Class II phosphoinositide 3-kinase α-isoform regulates Rho, myosin phosphatase and contraction in vascular smooth muscle

Biochemical Journal

Volumn 394, Issue 3, 2006, Pages 581-592

  Wang, Yu ^a   Yoshioka, Kazuaki ^a   Azam, Mohammed Ali ^a   Takuwa, Noriko ^a   Sakurada, Sotaro ^a   Kayaba, Yuji ^b   Sugimoto, Naotoshi ^a   Inoki, Isao ^a   Kimura, Takaharu ^a   Kuwaki, Tomoyuki ^b   Takuwa, Yoh ^a  

^a KANAZAWA UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCE   (Japan)

^b CHIBA UNIVERSITY   (Japan)

Author keywords

Class II phosphoinositide 3 kinase (PI3K C2 ); Myosin light chain phosphorylation; Myosin phosphatase; Phosphoinositide 3 kinase (PI3K); Rho; Smooth muscle

Indexed keywords

BIOCHEMISTRY; BIOLOGICAL MEMBRANES; CELLS; MUSCLE;

CLASS II PHOSPHOINOSITIDE 3-KINASE Α (PI3K-C2Α); MYOSIN LIGHT-CHAIN PHOSPHORYLATION; MYOSIN PHOSPHATASE; PHOSPHOINOSITIDE 3-KINASE (PI3K); RHO; SMOOTH MUSCLE;

ENZYMES;

2 MORPHOLINO 8 PHENYLCHROMONE; ISOENZYME; MEMBRANE PROTEIN; MYOSIN; MYOSIN LIGHT CHAIN; MYOSIN PHOSPHATASE; NORADRENALIN; PHOSPHATASE; PHOSPHATIDYLINOSITOL 3 KINASE; POTASSIUM CHLORIDE; PROTEIN MYPT1; PROTEIN P110; PROTEIN P110ALPHA; PROTEIN P110BETA; PROTEIN SUBUNIT; RHO KINASE; UNCLASSIFIED DRUG; WORTMANNIN;

ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DOSE RESPONSE; DOWN REGULATION; DRUG INHIBITION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; MEMBRANE DEPOLARIZATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEPHOSPHORYLATION; RAT; SMOOTH MUSCLE CONTRACTION; VASCULAR SMOOTH MUSCLE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; AORTA; CALCIUM; DOWN-REGULATION; GENE EXPRESSION REGULATION, ENZYMOLOGIC; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH, VASCULAR; MYOSIN-LIGHT-CHAIN PHOSPHATASE; PHOSPHORYLATION; RABBITS; RATS; RATS, WISTAR; RHO GTP-BINDING PROTEINS; RNA INTERFERENCE; RNA, SMALL INTERFERING;

ANIMALIA;

EID: 33644991658     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20051471     Document Type: Article

References (39)

