The structural neuroimaging of bipolar disorder

International Review of Psychiatry

Volumn 21, Issue 4, 2009, Pages 297-313

  Emsell, Louise ^a   McDonald, Colm ^a  

^a NATIONAL UNIVERSITY OF IRELAND   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

LITHIUM; MOOD STABILIZER; QUETIAPINE; VALPROIC ACID;

AMYGDALOID NUCLEUS; BASAL GANGLION; BIPOLAR DISORDER; BRAIN MALFORMATION; BRAIN REGION; BRAIN SIZE; BRAIN VENTRICLE; CEREBELLUM; CINGULATE GYRUS; CLINICAL RESEARCH; COURSE EVALUATION; CROSS-SECTIONAL STUDY; DEPRESSION; DISEASE ASSOCIATION; DRUG MECHANISM; GENETIC ASSOCIATION; GRAY MATTER; HIPPOCAMPUS; HUMAN; IMAGE ANALYSIS; IMAGE PROCESSING; LIMBIC SYSTEM; LONGITUDINAL STUDY; MAJOR DEPRESSION; METHODOLOGY; NERVE CELL NETWORK; NEUROANATOMY; NEUROIMAGING; NUCLEAR MAGNETIC RESONANCE IMAGING; ONSET AGE; OPTICAL RESOLUTION; PREFRONTAL CORTEX; PRIORITY JOURNAL; REVIEW; SCHIZOPHRENIA; STRUCTURE ANALYSIS; TEMPORAL LOBE; THALAMUS; TISSUE STRUCTURE; WHITE MATTER;

ANTICONVULSANTS; ANTIMANIC AGENTS; BIPOLAR DISORDER; BRAIN; DEPRESSIVE DISORDER, MAJOR; DIFFUSION MAGNETIC RESONANCE IMAGING; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE IMAGING; ORGAN SIZE; SCHIZOPHRENIA;

EID: 70350639621     PISSN: 09540261     EISSN: 13691627     Source Type: Journal    
DOI: 10.1080/09540260902962081     Document Type: Review

References (167)

1. Adler, C. M., Adams, J., DelBello, M. P., Holland, S. K., Schmithorst, V., Levine, A. et al. (2006). Evidence of white matter pathology in bipolar disorder adolescents experiencing their first episode of mania: A diffusion tensor imaging study. American Journal of Psychiatry, 163, 322-324.
2. Adler, C. M., DelBello, M. P., Jarvis, K., Levine, A., Adams, J., & Strakowski, S. M. (2007). Voxel-based study of structural changes in first-episode patients with bipolar disorder. Biological Psychiatry, 61, 776-781.
3. Adler, C. M., DelBello, M. P., Jarvis, K., Levine, A., Adams, J., & Strakowski, S. M. (2007). Voxel-based study of structural changes in first-episode patients with bipolar disorder. Biological Psychiatry, 61, 776-781.
4. Adler, C. M., Levine, A. D., DelBello, M. P., & Strakowski, S. M. (2005). Changes in gray matter volume in patients with bipolar disorder. Biological Psychiatry, 58, 151-157.
5. Ahearn, E. P., Steffens, D. C., Cassidy, F., Van Meter, S. A., Provenzale, J. M., Seldin, M. F. et al. (1998). Familial leukoencephalopathy in bipolar disorder. American Journal of Psychiatry, 155, 1605-1607.
6. Ahn, K. H., Lyoo, I. K., Lee, H. K., Song, I. C., Oh, J. S., Hwang, J. et al. (2004). White matter hyperintensities in subjects with bipolar disorder. Psychiatry and Clinical Neurosciences, 58, 516-521.
7. Altshuler, L. L., Bartzokis, G., Grieder, T., Curran, J., Jimenez, T., Leight, K. et al. (2000). An MRI study of temporal lobe structures in men with bipolar disorder or schizophrenia. Biological Psychiatry, 48, 147-162.
8. Altshuler, L. L., Bartzokis, G., Grieder, T., Curran, J., & Mintz, J. (1998). Amygdala enlargement in bipolar disorder and hippocampal reduction in schizophrenia: An MRI study demonstrating neuroanatomic specificity. Archives of General Psychiatry, 55, 663-664.
9. Altshuler, L. L., Conrad, A., Hauser, P., Li, X. M., Guze, B. H., Denikoff, K. et al. (1991). Reduction of temporal lobe volume in bipolar disorder: A preliminary report of magnetic resonance imaging. Archives of General Psychiatry, 48, 482-483.
10. Altshuler, L. L., Curran, J. G., Hauser, P., Mintz, J., Denicoff, K., & Post, R. (1995). T2 hyperintensities in bipolar disorder: Magnetic resonance imaging comparison and literature meta- analysis. American Journal of Psychiatry, 152, 1139-1144.
11. Ashburner, J., & Friston, K. J. (2000). Voxel-based morphometry - The methods. Neuroimage, 11, 805-821.
12. Ashburner, J., & Friston, K. J. (2001). Why 'voxel-based morphometry' should be used with imperfectly registered images. Neuroimage, 14, 1238-1243.
13. Atmaca, M., Ozdemir, H., Cetinkaya, S., Parmaksiz, S., Belli, H., Poyraz, A. K. et al. (2007). Cingulate gyrus volumetry in drug free bipolar patients and patients treated with valproate or valproate and quetiapine. Journal of Psychiatric Research, 41, 821-827.
14. Atmaca, M., Ozdemir, H., & Yildirim, H. (2007b). Corpus callosum areas in first-episode patients with bipolar disorder. Psychological Medicine, 37, 699-704.
