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Volumn 7, Issue 2, 2012, Pages 177-188

Regulation of lipid metabolism in breast cancer provides diagnostic and therapeutic opportunities

Author keywords

breast cancer; diagnostics; eicosanoids; glycolipids; lipid metabolism; lysophosphatidic acid; phospholipids; sphingolipids; therapeutics

Indexed keywords

C 75; CERAMIDE; CERULENIN; CHOLINE KINASE; CYCLOOXYGENASE 2; EPIDERMAL GROWTH FACTOR RECEPTOR 2; ESTROGEN RECEPTOR; FATTY ACID SYNTHASE; FATTY ACID SYNTHASE INHIBITOR; G PROTEIN COUPLED RECEPTOR; GLYCOSPHINGOLIPID; ICOSANOID; LIPOXYGENASE; LYSOPHOSPHATIDIC ACID; MALONYL COENZYME A; PROSTAGLANDIN E2; SPHINGOSINE; SPHINGOSINE 1 PHOSPHATE; TETRAHYDROLIPSTATIN; UNCLASSIFIED DRUG;

EID: 84860138891     PISSN: 17460875     EISSN: 17584302     Source Type: Journal    
DOI: 10.2217/clp.12.10     Document Type: Article
Times cited : (24)

References (108)
  • 1
    • 8144228566 scopus 로고    scopus 로고
    • Why do cancers have high aerobic glycolysis?
    • DOI 10.1038/nrc1478
    • Gatenby RA, Gillies RJ. Why do cancers have high aerobic glycolysis? Nat. Rev. Cancer 4(11), 891-899 (2004). (Pubitemid 39472955)
    • (2004) Nature Reviews Cancer , vol.4 , Issue.11 , pp. 891-899
    • Gatenby, R.A.1    Gillies, R.J.2
  • 2
    • 3042823722 scopus 로고    scopus 로고
    • Metabolic profles of cancer cells
    • Griffn JL, Shockcor JP. Metabolic profles of cancer cells. Nat. Rev. Cancer 4(7), 551-561 (2004).
    • (2004) Nat. Rev. Cancer , vol.4 , Issue.7 , pp. 551-561
    • Griffn, J.L.1    Shockcor, J.P.2
  • 3
    • 34748912615 scopus 로고    scopus 로고
    • Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis
    • DOI 10.1038/nrc2222, PII NRC2222
    • Menendez JA, Lupu R. Fatty acid synthase and the lipogenic phenotype in cancer pathogenesis. Nat. Rev. Cancer 7(10), 763-777 (2007). (Pubitemid 47469806)
    • (2007) Nature Reviews Cancer , vol.7 , Issue.10 , pp. 763-777
    • Menendez, J.A.1    Lupu, R.2
  • 4
    • 0031845136 scopus 로고    scopus 로고
    • Nutritional and hormonal regulation of enzymes in fat synthesis: Studies of fatty acid synthase and mitochondrial glycerol-3-phosphate acyltransferase gene transcription
    • DOI 10.1146/annurev.nutr.18.1.331
    • Sul HS, Wang D. Nutritional and hormonal regulation of enzymes in fat synthesis: studies of fatty acid synthase and mitochondrial glycerol-3-phosphate acyltransferase gene transcription. Annu. Rev. Nutr. 18, 331-351 (1998). (Pubitemid 28366871)
    • (1998) Annual Review of Nutrition , vol.18 , pp. 331-351
    • Sul, H.S.1    Wang, D.2
  • 6
    • 0033607176 scopus 로고    scopus 로고
    • Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis- related genes
    • DOI 10.1073/pnas.96.22.12737
    • Foretz M, Guichard C, Ferre P, Foufelle F. Sterol regulatory element binding protein-1c is a major mediator of insulin action on the hepatic expression of glucokinase and lipogenesis-related genes. Proc. Natl Acad. Sci. USA 96(22), 12737-12742 (1999). (Pubitemid 29513572)
    • (1999) Proceedings of the National Academy of Sciences of the United States of America , vol.96 , Issue.22 , pp. 12737-12742
    • Foretz, M.1    Guichard, C.2    Ferre, P.3    Foufelle, F.4
  • 7
    • 0035038782 scopus 로고    scopus 로고
    • Mechanisms of nutritional and hormonal regulation of lipogenesis
    • DOI 10.1093/embo-reports/kve071
    • Kersten S. Mechanisms of nutritional and hormonal regulation of lipogenesis. EMBO Rep. 2(4), 282-286 (2001). (Pubitemid 32401521)
    • (2001) EMBO Reports , vol.2 , Issue.4 , pp. 282-286
    • Kersten, S.1
  • 8
    • 0032532152 scopus 로고    scopus 로고
    • Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: Model for congenital generalized lipodystrophy
    • Shimomura I, Hammer RE, Richardson JA et al. Insulin resistance and diabetes mellitus in transgenic mice expressing nuclear SREBP-1c in adipose tissue: model for congenital generalized lipodystrophy. Genes Dev. 12(20), 3182-3194 (1998). (Pubitemid 28496263)
    • (1998) Genes and Development , vol.12 , Issue.20 , pp. 3182-3194
    • Shimomura, I.1    Hammer, R.E.2    Richardson, J.A.3    Ikemoto, S.4    Bashmakov, Y.5    Goldstein, J.L.6    Brown, M.S.7
  • 10
    • 0030706079 scopus 로고    scopus 로고
    • Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma
    • Milgraum LZ, Witters LA, Pasternack GR, Kuhajda FP. Enzymes of the fatty acid synthesis pathway are highly expressed in in situ breast carcinoma. Clin. Cancer Res. 3(11), 2115-2120 (1997). (Pubitemid 27505140)
    • (1997) Clinical Cancer Research , vol.3 , Issue.11 , pp. 2115-2120
    • Milgraum, L.Z.1    Witters, L.A.2    Pasternack, G.R.3    Kuhajda, F.P.4
  • 11
    • 0030063936 scopus 로고    scopus 로고
    • Expression of fatty acid synthase (FAS) as a predictor of recurrence in stage I breast carcinoma patients
    • DOI 10.1002/(SICI)1097-0142(19960201)77:3<474::AID-CNCR8>3.0.CO;2-K
    • Alo PL, Visca P, Marci A, Mangoni A, Botti C, Di Tondo U. Expression of fatty acid synthase (FAS) as a predictor of recurrence in stage I breast carcinoma patients. Cancer 77(3), 474-482 (1996). (Pubitemid 26047568)
    • (1996) Cancer , vol.77 , Issue.3 , pp. 474-482
    • Alo, P.L.1    Visca, P.2    Marci, A.3    Mangoni, A.4    Botti, C.5    Di Tondo, U.6
  • 13
    • 0037440477 scopus 로고    scopus 로고
    • Regulation of fatty acid synthase expression in breast cancer by sterol regulatory element binding protein-1c
    • DOI 10.1016/S0014-4827(02)00023-X, PII S001448270200023X
    • Yang YA, Morin PJ, Han WF et al. Regulation of fatty acid synthase expression in breast cancer by sterol regulatory element binding protein-1c. Exp. Cell Res. 282(2), 132-137 (2003). (Pubitemid 36259906)
    • (2003) Experimental Cell Research , vol.282 , Issue.2 , pp. 132-137
    • Yang, Y.-A.1    Morin, P.J.2    Han, W.F.3    Chen, T.4    Bornman, D.M.5    Gabrielson, E.W.6    Pizer, E.S.7
  • 14
    • 0036385719 scopus 로고    scopus 로고
    • Activation of fatty acid synthesis during neoplastic transformation: Role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase
    • Yang YA, Han WF, Morin PJ, Chrest FJ, Pizer ES. Activation of fatty acid synthesis during neoplastic transformation: role of mitogen-activated protein kinase and phosphatidylinositol 3-kinase. Exp. Cell Res. 279(1), 80-90 (2002).
