Increased choline-containing compounds in the orbitofrontal cortex and hippocampus in euthymic patients with bipolar disorder: A proton magnetic resonance spectroscopy study

Psychiatry Research - Neuroimaging

Volumn 172, Issue 3, 2009, Pages 205-209

  Senaratne, Rhandi ^a   Milne, Andrea M ^a   MacQueen, Glenda M ^a,b   Hall, Geoffrey B C ^a,b  

^a MCMASTER UNIVERSITY   (Canada)

^b Brain Body Institute   (Canada)

Author keywords

Bipolar affective disorder; Choline; Magnetic; Resonance; Spectroscopy

Indexed keywords

CHOLINE; GLUTAMIC ACID; GLYCEROPHOSPHORYLCHOLINE; N ACETYLASPARTIC ACID; PHOSPHORYLCHOLINE;

ADULT; ARTICLE; BIPOLAR DISORDER; CLINICAL ARTICLE; CONTROLLED STUDY; DIAGNOSTIC VALUE; FEMALE; HIPPOCAMPUS; HUMAN; MALE; NERVE DEGENERATION; ORBITAL CORTEX; PATHOPHYSIOLOGY; PHOSPHOLIPID METABOLISM; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; TISSUE DISTRIBUTION;

ADULT; ANALYSIS OF VARIANCE; ASPARTIC ACID; BIPOLAR DISORDER; CASE-CONTROL STUDIES; CHOLINE; FEMALE; FRONTAL LOBE; FUNCTIONAL LATERALITY; GLUTAMIC ACID; GLUTAMINE; GLYCERYLPHOSPHORYLCHOLINE; HIPPOCAMPUS; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; MAGNETIC RESONANCE SPECTROSCOPY; MALE; MIDDLE AGED; PHOSPHORYLCHOLINE; PSYCHIATRIC STATUS RATING SCALES; SEVERITY OF ILLNESS INDEX;

EID: 67349210197     PISSN: 09254927     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pscychresns.2008.07.007     Document Type: Article

References (46)