15. Aylward, E. H., Roberts-Twillie, J. V., Barta, P. E., Kumar, A. J., Harris, G. J., Geer, M. et al. (1994). Basal ganglia volumes and white matter hyperintensities in patients with bipolar disorder. American Journal of Psychiatry, 151, 687-693.
16. Basser, P. J., Mattiello, J., & LeBihan, D. (1994). Estimation of the effective self-diffusion tensor from the NMR spin echo. Journal of Magnetic Resonance B, 103, 247-254.
17. Bearden, C. E., Thompson, P. M., Dalwani, M., Hayashi, K. M., Lee, A. D., Nicoletti, M. et al. (2007). Greater cortical gray matter density in lithium-treated patients with bipolar disorder. Biological Psychiatry, 62, 7-16.
18. Bearden, C. E., Thompson, P. M., Dutton, R. A., Frey, B. N., Peluso, M. A., Nicoletti, M. et al. (2008). Three-dimensional mapping of hippocampal anatomy in unmedicated and lithium-treated patients with bipolar disorder. Neuropsychopharmacology, 33, 1229-1238.
19. Bechara, A., Damasio, H., & Damasio, A. R. (2000). Emotion, decision making and the orbitofrontal cortex. Cerebral Cortex, 10, 295-307.
20. Beyer, J. L., Kuchibhatla, M., Payne, M. E., Moo-Young, M., Cassidy, F., Macfall, J. et al. (2004b). Hippocampal volume measurement in older adults with bipolar disorder. American Journal of Geriatric Psychiatry, 12, 613-620. (Pubitemid 41031063)
21. Beyer, J. L., Kuchibhatla, M., Payne, M., Moo-Young, M., Cassidy, F., MacFall, J. et al. (2004a). Caudate volume measurement in older adults with bipolar disorder. International Journal of Geriatric Psychiatry, 19, 109-114. (Pubitemid 38247845)
22. Beyer, J. L., Taylor, W. D., MacFall, J. R., Kuchibhatla, M., Payne, M. E., Provenzale, J. M. et al. (2005). Cortical white matter microstructural abnormalities in bipolar disorder. Neuropsychopharmacology, 30, 2225-2229.
23. Blumberg, H. P., Fredericks, C., Wang, F., Kalmar, J. H., Spencer, L., Papademetris, X. et al. (2005). Preliminary evidence for persistent abnormalities in amygdala volumes in adolescents and young adults with bipolar disorder. Bipolar Disorders, 7, 570-576.
24. Blumberg, H. P., Kaufman, J., Martin, A., Whiteman, R., Zhang, J. H., Gore, J. C. et al. (2003). Amygdala and hippocampal volumes in adolescents and adults with bipolar disorder. Archives of General Psychiatry, 60, 1201-1208.
25. Blumberg, H. P., Stern, E., Martinez, D., Ricketts, S., de Asis, J., White, T. et al. (2000). Increased anterior cingulate and caudate activity in bipolar mania. Biological Psychiatry, 48, 1045-1052.
26. Bonelli, R. M., Kapfhammer, H. P., Pillay, S. S., & Yurgelun- Todd, D. A. (2006). Basal ganglia volumetric studies in affective disorder: What did we learn in the last 15 years? Journal of Neural Transmission, 113, 255-268.
27. Bookstein, F. L. (2001). ''Voxel-based morphometry'' should not be used with imperfectly registered images. Neuroimage, 14, 1454-1462.
28. Brambilla, P., Harenski, K., Nicoletti, M., Mallinger, A. G., Frank, E., Kupfer, D. J. et al. (2001). MRI study of posterior fossa structures and brain ventricles in bipolar patients. Journal of Psychiatric Research, 35, 313-322.
29. Brambilla, P., Harenski, K., Nicoletti, M., Sassi, R. B., Mallinger, A. G., Frank, E. et al. (2003). MRI investigation of temporal lobe structures in bipolar patients. Journal of Psychiatric Research, 37, 287-295.
30. Brambilla, P., Nicoletti, M. A., Harenski, K., Sassi, R. B., Mallinger, A. G., Frank, E. et al. (2002). Anatomical MRI study of subgenual prefrontal cortex in bipolar and unipolar subjects. Neuropsychopharmacology, 27, 792-799.
31. Brambilla, P., Nicoletti, M. A., Sassi, R. B., Mallinger, A. G., Frank, E., Kupfer, D. J. et al. (2003b). Magnetic resonance imaging study of corpus callosum abnormalities in patients with bipolar disorder. Biological Psychiatry, 54, 1294-1297.
32. Brambilla, P., Nicoletti, M., Sassi, R. B., Mallinger, A. G., Frank, E., Keshavan, M. S. et al. (2004). Corpus callosum signal intensity in patients with bipolar and unipolar disorder. Journal of Neurology, Neurosurgery and Psychiatry, 75, 221-225.
33. Brauch, R. A., Adnan, El-Masri, M., Parker Jr, J. C., & El-Mallakh, R. S. (2006). Glial cell number and neuron/glial cell ratios in postmortem brains of bipolar individuals. Journal of Affective Disorder, 91, 87-90.
34. Breeze, J. L., Hesdorffer, D. C., Hong, X., Frazier, J. A., & Renshaw, P. F. (2003). Clinical significance of brain white matter hyperintensities in young adults with psychiatric illness. Harvard Review of Psychiatry, 11, 269-283.
35. Bruno, S. D., Barker, G. J., Cercignani, M., Symms, M., & Ron, M. A. (2004). A study of bipolar disorder using magnetization transfer imaging and voxel-based morphometry. Brain, 127, 2433-2440.
36. Bruno, S., Cercignani, M., & Ron, M. A. (2008). White matter abnormalities in bipolar disorder: A voxelbased diffusion tensor imaging study. Bipolar Disorders, 10, 460-468.