    • (2002) Exp. Cell Res. , vol.279 , Issue.1 , pp. 80-90
    • Yang, Y.A.1    Han, W.F.2    Morin, P.J.3    Chrest, F.J.4    Pizer, E.S.5
  • 15
    • 34548814981 scopus 로고    scopus 로고
    • Up-regulation of acetyl-CoA carboxylase α and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells
    • DOI 10.1074/jbc.M702854200
    • Yoon S, Lee MY, Park SW et al. Up-regulation of acetyl-CoA carboxylase alpha and fatty acid synthase by human epidermal growth factor receptor 2 at the translational level in breast cancer cells. J. Biol. Chem. 282(36), 26122-26131 (2007). (Pubitemid 47443806)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.36 , pp. 26122-26131
    • Yoon, S.1    Lee, M.-Y.2    Park, S.W.3    Moon, J.-S.4    Koh, Y.-K.5    Ahn, Y.-H.6    Park, B.-W.7    Kim, K.-S.8
  • 16
    • 69449099939 scopus 로고    scopus 로고
    • Inhibition of stearoylCoA desaturase-1 inactivates acetyl-CoA carboxylase and impairs proliferation in cancer cells: Role of AMPK
    • Scaglia N, Chisholm JW, Igal RA. Inhibition of stearoylCoA desaturase-1 inactivates acetyl-CoA carboxylase and impairs proliferation in cancer cells: role of AMPK. PLoS ONE 4(8), e6812 (2009).
    • (2009) PLoS ONE , vol.4 , Issue.8
    • Scaglia, N.1    Chisholm, J.W.2    Igal, R.A.3
  • 17
    • 77958030867 scopus 로고    scopus 로고
    • Rapamycin regulates stearoyl CoA desaturase 1 expression in breast cancer
    • Luyimbazi D, Akcakanat A, McAuliffe PF et al. Rapamycin regulates stearoyl CoA desaturase 1 expression in breast cancer. Mol. Cancer Ther. 9(10), 2770-2784 (2010).
    • (2010) Mol. Cancer Ther. , vol.9 , Issue.10 , pp. 2770-2784
    • Luyimbazi, D.1    Akcakanat, A.2    McAuliffe, P.F.3
  • 18
    • 0032499787 scopus 로고    scopus 로고
    • The 'Spot 14' gene resides on the telomeric end of the 11q13 amplicon and is expressed in lipogenic breast cancers: Implications for control of tumor metabolism
    • Moncur JT, Park JP, Memoli VA, Mohandas TK, Kinlaw WB. The 'Spot 14' gene resides on the telomeric end of the 11q13 amplicon and is expressed in lipogenic breast cancers: implications for control of tumor metabolism. Proc. Natl Acad. Sci. USA 95(12), 6989-6994 (1998).
    • (1998) Proc. Natl Acad. Sci. USA , vol.95 , Issue.12 , pp. 6989-6994
    • Moncur, J.T.1    Park, J.P.2    Memoli, V.A.3    Mohandas, T.K.4    Kinlaw, W.B.5
  • 19
    • 33745923520 scopus 로고    scopus 로고
    • Expression of "Spot 14" (THRSP) predicts disease free survival in invasive breast cancer: Immunohistochemical analysis of a new molecular marker
    • DOI 10.1007/s10549-005-9154-z
    • Wells WA, Schwartz GN, Morganelli PM, Cole BF, Gibson JJ, Kinlaw WB. Expression of 'Spot 14' (THRSP) predicts disease free survival in invasive breast cancer: immunohistochemical ana lysis of a new molecular marker. Breast Cancer Res. Treat. 98(2), 231-240 (2006). (Pubitemid 44050774)
    • (2006) Breast Cancer Research and Treatment , vol.98 , Issue.2 , pp. 231-240
    • Wells, W.A.1    Schwartz, G.N.2    Morganelli, P.M.3    Cole, B.F.4    Gibson, J.J.5    Kinlaw, W.B.6
  • 21
    • 78650505999 scopus 로고    scopus 로고
    • Crystal structure of Spot 14, a modulator of fatty acid synthesis
    • Colbert CL, Kim CW, Moon YA et al. Crystal structure of Spot 14, a modulator of fatty acid synthesis. Proc. Natl Acad. Sci. USA 107(44), 18820-18825 (2010).
    • (2010) Proc. Natl Acad. Sci. USA , vol.107 , Issue.44 , pp. 18820-18825
    • Colbert, C.L.1    Kim, C.W.2    Moon, Y.A.3
  • 22
    • 77953591461 scopus 로고    scopus 로고
    • The Kennedy pathway-de novo synthesis of phosphatidylethanolamine and phosphatidylcholine
    • Gibellini F, Smith TK. The Kennedy pathway-de novo synthesis of phosphatidylethanolamine and phosphatidylcholine. IUBMB Life 62(6), 414-428 (2010).
