메뉴 건너뛰기




Volumn 387, Issue 2, 2009, Pages 310-315

Ablation of phosphoinositide-3-kinase class II alpha suppresses hepatoma cell proliferation

Author keywords

Apoptosis; Cell growth; HCC; Liver; Phosphoinositide 3 kinase; PI3K; PIK3C2

Indexed keywords

CASPASE 3; ISOPROTEIN; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3 KINASE 2ALPHA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

EID: 67949091004     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2009.07.013     Document Type: Article
Times cited : (21)

References (34)
  • 1
    • 41649114164 scopus 로고    scopus 로고
    • Enabling personalized cancer medicine through analysis of gene-expression patterns
    • van't Veer L.J., and Bernards R. Enabling personalized cancer medicine through analysis of gene-expression patterns. Nature 452 (2008) 564-570
    • (2008) Nature , vol.452 , pp. 564-570
    • van't Veer, L.J.1    Bernards, R.2
  • 2
    • 0141491273 scopus 로고    scopus 로고
    • Hepatocellular carcinoma
    • Llovet J.M., Burroughs A., and Bruix J. Hepatocellular carcinoma. Lancet 362 (2003) 1907-1917
    • (2003) Lancet , vol.362 , pp. 1907-1917
    • Llovet, J.M.1    Burroughs, A.2    Bruix, J.3
  • 3
    • 0035888074 scopus 로고    scopus 로고
    • Estimating the world cancer burden: Globocan 2000
    • Parkin D.M., Bray F., Ferlay J., and Pisani P. Estimating the world cancer burden: Globocan 2000. Int. J. Cancer 94 (2001) 153-156
    • (2001) Int. J. Cancer , vol.94 , pp. 153-156
    • Parkin, D.M.1    Bray, F.2    Ferlay, J.3    Pisani, P.4
  • 4
    • 37149004184 scopus 로고    scopus 로고
    • From molecular biology to targeted therapies for hepatocellular carcinoma: the future is now
    • Pang R.W., and Poon R.T. From molecular biology to targeted therapies for hepatocellular carcinoma: the future is now. Oncology 72 Suppl. 1 (2007) 30-44
    • (2007) Oncology , vol.72 , Issue.SUPPL. 1 , pp. 30-44
    • Pang, R.W.1    Poon, R.T.2
  • 5
    • 0036632368 scopus 로고    scopus 로고
    • The phosphatidylinositol 3-kinase AKT pathway in human cancer
    • Vivanco I., and Sawyers C.L. The phosphatidylinositol 3-kinase AKT pathway in human cancer. Nat. Rev. Cancer 2 (2002) 489-501
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 489-501
    • Vivanco, I.1    Sawyers, C.L.2
  • 6
    • 0033604577 scopus 로고    scopus 로고
    • Signaling by distinct classes of phosphoinositide 3-kinases
    • Vanhaesebroeck B., and Waterfield M.D. Signaling by distinct classes of phosphoinositide 3-kinases. Exp. Cell Res. 253 (1999) 239-254
    • (1999) Exp. Cell Res. , vol.253 , pp. 239-254
    • Vanhaesebroeck, B.1    Waterfield, M.D.2
  • 9
    • 31944444234 scopus 로고    scopus 로고
    • Cancer-specific mutations in PIK3CA are oncogenic in vivo
    • Bader A.G., Kang S., and Vogt P.K. Cancer-specific mutations in PIK3CA are oncogenic in vivo. Proc. Natl. Acad. Sci. USA 103 (2006) 1475-1479
    • (2006) Proc. Natl. Acad. Sci. USA , vol.103 , pp. 1475-1479
    • Bader, A.G.1    Kang, S.2    Vogt, P.K.3
  • 12
    • 1842532206 scopus 로고    scopus 로고
    • Identification of discriminators of hepatoma by gene expression profiling using a minimal dataset approach
    • Neo S.Y., Leow C.K., Vega V.B., Long P.M., Islam A.F., Lai P.B., Liu E.T., and Ren E.C. Identification of discriminators of hepatoma by gene expression profiling using a minimal dataset approach. Hepatology 39 (2004) 944-953
    • (2004) Hepatology , vol.39 , pp. 944-953