1. Altshuler L.L., Bookheimer S.Y., Townsend J., Proenza M.A., Eisenberger N., Sabb F., Mintz J., and Cohen M.S. Blunted activation in orbitofrontal cortex during mania: a functional magnetic resonance imaging study. Biological Psychiatry 58 (2005) 763-769
2. Amaral J.A.M.S., Lafer B., Tamada R.S., Issler C.K., Cerri G.G., and de Castro C.C. A HMRS study of the anterior cingulate gyrus in euthymic bipolar patients taking lithium. Biological Psychiatry 51S (2002) 87
3. Anderson S.W., Bechara A., Damasio H., Tranel D., and Damasio A.R. Impairment of social and moral behavior related to early damage in human prefrontal cortex. Nature Neuroscience 2 (1999) 1032-1037
4. Benes F.M., Kwok E.W., Vincent S.L., and Todtenkopf M.S. A reduction of nonpyramidal cells in sector CA2 of schizophrenics and manic depressives. Biological Psychiatry 44 (1998) 88-97
5. Bertolino A., Frye M., Callicott J.H., Mattay V.S., Rakow R., Shelton-Repella J., Post R., and Weinberger D.R. Neuronal pathology in the hippocampal area of patients with bipolar disorder: a study with proton magnetic resonance spectroscopic imaging. Biological Psychiatry 53 (2003) 906-913
6. Blumberg H., Kaufman J., Martin A., Whiteman R., Zhang J., Gore J., Charney D., Krystal J., and Peterson B. Amygdala and hippocampal volumes in adolescents and adults with bipolar disorder. Archives of General Psychiatry 60 (2003) 1201-1208
7. Brambilla P., Stanley J.A., Nicoletti M.A., Sassi R.B., Mallinger A.G., Frank E., Kupfer D., Keshavan M.S., and Soares J.C. H magnetic resonance spectroscopy investigation of the dorsolateral prefrontal cortex in bipolar disorder patients. Journal of Affective Disorders 86 (2005) 61-67
8. Bruhn H., Stoppe G., Staedt J., Merboldt K.D., Hanicke W., and Frahm J. Quantitative proton MRS in vivo shows cerebral myo-inositol and cholines to be unchanged in manic-depressive patients treated with lithium. Proceedings of the International Society for Magnetic Resonance in Medicine (1993) 1543
9. Castillo M., Kwock L., Courvoisie H., and Hooper S.R. Proton MR spectroscopy in children with bipolar affective disorder: preliminary observations. AJNR. American Journal of Neuroradiology 21 (2000) 832-838
10. Cecil K.M., Del Bello M.P., Morey R., and Strakowski S.M. Frontal lobe differences in bipolar disorder as determined by proton MR spectroscopy. Bipolar Disorders 4 (2002) 357-365
11. Chen G., Zeng W.Z., Jiang L., Yuang P.X., Zhao J., and Manji H.K. The mood stabilizing agents lithium and valproate robustly increase the expression of the neuroprotective protein bcl-2 in the CNS. Journal of Neurochemistry 72 (1999) 879-882
12. Cunningham W.A., Johnson M.K., Gatenby J.C., Gore J.C., and Banaji M.R. Neural components of social evaluation. Journal of Personality and Social Psychology 85 (2003) 639-649
13. Dager S.R., Friedman S.D., Parow A., Demopulos C., Stoll A.L., Lyoo I.K., Dunner D.L., and Renshaw P.F. Brain metabolic alterations in medication-free patients with bipolar disorder. Archives of General Psychiatry 61 (2004) 450-458
14. Dean B., Scarr E., and McLeod M. Changes in hippocampal GABAA receptor subunit composition in bipolar 1 disorder. Brain Research: Molecular Brain Research 138 (2005) 145-155
15. Elliot R., Ogilvie A., Rubinsztein J., Calderon G., Dolan R., and Sahakian B. Abnormal ventral frontal response during performance of an affective go/no go task in patients with mania. Biological Psychiatry 55 (2004) 1163-1170
16. Frey B.N., Folgierini M., Nicoletti M., Machado-Vieria R., Stanley J.A., Soares J.C., and Kapczinski F. A proton magnetic resonance spectroscopy investigation of the dorsolateral prefrontal cortex in acute mania. Human Psychopharmacology 30 (2005) 133-139
17. Frey B.N., Andreazza A.C., Nery F.G., Martins M.R., Quevedo J., Soares J.C., and Kapczinski F. The role of the hippocampus in the pathophysiology of bipolar disorder. Behavioural Pharmacology 18 (2007) 419-430
18. Friedman S.D., Dager S.R., Parow A., Hirashima F., Demopulos C., Stoll A.L., Lyoo I.K., Dunner D.L., and Renshaw P.F. Lithium and valproic acid treatment effects on brain chemistry in bipolar disorder. Biological Psychiatry 56 (2004) 340-348
19. Glitz D.A., Manji H.K., and Moore G.J. Mood disorders: treatment-induced changes in brain neurochemistry and structure. Seminars in Clinical Neuropsychiatry 7 (2002) 269-280
20. Hamakawa H., Kato T., Murashita J., and Kato N. Quantitative magnetic resonance spectroscopy of the basal ganglia in patients with affective disorders. European Archives of Psychiatry and Clinical Neuroscience 248 (1998) 53-58
21. Hamakawa H., Kato T., Shioiri T., Inubushi T., and Kato N. Quantitative proton magnetic resonance spectroscopy of the bilateral frontal lobes in patients with bipolar disorder. Psychological Medicine 29 (1999) 639-644
22. Harvey I., Persaud R., Ron M.A., Baker G., and Murray R.M. Volumetric MRI measurements in bipolars compared with schizophrenics and healthy controls. Psychological Medicine 24 (1994) 689-699
23. Heckers S., Stone D., Walsh J., Shick J., Koul P., and Benes F.M. Differential hippocampal expression of glutamic acid decarboxylase 65 and 67 messenger RNA in bipolar disorder and schizophrenia. Archives of General Psychiatry 59 (2002) 521-529