    • (2010) IUBMB Life , vol.62 , Issue.6 , pp. 414-428
    • Gibellini, F.1    Smith, T.K.2
  • 23
    • 81855226152 scopus 로고    scopus 로고
    • Choline metabolism in malignant transformation
    • Glunde K, Bhujwalla ZM, Ronen SM. Choline metabolism in malignant transformation. Nat. Rev. Cancer 11(12), 835-848 (2011).
    • (2011) Nat. Rev. Cancer , vol.11 , Issue.12 , pp. 835-848
    • Glunde, K.1    Bhujwalla, Z.M.2    Ronen, S.M.3
  • 24
    • 0037142610 scopus 로고    scopus 로고
    • Increased choline kinase activity in human breast carcinomas: Clinical evidence for a potential novel antitumor strategy
    • DOI 10.1038/sj.onc.1205556
    • Ramirez de Molina A, Gutierrez R, Ramos MA et al. Increased choline kinase activity in human breast carcinomas: clinical evidence for a potential novel antitumor strategy. Oncogene 21(27), 4317-4322 (2002). (Pubitemid 34753838)
    • (2002) Oncogene , vol.21 , Issue.27 , pp. 4317-4322
    • De Molina, A.R.1    Gutierrez, R.2    Ramos, M.A.3    Silva, J.M.4    Silva, J.5    Bonilla, F.6    Sanchez, J.J.7    Lacal, J.C.8
  • 25
    • 4644284916 scopus 로고    scopus 로고
    • Choline kinase activation is a critical requirement for the proliferation of primary human mammary epithelial cells and breast tumor progression
    • DOI 10.1158/0008-5472.CAN-04-0489
    • Ramirez de Molina A, Banez-Coronel M, Gutierrez R et al. Choline kinase activation is a critical requirement for the proliferation of primary human mammary epithelial cells and breast tumor progression. Cancer Res. 64(18), 6732-6739 (2004). (Pubitemid 39297936)
    • (2004) Cancer Research , vol.64 , Issue.18 , pp. 6732-6739
    • De Molina, A.R.1    Banez-Coronel, M.2    Gutierrez, R.3    Rodriguez-Gonzalez, A.4    Olmeda, D.5    Megias, D.6    Lacal, J.C.7
  • 26
    • 0037151369 scopus 로고    scopus 로고
    • Clinical utility of proton magnetic resonance spectroscopy in characterizing breast lesions
    • Katz-Brull R, Lavin PT, Lenkinski RE. Clinical utility of proton magnetic resonance spectroscopy in characterizing breast lesions. J. Natl Cancer Inst. 94(16), 1197-1203 (2002). (Pubitemid 34993869)
    • (2002) Journal of the National Cancer Institute , vol.94 , Issue.16 , pp. 1197-1203
    • Katz-Brull, R.1    Lavin, P.T.2    Lenkinski, R.E.3
  • 27
    • 69949091374 scopus 로고    scopus 로고
    • 11C] choline positron emission tomography in estrogen receptor-positive breast cancer
    • 11C]choline positron emission tomography in estrogen receptor-positive breast cancer. Clin. Cancer Res. 15(17), 5503-5510 (2009).
    • (2009) Clin. Cancer Res. , vol.15 , Issue.17 , pp. 5503-5510
    • Contractor, K.B.1    Kenny, L.M.2    Stebbing, J.3
  • 28
    • 77955751243 scopus 로고    scopus 로고
    • 11C]choline-positron emission tomography and effect of trastuzumab
    • 11C]choline-positron emission tomography and effect of trastuzumab. Clin. Cancer Res. 16(16), 4236-4245 (2010).
    • (2010) Clin. Cancer Res. , vol.16 , Issue.16 , pp. 4236-4245
    • Kenny, L.M.1    Contractor, K.B.2    Hinz, R.3
  • 29
  • 30
    • 79955518028 scopus 로고    scopus 로고
    • Novel theranostic opportunities offered by characterization of altered membrane lipid metabolism in breast cancer progression
    • Hilvo M, Denkert C, Lehtinen L et al. Novel theranostic opportunities offered by characterization of altered membrane lipid metabolism in breast cancer progression. Cancer Res. 71(9), 3236-3245 (2011).
    • (2011) Cancer Res. , vol.71 , Issue.9 , pp. 3236-3245
    • Hilvo, M.1    Denkert, C.2    Lehtinen, L.3
  • 31
    • 79952821017 scopus 로고    scopus 로고
    • Differential protein expression profles in estrogen receptor-positive and-negative breast cancer tissues using label-free quantitative proteomics
    • Rezaul K, Thumar JK, Lundgren DH et al. Differential protein expression profles in estrogen receptor-positive and-negative breast cancer tissues using label-free quantitative proteomics. Genes Cancer 1(3), 251-271 (2010).
    • (2010) Genes Cancer , vol.1 , Issue.3 , pp. 251-271
    • Rezaul, K.1    Thumar, J.K.2    Lundgren, D.H.3
  • 33
    • 56649086770 scopus 로고    scopus 로고
    • Overexpression of fatty acid synthase is associated with palmitoylation of Wnt1 and cytoplasmic stabilization of beta-catenin in prostate cancer
    • Fiorentino M, Zadra G, Palescandolo E et al. Overexpression of fatty acid synthase is associated with palmitoylation of Wnt1 and cytoplasmic stabilization of beta-catenin in prostate cancer. Lab. Invest. 88(12), 1340-1348 (2008).
    • (2008) Lab. Invest. , vol.88 , Issue.12 , pp. 1340-1348
    • Fiorentino, M.1    Zadra, G.2    Palescandolo, E.3
  • 34
    • 78049307002 scopus 로고    scopus 로고
    • De novo lipogenesis protects cancer cells from free radicals and chemotherapeutics by promoting membrane lipid saturation
    • Rysman E, Brusselmans K, Scheys K et al. De novo lipogenesis protects cancer cells from free radicals and chemotherapeutics by promoting membrane lipid saturation. Cancer Res. 70(20), 8117-8126 (2010).