    • Neo, S.Y.1    Leow, C.K.2    Vega, V.B.3    Long, P.M.4    Islam, A.F.5    Lai, P.B.6    Liu, E.T.7    Ren, E.C.8
  • 13
    • 58149340543 scopus 로고    scopus 로고
    • Emerging biomarkers and new understanding of traditional markers in personalized therapy for breast cancer
    • Dowsett M., and Dunbier A.K. Emerging biomarkers and new understanding of traditional markers in personalized therapy for breast cancer. Clin. Cancer Res. 14 (2008) 8019-8026
    • (2008) Clin. Cancer Res. , vol.14 , pp. 8019-8026
    • Dowsett, M.1    Dunbier, A.K.2
  • 14
    • 0031936410 scopus 로고    scopus 로고
    • Specificity within the EGF family/ErbB receptor family signaling network
    • Riese D.J., and Stern D.F. Specificity within the EGF family/ErbB receptor family signaling network. Bioessays 20 (1998) 41-48
    • (1998) Bioessays , vol.20 , pp. 41-48
    • Riese, D.J.1    Stern, D.F.2
  • 15
    • 0036479747 scopus 로고    scopus 로고
    • Roles of ERBB family receptor tyrosine kinases, and downstream signaling pathways, in the control of cell growth and survival
    • Grant S., Qiao L., and Dent P. Roles of ERBB family receptor tyrosine kinases, and downstream signaling pathways, in the control of cell growth and survival. Front. Biosci. 7 (2002) d376-d389
    • (2002) Front. Biosci. , vol.7
    • Grant, S.1    Qiao, L.2    Dent, P.3
  • 16
    • 0025339122 scopus 로고
    • Detection of integrated hepatitis B virus DNA in hepatocellular carcinoma cell lines by nonradioactive in situ hybridization
    • Tay N., Chan S.H., and Ren E.C. Detection of integrated hepatitis B virus DNA in hepatocellular carcinoma cell lines by nonradioactive in situ hybridization. J. Med. Virol. 30 (1990) 266-271
    • (1990) J. Med. Virol. , vol.30 , pp. 266-271
    • Tay, N.1    Chan, S.H.2    Ren, E.C.3
  • 18
    • 39449093070 scopus 로고    scopus 로고
    • Caspase activation cascades in apoptosis
    • Logue S.E., and Martin S.J. Caspase activation cascades in apoptosis. Biochem. Soc. Trans. 36 (2008) 1-9
    • (2008) Biochem. Soc. Trans. , vol.36 , pp. 1-9
    • Logue, S.E.1    Martin, S.J.2
  • 20
    • 40149098824 scopus 로고    scopus 로고
    • Effects of the mTOR inhibitor sirolimus in patients with hepatocellular and cholangiocellular cancer
    • Rizell M., Andersson M., Cahlin C., Hafstrom L., Olausson M., and Lindner P. Effects of the mTOR inhibitor sirolimus in patients with hepatocellular and cholangiocellular cancer. Int. J. Clin. Oncol. 13 (2008) 66-70
    • (2008) Int. J. Clin. Oncol. , vol.13 , pp. 66-70
    • Rizell, M.1    Andersson, M.2    Cahlin, C.3    Hafstrom, L.4    Olausson, M.5    Lindner, P.6
  • 21
    • 0035907311 scopus 로고    scopus 로고
    • The hepatitis B virus-X protein activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade
    • Lee Y.I., Kang-Park S., Do S.I., and Lee Y.I. The hepatitis B virus-X protein activates a phosphatidylinositol 3-kinase-dependent survival signaling cascade. J. Biol. Chem. 276 (2001) 16969-16977
    • (2001) J. Biol. Chem. , vol.276 , pp. 16969-16977
    • Lee, Y.I.1    Kang-Park, S.2    Do, S.I.3    Lee, Y.I.4
  • 22
    • 1842478144 scopus 로고    scopus 로고
    • The hepatitis C virus NS5A protein activates a phosphoinositide 3-kinase-dependent survival signaling cascade
    • Street A., Macdonald A., Crowder K., and Harris M. The hepatitis C virus NS5A protein activates a phosphoinositide 3-kinase-dependent survival signaling cascade. J. Biol. Chem. 279 (2004) 12232-12241
