Decrease and recovery of N-acetylaspartate/creatine in rat brain remote from focal injury

Journal of Neurotrauma

Volumn 18, Issue 3, 2001, Pages 241-246

  Gasparovic, C ^a   Arfai, N ^b   Smid, N ^b   Feeney, D M ^a,b  

^a UNIVERSITY OF NEW MEXICO SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF NEW MEXICO   (United States)

Author keywords

Brain; Diaschisis; Injury; Metabolism; MRS; N acetylaspartate; Spectroscopy

Indexed keywords

CREATINE; DEOXYGLUCOSE; GLYCEROL 3 PHOSPHATE DEHYDROGENASE; N ACETYLASPARTIC ACID;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN INJURY; BRAIN REGION; CONTROLLED STUDY; DIFFUSE AXONAL INJURY; NERVE CELL NECROSIS; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OCCIPITAL CORTEX; PROTON NUCLEAR MAGNETIC RESONANCE; RAT;

EID: 0035076448     PISSN: 08977151     EISSN: None     Source Type: Journal    
DOI: 10.1089/08977150151070856     Document Type: Article

References (41)

1. Fluorine-18-FDG evaluation of crossed cerebellar diaschisis in head injury
2. 31P nuclear-magnetic-resonance studies on superfused cerebral tissues
3. 1H-NMR spectroscopic studies of brain
4. Metabolic and cognitive response to human traumatic brain injury: A quantitative proton magnetic resonance study
5. Proton magnetic resonance spectroscopy for detection of axonal injury in the splenium of the corpus callosum of brain-injured patients
6. High-field proton magnetic resonance spectroscopy of a swine model for axonal injury
7. 1H magnetic resonance spectroscopy
8. N-Acetyl aspartate: A marker for neuronal loss or mitochondrial dysfunction
9. Responses to cortical injury: II. Widespread depression of the activity of an enzyme in cortex remote from a focal injury
10. Serial proton magnetic resonance spectroscopy in acute multiple sclerosis lesions
11. Quantitative cerebral blood flow and metabolism determination in the first 48 hours after severe head injury with a new dynamic SPECT device
12. Reversible decreases in N-acetylaspartate after acute brain injury
13. Short-term dichloroacetate treatment improves indices of cerebral metabolism in patients with mitochondrial disorders
14. Pharmacologic modulation of recovery after brain injury: A reconsideration of diaschisis
15. Responses to cortical injury: I. Methodology and local effects of contusions in the rat
16. Pattern of brain damage in a traumatic brain injury model: Noradrenergic pharmacotherapy promotes recovery of function
17. Mechanisms of delayed cell death in cortical contusions
18. Proton MR spectroscopic findings correspond to neuropsychological function in traumatic brain injury
19. Quantitative proton MRS predicts outcome after traumatic brain injury
20. 2+ modulated lipolysis in neonatal rat brain slices observed by 1D and 2D NMR
21. Metabolism in single rat brain slices measured by magnetic resonance spectroscopy
22. Local cerebral glucose metabolism in patients with long-term behavioral and cognitive deficits following mild traumatic brain injury
23. Early perfusion after controlled cortical impact in rats: Quantification by arterial spin-labeled MRI and the influence of spin-lattice relaxation time heterogeneity
24. Diffuse prolonged depression of cerebral oxidative-metabolism following concussive brain injury in the rat: A cytochrome-oxidase histochemistry study
25. Metabolic dysfunction
26. Recovery of N-acetylaspartate in corticomotor neurons of patients with ALS after riluzole therapy
27. Biological markers in the diagnosis and treatment of ALS
28. An intrathecal bolus of cyclosporin a before injury preserves mitochondrial integrity and attenuates axonal disruption in traumatic brain injury
29. Synthesis of N-acetyl-L-aspartate by rat brain mitochondria and its involvement in mitochondrial/cytoslic carbon transport
30. Temporally changing patterns of hippocampal cerebral glucose utilization following hypermetabolism sensorimotor cortex contusion in rats
31. D-Amphetamine attenuates decreased cerebral glucose utilization after unilateral sensorimotor cortex contusion in rats
32. 1H MRS in acute traumatic brain injury
33. 1H NMR spectroscopy following experimental brain trauma
34. Cholinergic modulation of cerebral cortical blood flow changes induced by trauma
35. Mitochondral dysfunction assessed by NAA reduction in traumatic brain injury
36. Magnetic resonance spectroscopy of diffuse brain trauma in the pig
37. Changes of cerebral energy metabolism and lipid peroxidation in rats leading to mitochondrial dysfunction after diffuse brain injury
38. The relationship between traumatic brain injury-induced changes in brain temperature and behavioral and anatomical outcome
39. 1H spectroscopic imaging of acute head injury-evidence of diffuse axonal injury
40. Mitochondrial dysfunction and calcium perturbation induced by traumatic brain injury
41. Dynamic changes in local cerebral glucose utilization following cerebral conclusion in rats: Evidence of a hyper- And subsequent hypometabolic state