37. Bush, G., Luu, P., & Posner, M. I. (2000). Cognitive and emotional influences in anterior cingulate cortex. Trends in Cognitive Science, 4, 215-222.
38. Caetano, S. C., Sassi, R., Brambilla, P., Nicoletti, M., Mallinger, A. G. et al. (2001). MRI study of thalamic volumes in bipolar and unipolar patients and healthy individuals. Psychiatry Research, 108, 161-168.
39. Caligiuri, M. P., Brown, G. G., Meloy, M. J., Eberson, S. C., Kindermann, S. S., Frank, L. R. et al. (2003). An fMRI study of affective state and medication on cortical and subcortical brain regions during motor performance in bipolar disorder. Psychiatry Research, 123, 171-182.
40. Carlson, G. A., & Meyer, S. E. (2006). Phenomenology and diagnosis of bipolar disorder in children, adolescents, and adults: Complexities and developmental issues. Development and Psychotherapy, 18, 939-969.
41. Chaddock, C., Barker, G.J., Marshall, N., Schulze, K., Hall, M.H., Fern, A., et al. (2009). White matter microstructural impairments and genetic liability to familial bipolar I disorder. British Journal of Psychiatry, 194, 527-534.
42. Chang, K. (2007). Adult bipolar disorder is continuous with pediatric bipolar disorder. Canadian Journal of Psychiatry, 52, 418-425. (Pubitemid 47195846)
43. Chang, K., Barnea-Goraly, N., Karchemskiy, A., Simeonova, D. I., Barnes, P., Ketter, T. et al. (2005a). Cortical magnetic resonance imaging findings in familial pediatric bipolar disorder. Biological Psychiatry, 58, 197-203.
44. Chang, K., Barnea-Goraly, N., Karchemskiy, A., Simeonova, D. I., Barnes, P., Ketter, T. et al. (2005b). Cortical magnetic resonance imaging findings in familial pediatric bipolar disorder. Biological Psychiatry, 58, 197-203.
45. Chang, K., Karchemskiy, A., Barnea-Goraly, N., Garrett, A., Simeonova, D. I., & Reiss, A. (2005). Reduced amygdalar gray matter volume in familial pediatric bipolar disorder. Journal of American Academy of Child and Adolescent Psychiatry, 44, 565-573.
46. Chen, B. K., Sassi, R., Axelson, D., Hatch, J. P., Sanches, M., et al. (2004a). Cross-sectional study of abnormal amygdala development in adolescents and young adults with bipolar disorder. Biological Psychiatry, 56, 399-405.
47. Chen, H. H., Nicoletti, M. A., Hatch, J. P., Sassi, R. B., Axelson, D., Brambilla, P. et al. (2004b). Abnormal left superior temporal gyrus volumes in children and adolescents with bipolar disorder: A magnetic resonance imaging study. Neuroscience Letters, 363, 65-68. (Pubitemid 38639853)
48. Cosgrove, K. P., Mazure, C. M., & Staley, J. K. (2007). Evolving knowledge of sex differences in brain structure, function, and chemistry. Biological Psychiatry, 62, 847-855.
49. Craddock, N., & Owen, M. J. (2007). Rethinking psychosis: The disadvantages of a dichotomous classification now outweigh the advantages. World Psychiatry, 6, 84-91.
50. Dasari, M., Friedman, L., Jesberger, J., Stuve, T. A., Findling, R. L., Swales, T. P. et al. (1999). A magnetic resonance imaging study of thalamic area in adolescent patients with either schizophrenia or bipolar disorder as compared to healthy controls. Psychiatry Research, 91, 155-162. (Pubitemid 29474050)
51. Davis, K. A., Kwon, A., Cardenas, V. A., & Deicken, R. F. (2004). Decreased cortical gray and cerebral white matter in male patients with familial bipolar I disorder. Journal of Affective Disorders, 82, 475-485.
52. de Asis, J. M., Greenwald, B. S., Alexopoulos, G. S., Kiosses, D. N., Ashtari, M., Heo, M. et al. (2006). Frontal signal hyperintensities in mania in old age. American Journal of Geriatric Psychiatry, 14, 598-604.
53. DelBello, M. P., Strakowski, S. M., Zimmerman, M. E., Hawkins, J. M., & Sax, K. W. (1999). MRI analysis of the cerebellum in bipolar disorder: A pilot study. Neuropsychopharmacology, 21, 63-68.
54. DelBello, M. P., Zimmerman, M. E., Mills, N. P., Getz, G. E., & Strakowski, S. M. (2004). Magnetic resonance imaging analysis of amygdala and other subcortical brain regions in adolescents with bipolar disorder. Bipolar Disorders, 6, 43-52.
55. Dickstein, D. P., Milham, M. P., Nugent, A. C., Drevets, W. C, Charney, D. S., Pine, D. S. et al. (2005). Frontotemporal alterations in pediatric bipolar disorder: Results of a voxelbased morphometry study. Archives of General Psychiatry, 62, 734-741.
56. Doris, A., Belton, E., Ebmeier, K. P., Glabus, M. F., & Marshall, I. (2004). Reduction of cingulate gray matter density in poor outcome bipolar illness. Psychiatry Research, 130, 153-159.
57. Doty, T. J., Payne, M. E., Steffens, D. C., Beyer, J. L., Krishnan, K. R., & Labar, K. S. (2008). Age-dependent reduction of amygdala volume in bipolar disorder. Psychiatry Research, 163, 84-94.
58. Drevets, W. C., Price, J. L., Simpson Jr, J. R., Todd, R. D., Reich, T., Vannier, M. et al. (1997). Subgenual prefrontal cortex abnormalities in mood disorders. Nature, 386, 824-827.
