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Volumn 20, Issue 9, 2011, Pages 1611-1615

Studies on toxicity of antitubercular drugs namely isoniazid, rifampicin, and pyrazinamide in an in vitro model of HepG2 cell line

Author keywords

Antitubercular therapy; ATT induced drug hepatotoxicity; Drug metabolizing enzyme; Human hepatocellular liver carcinoma cell line

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ISONIAZID; PYRAZINAMIDE; RIFAMPICIN;

EID: 84856209100     PISSN: 10542523     EISSN: 15548120     Source Type: Journal    
DOI: 10.1007/s00044-010-9405-3     Document Type: Conference Paper
Times cited : (49)

References (22)
  • 2
    • 34249083462 scopus 로고    scopus 로고
    • Isoniazid induces oxidative stress, mitochondrial dysfunction and apoptosis in Hep G2 cells
    • DOI 10.1170/T781
    • Bhadauria S, Singh G, Sinha N, Srivastava S (2007) Isoniazid induces oxidative stress, mitochondrial dysfunction and apoptosis in Hep G2 cells. Cell Mol Biol (Noisy-le-grand) 15:102-114 (Pubitemid 46799697)
    • (2007) Cellular and Molecular Biology , vol.53 , Issue.1 , pp. 102-114
    • Bhadauria, S.1    Singh, G.2    Sinha, N.3    Srivastava, S.4
  • 3
    • 1342323673 scopus 로고    scopus 로고
    • Oxidative stress, toxicology, and pharmacology of CYP2E1
    • DOI 10.1146/annurev.pharmtox.44.101802.121704
    • Caro AA, Cederbaum AI (2004) Oxidative stress, toxicology, and pharmacology of CYP2E1. Annu Rev Pharmacol Toxicol 44:27-42 (Pubitemid 38263832)
    • (2004) Annual Review of Pharmacology and Toxicology , vol.44 , pp. 27-42
    • Caro, A.A.1    Cederbaum, A.I.2
  • 4
    • 0019027896 scopus 로고
    • The inhibitory effect of pyrazinamide on microsomal monooxygenase activities is related to the binding to reduced cytochrome P-450
    • Facino RF, Carini M (1980) The inhibitory effect of pyrazinamide on microsomal monooxygenase activities is related to the binding to reduced cytochrome P-450. Pharmacol Res Commun 12:523-537
    • (1980) Pharmacol Res Commun , vol.12 , pp. 523-537
    • Facino, R.F.1    Carini, M.2
  • 5
    • 27644544444 scopus 로고    scopus 로고
    • In vitro cytotoxicity assays: Comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride
    • Fotakis George JAT (2006) In vitro cytotoxicity assays: Comparison of LDH, neutral red, MTT and protein assay in hepatoma cell lines following exposure to cadmium chloride. Toxicol Lett 160:171-177
    • (2006) Toxicol Lett , vol.160 , pp. 171-177
    • Fotakis George, J.A.T.1
  • 6
    • 0018088653 scopus 로고
    • The hepatic toxicity of antituberculosis regimens containing isoniazid, rifampicin and pyrazinamide
    • Girling DJ (1978) The hepatic toxicity of antituberculosis regimens containing isoniazid, rifampicin and pyrazinamide. Tuberclosis 59:13-32 (Pubitemid 8283038)
    • (1978) Tubercle , vol.59 , Issue.1 , pp. 13-32
    • Girling, D.J.1
  • 8
    • 34548805504 scopus 로고    scopus 로고
    • Mechanism-based inactivation of cytochrome P450 enzymes: Chemical mechanisms, structure-activity relationships and relationship to clinical drug-drug interactions and idiosyncratic adverse drug reactions
    • DOI 10.2174/138920007780866807
    • Kalgutkar AS, Obach RS, Maurer TS (2007) Mechanism-based inactivation of cytochrome P450 enzymes: Chemical mechanisms, structure-activity relationships and relationship to clinical drug-drug interactions and idiosyncratic adverse drug reactions. Curr Drug Metab 8:407-447 (Pubitemid 47603408)
    • (2007) Current Drug Metabolism , vol.8 , Issue.5 , pp. 407-447
    • Kalgutkar, A.S.1    Obach, R.S.2    Maurer, T.S.3
  • 9
    • 0037245531 scopus 로고    scopus 로고
    • Pyrazinamide and rifampin vs isoniazid for the treatment of latent tuberculosis: Improved completion rates but more hepatotoxicity
    • DOI 10.1378/chest.123.1.102
    • McNeill L, Allen M, Estrada C, Cook P (2003) Pyrazinamide and rifampin vs isoniazid for the treatment of latent tuberculosis: Improved completion rates but more hepatotoxicity. Chest 123:102-106 (Pubitemid 36126720)
    • (2003) Chest , vol.123 , Issue.1 , pp. 102-106
