The novel antibacterial compound walrycin a induces human PXR transcriptional activity

Toxicological Sciences

Volumn 127, Issue 1, 2012, Pages 225-235

  Berthier, Alexandre ^a,b,c   Oger, Frédérik ^a,b,c   Gheeraert, Céline ^a,b,c   Boulahtouf, Abdel ^d,e,f   Le Guével, Rémy ^g   Balaguer, Patrick ^d,e,f   Staels, Bart ^a,b,c   Salbert, Gilles ^h   Lefebvre, Philippe ^a,b,c  

^a UNIV LILLE   (France)

^b INSERM   (France)

^c INSTITUT PASTEUR DE LILLE   (France)

^d INSTITUT DE RECHERCHE EN CANCÉROLOGIE DE MONTPELLIER   (France)

^e UNIV MONTPELLIER   (France)

^f CENTRE VAL D AURELLE   (France)

^g Institut Federatif de Recherche IFR 140 Genetique Fonctionnelle Agronomie et Sante GFAS   (France)

^h UNIVERSITÉ DE RENNES 1   (France)

Author keywords

CYP3A4; Ligand binding domain; Nuclear receptor; Pregnane X receptor; Walrycin A; Xenobiotic

Indexed keywords

ANTIINFECTIVE AGENT; CYTOCHROME P450 3A4; LIGAND; PREGNANE X RECEPTOR; RIFAMPICIN; UNCLASSIFIED DRUG; WALRYCIN A;

ARTICLE; COMPUTER MODEL; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DRUG OXIDATION; GENE ACTIVATION; GENE EXPRESSION; GENETIC TRANSCRIPTION; HEPATOMA CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; MOLECULAR DOCKING; NUCLEOTIDE SEQUENCE; PROTEIN DEGRADATION; TRANSACTIVATION;

EID: 84860147844     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfs073     Document Type: Article

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