59. Duffy, A. (2007). Does bipolar disorder exist in children? A selected review. Canadian Journal of Psychiatry, 52, 409-417.
60. El-Badri, S. M., Cousins, D. A., Parker, S., Ashton, H. C., McAllister, V. L., Ferrier, I. N. et al. (2006). Magnetic resonance imaging abnormalities in young euthymic patients with bipolar affective disorder. British Journal of Psychiatry, 189, 81-82.
61. Elkis, H., Friedman, L., Wise, A., & Meltzer, H. Y. (1995). Metaanalyses of studies of ventricular enlargement and cortical sulcal prominence in mood disorders. Comparisons with controls or patients with schizophrenia. Archives of General Psychiatry, 52, 735-746.
62. Farrow, T. F., Whitford, T. J., Williams, L. M., Gomes, L., & Harris, A. W. (2005). Diagnosis-related regional gray matter loss over two years in first episode schizophrenia and bipolar disorder. Biological Psychiatry, 58, 713-723.
63. Fischl, B., & Dale, A. M. (2000). Measuring the thickness of the human cerebral cortex from magnetic resonance images. Proceedings of the National Academy of Sciences of the United States, 97, 11050-11055.
64. Foland, L. C., Altshuler, L. L., Sugar, C. A., Lee, A. D., Leow, A. D., Townsend, J. et al. (2008). Increased volume of the amygdala and hippocampus in bipolar patients treated with lithium. Neuroreport, 19, 221-224.
65. Fornito, A., Malhi, G. S., Lagopoulos, J., Ivanovski, B., Wood, S. J., Saling, M. M. et al. (2008). Anatomical abnormalities of the anterior cingulate and paracingulate cortex in patients with bipolar I disorder. Psychiatry Research, 162, 123-132.
66. Fornito, A., Malhi, G. S., Lagopoulos, J., Ivanovski, B., Wood, S. J., Velakoulis, D. et al. (2007). In vivo evidence for early neurodevelopmental anomaly of the anterior cingulate cortex in bipolar disorder. Acta Psychiatrica Scandinavica, 116, 467-472.
67. Fornito, A., Whittle, S., Wood, S. J., Velakoulis, D., Pantelis, C., & Yucel, M. (2006). The influence of sulcal variability on morphometry of the human anterior cingulate and paracingulate cortex. Neuroimage, 33, 843-854.
68. Frackowiak, R. S. J., Friston, K. J., Frith, C., Dolan, R., Price, C. J., Zeki, S. et al. (2003). Human Brain Function (2nd edn) London: Academic Press.
69. Frangou, S. (2005). The Maudsley Bipolar Disorder Project. Epilepsia, 46(Suppl.4), 19-25.
70. Frazier, J. A., Ahn, M. S., DeJong, S., Bent, E. K., Breeze, J. L., & Giuliano, A. J. (2005a). Magnetic resonance imaging studies in early-onset bipolar disorder: A critical review. Harvard Review of Psychiatry, 13, 125-140.
71. Frazier, J. A., Breeze, J. L., Makris, N., Giuliano, A. S., Herbert, M. R., Seidman, L. et al. (2005b). Cortical gray matter differences identified by structural magnetic resonance imaging in pediatric bipolar disorder. Bipolar Disorders, 7, 555-569. (Pubitemid 41830003)
72. Frazier, J. A., Breeze, J. L., Papadimitriou, G., Kennedy, D. N., Hodge, S. M., Moore, C. M. et al. (2007). White matter abnormalities in children with and at risk for bipolar disorder. Bipolar Disorders, 9, 799-809.
73. Frazier, J. A., Chiu, S., Breeze, J. L., Makris, N., Lange, N., Kennedy, D. N. et al. (2005c). Structural brain magnetic resonance imaging of limbic and thalamic volumes in pediatric bipolar disorder. American Journal of Psychiatry, 162, 1256-1265. (Pubitemid 40905575)
74. Frazier, J. A., Hodge, S. M., Breeze, J. L., Giuliano, A. J., Terry, J. E., Moore, C. M. et al. (2008). Diagnostic and sex effects on limbic volumes in early-onset bipolar disorder and schizophrenia. Schizophrenia Bulletin, 34, 37-46.
75. Geuze, E., Vermetten, E., & Bremner, J. D. (2005). MR-based in vivo hippocampal volumetrics: 2. Findings in neuropsychiatric disorders. Molecular Psychiatry, 10, 160-184. (Pubitemid 40188512)
76. Greene, T. (2007). The Kraepelinian dichotomy: The twin pillars crumbling? History of Psychiatry, 18, 361-379.
77. Gulseren, S., Gurcan, M., Gulseren, L., Gelal, F., & Erol, A. (2006). T2 hyperintensities in bipolar patients and their healthy siblings. Archives of Medical Research, 37, 79-85.
78. Hajek, T., Gunde, E., Bernier, D., Slaney, C., Propper, L., Grof, P. et al. (2008a). Subgenual cingulate volumes in affected and unaffected offspring of bipolar parents. Journal of Affective Disorder, 108, 263-269.
79. Hajek, T., Kozeny, J., Kopecek, M., Alda, M., & Hoschl, C. (2008b). Reduced subgenual cingulate volumes in mood disorders: A meta-analysis. Journal of Psychiatry and Neuroscience, 33, 91-99.
80. Hasler, G., Drevets, W. C., Gould, T. D., Gottesman, I. I., & Manji, H. K. (2006). Toward constructing an endophenotype strategy for bipolar disorders. Biological Psychiatry, 60, 93-105.
