H.K.1    Drevets, W.C.2    Charney, D.S.3
  • 5
    • 0033564043 scopus 로고    scopus 로고
    • Depression duration but not age predicts hippocampal volume loss in medically healthy women with recurrent major depression
    • Sheline YI, Sanghavi M, Mintun MA, Gado MH. Depression duration but not age predicts hippocampal volume loss in medically healthy women with recurrent major depression. J Neurosci 1999; 19: 5034-5043.
    • (1999) J Neurosci , vol.19 , pp. 5034-5043
    • Sheline, Y.I.1    Sanghavi, M.2    Mintun, M.A.3    Gado, M.H.4
  • 6
    • 0032527572 scopus 로고    scopus 로고
    • A reduction of nonpyramidal cells in sector CA2 of schizophrenics and manic depressives
    • Benes FM, Kwok EW, Vincent SL, Todtenkopf MS. A reduction of nonpyramidal cells in sector CA2 of schizophrenics and manic depressives. Biol Psychiatry 1998; 44: 88-97.
    • (1998) Biol Psychiatry , vol.44 , pp. 88-97
    • Benes, F.M.1    Kwok, E.W.2    Vincent, S.L.3    Todtenkopf, M.S.4
  • 7
    • 32844457642 scopus 로고    scopus 로고
    • Glial cell number and neuron/glial cell ratios in postmortem brains of bipolar individuals
    • Brauch RA, Adnan El-Masri M, Parker Jr JC, El-Mallakh RS. Glial cell number and neuron/glial cell ratios in postmortem brains of bipolar individuals. J Affect Disord 2006; 91: 87-90.
    • (2006) J Affect Disord , vol.91 , pp. 87-90
    • Brauch, R.A.1    Adnan El-Masri, M.2    Parker Jr, J.C.3    El-Mallakh, R.S.4
  • 8
    • 3042784509 scopus 로고    scopus 로고
    • Molecular abnormalities of the hippocampus in severe psychiatric illness: Postmortem findings from the Stanley Neuropathology Consortium
    • Knable MB, Barci BM, Webster MJ, Meador-Woodruff J, Torrey ER Molecular abnormalities of the hippocampus in severe psychiatric illness: postmortem findings from the Stanley Neuropathology Consortium. Mol Psychiatry 2004; 9: 609-620.
    • (2004) Mol Psychiatry , vol.9 , pp. 609-620
    • Knable, M.B.1    Barci, B.M.2    Webster, M.J.3    Meador-Woodruff, J.4    Torrey, E.R.5
  • 10
    • 0026574983 scopus 로고
    • Subcortical and temporal structures in affective disorder and schizophrenia: A magnetic resonance imaging study
    • Swayze II VW, Andreasen NC, Alliger RJ, Yuh WT, Ehrhardt JC. Subcortical and temporal structures in affective disorder and schizophrenia: a magnetic resonance imaging study. Biol Psychiatry 1992; 31: 221-240.
    • (1992) Biol Psychiatry , vol.31 , pp. 221-240
    • Swayze II, V.W.1    Andreasen, N.C.2    Alliger, R.J.3    Yuh, W.T.4    Ehrhardt, J.C.5
  • 11
    • 20844432889 scopus 로고    scopus 로고
    • Supraphysiological doses of levothyroxine alter regional cerebral metabolism and improve mood in bipolar disorder
    • Bauer M, London ED, Rasgon N, Berman SM, Frye MA, Altshuler LL et al. Supraphysiological doses of levothyroxine alter regional cerebral metabolism and improve mood in bipolar disorder. Mol Psychiatry 2005; 10: 456-469.
    • (2005) Mol Psychiatry , vol.10 , pp. 456-469
    • Bauer, M.1    London, E.D.2    Rasgon, N.3    Berman, S.M.4    Frye, M.A.5    Altshuler, L.L.6
  • 13
    • 0038735643 scopus 로고    scopus 로고
    • Neuronal pathology in the hippocampal area of patients with bipolar disorder: A study with proton magnetic resonance spectroscopic imaging
    • Bertolino A, Frye M, Callicott JH, Mattay VS, Rakow R, Shelton-Repella J et al. Neuronal pathology in the hippocampal area of patients with bipolar disorder: a study with proton magnetic resonance spectroscopic imaging. Biol Psychiatry 2003; 53: 906-913.
    • (2003) Biol Psychiatry , vol.53 , pp. 906-913
    • Bertolino, A.1    Frye, M.2    Callicott, J.H.3    Mattay, V.S.4    Rakow, R.5    Shelton-Repella, J.6
  • 14
    • 0038521214 scopus 로고    scopus 로고
    • Lower concentrations of hippocampal N-acetylaspartate in familial bipolar I disorder
    • Deicken R, Pegues MP, Anzalone S, Feiwell R, Soher B. Lower concentrations of hippocampal N-acetylaspartate in familial bipolar I disorder. Am J Psychiatry 2003; 160: 873-882.