1. Somlyo, A. P. and Somlyo, A. V. (1994) Signal transduction and regulation in smooth muscle. Nature (London) 372, 231-236
2. Hartshorne, D. J., Ito, M. and Ikebe, M. (1989) Myosin and contractile activity in smooth muscle. Adv. Exp. Med. Biol. 255, 269-277
3. 2+ sensitivity of smooth muscle and nonmuscle myosin II: modulated by G proteins, kinases, and myosin phosphatase. Physiol. Rev. 83, 1325-1358
4. 2+ sensitization of smooth muscle contraction through myosin light chain phosphorylation. J. Biol. Chem. 266, 1708-1715
5. Noda, M., Yasuda-Fukazawa, C., Moriishi, K., Kato, T., Okuda, T., Kurokawa, K. and Takuwa, Y. (1995) Involvement of Rho in GTPγS-induced enhancement of phosphorylation of 20 kDa myosin light chain in vascular smooth muscle cells: inhibition of phosphatase activity. FEBS. Lett. 367, 246-250
6. Lucius, C., Anders, A., Steusloff, A., Troschka, M., Hofman, F., Aktories, K. and Pfitzer, G. (1998) Clostridium difficile toxin B inhibits carbachol-induced force and myosin light chain phosphorylation in guinea-pig smooth muscle: role of Rho proteins. J. Physiol. (Cambridge, U.K.) 506, 83-93
7. Feng, J., Ito, M., Ichikawa, K., Nishikawa, M., Hartshorne, D. J. and Nakano, T. (1999) Inhibitory phosphorylation site for Rho-associated kinase on smooth muscle myosin phosphatase. J. Biol. Chem. 274, 37385-37390
8. Nagumo, H., Sasaki, Y., Ono, Y., Okamoto, H., Seto, M. and Takuwa, Y. (2000) Rho kinase inhibitor HA1077 prevents Rho-mediated myosin phosphatase inhibition in smooth muscle cells. Am. J. Physiol. Cell Physiol. 278, C57-C65
9. Hartshorne, D. J., Ito, M. and Erdodi, F. (2004) Role of protein phosphatase type I in contractile functions: myosin phosphatase. J. Biol. Chem. 279, 37211-37214
10. Kitazawa, T., Eto, M., Woodsome, T. P. and Brautigan, D. L. (2000) Agonist trigger G protein-mediated activation of the CPI-17 inhibitor phopsphoprotein of myosin light chain phosphatase to enhance vascular smooth muscle contractility. J. Biol. Chem. 275, 9897-9900
11. Sakurada, S., Okamoto, H., Takuwa, N., Sugimoto, N. and Takuwa, Y. (2001) Rho activation in excitatory agonist-stimulated vascular smooth muscle. Am. J. Physiol. Cell Physiol. 281, C571-C578
12. 2+-dependent activation of Rho and Rho kinase in membrane depolarization-induced and receptor stimulation-induced vascular smooth muscle contraction. Circ. Res. 93, 548-556
13. 12/13 in agonist-induced vascular smooth muscle cell contraction. Circ. Res. 87, 221-227
14. Mita, M., Yanagihara, H., Hishinuma, S., Saito, M. and Walsh, M. P. (2002) Membrane depolarization-induced contraction of rat caudal arterial smooth muscle involves Rho-associated kinase. Biochem. J. 364, 431-440
15. Rameh, L. E. and Cantley, L. C. (1999) The role of phosphoinositide 3-kinase lipid products in cell function. J. Biol. Chem. 274, 8347-8350
16. Stein, R. C. and Waterfield, M. D. (2000) PI3-kinase inhibition: a target for drug development? Mol. Med. Today 6, 347-357
17. Domin, J., Pages, R, Volinia, S., Rittenhouse, S. E., Zvelebil, M. J., Stein, R. C. and Waterfield, M. D. (1997) Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin. Biochem. J. 326, 139-147
18. Northcott, C. A., Hayflick, J. S. and Watts, S. W. (2004) PI3-kinase upregulation and involvement in spontaneous tone in arteries from DOCA-salt rats: is p110δ the culprit? Hypertension 43, 885-890
19. Fulton, D., Gratton, J. P., McCabe, T. J., Fontana, J., Fujio, Y., Walsh, K., Franke, T. F., Papapetropoulos, A. and Sessa, W. C. (1999) Regulation of endothelium-derived nitric oxide production by the protein kinase Akt. Nature (London) 399, 597-601
20. 2+ levels, myosin light chain phosphorylation and force in vascular smooth muscle. Naunyn-Schmiedeberg's Arch. Pharmacol. 364, 120-127
21. Northcott, C. A., Poy, M. N., Najjar, S. M. and Watts, S. W. (2002) Phosphoinositide 3-kinase mediates enhanced spontaneous and agonist-induced contraction in aorta of deoxycorticosterone acetate-salt hypertensive rats. Circ. Res. 91, 360-369
22. Su, X., Smolock, E. M., Marcel, K. N. and Moreland, R. S. (2004) Phosphatidylinositol 3-kinase modulates vascular smooth muscle contraction by calcium and myosin light chain phosphorylation-independentand -dependent pathways. Am. J. Physiol. Heart Circ. Physiol. 286, H657-H666