81. Hauser, P., Matochik, J., Altshuler, L. L., Denicoff, K. D., Conrad, A., Li, X. et al. (2000). MRI-based measurements of temporal lobe and ventricular structures in patients with bipolar I and bipolar II disorders. Journal of Affective Disorder, 60, 25-32.
82. Haznedar, M. M., Roversi, F., Pallanti, S., Baldini-Rossi, N., Schnur, D. B., Licalzi, E. M et al. (2005). Fronto-thalamostriatal gray and white matter volumes and anisotropy of their connections in bipolar spectrum illnesses. Biological Psychiatry, 57, 733-742.
83. Hirayasu, Y., McCarley, R. W., Salisbury, D. F., Tanaka, S., Kwon, J. S., Frumin, M. et al. (2000). Planum temporale and Heschl gyrus volume reduction in schizophrenia: A magnetic resonance imaging study of first-episode patients. Archives of General Psychiatry, 57, 692-699.
84. Hirayasu, Y., Shenton, M. E., Salisbury, D. F., Kwon, J. S., Wible, C. G., Fischer, I. A. et al. (1999). Subgenual cingulate cortex volume in first-episode psychosis. American Journal of Psychiatry, 156, 1091-1093.
85. Hirayasu, Y., Tanaka, S., Shenton, M. E., Salisbury, D. F., DeSantis, M. A., Levitt, J. J. et al. (2001). Prefrontal gray matter volume reduction in first episode schizophrenia. Cerebral Cortex, 11, 374-381.
86. Hoge, E. A., Friedman, L., & Schulz, S. C. (1999). Meta-analysis of brain size in bipolar disorder. Schizophrenia Research, 37, 177-181.
87. Houenou, J., Wessa, M., Douaud, G., Leboyer, M., Chanraud, S., Perrin, M. et al. (2007). Increased white matter connectivity in euthymic bipolar patients: Diffusion tensor tractography between the subgenual cingulate and the amygdalo-hippocampal complex. Molecular Psychiatry, 12, 1001-1010.
88. Hwang, J., Lyoo, I. K., Dager, S. R., Friedman, S. D., Oh, J. S., Lee, J. Y. et al. (2006). Basal ganglia shape alterations in bipolar disorder. American Journal of Psychiatry, 163, 276-285.
89. Javadapour, A., Malhi, G. S., Ivanovski, B., Chen, X., Wen, W., & Sachdev, P. (2007). Increased anterior cingulate cortex volume in bipolar I disorder. Australian and New Zealand Journal of Psychiatry, 41, 910-916.
90. Javadapour, A., Malhi, G. S., Ivanovski, B., Chen, X., Wen, W., & Sachdev, P. (2007). Increased anterior cingulate cortex volume in bipolar I disorder. The Australian and New Zealand Journal of Psychiatry, 41, 910-916.
91. Kaur, S., Sassi, R. B., Axelson, D., Nicoletti, M., Brambilla, P., Monkul, E. S. et al. (2005). Cingulate cortex anatomical abnormalities in children and adolescents with bipolar disorder. American Journal of Psychiatry, 162, 1637-1643.
92. Kempton, M. J., Geddes, J. R., Ettinger, U., Williams, S. C., & Grasby, P. M. (2008). Meta-analysis, database, and metaregression of 98 structural imaging studies in bipolar disorder. Archives of General Psychiatry, 65, 1017-1032.
93. Kieseppa, T., van Erp, T. G., Haukka, J., Partonen, T., Cannon, T. D., Poutanen, V. P. et al. (2003). Reduced left hemispheric white matter volume in twins with bipolar I disorder. Biological Psychiatry, 54, 896-905.
94. Konarski, J. Z., McIntyre, R. S., Kennedy, S. H., Rafi-Tari, S., Soczynska, J. K., & Ketter, T. A. (2008). Volumetric neuroimaging investigations in mood disorders: Bipolar disorder versus major depressive disorder. Bipolar Disorders, 10, 31-37.
95. Lenroot, R. K., Gogtay, N., Greenstein, D. K., Wells, E. M., Wallace, G. L., Clasen, L. S. et al. (2007). Sexual dimorphism of brain developmental trajectories during childhood and adolescence. Neuroimage, 36, 1065-1073.
96. Lin, P. I., & Mitchell, B. D. (2008). Approaches for unraveling the joint genetic determinants of schizophrenia and bipolar disorder. Schizophrenia Bulletin, 34, 791-797.
97. Lochhead, R. A., Parsey, R. V., Oquendo, M. A., & Mann, J. J. (2004). Regional brain gray matter volume differences in patients with bipolar disorder as assessed by optimized voxelbased morphometry. Biological Psychiatry, 55, 1154-1162.
98. Lopez-Larson, M. P., DelBello, M. P., Zimmerman, M. E., Schwiers, M. L., & Strakowski, S. M. (2002). Regional prefrontal gray and white matter abnormalities in bipolar disorder. Biological Psychiatry, 52, 93-100.
99. Lyoo, I. K., Kim, M. J., Stoll, A. L., Demopulos, C. M., Parow, A. M., Dager, S. R. et al. (2004). Frontal lobe gray matter density decreases in bipolar I disorder. Biological Psychiatry, 55, 648-651.
100. Lyoo, I. K., Lee, H. K., Jung, J. H., Noam, G. G., & Renshaw, P. F. (2002). White matter hyperintensities on magnetic resonance imaging of the brain in children with psychiatric disorders. Comprehensive Psychiatry, 43, 361-368.
101. Lyoo, I. K., Sung, Y. H., Dager, S. R., Friedman, S. D., Lee, J. Y., Kim, S. J. et al. (2006). Regional cerebral cortical thinning in bipolar disorder. Bipolar Disorders, 8, 65-74.