    • (2003) Am J Psychiatry , vol.160 , pp. 873-882
    • Deicken, R.1    Pegues, M.P.2    Anzalone, S.3    Feiwell, R.4    Soher, B.5
  • 16
    • 0031021451 scopus 로고    scopus 로고
    • Forty years of lithium treatment
    • Schou M. Forty years of lithium treatment. Arch Gen Psychiatry 1997; 54: 9-13.
    • (1997) Arch Gen Psychiatry , vol.54 , pp. 9-13
    • Schou, M.1
  • 17
    • 0032956630 scopus 로고    scopus 로고
    • The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS
    • Chen G, Zeng WZ, Yuan PX, Huang LD, Jiang YM, Zhao ZH et al. The mood-stabilizing agents lithium and valproate robustly increase the levels of the neuroprotective protein bcl-2 in the CNS. J Neurochem 1999; 72: 879-882.
    • (1999) J Neurochem , vol.72 , pp. 879-882
    • Chen, G.1    Zeng, W.Z.2    Yuan, P.X.3    Huang, L.D.4    Jiang, Y.M.5    Zhao, Z.H.6
  • 18
    • 0037967151 scopus 로고    scopus 로고
    • Chronic treatment with a low dose of lithium protects the brain against ischemic injury by reducing apoptotic death
    • Xu J, Culman J, Blume A, Brecht S, Gohlke P. Chronic treatment with a low dose of lithium protects the brain against ischemic injury by reducing apoptotic death. Stroke 2003; 34: 1287-1292.
    • (2003) Stroke , vol.34 , pp. 1287-1292
    • Xu, J.1    Culman, J.2    Blume, A.3    Brecht, S.4    Gohlke, P.5
  • 19
    • 0036024262 scopus 로고    scopus 로고
    • Subchronic treatment with lithium increases nerve growth factor content in distinct brain regions of adult rats
    • Hellweg R, Lang UE, Nagel M, Baumgartner A. Subchronic treatment with lithium increases nerve growth factor content in distinct brain regions of adult rats. Mol Psychiatry 2002; 7: 604-608.
    • (2002) Mol Psychiatry , vol.7 , pp. 604-608
    • Hellweg, R.1    Lang, U.E.2    Nagel, M.3    Baumgartner, A.4
  • 21
    • 18744435263 scopus 로고    scopus 로고
    • Lithium increases in N-acetylaspartate in the human brain: In vivo evidence in support of bcl-2′s neurotrophic effects?
    • Moore GJ, Bebchuk JM, Hasanat K, Chen G, Seraji-Bozorgzad N, Wilds IB et al. Lithium increases in N-acetylaspartate in the human brain: in vivo evidence in support of bcl-2′s neurotrophic effects? Biol Psychiatry 2000; 48: 1-8.
    • (2000) Biol Psychiatry , vol.48 , pp. 1-8
    • Moore, G.J.1    Bebchuk, J.M.2    Hasanat, K.3    Chen, G.4    Seraji-Bozorgzad, N.5    Wilds, I.B.6
  • 23
    • 36949014949 scopus 로고    scopus 로고
    • Bilateral hippocampal volume increase in patients with bipolar disorder and short-term lithium treatment
    • Yucel K, Taylor VH, McKinnon MC, Macdonald K, Alda M, Young LT et al. Bilateral hippocampal volume increase in patients with bipolar disorder and short-term lithium treatment. Neuropsycho-pharmacology 2007; 33: 361-367.
    • (2007) Neuropsycho-pharmacology , vol.33 , pp. 361-367
    • Yucel, K.1    Taylor, V.H.2    McKinnon, M.C.3    Macdonald, K.4    Alda, M.5    Young, L.T.6
  • 24
    • 3242753683 scopus 로고    scopus 로고
    • Modulation of synaptic plasticity by antimanic agents: The role of AMPA glutamate receptor subunit 1 synaptic expression
    • Du J, Gray NA, Falke CA, Chen W, Yuan P, Szabo ST et al. Modulation of synaptic plasticity by antimanic agents: the role of AMPA glutamate receptor subunit 1 synaptic expression. J Neurosci 2004; 24: 6578-6589.
    • (2004) J Neurosci , vol.24 , pp. 6578-6589
    • Du, J.1    Gray, N.A.2    Falke, C.A.3    Chen, W.4    Yuan, P.5    Szabo, S.T.6
  • 25
    • 13444310754 scopus 로고    scopus 로고
    • An open-label trial of the glutamate-modulating agent riluzole in combination with lithium for the treatment of bipolar depression
    • Zarate CA, Quiros JA, Singh JB, Denicoff KD, De Jesus G, Luckenbaugh DA et al. An open-label trial of the glutamate-modulating agent riluzole in combination with lithium for the treatment of bipolar depression. Biol Psychiatry 2006; 57: 430-432.
