Suppression of the α-isoform of class II phosphoinositide 3-kinase gene expression leads to apoptotic cell death

Biochemical and Biophysical Research Communications

Volumn 329, Issue 1, 2005, Pages 6-10

  Kang, Shinhae ^a   Song, Jihoon ^a   Kang, Jihoon ^a   Kang, Heekyoung ^a   Lee, Daeho ^a   Lee, Youngki ^a   Park, Deokbae ^a  

^a Jeju National University   (South Korea)

Author keywords

Apoptotic body; Apoptotic cell death; C2 domain; Chinese hamster ovary cells expressing human insulin receptors; CHO IR cells; DNA fragmentation; Nuclear condensation; PI3K C2 ; Survival factor; isoform of class II phosphoinositide 3 kinase

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; DNA FRAGMENT; INSULIN; ISOENZYME; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE CLASS II ALPHA; UNCLASSIFIED DRUG;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL NUCLEUS; CONTROLLED STUDY; CULTURE MEDIUM; GENE EXPRESSION REGULATION; GENETIC TRANSFECTION; NONHUMAN; POLYMERIZATION; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN DOMAIN; SERUM; SYNTHESIS;

CRICETINAE; CRICETULUS GRISEUS;

EID: 13844271421     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbrc.2005.01.091     Document Type: Article

References (17)

1. R. Katso, K. Okkenhaug, K. Ahmadi, S. White, J. Timms, and M.D. Waterfield Cellular function of phosphoinositide 3-kinases: Implications for development, homeostasis, and cancer Annu. Rev. Cell Dev. Biol. 17 2001 615 675
2. D.A. Cantrell Phosphoinositide 3-kinase signalling pathways J. Cell Sci. 114 2001 1439 1445
3. J. Domin, and M.D. Waterfield Using structure to define the function of phosphoinositide 3-kinase family members FEBS Lett. 410 1997 91 95
4. S. Volinia, R. Dhand, B. Vanhaesebroeck, L.K. MacDougall, R. Stein, M.J. Zvelebil, J. Domin, C. Panaretou, and M.D. Waterfield A human phosphatidylinositol 3-kinase complex related to the yeast Vps34p-Vps15p protein sorting system EMBO J. 14 1995 3339 3348
5. B. Vanhaesebroeck, and M.D. Waterfield Signaling by distinct classes of phosphoinositide 3-kinases Exp. Cell Res. 253 1999 239 254
6. S.S. El Sheikh, J. Domin, P. Tomtitchong, P. Abel, G. Stamp, and E.N. Lalani Topographical expression of class IA and class II phosphoinositide 3-kinase enzymes in normal human tissues is consistent with a role in differentiation BMC Clin. Pathol. 3 2003 1 14
7. A. Arcaro, S. Volinia, M.J. Zvelebil, R. Stein, S.J. Watton, M.J. Layton, I. Gout, K. Ahmadi, J. Downward, and M.D. Waterfield Human phosphoinositide 3-kinase C2beta, the role of calcium and the C2 domain in enzyme activity J. Biol. Chem. 273 1998 33082 33090
8. J. Domin, F. Pages, S. Volinia, S.E. Rittenhouse, M.J. Zvelebil, R.C. Stein, and M.D. Waterfield Cloning of a human phosphoinositide 3-kinase with a C2 domain that displays reduced sensitivity to the inhibitor wortmannin Biochem. J. 326 1997 139 147
9. M. Rozycka, Y.J. Lu, R.A. Brown, M.R. Lau, J.M. Shipley, and M.J. Fry cDNA cloning of a third human C2-domain-containing class II phosphoinositide 3-kinase, PI3K-C2gamma, and chromosomal assignment of this gene (PIK3C2G) to 12p12 Genomics 54 1998 569 574
10. L.K. Ho, D. Liu, M. Rozycka, R.A. Brown, and M.J. Fry Identification of four novel human phosphoinositide 3-kinases defines a multi-isoform subfamily Biochem. Biophys. Res. Commun. 235 1997 130 137
11. R.A. Brown, J. Domin, A. Arcaro, M.D. Waterfield, and P.R. Shepherd Insulin activates the alpha isoform of class II phosphoinositide 3-kinase J. Biol. Chem. 274 1999 14529 14532
12. D. Park D, S.K. Pandey, E. Maksimova, S. Kole, and M. Bernier Akt-dependent antiapoptotic action of insulin is sensitive to farnesyltransferase inhibitor Biochemistry 39 2000 12513 12521
13. W. Lee-Kwon, D. Park, and M. Bernier Involvement of the Ras/extracellular signal-regulated kinase signalling pathway in the regulation of ERCC-1 mRNA levels by insulin Biochem. J. 331 1998 591 597
14. W. Lee-Kwon, D. Park, P.V. Baskar, S. Kole, and M. Bernier Antiapoptotic signaling by the insulin receptor in Chinese hamster ovary cells Biochemistry 37 1998 15747 15757
15. A. Arcaro, M.J. Zvelebil, C. Wallasch, A. Ullrich, M.D. Waterfield, and J. Domin Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors Mol. Cell. Biol. 20 2000 3817 3830
16. S.J. Turner, J. Domin, M.D. Waterfield, S.G. Ward, and J. Westwick The CC chemokine monocyte chemotactic peptide-1 activates both the class I p85/p110 phosphatidylinositol 3-kinase and the class II PI3K-C2alpha J. Biol. Chem. 273 1998 25987 25995
17. S.A. Didichenko, C.M. Fragoso, and M. Thelen Mitotic and stress-induced phosphorylation of HsPI3K-C2alpha targets the protein for degradation J. Biol. Chem. 278 2003 26055 26064