102. Manji, H. K., Moore, G. J., & Chen, G. (2000). Clinical and preclinical evidence for the neurotrophic effects of mood stabilizers: Implications for the pathophysiology and treatment of manic-depressive illness. Biological Psychiatry, 48, 740-754.
103. McDonald, C., Bullmore, E. T., Sham, P. C., Chitnis, X., Wickham, H., Bramon, E. et al. (2004a). Association of genetic risks for schizophrenia and bipolar disorder with specific and generic brain structural endophenotypes. Arch Gen Psychiatry, 61, 974-984.
104. McDonald, C., Bullmore, E., Sham, P., Chitnis, X., Suckling, J., MacCabe, J. et al. (2005). Regional volume deviations of brain structure in schizophrenia and psychotic bipolar disorder: Computational morphometry study. British Journal of Psychiatry, 186, 369-377.
105. McDonald, C., Marshall, N., Sham, P. C., Bullmore, E. T., Schulze, K., Chapple, B. et al. (2006). Regional brain morphometry in patients with schizophrenia or bipolar disorder and their unaffected relatives. American Journal of Psychiatry, 163, 478-487. (Pubitemid 44469391)
106. McDonald, C., Zanelli, J., Rabe-Hesketh, S., Ellison-Wright, I., Sham, P., Kalidindi, S. et al. (2004b). Meta-analysis of magnetic resonance imaging brain morphometry studies in bipolar disorder. Biological Psychiatry, 56, 411-417.
107. McGuffin, P., Rijsdijk, F., Andrew, M., Sham, P., Katz, R., & Cardno, A. (2003). The heritability of bipolar affective disorder and the genetic relationship to unipolar depression. Archives of General Psychiatry, 60, 497-502.
108. McIntosh, A. M., Job, D. E., Moorhead, T. W., Harrison, L. K., Forrester, K., Lawrie, S. M. et al. (2004). Voxel-based morphometry of patients with schizophrenia or bipolar disorder and their unaffected relatives. Biological Psychiatry, 56, 544-552.
109. McIntosh, A. M., Job, D. E., Moorhead, T. W., Harrison, L. K., Lawrie, S. M., & Johnstone, E. C. (2005). White matter density in patients with schizophrenia, bipolar disorder and their unaffected relatives. Biological Psychiatry, 58, 254-257.
110. McIntosh, A. M., Maniega, S. M., Lymer, G. K., McKirdy, J., Hall, J., Sussmann, J. E. et al. (2008). White matter tractography in bipolar disorder and schizophrenia. Biological Psychiatry, 64, 1088-1092.
111. Mills, N. P., Delbello, M. P., Adler, C. M., & Strakowski, S. M. (2005). MRI analysis of cerebellar vermal abnormalities in bipolar disorder. American Journal of Psychiatry, 162, 1530-1532.
112. Monkul, E. S., Hatch, J. P., Sassi, R. B., Axelson, D., Brambilla, P., Nicoletti, M. A. et al. (2008). MRI study of the cerebellum in young bipolar patients. Progress in Neuropsychopharmacology and Biological Psychiatry, 32, 613-619.
113. Monkul, E. S., Nicoletti, M. A., Spence, D., Sassi, R. B., Axelson, D., Brambilla, P. et al. (2006). MRI study of thalamus volumes in juvenile patients with bipolar disorder. Depression and Anxiety, 23, 347-352. (Pubitemid 44619786)
114. Moore, G. J., Bebchuk, J. M., Wilds, I. B., Chen, G., & Manji, H. K. (2000). Lithium-induced increase in human brain grey matter. Lancet, 356, 1241-1242.
115. Moore, P. B., Shepherd, D. J., Eccleston, D., Macmillan, I. C., Goswami, U., McAllister, V. L. et al. (2001). Cerebral white matter lesions in bipolar affective disorder: Relationship to outcome. British Journal of Psychiatry, 178, 172-176.
116. Najt, P., Nicoletti, M., Chen, H. H., Hatch, J. P., Caetano, S. C., Sassi, R. B. et al. (2007). Anatomical measurements of the orbitofrontal cortex in child and adolescent patients with bipolar disorder. Neuroscience Letters, 413, 183-186.
117. Noga, J. T, Vladar, K., & Torrey, E. F. (2001). A volumetric magnetic resonance imaging study of monozygotic twins discordant for bipolar disorder. Psychiatry research, 106, 25-34.
118. Nugent, A. C., Milham, M. P., Bain, E. E., Mah, L., Cannon, D. M., Marrett, S. et al. (2006). Cortical abnormalities in bipolar disorder investigated with MRI and voxel-based morphometry. Neuroimage, 30, 485-497.
119. Pearlson, G. D., Barta, P. E., Powers, R. E., Menon, R. R., Richards, S. S., Aylward, E. H. et al. (1997). Ziskind-Somerfeld Research Award 1996. Medial and superior temporal gyral volumes and cerebral asymmetry in schizophrenia versus bipolar disorder. Biological Psychiatry, 41, 11-14.
120. Phillips, M. L., Travis, M. J., Fagiolini, A., & Kupfer, D. J. (2008). Medication effects in neuroimaging studies of bipolar disorder. American Journal of Psychiatry, 165, 313-320.
121. Phillips, M. L., & Vieta, E. (2007). Identifying functional neuroimaging biomarkers of bipolar disorder: Toward DSM-V. Schizophrenia Bulletin, 33, 893-904.
122. Picard, H., Amado, I., Mouchet-Mages, S., Olie, J. P., & Krebs, M. O. (2008). The role of the cerebellum in schizophrenia: An update of clinical, cognitive, and functional evidences. Schizophrenia Bulletin, 34, 155-172.