    • (2006) Biol Psychiatry , vol.57 , pp. 430-432
    • Zarate, C.A.1    Quiros, J.A.2    Singh, J.B.3    Denicoff, K.D.4    De Jesus, G.5    Luckenbaugh, D.A.6
  • 26
    • 33745264436 scopus 로고    scopus 로고
    • Neurochemical alterations of the brain in bipolar disorder and their implications for patho-physiology: A systematic review of the in vivo proton magnetic resonance spectroscopy findings
    • Yildiz-Yesiloglu A, Ankerst DP. Neurochemical alterations of the brain in bipolar disorder and their implications for patho-physiology: a systematic review of the in vivo proton magnetic resonance spectroscopy findings. Prog Neuropsychopharmacol Biol Psychiatry 2006; 30: 969-995.
    • (2006) Prog Neuropsychopharmacol Biol Psychiatry , vol.30 , pp. 969-995
    • Yildiz-Yesiloglu, A.1    Ankerst, D.P.2
  • 27
    • 35848939420 scopus 로고    scopus 로고
    • Increased levels of glutamate in brain from patients with mood disorders
    • Epub ahead of print
    • Hashimoto K, Sawa A, Iyo M. Increased levels of glutamate in brain from patients with mood disorders. Biol Psychiatry 2007; 62: 1310-1316, Epub ahead of print.
    • (2007) Biol Psychiatry , vol.62 , pp. 1310-1316
    • Hashimoto, K.1    Sawa, A.2    Iyo, M.3
  • 28
    • 0032840527 scopus 로고    scopus 로고
    • G protein-coupled cyclic AMP signaling in postmortem brain of subjects with mood disorders: Effects of diagnosis, suicide, and treatment at the time of death
    • Dowlatshahi D, MacQueen GM, Wang JF, Reiach JS, Young LT. G protein-coupled cyclic AMP signaling in postmortem brain of subjects with mood disorders: effects of diagnosis, suicide, and treatment at the time of death. J Neurochem 1999; 73: 1121-1126.
    • (1999) J Neurochem , vol.73 , pp. 1121-1126
    • Dowlatshahi, D.1    MacQueen, G.M.2    Wang, J.F.3    Reiach, J.S.4    Young, L.T.5
  • 30
    • 0029646115 scopus 로고
    • Combined dexamethasone/corticotropin-releasing hormone test in acute and remitted manic patients, in acute depression, and in normal controls: I
    • Schmider J, Lammers CH, Gotthardt U, Dettling M, Holsboer F, Heuserl J. Combined dexamethasone/corticotropin-releasing hormone test in acute and remitted manic patients, in acute depression, and in normal controls: I. Biol Psychiatry 1995; 38: 797-802.
    • (1995) Biol Psychiatry , vol.38 , pp. 797-802
    • Schmider, J.1    Lammers, C.H.2    Gotthardt, U.3    Dettling, M.4    Holsboer, F.5    Heuserl, J.6
  • 31
    • 30044444607 scopus 로고    scopus 로고
    • Mineralocorticoid receptors are indispensable for nongenomic modulation of hippocampal glutamate transmission by cortico-sterone
    • Karst H, Berger S, Turiault M, Tronche F, Schutz G, Joels M. Mineralocorticoid receptors are indispensable for nongenomic modulation of hippocampal glutamate transmission by cortico-sterone. Proc Natl Acad Sci USA 2005; 102: 19204-19207.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 19204-19207
    • Karst, H.1    Berger, S.2    Turiault, M.3    Tronche, F.4    Schutz, G.5    Joels, M.6
  • 32
    • 0029014381 scopus 로고
    • Effect of acute stress on hippocampal glutamate levels and spectrin proteolysis in young and aged rats
    • Lowy MT, Wittenberg L, Yamamoto BK. Effect of acute stress on hippocampal glutamate levels and spectrin proteolysis in young and aged rats. J Neurochem 1995; 65: 268-274.
    • (1995) J Neurochem , vol.65 , pp. 268-274
    • Lowy, M.T.1    Wittenberg, L.2    Yamamoto, B.K.3
  • 33
    • 0029120661 scopus 로고
    • Stress-induced atrophy of apical dendrites of hippocampal CA3c neurons: Involvement of gluco-corticoid secretion and excitatory amino acid receptors
    • Magarinos AM, McEwen BS. Stress-induced atrophy of apical dendrites of hippocampal CA3c neurons: involvement of gluco-corticoid secretion and excitatory amino acid receptors. Neuro-science 1995; 69: 89-98.
