Zearalenone activates pregnane X receptor, constitutive androstane receptor and aryl hydrocarbon receptor and corresponding phase I target genes mRNA in primary cultures of human hepatocytes

Environmental Toxicology and Pharmacology

Volumn 31, Issue 1, 2011, Pages 79-87

  Ayed Boussema, Imen ^a   Pascussi, Jean Marc ^b,c,d,e   Maurel, Patrick ^b,c   Bacha, Hassen ^a   Hassen, Wafa ^a  

^a Faculty of Dentistry   (Tunisia)

^b INSERM   (France)

^c HÔPITAL SAINT ELOI   (France)

^d INSTITUT DE GÉNOMIQUE FONCTIONNELLE   (France)

^e UFR Medecine   (France)

Author keywords

Cytochromes P450; Nuclear receptor; Zearalenone

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; CONSTITUTIVE ANDROSTANE RECEPTOR; CYTOCHROME P450 1A1; CYTOCHROME P450 1A2; CYTOCHROME P450 2B6; CYTOCHROME P450 2C9; CYTOCHROME P450 3A4; CYTOCHROME P450 3A5; LUCIFERASE; MESSENGER RNA; PREGNANE X RECEPTOR; ZEARALENONE;

ADULT; AGED; ARTICLE; CELL STRAIN HEPG2; CELL VIABILITY; CHEMICAL STRUCTURE; CONCENTRATION (PARAMETERS); ENZYME ASSAY; ENZYME REGULATION; FEMALE; GENE ACTIVATION; GENE EXPRESSION; HOUSEKEEPING GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL CULTURE; LIVER TOXICITY; MALE; PRIORITY JOURNAL; REAL TIME POLYMERASE CHAIN REACTION;

ADENOSINE TRIPHOSPHATE; AGED; CELL SURVIVAL; CELLS, CULTURED; CYTOCHROME P-450 ENZYME SYSTEM; DNA PRIMERS; ESTROGENS, NON-STEROIDAL; FEMALE; HEPATOCYTES; HUMANS; LUCIFERASES; MALE; MIDDLE AGED; REAL-TIME POLYMERASE CHAIN REACTION; RECEPTORS, ARYL HYDROCARBON; RECEPTORS, CYTOPLASMIC AND NUCLEAR; RECEPTORS, STEROID; RNA, MESSENGER; ZEARALENONE;

MAMMALIA;

EID: 78650210958     PISSN: 13826689     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.etap.2010.09.008     Document Type: Article

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