123. Pillai, J. J., Friedman, L., Stuve, T. A., Trinidad, S., Jesberger, J. A., Lewin, J. S. et al. (2002). Increased presence of white matter hyperintensities in adolescent patients with bipolar disorder. Psychiatry Research, 114, 51-56.
124. Poldrack, R. A., Fletcher, P. C., Henson, R. N., Worsley, K. J., Brett, M., & Nichols, T. E. (2008). Guidelines for reporting an fMRI study. Neuroimage, 40, 409-414.
125. Pompili, M., Ehrlich, S., De Pisa, E., Mann, J. J., Innamorati, M., Cittadini, A. et al. (2007). White matter hyperintensities and their associations with suicidality in patients with major affective disorders. European Archives of Psychiatry and Clinical Neuroscience, 257, 494-499.
126. Pugh, G. E. (1977). The Biological Origin of Human Values. Basic Books: New York.
127. Radonic, E., Henigsberg, N., Rados, M., Mimica, N., & Folnegovic-Smalc, V. (2008). Temporal lobe volume in disorders with psychotic features. Collegium Antropologicum, 32(Supplement 1), 139-142.
128. Rajkowska, G., Halaris, A., & Selemon, L. D. (2001). Reductions in neuronal and glial density characterize the dorsolateral prefrontal cortex in bipolar disorder. Biological Psychiatry, 49, 741-752.
129. Regenold, W. T. (2008). Lithium and increased cortical gray matter-more tissue or more water? Biological Psychiatry, 63, e17; author reply e19.
130. Ridgway, G. R., Henley, S. M., Rohrer, J. D., Scahill, R. I., Warren, J. D., & Fox, N. C. (2008). Ten simple rules for reporting voxel-based morphometry studies. Neuroimage, 40, 1429-1435.
131. Robinson, L. J., Thompson, J. M., Gallagher, P., Goswami, U., Young, A. H., Ferrier, I. N. et al. (2006). A meta-analysis of cognitive deficits in euthymic patients with bipolar disorder. Journal of Affective Disorders, 93, 105-115.
132. Rosso, I. M., Killgore, W. D., Cintron, C. M., Gruber, S. A., Tohen, M., & Yurgelun-Todd, D. A. (2007). Reduced amygdala volumes in first-episode bipolar disorder and correlation with cerebral white matter. Biological Psychiatry, 61, 743-749.
133. Roy, P. D., Zipursky, R. B., Saint-Cyr, J. A., Bury, A., Langevin, R., & Seeman, M. V. (1998). Temporal horn enlargement is present in schizophrenia and bipolar disorder. Biological Psychiatry, 44, 418-422.
134. Sanches, M., Roberts, R. L., Sassi, R. B., Axelson, D., Nicoletti, M., Brambilla, P. et al. (2005). Developmental abnormalities in striatum in young bipolar patients: A preliminary study. Bipolar Disorders, 7, 153-158.
135. Sanches, M., Sassi, R. B., Axelson, D., Nicoletti, M., Brambilla, P., Hatch, J. P. et al. (2005b). Subgenual prefrontal cortex of child and adolescent bipolar patients: A morphometric magnetic resonance imaging study. Psychiatry Research, 138, 43-49.
136. Sapolsky, R. M. (2000). Glucocorticoids and hippocampal atrophy in neuropsychiatric disorders. Archives of General Psychiatry, 57, 925-935.
137. Sassi, R. B., Nicoletti, M., Brambilla, P., Mallinger, A. G., Frank, E., Kupfer, D. J. et al. (2002). Increased gray matter volume in lithium-treated bipolar disorder patients. Neuroscience Letters, 329, 243-245.
138. Sax, K. W., Strakowski, S. M., Zimmerman, M. E., DelBello, M. P., Keck Jr., P. E, & Hawkins, J. M. (1999). Frontosubcortical neuroanatomy and the continuous performance test in mania. American Journal of Psychiatry, 156, 139-141.
139. Scherk, H., Kemmer, C., Usher, J., Reith, W., Falkai, P., & Gruber, O. (2008). No change to grey and white matter volumes in bipolar I disorder patients. European Archives of Psychiatry and Clinical Neuroscience, 258, 345-349.
140. Schlaepfer, T. E., Harris, G. J., Tien, A. Y., Peng, L., Lee, S., & Pearlson, G. D. (1995). Structural differences in the cerebral cortex of healthy female and male subjects: A magnetic resonance imaging study. Psychiatry Research, 61, 129-135.
141. Schmahmann, J. D., Weilburg, J. B., & Sherman, J. C. (2007). The neuropsychiatry of the cerebellum - Insights from the clinic. Cerebellum, 6, 254-267.
142. Sharma, V., Menon, R., Carr, T. J., Densmore, M., Mazmanian, D., & Williamson, P. C. (2003). An MRI study of subgenual prefrontal cortex in patients with familial and non-familial bipolar I disorder. Journal of Affective Disorders, 77, 167-171.
143. Silverstone, T., McPherson, H., Li, Q., & Doyle, T. (2003). Deep white matter hyperintensities in patients with bipolar depression, unipolar depression and age-matched control subjects. Bipolar Disorders, 5, 53-57.
144. Singh, M. K., Delbello, M. P., Adler, C. M., Stanford, K. E., & Strakowski, S. M. (2008). Neuroanatomical characterization of child offspring of bipolar parents. Journal of the American Academy of Child and Adolescent Psychiatry, 47, 526-531.
145. Sneed, J. R., Roose, S. P., & Sackeim, H. A. (2006). Vascular depression: A distinct diagnostic subtype? Biological Psychiatry, 60, 1295-1298.
146. Soares, J. C., Kochunov, P., Monkul, E. S., Nicoletti, M. A., Brambilla, P., Sassi, R. B. et al. (2005). Structural brain changes in bipolar disorder using deformation field morphometry. Neuroreport, 16, 541-544.