    • (1995) Neuro-science , vol.69 , pp. 89-98
    • Magarinos, A.M.1    McEwen, B.S.2
  • 34
    • 0029988191 scopus 로고    scopus 로고
    • Chronic psychosocial stress causes apical dendritic atrophy of hippocampal CA3 pyramidal neurons in subordinate tree shrews
    • Magarinos AM, McEwen BS, Flugge G, Fuchs E. Chronic psychosocial stress causes apical dendritic atrophy of hippocampal CA3 pyramidal neurons in subordinate tree shrews. J Neurosci 1996; 16: 3534-3540.
    • (1996) J Neurosci , vol.16 , pp. 3534-3540
    • Magarinos, A.M.1    McEwen, B.S.2    Flugge, G.3    Fuchs, E.4
  • 35
    • 1642280965 scopus 로고    scopus 로고
    • Stress-induced structural remodeling in hippocampus: Prevention by lithium treatment
    • Wood GE, Young LT, Reagan LP, Chen B, McEwen BS. Stress-induced structural remodeling in hippocampus: prevention by lithium treatment. Proc Natl Acad Sci USA 2004; 101: 3973-3978.
    • (2004) Proc Natl Acad Sci USA , vol.101 , pp. 3973-3978
    • Wood, G.E.1    Young, L.T.2    Reagan, L.P.3    Chen, B.4    McEwen, B.S.5
  • 36
    • 0032493304 scopus 로고    scopus 로고
    • Lithium acutely inhibits and chronically up-regulates and stabilizes glutamate uptake by presynaptic nerve endings in mouse cerebral cortex
    • Dixon JF, Hokin LE. Lithium acutely inhibits and chronically up-regulates and stabilizes glutamate uptake by presynaptic nerve endings in mouse cerebral cortex. Proc Natl Acad Sci USA 1998; 95: 8363-8368.
    • (1998) Proc Natl Acad Sci USA , vol.95 , pp. 8363-8368
    • Dixon, J.F.1    Hokin, L.E.2
  • 37
    • 29044447411 scopus 로고    scopus 로고
    • Chronic treatment with mood stabilizers lithium and valproate prevents excitotoxicity by inhibiting oxidative stress in rat cerebral cortical cells
    • Shao L, Young LT, Wang JF. Chronic treatment with mood stabilizers lithium and valproate prevents excitotoxicity by inhibiting oxidative stress in rat cerebral cortical cells. Biol Psychiatry 2005; 58: 879-884.
    • (2005) Biol Psychiatry , vol.58 , pp. 879-884
    • Shao, L.1    Young, L.T.2    Wang, J.F.3
  • 38
    • 0030992982 scopus 로고    scopus 로고
    • Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and NMDA receptor activation
    • Gould E, McEwen BS, Tanapat P, Galea LA, Fuchs E. Neurogenesis in the dentate gyrus of the adult tree shrew is regulated by psychosocial stress and NMDA receptor activation. J Neurosci 1997; 17: 2492-2498.
    • (1997) J Neurosci , vol.17 , pp. 2492-2498
    • Gould, E.1    McEwen, B.S.2    Tanapat, P.3    Galea, L.A.4    Fuchs, E.5
  • 39
    • 0036891428 scopus 로고    scopus 로고
    • Chronic psychosocial stress and concomitant repetitive transcranial magnetic stimulation: Effects on stress hormone levels and adult hippocampal neurogenesis
    • Czeh B, Welt T, Fischer AK, Ehrhardt A, Schmitt W, Muller MB et al. Chronic psychosocial stress and concomitant repetitive transcranial magnetic stimulation: effects on stress hormone levels and adult hippocampal neurogenesis. Biol Psychiatry 2002; 52: 1057-1065.
    • (2002) Biol Psychiatry , vol.52 , pp. 1057-1065
    • Czeh, B.1    Welt, T.2    Fischer, A.K.3    Ehrhardt, A.4    Schmitt, W.5    Muller, M.B.6
  • 40
    • 1842504496 scopus 로고    scopus 로고
    • Glutamate concentrations in human brain using single voxel proton magnetic resonance spectroscopy at 3 Tesla
    • Schubert F, Gallinat J, Seifert F, Rinneberg H. Glutamate concentrations in human brain using single voxel proton magnetic resonance spectroscopy at 3 Tesla. NeuroImage 2004; 21: 1762-1771.
    • (2004) NeuroImage , vol.21 , pp. 1762-1771
    • Schubert, F.1    Gallinat, J.2    Seifert, F.3    Rinneberg, H.4
  • 41
    • 33745016069 scopus 로고    scopus 로고
    • Hippocampal glutamate concentration predicts cerebral theta oscillations during cognitive processing
    • Gallinat J, Kunz D, Senkowski D, Kienast T, Seifert F, Schubert F et al Hippocampal glutamate concentration predicts cerebral theta oscillations during cognitive processing. Psychopharmacology 2006; 187: 103-111.