    • (2010) Cancer Res. , vol.70 , Issue.20 , pp. 8117-8126
    • Rysman, E.1    Brusselmans, K.2    Scheys, K.3
  • 35
    • 58149290260 scopus 로고    scopus 로고
    • Mediation of apoptosis by oxidized phospholipids
    • Fruhwirth GO, Hermetter A. Mediation of apoptosis by oxidized phospholipids. Subcell. Biochem. 49, 351-367 (2008).
    • (2008) Subcell. Biochem. , vol.49 , pp. 351-367
    • Fruhwirth, G.O.1    Hermetter, A.2
  • 36
    • 0034650757 scopus 로고    scopus 로고
    • Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts
    • Pizer ES, Thupari J, Han WF et al. Malonyl-coenzyme-A is a potential mediator of cytotoxicity induced by fatty-acid synthase inhibition in human breast cancer cells and xenografts. Cancer Res. 60(2), 213-218 (2000). (Pubitemid 30070736)
    • (2000) Cancer Research , vol.60 , Issue.2 , pp. 213-218
    • Pizer, E.S.1    Thupari, J.2    Han, W.F.3    Pinn, M.L.4    Chrest, F.J.5    Frehywot, G.L.6    Townsend, C.A.7    Kuhajda, F.P.8
  • 38
    • 27144469291 scopus 로고    scopus 로고
    • The connections between C75 and obesity drug-target pathways
    • DOI 10.1016/j.tips.2005.09.002, PII S0165614705002178
    • Kuhajda FP, Landree LE, Ronnett GV. The connections between C75 and obesity drug-target pathways. Trends Pharmacol. Sci. 26(11), 541-544 (2005). (Pubitemid 41505218)
    • (2005) Trends in Pharmacological Sciences , vol.26 , Issue.11 , pp. 541-544
    • Kuhajda, F.P.1    Landree, L.E.2    Ronnett, G.V.3
  • 39
    • 1542720382 scopus 로고    scopus 로고
    • Orlistat Is a Novel Inhibitor of Fatty Acid Synthase with Antitumor Activity
    • DOI 10.1158/0008-5472.CAN-03-3645
    • Kridel SJ, Axelrod F, Rozenkrantz N, Smith JW. Orlistat is a novel inhibitor of fatty acid synthase with antitumor activity. Cancer Res. 64(6), 2070-2075 (2004). (Pubitemid 38339455)
    • (2004) Cancer Research , vol.64 , Issue.6 , pp. 2070-2075
    • Kridel, S.J.1    Axelrod, F.2    Rozenkrantz, N.3    Smith, J.W.4
  • 40
    • 33845909566 scopus 로고    scopus 로고
    • Pharmacological inhibitors of fatty acid synthase (FASN)-catalyzed endogenous fatty acid biogenesis: A new family of anti-cancer agents?
    • Lupu R, Menendez JA. Pharmacological inhibitors of fatty acid synthase (FASN)-catalyzed endogenous fatty acid biogenesis: a new family of anti-cancer agents? Curr. Pharm. Biotechnol. 7(6), 483-493 (2006).
    • (2006) Curr. Pharm. Biotechnol. , vol.7 , Issue.6 , pp. 483-493
    • Lupu, R.1    Menendez, J.A.2
  • 41
    • 3142720785 scopus 로고    scopus 로고
    • Novel signaling molecules implicated in tumor-associated fatty acid synthase-dependent breast cancer cell proliferation and survival: Role of exogenous dietary fatty acids, p53-p21WAF1/CIP1, ERK1/2 MAPK, p27KIP1, BRCA1, and NF-kappaB
    • Menendez JA, Mehmi I, Atlas E, Colomer R, Lupu R. Novel signaling molecules implicated in tumor-associated fatty acid synthase-dependent breast cancer cell proliferation and survival: role of exogenous dietary fatty acids, p53-p21WAF1/CIP1, ERK1/2 MAPK, p27KIP1, BRCA1, and NF-kappaB. Int. J. Oncol. 24(3), 591-608 (2004).
    • (2004) Int. J. Oncol. , vol.24 , Issue.3 , pp. 591-608
    • Menendez, J.A.1    Mehmi, I.2    Atlas, E.3    Colomer, R.4    Lupu, R.5
  • 42
    • 33744808464 scopus 로고    scopus 로고
    • Acetyl-CoA carboxylase α is essential to breast cancer cell survival
    • DOI 10.1158/0008-5472.CAN-05-1489
    • Chajès V, Cambot M, Moreau K, Lenoir GM, Joulin V. Acetyl-CoA carboxylase alpha is essential to breast cancer cell survival. Cancer Res. 66(10), 5287-5294 (2006). (Pubitemid 43844953)
    • (2006) Cancer Research , vol.66 , Issue.10 , pp. 5287-5294
    • Chajes, V.1    Cambot, M.2    Moreau, K.3    Lenoir, G.M.4    Joulin, V.5
  • 43
    • 17644394237 scopus 로고    scopus 로고
    • Pharmacological and small interference RNA-mediated inhibition of breast cancer-associated fatty acid synthase (oncogenic antigen-519) synergistically enhances Taxol (Paclitaxel)-induced cytotoxicity
    • DOI 10.1002/ijc.20754
    • Menendez JA, Vellon L, Colomer R, Lupu R. Pharmacological and small interference RNA-mediated inhibition of breast cancer-associated fatty acid synthase (oncogenic antigen-519) synergistically enhances Taxol (paclitaxel)-induced cytotoxicity. Int. J. Cancer 115(1), 19-35 (2005). (Pubitemid 40559665)
    • (2005) International Journal of Cancer , vol.115 , Issue.1 , pp. 19-35
    • Menendez, J.A.1    Vellon, L.2    Colomer, R.3    Lupu, R.4
  • 44
    • 21644488027 scopus 로고    scopus 로고
    • RNA interference-mediated silencing of the p53 tumor-suppressor protein drastically increases apoptosis after inhibition of endogenous fatty acid metabolism in breast cancer cells
    • Menendez JA, Lupu R. RNA interference-mediated silencing of the p53 tumor-suppressor protein drastically increases apoptosis after inhibition of endogenous fatty acid metabolism in breast cancer cells. Int. J. Mol. Med. 15(1), 33-40 (2005).