    • McNeill, L.1    Allen, M.2    Estrada, C.3    Cook, P.4
  • 10
    • 0031014510 scopus 로고    scopus 로고
    • Rifampicin and isoniazid increase acetaminophen and isoniazid cytotoxicity in human HepG2 hepatoma cells
    • Nicod L, Viollon C, Regnier A, Jacqueson A, Richert L (1997) Rifampicin and isoniazid increase acetaminophen and isoniazid cytotoxicity in human HepG2 hepatoma cells. Hum Exp Toxicol 16:28-34 (Pubitemid 27047315)
    • (1997) Human and Experimental Toxicology , vol.16 , Issue.1 , pp. 28-34
    • Nicod, L.1    Viollon, C.2    Regnier, A.3    Jacqueson, A.4    Richert, L.5
  • 11
    • 10944240204 scopus 로고    scopus 로고
    • Inhibitory effect of antituberculosis drugs on human cytochrome P450-mediated activities
    • DOI 10.1254/jphs.FP0040296
    • Nishimura Y, Kurata N, Sakurai E, Yasuhara H (2004) Inhibitory effect of antituberculosis drugs on human cytochrome P450-mediated activities. J Pharmacol Sci 96:293-300 (Pubitemid 40013338)
    • (2004) Journal of Pharmacological Sciences , vol.96 , Issue.3 , pp. 293-300
    • Nishimura, Y.1    Kurata, N.2    Sakurai, E.3    Yasuhara, H.4
  • 12
    • 0029779308 scopus 로고    scopus 로고
    • Risk factors for side-effects of isoniazid, rifampin and pyrazinamide in patients hospitalized for pulmonary tuberculosis
    • Schaberg T, Rebhan K, Lode H (1996) Risk factors for side-effects of isoniazid, rifampin, pyrazinamide in patients hospitalized for pulmonary tuberculosis. Eur Respir J 9:2026-2030 (Pubitemid 26333539)
    • (1996) European Respiratory Journal , vol.9 , Issue.10 , pp. 2026-2030
    • Schaberg, T.1    Rebhan, K.2    Lode, H.3
  • 13
    • 33749618673 scopus 로고    scopus 로고
    • Isoniazid-induced hepatotoxicity in rat hepatocytes of gel entrapment culture
    • DOI 10.1016/j.toxlet.2006.08.010, PII S0378427406012513
    • Shen C, Zhang H, Zhang G, Meng Q (2006) Isoniazid-induced hepatotoxicity in rat hepatocytes of gel entrapment culture. Toxicol Lett 167:66-74 (Pubitemid 44548278)
    • (2006) Toxicology Letters , vol.167 , Issue.1 , pp. 66-74
    • Shen, C.1    Zhang, H.2    Zhang, G.3    Meng, Q.4
  • 14
    • 39449117503 scopus 로고    scopus 로고
    • Rifampicin exacerbates isoniazid-induced toxicity in human but not in rat hepatocytes in tissue-like cultures
    • DOI 10.1038/sj.bjp.0707611, PII 0707611
    • Shen C, Meng Q, Zhang G, Hu W (2008) Rifampicin exacerbates isoniazid-induced toxicity in human but not in rat hepatocytes in tissue-like cultures. Br J Pharmacol 153:784-791 (Pubitemid 351271758)
    • (2008) British Journal of Pharmacology , vol.153 , Issue.4 , pp. 784-791
    • Shen, C.1    Meng, Q.2    Zhang, G.3    Hu, W.4
  • 17
    • 0003635217 scopus 로고    scopus 로고
    • WHO-Report, Surveillance planning financing
    • WHO-Report, Global Tuberculosis Control (2008) Surveillance planning financing
    • (2008) Global Tuberculosis Control.
  • 18
    • 0029816454 scopus 로고    scopus 로고
    • Ethanol cytotoxicity to a transfected HepG2 cell line expressing human cytochrome P4502E1
    • DOI 10.1074/jbc.271.39.23914
    • Wu D, Cederbaum AI (1996) Ethanol cytotoxicity to a transfected HepG2 cell line expressing human cytochrome P4502E1. J Biol Chem 271:23914-23919 (Pubitemid 26327366)
    • (1996) Journal of Biological Chemistry , vol.271 , Issue.39 , pp. 23914-23919
    • Wu, D.1    Cederbaum, A.I.2
  • 20
    • 0036196202 scopus 로고    scopus 로고
    • Clinically significant interactions with drugs used in the treatment of tuberculosis
    • Yew WW (2002) Clinically significant interactions with drugs used in the treatment of tuberculosis. Drug Saf 25:111-133 (Pubitemid 34261186)
    • (2002) Drug Safety , vol.25 , Issue.2 , pp. 111-133
    • Yew, W.W.1
  • 21
    • 33750066952 scopus 로고    scopus 로고
    • Antituberculosis drugs and hepatotoxicity
    • DOI 10.1111/j.1440-1843.2006.00941.x
    • Yew WW, Leung CC (2006) Antituberculosis drugs and hepatotoxicity. Respirology 11:699-707 (Pubitemid 44581433)
    • (2006) Respirology , vol.11 , Issue.6 , pp. 699-707
    • Yew, W.W.1    Leung, C.C.2
  • 22


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.