    • (2006) Psychopharmacology , vol.187 , pp. 103-111
    • Gallinat, J.1    Kunz, D.2    Senkowski, D.3    Kienast, T.4    Seifert, F.5    Schubert, F.6
  • 43
    • 32944470806 scopus 로고    scopus 로고
    • Metabolic changes in elderly patients with major depression: Evidence for increased accumulation of visceral fat at follow-up
    • Weber-Hamann B, Werner M, Hentschel F, Bindeballe N, Lederbogen F, Deuschle M, et al, Metabolic changes in elderly patients with major depression: evidence for increased accumulation of visceral fat at follow-up. Psychoneuroendocrinology 2006; 31: 347-354.
    • (2006) Psychoneuroendocrinology , vol.31 , pp. 347-354
    • Weber-Hamann, B.1    Werner, M.2    Hentschel, F.3    Bindeballe, N.4    Lederbogen, F.5    Deuschle, M.6
  • 44
    • 23844434299 scopus 로고    scopus 로고
    • Activity of the hypothalamus-pituitary-adrenal system and oral glucose tolerance in depressed patients
    • Weber-Hamann B, Kopf D, Lederbogen F, Gilles M, Heuser I, Colla M et al. Activity of the hypothalamus-pituitary-adrenal system and oral glucose tolerance in depressed patients. Neuroendocrinology 2005; 81: 200-204.
    • (2005) Neuroendocrinology , vol.81 , pp. 200-204
    • Weber-Hamann, B.1    Kopf, D.2    Lederbogen, F.3    Gilles, M.4    Heuser, I.5    Colla, M.6
  • 46
    • 0033934305 scopus 로고    scopus 로고
    • Quantitative MRS: Comparison of time domain and time domain frequency domain methods using a novel test procedure
    • Elster C, Link A, Schubert F, Seifert F, Walzel M, Rinneberg H. Quantitative MRS: comparison of time domain and time domain frequency domain methods using a novel test procedure. Magn Reson Imaging 2000; 18: 597-606.
    • (2000) Magn Reson Imaging , vol.18 , pp. 597-606
    • Elster, C.1    Link, A.2    Schubert, F.3    Seifert, F.4    Walzel, M.5    Rinneberg, H.6
  • 47
    • 19544390159 scopus 로고    scopus 로고
    • Quantitative magnetic resonance spectroscopy: Semi-parametric modeling and determination of uncertainties
    • Elster C, Schubert F, Link A, Walzel M, Seifert F, Rinneberg H. Quantitative magnetic resonance spectroscopy: semi-parametric modeling and determination of uncertainties. Magn Reson Med 2005; 53: 1288-1296.
    • (2005) Magn Reson Med , vol.53 , pp. 1288-1296
    • Elster, C.1    Schubert, F.2    Link, A.3    Walzel, M.4    Seifert, F.5    Rinneberg, H.6
  • 48
    • 0034875929 scopus 로고    scopus 로고
    • Proton T (1) and T (2) relaxation times of human brain metabolites at 3 Tesla
    • Mlynarik V, Gruber S, Moser E. Proton T (1) and T (2) relaxation times of human brain metabolites at 3 Tesla. NMR Biomed 2001; 14: 325-331.
    • (2001) NMR Biomed , vol.14 , pp. 325-331
    • Mlynarik, V.1    Gruber, S.2    Moser, E.3
  • 49
    • 0030668370 scopus 로고    scopus 로고
    • Multimodal image coregistration and partitioning - a unified framework
    • Ashburner J, Friston K. Multimodal image coregistration and partitioning - a unified framework. Neuroimage 1997; 6: 209-217.
    • (1997) Neuroimage , vol.6 , pp. 209-217
    • Ashburner, J.1    Friston, K.2
  • 50
    • 0023115468 scopus 로고
    • Amino acid neurotransmitters in postmortem human brain analyzed by high performance liquid chromatography with electrochemical detection
    • Ellison DW, Beal MF, Martin JB. Amino acid neurotransmitters in postmortem human brain analyzed by high performance liquid chromatography with electrochemical detection. J Neurosci Methods 1987; 19: 305-315.
    • (1987) J Neurosci Methods , vol.19 , pp. 305-315
    • Ellison, D.W.1    Beal, M.F.2    Martin, J.B.3
  • 51
    • 0022588911 scopus 로고
    • Regional distribution of amino acid transmitters in postmortem brains of presenile and senile dementia of Alzheimer type
    • Sasaki H, Muramoto O, Kanazawa I, Arai H, Kosaka K, Iizuka R. Regional distribution of amino acid transmitters in postmortem brains of presenile and senile dementia of Alzheimer type. Ann Neurol 1986; 19: 263-269.