    • (2005) Int. J. Mol. Med. , vol.15 , Issue.1 , pp. 33-40
    • Menendez, J.A.1    Lupu, R.2
  • 45
    • 34447300423 scopus 로고    scopus 로고
    • Genome-wide changes accompanying knockdown of fatty acid synthase in breast cancer
    • Knowles LM, Smith JW. Genome-wide changes accompanying knockdown of fatty acid synthase in breast cancer. BMC Genomics 8, 168 (2007).
    • (2007) BMC Genomics , vol.8 , pp. 168
    • Knowles, L.M.1    Smith, J.W.2
  • 47
    • 33847034466 scopus 로고    scopus 로고
    • Inhibition of fatty acid synthase induces endoplasmic reticulum stress in tumor cells
    • Little JL, Wheeler FB, Fels DR, Koumenis C, Kridel SJ. Inhibition of fatty acid synthase induces endoplasmic reticulum stress in tumor cells. Cancer Res. 67(3), 1262-1269 (2007).
    • (2007) Cancer Res. , vol.67 , Issue.3 , pp. 1262-1269
    • Little, J.L.1    Wheeler, F.B.2    Fels, D.R.3    Koumenis, C.4    Kridel, S.J.5
  • 48
    • 0042887042 scopus 로고    scopus 로고
    • The emerging role of lysophosphatidic acid in cancer
    • DOI 10.1038/nrc1143
    • Mills GB, Moolenaar WH. The emerging role of lysophosphatidic acid in cancer. Nat. Rev. Cancer 3(8), 582-591 (2003). (Pubitemid 37328830)
    • (2003) Nature Reviews Cancer , vol.3 , Issue.8 , pp. 582-591
    • Mills, G.B.1    Moolenaar, W.H.2
  • 49
    • 77949504534 scopus 로고    scopus 로고
    • Lysophosphatidic acid production and action: Critical new players in breast cancer initiation and progression
    • Panupinthu N, Lee HY, Mills GB. Lysophosphatidic acid production and action: critical new players in breast cancer initiation and progression. Br. J. Cancer 102(6), 941-946 (2010).
    • (2010) Br. J. Cancer , vol.102 , Issue.6 , pp. 941-946
    • Panupinthu, N.1    Lee, H.Y.2    Mills, G.B.3
  • 50
    • 67650522890 scopus 로고    scopus 로고
    • Identifcation and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA
    • Yanagida K, Masago K, Nakanishi H et al. Identifcation and characterization of a novel lysophosphatidic acid receptor, p2y5/LPA. J. Biol. Chem. 284(26), 17731-17741 (2009).
    • (2009) J. Biol. Chem. , vol.284 , Issue.26 , pp. 17731-17741
    • Yanagida, K.1    Masago, K.2    Nakanishi, H.3
  • 51
    • 65649132676 scopus 로고    scopus 로고
    • Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases
    • Liu S, Umezu-Goto M, Murph M et al. Expression of autotaxin and lysophosphatidic acid receptors increases mammary tumorigenesis, invasion, and metastases. Cancer Cell 15(6), 539-550 (2009).
    • (2009) Cancer Cell , vol.15 , Issue.6 , pp. 539-550
    • Liu, S.1    Umezu-Goto, M.2    Murph, M.3
  • 53
    • 60549083280 scopus 로고    scopus 로고
    • Autotaxin protects MCF-7 breast cancer and MDA-MB-435 melanoma cells against Taxol-induced apoptosis
    • Samadi N, Gaetano C, Goping IS, Brindley DN. Autotaxin protects MCF-7 breast cancer and MDA-MB-435 melanoma cells against Taxol-induced apoptosis. Oncogene 28(7), 1028-1039 (2009).
    • (2009) Oncogene , vol.28 , Issue.7 , pp. 1028-1039
    • Samadi, N.1    Gaetano, C.2    Goping, I.S.3    Brindley, D.N.4
  • 54
    • 67650458524 scopus 로고    scopus 로고
    • Dual activity lysophosphatidic acid receptor pan-antagonist/autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivo
    • Zhang H, Xu X, Gajewiak J et al. Dual activity lysophosphatidic acid receptor pan-antagonist/autotaxin inhibitor reduces breast cancer cell migration in vitro and causes tumor regression in vivo. Cancer Res. 69(13), 5441-5449 (2009).
    • (2009) Cancer Res. , vol.69 , Issue.13 , pp. 5441-5449
    • Zhang, H.1    Xu, X.2    Gajewiak, J.3
  • 56
    • 77649179672 scopus 로고    scopus 로고
    • Eicosanoids and cancer
    • Wang D, Dubois RN. Eicosanoids and cancer. Nat. Rev. Cancer 10(3), 181-193 (2010).
    • (2010) Nat. Rev. Cancer , vol.10 , Issue.3 , pp. 181-193
    • Wang, D.1    Dubois, R.N.2
  • 60
    • 38849189289 scopus 로고    scopus 로고
    • NSAIDs and breast cancer: A possible prevention and treatment strategy
    • DOI 10.1111/j.1742-1241.2007.01668.x
    • Agrawal A, Fentiman IS. NSAIDs and breast cancer: a possible prevention and treatment strategy. Int. J. Clin. Pract. 62(3), 444-449 (2008). (Pubitemid 351197419)
    • (2008) International Journal of Clinical Practice , vol.62 , Issue.3 , pp. 444-449
    • Agrawal, A.1    Fentiman, I.S.2
  • 61
    • 19944430970 scopus 로고    scopus 로고
    • Interactions between prostaglandin E(2), liver receptor homologue-1, and aromatase in breast cancer
    • Zhou J, Suzuki T, Kovacic A et al. Interactions between prostaglandin E(2), liver receptor homologue-1, and aromatase in breast cancer. Cancer Res. 65(2), 657-663 (2005).
    • (2005) Cancer Res. , vol.65 , Issue.2 , pp. 657-663
    • Zhou, J.1    Suzuki, T.2    Kovacic, A.3
  • 62
    • 45549109399 scopus 로고    scopus 로고
    • Cyclooxygenase-2 up-regulates CCR7 via EP2/EP4 receptor signaling pathways to enhance lymphatic invasion of breast cancer cells
    • Pan MR, Hou MF, Chang HC, Hung WC. Cyclooxygenase-2 up-regulates CCR7 via EP2/EP4 receptor signaling pathways to enhance lymphatic invasion of breast cancer cells. J. Biol. Chem. 283(17), 11155-11163 (2008).