147. Strakowski, S. M., Adler, C. M., Holland, S. K., Mills, N., & DelBello, M. P. (2004). A preliminary FMRI study of sustained attention in euthymic, unmedicated bipolar disorder. Neuropsychopharmacology, 29, 1734-1740.
148. Strakowski, S. M., Delbello, M. P., & Adler, C. M. (2005). The functional neuroanatomy of bipolar disorder: A review of neuroimaging findings. Molecular Psychiatry, 10, 105-116.
149. Strakowski, S. M., DelBello, M. P., Sax, K. W., Zimmerman, M. E., Shear, P. K., Hawkins, J. M. et al. (1999). Brain magnetic resonance imaging of structural abnormalities in bipolar disorder. Archives of General Psychiatry, 56, 254-260.
150. Strakowski, S. M., DelBello, M. P., Zimmerman, M. E., Getz, G. E., Mills, N. P., Ret, J. et al. (2002). Ventricular and periventricular structural volumes in first- versus multipleepisode bipolar disorder. American Journal of Psychiatry, 159, 1841-1847.
151. Strasser, H. C., Lilyestrom, J., Ashby, E. R., Honeycutt, N. A., Schretlen, D. J., Pulver, A. E. et al. (2005). Hippocampal and ventricular
152. Swayze, V. W. II, Andreasen, N. C., Alliger, R. J., Yuh, W. T., & Ehrhardt, J. C. (1992). Subcortical and temporal structures in affective disorder and schizophrenia: A magnetic resonance imaging study. Biological Psychiatry, 31, 221-240.
153. Uranova, N. A., Vostrikov, V. M., Orlovskaya, D. D., & Rachmanova, V. I. (2004). Oligodendroglial density in the prefrontal cortex in schizophrenia and mood disorders: A study from the Stanley Neuropathology Consortium. Schizophrenia Research, 67, 269-275.
154. Vawter, M. P., Freed, W. J., & Kleinman, J. E. (2000). Neuropathology of bipolar disorder. Biological Psychiatry, 48, 486-504.
155. Velakoulis, D., Wood, S. J., Wong, M. T., McGorry, P. D., Yung, A., Phillips, L. et al. (2006). Hippocampal and amygdala volumes according to psychosis stage and diagnosis: A magnetic resonance imaging study of chronic schizophrenia, first-episode psychosis, and ultra-high-risk individuals. Archives of General Psychiatry, 63, 139-149.
156. Versace, A., Almeida, J. R., Hassel, S., Walsh, N. D., Novelli, M., Klein, C. R. et al. (2008). Elevated left and reduced right orbitomedial prefrontal fractional anisotropy in adults with bipolar disorder revealed by tract-based spatial statistics. Archives of General Psychiatry, 65, 1041-1052.
157. Videbech, P., & Ravnkilde, B. (2004). Hippocampal volume and depression: A meta-analysis of MRI studies. American Journal of Psychiatry, 161, 1957-1966.
158. Vogt, B. A., Finch, D. M., & Olson, C. R. (1992). Functional heterogeneity in cingulate cortex: The anterior executive and posterior evaluative regions. Cerebral Cortex, 2, 435-443.
159. Wang, F., Jackowski, M., Kalmar, J. H., Chepenik, L. G., Tie, K., Qiu, M. et al. (2008a). Abnormal anterior cingulum integrity in bipolar disorder determined through diffusion tensor imaging. British Journal of Psychiatry, 193, 126-129.
160. Wang, F., Kalmar, J. H., Edmiston, E., Chepenik, L. G., Bhagwagar, Z., Spencer, L. et al. (2008b). Abnormal corpus callosum integrity in bipolar disorder: A diffusion tensor imaging study. Biological Psychiatry, 64, 730-733.
161. Wilke, M., Kowatch, R. A., DelBello, M. P., Mills, N. P., & Holland, S. K. (2004). Voxel-based morphometry in adolescents with bipolar disorder: First results. Psychiatry Research, 131, 57-69.
162. Wright, I. C., Rabe-Hesketh, S., Woodruff, P. W., David, A. S., Murray, R. M., & Bullmore, E. T. (2000). Meta-analysis of regional brain volumes in schizophrenia. American Journal of Psychiatry, 157, 16-25.
163. Yatham, L. N., Lyoo, I. K., Liddle, P., Renshaw, P. F., Wan, D., Lam, R. W. et al. (2007). A magnetic resonance imaging study of mood stabilizer- and neuroleptic-naive first-episode mania. Bipolar Disorders, 9, 693-697.
164. Yucel, K., McKinnon, M. C., Taylor, V. H., Macdonald, K., Alda, M., Young, L. T. et al. (2007). Bilateral hippocampal volume increases after long-term lithium treatment in patients with bipolar disorder: A longitudinal MRI study. Psychopharmacology (Berlin), 195, 357-367.
165. Yucel, K., Taylor, V. H., McKinnon, M. C., Macdonald, K., Alda, M., Young, L. T. et al. (2008). Bilateral hippocampal volume increase in patients with bipolar disorder and short-term lithium treatment. Neuropsychopharmacology, 33, 361-367.
166. Yurgelun-Todd, D. A., Silveri, M. M., Gruber, S. A., Rohan, M. L., & Pimentel, P. J. (2007). White matter abnormalities observed in bipolar disorder: A diffusion tensor imaging study. Bipolar Disorders, 9, 504-512.
167. Zimmerman, M. E., DelBello, M. P., Getz, G. E., Shear, P. K., & Strakowski, S. M. (2006). Anterior cingulate subregion volumes and executive function in bipolar disorder. Bipolar Disorders, 8, 281-288.