    • (1986) Ann Neurol , vol.19 , pp. 263-269
    • Sasaki, H.1    Muramoto, O.2    Kanazawa, I.3    Arai, H.4    Kosaka, K.5    Iizuka, R.6
  • 52
    • 36248931550 scopus 로고    scopus 로고
    • Increased anterior cingulate/medial prefrontal cortical glutamate and creatine in bipolar depression
    • e-pub ahead of print
    • Frye MA, Watzl J, Banakar S, O'Neill J, Mintz J, Davanzo P et al. Increased anterior cingulate/medial prefrontal cortical glutamate and creatine in bipolar depression. Neuropsychopharmacology 2007 e-pub ahead of print.
    • (2007) Neuropsychopharmacology
    • Frye, M.A.1    Watzl, J.2    Banakar, S.3    O'Neill, J.4    Mintz, J.5    Davanzo, P.6
  • 53
    • 4143062529 scopus 로고    scopus 로고
    • Hippocampal neurochemical pathology in patients at first episode of affective psychosis: A proton magnetic resonance spectro-scopic imaging study
    • Blasi G, Bertolino A, Brudaglio F, Sciota D, Altamura M, Antonucci N et al. Hippocampal neurochemical pathology in patients at first episode of affective psychosis: a proton magnetic resonance spectro-scopic imaging study. Psychiatry Res 2004; 131: 95-105.
    • (2004) Psychiatry Res , vol.131 , pp. 95-105
    • Blasi, G.1    Bertolino, A.2    Brudaglio, F.3    Sciota, D.4    Altamura, M.5    Antonucci, N.6
  • 54
    • 25844452847 scopus 로고    scopus 로고
    • Mood stabilizers target cellular plasticity and resilience cascades: Implications for the development of novel therapeutics
    • Bachmann RF, Schloesser RJ, Gould TD, Manji HK. Mood stabilizers target cellular plasticity and resilience cascades: implications for the development of novel therapeutics. Mol Neurobiol 2005; 32: 173-202.
    • (2005) Mol Neurobiol , vol.32 , pp. 173-202
    • Bachmann, R.F.1    Schloesser, R.J.2    Gould, T.D.3    Manji, H.K.4
  • 55
    • 0032827466 scopus 로고    scopus 로고
    • Lithium at 50: Have the neuro-protective effects of this unique cation been overlooked?
    • Manji HK, Moore GJ, Chen G. Lithium at 50: have the neuro-protective effects of this unique cation been overlooked? Biol Psychiatry 1999; 46: 929-940.
    • (1999) Biol Psychiatry , vol.46 , pp. 929-940
    • Manji, H.K.1    Moore, G.J.2    Chen, G.3
  • 57
    • 0035089253 scopus 로고    scopus 로고
    • Direct determination of the N-acetyl-L-aspartate synthesis rate in the human brain by (13)C MRS and [1-(13)C]glucose infusion
    • Moreno A, Ross BD, Bluml S. Direct determination of the N-acetyl-L-aspartate synthesis rate in the human brain by (13)C MRS and [1-(13)C]glucose infusion. J Neurochem 2001; 77: 347-350.
    • (2001) J Neurochem , vol.77 , pp. 347-350
    • Moreno, A.1    Ross, B.D.2    Bluml, S.3
  • 58
    • 33745266134 scopus 로고    scopus 로고
    • Clark JF, Doepke A, Filosa JA, Wardle RL, Lu A, Meeker TJ et al. N-acetylaspartate as a reservoir for glutamate. Med Hypotheses 2006; 67: 506-512.
    • Clark JF, Doepke A, Filosa JA, Wardle RL, Lu A, Meeker TJ et al. N-acetylaspartate as a reservoir for glutamate. Med Hypotheses 2006; 67: 506-512.
  • 60
    • 0034102167 scopus 로고    scopus 로고
    • Proton MR spectroscopy in children with bipolar affective disorder: Preliminary observations
    • Castillo M, Kwock L, Courvoisie H, Hooper SR, Proton MR. Proton MR spectroscopy in children with bipolar affective disorder: preliminary observations. AJNR Am J Neuroradiol 2000; 21: 832-838.
    • (2000) AJNR Am J Neuroradiol , vol.21 , pp. 832-838
    • Castillo, M.1    Kwock, L.2    Courvoisie, H.3    Hooper, S.R.4    Proton, M.R.5
  • 61
    • 0041665135 scopus 로고    scopus 로고
    • Acute mania is accompanied by elevated glutamate/glutamine levels within the left dorsolateral prefrontal cortex
    • Michael N, Erfurth A, Ohrmann P, Gossling M, Arolt V, Heindel W et al Acute mania is accompanied by elevated glutamate/glutamine levels within the left dorsolateral prefrontal cortex. Psychopharmacology (Berl) 2003; 168: 344-346.