    • (2008) J. Biol. Chem. , vol.283 , Issue.17 , pp. 11155-11163
    • Pan, M.R.1    Hou, M.F.2    Chang, H.C.3    Hung, W.C.4
  • 63
    • 34249300128 scopus 로고    scopus 로고
    • Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cells
    • DOI 10.1158/0008-5472.CAN-06-4174
    • Sinha P, Clements VK, Fulton AM, Ostrand-Rosenberg S. Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cells. Cancer Res. 67(9), 4507-4513 (2007). (Pubitemid 46815102)
    • (2007) Cancer Research , vol.67 , Issue.9 , pp. 4507-4513
    • Sinha, P.1    Clements, V.K.2    Fulton, A.M.3    Ostrand-Rosenberg, S.4
  • 65
    • 33750855287 scopus 로고    scopus 로고
    • 2, regulates tumor angiogenesis through direct effects on endothelial cell motility and survival
    • DOI 10.1038/sj.onc.1209694, PII 1209694
    • Kamiyama M, Pozzi A, Yang L, DeBusk LM, Breyer RM, Lin PC. EP2, a receptor for PGE2, regulates tumor angiogenesis through direct effects on endothelial cell motility and survival. Oncogene 25(53), 7019-7028 (2006). (Pubitemid 44722070)
    • (2006) Oncogene , vol.25 , Issue.53 , pp. 7019-7028
    • Kamiyama, M.1    Pozzi, A.2    Yang, L.3    DeBusk, L.M.4    Breyer, R.M.5    Lin, P.C.6
  • 67
    • 84856746129 scopus 로고    scopus 로고
    • 15-hydroxyprostaglandin dehydrogenase associates with poor prognosis in breast cancer, induces epithelial-mesenchymal transition, and promotes cell migration in cultured breast cancer cells
    • Lehtinen L, Vainio P, Wikman H et al. 15-hydroxyprostaglandin dehydrogenase associates with poor prognosis in breast cancer, induces epithelial-mesenchymal transition, and promotes cell migration in cultured breast cancer cells. J. Pathol. 226(4), 674-686 (2012).
    • (2012) J. Pathol. , vol.226 , Issue.4 , pp. 674-686
    • Lehtinen, L.1    Vainio, P.2    Wikman, H.3
  • 71
    • 30544440084 scopus 로고    scopus 로고
    • Aberrant expression of 5-lipoxygenase-activating protein (5-LOXAP) has prognostic and survival significance in patients with breast cancer
    • DOI 10.1016/j.plefa.2005.10.005, PII S0952327805001766
    • Jiang WG, Douglas-Jones AG, Mansel RE. Aberrant expression of 5-lipoxygenase-activating protein (5-LOXAP) has prognostic and survival signifcance in patients with breast cancer. Prostaglandins Leukot. Essent. Fatty Acids 74(2), 125-134 (2006). (Pubitemid 43082137)
    • (2006) Prostaglandins Leukotrienes and Essential Fatty Acids , vol.74 , Issue.2 , pp. 125-134
    • Jiang, W.G.1    Douglas-Jones, A.G.2    Mansel, R.E.3
  • 72
    • 0036384212 scopus 로고    scopus 로고
    • The mechanisms of lipoxygenase inhibitor-induced apoptosis in human breast cancer cells
    • Tong WG, Ding XZ, Adrian TE. The mechanisms of lipoxygenase inhibitor-induced apoptosis in human breast cancer cells. Biochem. Biophys. Res. Commun. 296(4), 942-948 (2002).
    • (2002) Biochem. Biophys. Res. Commun. , vol.296 , Issue.4 , pp. 942-948
    • Tong, W.G.1    Ding, X.Z.2    Adrian, T.E.3
  • 73
    • 24744455897 scopus 로고    scopus 로고
    • 15(S)-lipoxygenase-2 mediates arachidonic acid-stimulated adhesion of human breast carcinoma cells through the activation of TAK1, MKK6, and p38 MAPK
    • DOI 10.1074/jbc.M500418200
    • Nony PA, Kennett SB, Glasgow WC, Olden K, Roberts JD. 15(S)-lipoxygenase-2 mediates arachidonic acid-stimulated adhesion of human breast carcinoma cells through the activation of TAK1, MKK6, and p38 MAPK. J. Biol. Chem. 280(36), 31413-31419 (2005). (Pubitemid 41291882)
    • (2005) Journal of Biological Chemistry , vol.280 , Issue.36 , pp. 31413-31419
    • Nony, P.A.1    Kennett, S.B.2    Glasgow, W.C.3    Olden, K.4    Roberts, J.D.5
  • 74
    • 0036931477 scopus 로고    scopus 로고
    • Omega-3 fatty acids in inflammation and autoimmune diseases
    • Simopoulos AP. Omega-3 fatty acids in infammation and autoimmune diseases. J. Am. Coll. Nutr. 21(6), 495-505 (2002). (Pubitemid 36026261)
    • (2002) Journal of the American College of Nutrition , vol.21 , Issue.6 , pp. 495-505
    • Simopoulos, A.P.1
  • 75
    • 0028906908 scopus 로고
    • Infuence of diets containing eicosapentaenoic or docosahexaenoic acid on growth and metastasis of breast cancer cells in nude mice
    • Rose DP, Connolly JM, Rayburn J, Coleman M. Infuence of diets containing eicosapentaenoic or docosahexaenoic acid on growth and metastasis of breast cancer cells in nude mice. J. Natl Cancer Inst. 87(8), 587-592 (1995).
    • (1995) J. Natl Cancer Inst. , vol.87 , Issue.8 , pp. 587-592
    • Rose, D.P.1    Connolly, J.M.2    Rayburn, J.3    Coleman, M.4
  • 80
  • 81
    • 3543093606 scopus 로고    scopus 로고
    • Novel ceramide analogues display selective cytotoxicity in drug-resistant breast tumor cell lines compared with normal breast epithelial cells
    • Crawford K W, Bittman R, Chun J, Byun HS, Bowen WD. Novel ceramide analogues display selective cytotoxicity in drug-resistant breast tumor cell lines compared with normal breast epithelial cells. Cell. Mol. Biol. (Noisy-le-grand) 49(7), 1017-1023 (2003).