    • (2004) J. Biol. Chem. , vol.279 , pp. 12232-12241
    • Street, A.1    Macdonald, A.2    Crowder, K.3    Harris, M.4
  • 24
    • 0141532180 scopus 로고    scopus 로고
    • class I phosphoinositide 3-kinase p110beta is required for apoptotic cell and Fcgamma receptor-mediated phagocytosis by macrophage
    • Leverrier Y., Okkenhaug K., Sawyer C., Bilancio A., Vanhaesebroeck B., and Ridley A.J. class I phosphoinositide 3-kinase p110beta is required for apoptotic cell and Fcgamma receptor-mediated phagocytosis by macrophage. J. Biol. Chem. 278 (2003) 38437-38442
    • (2003) J. Biol. Chem. , vol.278 , pp. 38437-38442
    • Leverrier, Y.1    Okkenhaug, K.2    Sawyer, C.3    Bilancio, A.4    Vanhaesebroeck, B.5    Ridley, A.J.6
  • 29
    • 0034024403 scopus 로고    scopus 로고
    • Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors
    • Arcaro A., Zvelebil M.J., Wallasch C., Ullrich A., Waterfield M.D., and Domin J. Class II phosphoinositide 3-kinases are downstream targets of activated polypeptide growth factor receptors. Mol. Cell. Biol. 20 (2000) 3817-3830
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 3817-3830
    • Arcaro, A.1    Zvelebil, M.J.2    Wallasch, C.3    Ullrich, A.4    Waterfield, M.D.5    Domin, J.6
  • 30
    • 0038392645 scopus 로고    scopus 로고
    • TNF-alpha and leptin activate the alpha-isoform of class II phosphoinositide 3-kinase
    • Ktori C., Shepherd P.R., and O'Rourke L. TNF-alpha and leptin activate the alpha-isoform of class II phosphoinositide 3-kinase. Biochem. Biophys. Res. Commun. 306 (2003) 139-143
    • (2003) Biochem. Biophys. Res. Commun. , vol.306 , pp. 139-143
    • Ktori, C.1    Shepherd, P.R.2    O'Rourke, L.3
  • 31
    • 33847174231 scopus 로고    scopus 로고
    • 2+-induced, Rho- and Rho kinase-dependent regulation of myosin phosphatase and contraction in isolated vascular smooth muscle cells
    • 2+-induced, Rho- and Rho kinase-dependent regulation of myosin phosphatase and contraction in isolated vascular smooth muscle cells. Mol. Pharmacol. 71 (2007) 912-920
    • (2007) Mol. Pharmacol. , vol.71 , pp. 912-920
    • Yoshioka, K.1    Sugimoto, N.2    Takuwa, N.3    Takuwa, Y.4
  • 32
    • 26244461921 scopus 로고    scopus 로고
    • Phosphatidylinositol 3-kinase C2alpha is essential for ATP-dependent priming of neurosecretory granule exocytosis
    • Meunier F.A., Osborne S.L., Hammond G.R., Cooke F.T., Parker P.J., Domin J., and Schiavo G. Phosphatidylinositol 3-kinase C2alpha is essential for ATP-dependent priming of neurosecretory granule exocytosis. Mol. Biol. Cell 16 (2005) 4841-4851
    • (2005) Mol. Biol. Cell , vol.16 , pp. 4841-4851
    • Meunier, F.A.1    Osborne, S.L.2    Hammond, G.R.3    Cooke, F.T.4    Parker, P.J.5    Domin, J.6    Schiavo, G.7
  • 33
    • 13844271421 scopus 로고    scopus 로고
    • Suppression of the alpha-isoform of class II phosphoinositide 3-kinase gene expression leads to apoptotic cell death
    • Kang S., Song J., Kang J., Kang H., Lee D., Lee Y., and Park D. Suppression of the alpha-isoform of class II phosphoinositide 3-kinase gene expression leads to apoptotic cell death. Biochem. Biophys. Res. Commun. 329 (2005) 6-10
    • (2005) Biochem. Biophys. Res. Commun. , vol.329 , pp. 6-10
    • Kang, S.1    Song, J.2    Kang, J.3    Kang, H.4    Lee, D.5    Lee, Y.6    Park, D.7


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.