    • (2003) Psychopharmacology (Berl) , vol.168 , pp. 344-346
    • Michael, N.1    Erfurth, A.2    Ohrmann, P.3    Gossling, M.4    Arolt, V.5    Heindel, W.6
  • 62
    • 0036930972 scopus 로고    scopus 로고
    • Frontal lobe differences in bipolar disorder as determined by proton MR spectroscopy
    • Cecil KM, DelBello MP, Morey R, Strakowski SM. Frontal lobe differences in bipolar disorder as determined by proton MR spectroscopy. Bipolar Disord 2002; 4: 357-365.
    • (2002) Bipolar Disord , vol.4 , pp. 357-365
    • Cecil, K.M.1    DelBello, M.P.2    Morey, R.3    Strakowski, S.M.4
  • 64
    • 0027630704 scopus 로고
    • Cerebral metabolism of [1,2-13C2] glucose and [U-13C4]3-hydroxybutyrate in rat brain as detected by 13C NMR spectroscopy
    • Kunnecke B, Cerdan S, Seelig J. Cerebral metabolism of [1,2-13C2] glucose and [U-13C4]3-hydroxybutyrate in rat brain as detected by 13C NMR spectroscopy. NMR Biomed 1993; 6: 264-277.
    • (1993) NMR Biomed , vol.6 , pp. 264-277
    • Kunnecke, B.1    Cerdan, S.2    Seelig, J.3
  • 65
    • 0028797115 scopus 로고
    • Adult-onset hypothyroidism and the cerebral metabolism of (1,2-13C2) acetate as detected by 13C nuclear magnetic resonance
    • Chapa F, Kunnecke B, Calvo R, Escobar del Rey F, Morreale de Escobar G, Cerdan S. Adult-onset hypothyroidism and the cerebral metabolism of (1,2-13C2) acetate as detected by 13C nuclear magnetic resonance. Endocrinology 1995; 136: 296-305.
    • (1995) Endocrinology , vol.136 , pp. 296-305
    • Chapa, F.1    Kunnecke, B.2    Calvo, R.3    Escobar del Rey, F.4    Morreale de Escobar, G.5    Cerdan, S.6
  • 66
    • 0033233212 scopus 로고    scopus 로고
    • Quantitative 13C NMR studies of metabolic compartmentation in the adult mammalian brain
    • Cruz F, Cerdan S. Quantitative 13C NMR studies of metabolic compartmentation in the adult mammalian brain. NMR Biomed 1999; 12: 451-462.
    • (1999) NMR Biomed , vol.12 , pp. 451-462
    • Cruz, F.1    Cerdan, S.2
  • 67
    • 0034238122 scopus 로고    scopus 로고
    • Metabolism of (1-(13)C) glucose and (2-(13)C, 2-(2)H(3)) acetate in the neuronal and glial compartments of the adult rat brain as detected by [(13)C, (2)H] NMR spectroscopy
    • Chapa F, Cruz F, Garcia-Martin ML, Garcia-Espinosa MA, Cerdan S. Metabolism of (1-(13)C) glucose and (2-(13)C, 2-(2)H(3)) acetate in the neuronal and glial compartments of the adult rat brain as detected by [(13)C, (2)H] NMR spectroscopy. Neurochem Int 2000; 37: 217-228.
    • (2000) Neurochem Int , vol.37 , pp. 217-228
    • Chapa, F.1    Cruz, F.2    Garcia-Martin, M.L.3    Garcia-Espinosa, M.A.4    Cerdan, S.5
  • 68
    • 0021330769 scopus 로고
    • Glutamate: A neurotransmitter in mammalian brain
    • Fonnum F. Glutamate: a neurotransmitter in mammalian brain. J Neurochem 1984; 42: 1-11.
    • (1984) J Neurochem , vol.42 , pp. 1-11
    • Fonnum, F.1
  • 69
    • 0021173149 scopus 로고
    • Extra- and intracellular amino acids in the hippocampus during development of hepatic encephalopathy
    • Hamberger A, Nystrom B. Extra- and intracellular amino acids in the hippocampus during development of hepatic encephalopathy. Neurochem Res 1984; 9: 1181-1192.
    • (1984) Neurochem Res , vol.9 , pp. 1181-1192
    • Hamberger, A.1    Nystrom, B.2
  • 70
    • 33847421861 scopus 로고    scopus 로고
    • Metabolic alterations in the dorsolateral prefrontal cortex after treatment with high-frequency repetitive transcranial magnetic stimulation in patients with unipolar major depression
    • Luborzewski A, Schubert F, Seifert F, Danker-Hopfe H, Brakemeier E, Schlattmann P et al Metabolic alterations in the dorsolateral prefrontal cortex after treatment with high-frequency repetitive transcranial magnetic stimulation in patients with unipolar major depression. J Psychiatry Res 2006; 41: 606-615.