    • (2003) Cell. Mol. Biol. (Noisy-le-grand) , vol.49 , Issue.7 , pp. 1017-1023
    • Crawford, K.W.1    Bittman, R.2    Chun, J.3    Byun, H.S.4    Bowen, W.D.5
  • 82
    • 18244404047 scopus 로고    scopus 로고
    • Systemic delivery of liposomal short-chain ceramide limits solid tumor growth in murine models of breast adenocarcinoma
    • DOI 10.1158/1078-0432.CCR-04-1770
    • Stover TC, Sharma A, Robertson GP, Kester M. Systemic delivery of liposomal short-chain ceramide limits solid tumor growth in murine models of breast adenocarcinoma. Clin. Cancer Res. 11(9), 3465-3474 (2005). (Pubitemid 40627901)
    • (2005) Clinical Cancer Research , vol.11 , Issue.9 , pp. 3465-3474
    • Stover, T.C.1    Sharma, A.2    Robertson, G.P.3    Kester, M.4
  • 83
    • 65549143292 scopus 로고    scopus 로고
    • Ceramide synthases and ceramide levels are increased in breast cancer tissue
    • Schiffmann S, Sandner J, Birod K et al. Ceramide synthases and ceramide levels are increased in breast cancer tissue. Carcinogenesis 30(5), 745-752 (2009).
    • (2009) Carcinogenesis , vol.30 , Issue.5 , pp. 745-752
    • Schiffmann, S.1    Sandner, J.2    Birod, K.3
  • 84
    • 52949143502 scopus 로고    scopus 로고
    • Microarray ana lysis of altered sphingolipid metabolism reveals prognostic signifcance of sphingosine kinase 1 in breast cancer
    • Ruckhaberle E, Rody A, Engels K et al. Microarray ana lysis of altered sphingolipid metabolism reveals prognostic signifcance of sphingosine kinase 1 in breast cancer. Breast Cancer Res. Treat. 112(1), 41-52 (2008).
    • (2008) Breast Cancer Res. Treat. , vol.112 , Issue.1 , pp. 41-52
    • Ruckhaberle, E.1    Rody, A.2    Engels, K.3
  • 87
    • 70249125866 scopus 로고    scopus 로고
    • Sphingosine kinase 2 defcient tumor xenografts show impaired growth and fail to polarize macrophages towards an antiinfammatory phenotype
    • Weigert A, Schiffmann S, Sekar D et al. Sphingosine kinase 2 defcient tumor xenografts show impaired growth and fail to polarize macrophages towards an antiinfammatory phenotype. Int. J. Cancer 125(9), 2114-2121 (2009).
    • (2009) Int. J. Cancer , vol.125 , Issue.9 , pp. 2114-2121
    • Weigert, A.1    Schiffmann, S.2    Sekar, D.3
  • 88
    • 34249656324 scopus 로고    scopus 로고
    • Sphingosine kinase type 2 activation by ERK-mediated phosphorylation
    • DOI 10.1074/jbc.M609559200
    • Hait NC, Bellamy A, Milstien S, Kordula T, Spiegel S. Sphingosine kinase type 2 activation by ERK-mediated phosphorylation. J. Biol. Chem. 282(16), 12058-12065 (2007). (Pubitemid 47100715)
    • (2007) Journal of Biological Chemistry , vol.282 , Issue.16 , pp. 12058-12065
    • Hait, N.C.1    Bellamy, A.2    Milstien, S.3    Kordula, T.4    Spiegel, S.5
  • 89
    • 77953966511 scopus 로고    scopus 로고
    • Sphingosine 1-phosphate and cancer
    • Pyne NJ, Pyne S. Sphingosine 1-phosphate and cancer. Nat. Rev. Cancer 10(7), 489-503 (2010).
    • (2010) Nat. Rev. Cancer , vol.10 , Issue.7 , pp. 489-503
    • Pyne, N.J.1    Pyne, S.2
  • 90
    • 40049096040 scopus 로고    scopus 로고
    • Sphingosine kinase-1 is a hypoxia-regulated gene that stimulates migration of human endothelial cells
    • Schwalm S, Doll F, Romer I, Bubnova S, Pfeilschifter J, Huwiler A. Sphingosine kinase-1 is a hypoxia-regulated gene that stimulates migration of human endothelial cells. Biochem. Biophys. Res. Commun. 368(4), 1020-1025 (2008).
    • (2008) Biochem. Biophys. Res. Commun. , vol.368 , Issue.4 , pp. 1020-1025
    • Schwalm, S.1    Doll, F.2    Romer, I.3    Bubnova, S.4    Pfeilschifter, J.5    Huwiler, A.6
  • 91
    • 54249088951 scopus 로고    scopus 로고
    • Sphingosine kinase 1: A new modulator of hypoxia inducible factor 1alpha during hypoxia in human cancer cells
    • Ader I, Brizuela L, Bouquerel P, Malavaud B, Cuvillier O. Sphingosine kinase 1: a new modulator of hypoxia inducible factor 1alpha during hypoxia in human cancer cells. Cancer Res. 68(20), 8635-8642 (2008).
    • (2008) Cancer Res. , vol.68 , Issue.20 , pp. 8635-8642
    • Ader, I.1    Brizuela, L.2    Bouquerel, P.3    Malavaud, B.4    Cuvillier, O.5
  • 92
    • 41249103991 scopus 로고    scopus 로고
    • Sphingosine kinase 1 is up-regulated during hypoxia in U87MG glioma cells. Role of hypoxia-inducible factors 1 and 2
    • Anelli V, Gault CR, Cheng AB, Obeid LM. Sphingosine kinase 1 is up-regulated during hypoxia in U87MG glioma cells. Role of hypoxia-inducible factors 1 and 2. J. Biol. Chem. 283(6), 3365-3375 (2008).
    • (2008) J. Biol. Chem. , vol.283 , Issue.6 , pp. 3365-3375
    • Anelli, V.1    Gault, C.R.2    Cheng, A.B.3    Obeid, L.M.4
  • 93
    • 0141567617 scopus 로고    scopus 로고
    • 3 (EDG3)
    • DOI 10.1182/blood-2002-12-3634
    • Licht T, Tsirulnikov L, Reuveni H, Yarnitzky T, Ben-Sasson SA. Induction of pro-angiogenic signaling by a synthetic peptide derived from the second intracellular loop of S1P3 (EDG3). Blood 102(6), 2099-2107 (2003). (Pubitemid 37122386)
    • (2003) Blood , vol.102 , Issue.6 , pp. 2099-2107
    • Licht, T.1    Tsirulnikov, L.2    Reuveni, H.3    Yarnitzky, T.4    Ben-Sasson, S.A.5
  • 95
    • 33646117016 scopus 로고    scopus 로고
    • Estrogen transactivates EGFR via the sphingosine 1-phosphate receptor Edg-3: The role of sphingosine kinase-1
    • Sukocheva O, Wadham C, Holmes A et al. Estrogen transactivates EGFR via the sphingosine 1-phosphate receptor Edg-3: the role of sphingosine kinase-1. J. Cell Biol. 173(2), 301-310 (2006).