24. Jenkins B.G., Koroshetz W.J., Beal F., and Rosen B.R. Evidence for impairment of energy metabolism in vivo in Huntington's disease using localized 1H NMR spectroscopy. Neurology 43 (1993) 2689-2695
25. Kato T., Hamakawa H., Shioiri T., Murashita J., Takahashi Y., Takahashi S., and Inubushi T. Choline containing compounds detected by proton magnetic resonance spectroscopy in the basal ganglia in bipolar disorder. Journal of Psychiatry and Neuroscience 21 (1996) 248-254
26. Lafer B., Renshaw P.F., Sachs G., Christensen J.D., Yurgelun-Todd D., and Stoll A.L. Proton MRS of the basal ganglia in bipolar disorder. Biological Psychiatry 35 (1994) 685
27. Liu L., Schulz S.C., Lee S., Reutiman T.J., and Fatemi S.H. Hippocampal CA1 pyramidal cell size is reduced in bipolar disorder. Cellular and Molecular Neurobiology 27 (2007) 351-358
28. Malhi G.S., Valenzuela M., Wen W., and Sachdev P. Magnetic resonance spectroscopy and its applications in psychiatry. The Australian and New Zealand Journal of Psychiatry 36 (2002) 31-43
29. Manji H.K., Moore G.J., and Chen G. Lithium up-regulates the cytoprotective protein Bcl-2 in the CNS in vivo: a role for neurotrophic and neuroprotective effects in manic depressive illness. Journal of Clinical Psychiatry 61 (2000) 82-96
30. Meyerhoff D.J., Mackay S., Constans J.M., Norman D., Van Dyke C., Fein G., and Weiner M.W. Axonal injury and membrane alterations in Alzheimer's disease suggested by in vivo proton magnetic resonance spectroscopic imaging. Annals of Neurology 36 (1994) 40-47
31. Michael N., Erfurth A., Ohrmann P., Gossling M., Arolt V., Heindel W., and Pfleiderer B. Acute mania is accompanied by elevated glutamate/glutamine levels the left dorsolateral prefrontal cortex. Psychopharmacology 168 (2003) 344-346
32. Moore G.J., and Galloway M.P. MRS: neurochemistry and treatment effects in affective disorders. Psychopharmacology Bulletin 36 (2002) 5-23
33. Moore C.M., Breeze J.L., Gruber S.A., Babb S.M., Frederick B.B., Villafuerte R.A., Stoll A.L., Hennen J., Yurgelun-Todd D.A., Cohen B.M., and Renshaw P.F. Choline, myo-inositol and mood in bipolar disorder: a proton magnetic resonance spectroscopic imaging study of the anterior cingulated cortex. Bipolar Disorders 2 (2000) 207-216
34. Moore G.J., Bebchuk J.M., Hasanat K., Chen G., Seraji-Bozorgzad N., Wilds I.B., Faulk M.W., Koch S., Glitz D.A., Jolkovsky L., and Manji H.K. Lithium increases N-acetyl-aspartate in the human brain: in vivo evidence in support of bcl-2's neurotrophic effects?. Biological Psychiatry 48 (2000) 1-8
35. Ohara K., Isoda H., Suzuki Y., Takehera Y., Ochiai M., Takeda H., Igarashi Y., and Ohara K. Proton magnetic resonance spectroscopy of the lenticular nuclei in bipolar 1 affective disorder. Psychiatry Research: Neuroimaging 84 (1998) 55-60
36. Provencher S.W. Estimation of metabolite concentrations from localized in vivo proton NMR spectra. Magnetic Resonance in Medicine 30 (1993) 672-679
37. Rolls E.T., Hornak J., Wade D., and McGrath J. Emotion-related learning in patients with social and emotional changes associated with frontal lobe damage. Journal of Neurology, Neurosurgery, and Psychiatry 57 (1994) 1518-1524
38. Rowe M.K., and Chuang D.M. Lithium neuroprotection: molecular mechanisms and clinical implications. Expert Reviews in Molecular Medicine 6 (2004) 1-18
39. Silverstone P.H., Wu R.H., O'Donnel T., Ulrich M., Asghar S.J., and Hanstock C.C. Chronic treatment with both lithium but not sodium valproate increases cortical n-acetyl-aspartate concentrations in euthymic bipolar patients. International Clinical Psychopharmacology 18 (2003) 73-79
40. Stanley J.A. In Vivo magnetic resonance spectroscopy and its application to neuropsychiatric disorders. Canadian Psychiatric Association Journal 47 (2002) 315-326
41. Stoll A.L., Renshaw P.F., Sachs G.S., Guimaraes A.R., Miller C., Cohen B.M., Lafer B., and Gonzalez R.G. The human brain resonance of choline-containing compounds is similar in patients receiving lithium treatment and controls: an in vivo proton magnetic resonance spectroscopy study. Biological Psychiatry 32 (1992) 944-949
42. Videbech P., and Ravnkilde B. Hippocampal volume and depression: a meta-analysis of MRI studies. The American Journal of Psychiatry 161 (2004) 1957-1966
43. Wessa M., Houenou J., Paillere-Martinot M., Berthoz S., Artiges E., Leboyer M., and Martinot J. Fronto-striatal overactivation in euthymic bipolar patients during an emotional go/nogo task. The American Journal of Psychiatry 164 (2007) 638-646
44. Winsberg M.E., Sachs N., Tate D.L., Adalsteinsson E., Spielman D., and Ketter T.A. Decreased dorsolateral prefrontal N-acetyl aspartate in bipolar disorder. Biological Psychiatry 133 (2000) 429-435
45. Yildiz-Yesioglu A., and Ankerst D.P. Neurochemical alterations of the brain in bipolar disorder and their implications for pathophysiology: a systematic review of the in vivo proton magnetic resonance spectroscopy findings. Progress in Neuro-Psychopharmacology and Biological Psychiatry 30 (2006) 969-995
46. Yucel K., Taylor V., McKinnon M.C., MacDonald K., Alda M., Young L.T., and MacQueen G.M. Bilateral hippocampal volume increase in patients with bipolar disorder and short-term lithium treatment. Neuropsychopharmacology 33 (2008) 361-367