    • (2006) J Psychiatry Res , vol.41 , pp. 606-615
    • Luborzewski, A.1    Schubert, F.2    Seifert, F.3    Danker-Hopfe, H.4    Brakemeier, E.5    Schlattmann, P.6
  • 72
    • 0034577323 scopus 로고    scopus 로고
    • Differential effects of acute and short-term lithium administration on dialysate glutamate and GABA levels in the frontal cortex of the conscious rat
    • Antonelli T, Ferioli V, Lo Gallo G, Tomasini MC, Fernandez M, O'Connor WT et al Differential effects of acute and short-term lithium administration on dialysate glutamate and GABA levels in the frontal cortex of the conscious rat. Synapse 2000; 38: 355-362.
    • (2000) Synapse , vol.38 , pp. 355-362
    • Antonelli, T.1    Ferioli, V.2    Lo Gallo, G.3    Tomasini, M.C.4    Fernandez, M.5    O'Connor, W.T.6
  • 73
    • 0033767639 scopus 로고    scopus 로고
    • Future therapeutic targets in mood disorders: The glucocorticoid receptor
    • McQuade R, Young AH. Future therapeutic targets in mood disorders: the glucocorticoid receptor. Br J Psychiatry 2000; 177: 390-395.
    • (2000) Br J Psychiatry , vol.177 , pp. 390-395
    • McQuade, R.1    Young, A.H.2
  • 74
    • 33645346751 scopus 로고    scopus 로고
    • Reduced glucocorticoid receptor alpha expression in mood disorder patients and first-degree relatives
    • Matsubara T, Funato H, Kobayashi A, Nobumoto M, Watanabe Y. Reduced glucocorticoid receptor alpha expression in mood disorder patients and first-degree relatives. Biol Psychiatry 2006; 59: 689-695.
    • (2006) Biol Psychiatry , vol.59 , pp. 689-695
    • Matsubara, T.1    Funato, H.2    Kobayashi, A.3    Nobumoto, M.4    Watanabe, Y.5
  • 76
    • 0036266738 scopus 로고    scopus 로고
    • Regulation of adult hippocampal neurogenesis-implications for novel theories of major depression
    • Kempermann G. Regulation of adult hippocampal neurogenesis-implications for novel theories of major depression. Bipolar Disord 2002; 4: 17-33.
    • (2002) Bipolar Disord , vol.4 , pp. 17-33
    • Kempermann, G.1
  • 77
    • 0033800486 scopus 로고    scopus 로고
    • Glucocorticoids and hippocampal atrophy in neuro-psychiatric disorders
    • Sapolsky RM. Glucocorticoids and hippocampal atrophy in neuro-psychiatric disorders. Arch Gen Psychiatry 2000; 57: 925-935.
    • (2000) Arch Gen Psychiatry , vol.57 , pp. 925-935
    • Sapolsky, R.M.1
  • 78
    • 17444413709 scopus 로고    scopus 로고
    • Glucocorticoids, depression, and mood disorders: Structural remodeling in the brain
    • McEwen BS. Glucocorticoids, depression, and mood disorders: structural remodeling in the brain. Metabolism 2005; 54(5 Suppl 1): 20-23.
    • (2005) Metabolism , vol.54 , Issue.5 SUPPL. 1 , pp. 20-23
    • McEwen, B.S.1
  • 79
    • 12144289251 scopus 로고    scopus 로고
    • Hippocampal volume, spectroscopy, cognition, and mood in patients receiving corticosteroid therapy
    • Brown ES, Woolston DJ, Frol A, Bobadilla L, Khan DA, Hanczyc M et al Hippocampal volume, spectroscopy, cognition, and mood in patients receiving corticosteroid therapy. Biol Psychiatry 2004; 55: 538-545.
    • (2004) Biol Psychiatry , vol.55 , pp. 538-545
    • Brown, E.S.1    Woolston, D.J.2    Frol, A.3    Bobadilla, L.4    Khan, D.A.5    Hanczyc, M.6
  • 80
    • 21544434047 scopus 로고    scopus 로고
    • Mice with genetically altered glucocorticoid receptor expression show altered sensitivity for stress-induced depressive reactions
    • Ridder S, Chourbaji S, Hellweg R, Urani A, Zacher C, Schmid W et al Mice with genetically altered glucocorticoid receptor expression show altered sensitivity for stress-induced depressive reactions. J Neurosci 2005; 25: 6243-6250.
    • (2005) J Neurosci , vol.25 , pp. 6243-6250
    • Ridder, S.1    Chourbaji, S.2    Hellweg, R.3    Urani, A.4    Zacher, C.5    Schmid, W.6
  • 81
    • 67649362524 scopus 로고    scopus 로고
    • Glucocorticoid receptor transgenic mice as models for depression
    • e-pub ahead of print
    • Chourbaji S, Gass P. Glucocorticoid receptor transgenic mice as models for depression. Brain Res Rev 2007; e-pub ahead of print.
    • (2007) Brain Res Rev
    • Chourbaji, S.1    Gass, P.2


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