23. Komalavilas, P., Mehta, S., Wingard, C. J., Dransfield, D. T., Bhalla, J., Woodrum, J. E., Molinaro, J. R. and Brophy, C. M. (2001) PI3-kinase/Akt modulates vascular smooth muscle tone via cAMP signaling pathways. J. Appl. Physiol. 91, 1819-1827
24. Turner, S. J., Domin, J., Waterfield, M. D., Ward, S. G. and Westwick, J. (1998) The CC chemokine monocyte chemotactic peptide-1 activates both the class I p85/p110 Phosphatidylinositol 3-kinase and the class II PI3K-C2α. J. Biol. Chem. 273, 25987-25995
25. Nakanishi, S., Kakita, S., Takahashi, I., Kawatiara, K., Tsukuda, E., Sano, T., Yamada, K., Yoshida, M., Kase, H. and Matsuda, Y. (1992) Wortmannin, a microbial product inhibitor of myosin light chain kinase. J. Biol. Chem. 267, 2157-2163
26. Yano, H., Agatsuma, T., Nakanishi, S., Saitoh, Y., Fukui, Y., Nonomura, Y. and Matsuda, Y. (1995) Biochemical and pharmacological studies with KT7692 and LY294002 on the role of Phosphatidylinositol 3-kinase in FcεRI-mediated signal transduction. Biochem. J. 312, 145-150
27. Davies, S. P., Reddy, H., Caivano, M. and Cohen, P. (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem. J. 351, 95-105
28. Hayashi, K., Takahashi, M., Nishida, W., Yoshida, K., Ohkawa, Y., Kitabatake, A., Aoki, J., Aral, H. and Sobue, K. (2001) Phenotypic modulation of vascular smooth muscle cells induced by unsaturated lysophosphatidic acids. Circ. Res. 89, 251-258
29. 19 in smooth muscle cells in culture. Am. J. Physiol. 274, C1563-C1572
30. Okamoto, H., Takuwa, N., Yokomizo, Y., Sugimoto, N., Sakurada, S., Shigematsu, H. and Takuwa, Y. (2000) Inhibitory regulation of Rac activation, membrane ruffling, and cell migration by the G protein-coupled sphingosine-1-phosphate receptor EDG5 but not EDG1 or EDG3. Mol. Cell. Biol. 20, 9247-9261
31. Kayaba, Y., Nakamura, A., Kasuya, Y., Ohuchi, T., Yanagisawa, M., Komuro, I., Fukuda, Y. and Kuwaki, T. (2003) Attenuated defense response and low basal blood pressure in orexin knockout mice. Am. J. Physiol. Regulatory Integrative Comp. Physiol. 285, R581-R593
32. Franke, T. F., Yang, S. I., Chan, T. O., Datta, K., Kazlauskas, A., Morrison, D. K., Kaplan, D. R. and Tsichlis, P. N. (1995) The protein kinase encoded by the Akt proto-oncogene is a target of the PDGF-activated phosphatidylinositol 3-kinase. Cell 81, 727-736
33. Arcaro, A., Volinia, S., Zvelebil, M. J., Stein, R., Watton, S. J., Layton, M. J., Gout, I., Ahmadi, K., Downward, J. and Waterfield, M. D. (1998) Human phosphoinositide 3-kinase C2β, the role of calcium and the C2 domain in enzyme activity. J. Biol. Chem. 273, 33082-33090
34. Vanhaesebroeck, B., Welham, M. J., Kotani, K., Stein, R., Warne, P. H., Zvelebil, M. J., Higashi, K., Volinia, S., Downward, J. and Waterfield, M. D. (1997) P110δ, a novel phosphoinositide 3-kinase in leukocytes. Proc. Natl. Acad. Sci. U.S.A. 94, 4330-4335
35. Vecchione, C., Patrucco, E., Marino, G., Barberis, L., Poulet, R., Aretini, A., Maffei, A., Gentile, M. T., Storto, M., Azzolino, O. et al. (2005) Protection from angiotensin II-mediated vasculotoxic and hypertensive response in mice lacking PI3Kγ. Nat. Med. 201, 1217-1228
36. 2+ sensitization in rabbit smooth muscle. J. Physiol. (Cambridge, U.K.) 546, 879-889
37. Niiro, N., Koga, Y. and Ikebe, M. (2003) Agonist-induced changes in the phosphorylation of the myosin-targeting subunit of myosin light chain phosphatase and CPI17, two regulatory factors of myosin light chain phosphatase, in smooth muscle. Biochem. J. 369, 117-128
38. Arcaro, A., Zvelebil, M. J., Wallasch, C., Ullrich, A., Waterfield, M. D. and Domin, J. (2000) Class II phosphoinositide 3-kinase are downstream targets of activated polypeptide growth factor receptors. Mol. Cell. Biol. 20, 3817-3830
39. Seko, T., Ito, M., Kureishi, Y., Okamoto, R., Moriki, N., Onishi, K., Isaka, N., Hartshorne, D. J. and Nakano, T. (2003) Activation of RhoA and inhibition of myosin phosphatase as important components in hypertension in vascular smooth muscle. Circ. Res. 92, 411-418