    • (2006) J. Cell Biol. , vol.173 , Issue.2 , pp. 301-310
    • Sukocheva, O.1    Wadham, C.2    Holmes, A.3
  • 96
    • 70349333252 scopus 로고    scopus 로고
    • Restoring endocrine response in breast cancer cells by inhibition of the sphingosine kinase-1 signaling pathway
    • Sukocheva O, Wang L, Verrier E, Vadas MA, Xia P. Restoring endocrine response in breast cancer cells by inhibition of the sphingosine kinase-1 signaling pathway. Endocrinology 150(10), 4484-4492 (2009).
    • (2009) Endocrinology , vol.150 , Issue.10 , pp. 4484-4492
    • Sukocheva, O.1    Wang, L.2    Verrier, E.3    Vadas, M.A.4    Xia, P.5
  • 97
    • 78149348826 scopus 로고    scopus 로고
    • High expression of sphingosine 1-phosphate receptors, S1P1 and S1P3, sphingosine kinase 1, and extracellular signal-regulated kinase-1/2 is associated with development of tamoxifen resistance in estrogen receptor-positive breast cancer patients
    • Watson C, Long JS, Orange C et al. High expression of sphingosine 1-phosphate receptors, S1P1 and S1P3, sphingosine kinase 1, and extracellular signal-regulated kinase-1/2 is associated with development of tamoxifen resistance in estrogen receptor-positive breast cancer patients. Am J. Pathol. 177(5), 2205-2215 (2010).
    • (2010) Am J. Pathol. , vol.177 , Issue.5 , pp. 2205-2215
    • Watson, C.1    Long, J.S.2    Orange, C.3
  • 98
    • 69949113620 scopus 로고    scopus 로고
    • Regulation of histone acetylation in the nucleus by sphingosine-1- phosphate
    • Hait NC, Allegood J, Maceyka M et al. Regulation of histone acetylation in the nucleus by sphingosine-1-phosphate. Science 325(5945), 1254-1257 (2009).
    • (2009) Science , vol.325 , Issue.5945 , pp. 1254-1257
    • Hait, N.C.1    Allegood, J.2    MacEyka, M.3
  • 99
    • 0142122853 scopus 로고    scopus 로고
    • The cerebrosides
    • DOI 10.1039/b307243f
    • Tan RX, Chen JH. The cerebrosides. Nat. Prod. Rep. 20(5), 509-534 (2003). (Pubitemid 37284050)
    • (2003) Natural Product Reports , vol.20 , Issue.5 , pp. 509-534
    • Tan, R.X.1    Chen, J.H.2
  • 100
    • 0035079539 scopus 로고    scopus 로고
    • Ceramide glycosylation potentiates cellular multidrug resistance
    • DOI 10.1096/fj.00-0223com
    • Liu YY, Han TY, Giuliano AE, Cabot MC. Ceramide glycosylation potentiates cellular multidrug resistance. FASEB J. 15(3), 719-730 (2001). (Pubitemid 32245990)
    • (2001) FASEB Journal , vol.15 , Issue.3 , pp. 719-730
    • Liu, Y.-Y.1    Han, T.-Y.2    Giuliano, A.E.3    Cabot, M.C.4
  • 101
    • 0035888295 scopus 로고    scopus 로고
    • Elevation of glucosylceramide in multidrug-resistant cancer cells and accumulation in cytoplasmic droplets
    • DOI 10.1002/ijc.1449
    • Morjani H, Aouali N, Belhoussine R, Veldman RJ, Levade T, Manfait M. Elevation of glucosylceramide in multidrug-resistant cancer cells and accumulation in cytoplasmic droplets. Int. J. Cancer 94(2), 157-165 (2001). (Pubitemid 32911407)
    • (2001) International Journal of Cancer , vol.94 , Issue.2 , pp. 157-165
    • Morjani, H.1    Aouali, N.2    Belhoussine, R.3    Veldman, R.J.4    Levade, T.5    Manfait, M.6
  • 102
    • 56649099155 scopus 로고    scopus 로고
    • Prognostic relevance of glucosylceramide synthase (GCS) expression in breast cancer
    • Ruckhaberle E, Karn T, Hanker L et al. Prognostic relevance of glucosylceramide synthase (GCS) expression in breast cancer. J. Cancer Res. Clin. Oncol. 135(1), 81-90 (2009).
    • (2009) J. Cancer Res. Clin. Oncol. , vol.135 , Issue.1 , pp. 81-90
    • Ruckhaberle, E.1    Karn, T.2    Hanker, L.3
  • 103
    • 18144371163 scopus 로고    scopus 로고
    • Glucosylceramide synthase blockade down-regulates P-glycoprotein and resensitizes multidrug-resistant breast cancer cells to anticancer drugs
    • DOI 10.1158/0008-5472.CAN-04-2329
    • Gouaze V, Liu YY, Prickett CS, Yu JY, Giuliano AE, Cabot MC. Glucosylceramide synthase blockade down-regulates P-glycoprotein and resensitizes multidrug-resistant breast cancer cells to anticancer drugs. Cancer Res. 65(9), 3861-3867 (2005). (Pubitemid 40616367)
    • (2005) Cancer Research , vol.65 , Issue.9 , pp. 3861-3867
    • Gouaze, V.1    Liu, Y.-Y.2    Prickett, C.S.3    Yu, J.Y.4    Giuliano, A.E.5    Cabot, M.C.6
  • 104
    • 80053060999 scopus 로고    scopus 로고
    • Structures, biosynthesis, and functions of gangliosides-an overview
    • Yu RK, Tsai YT, Ariga T, Yanagisawa M. Structures, biosynthesis, and functions of gangliosides-an overview. J. Oleo. Sci. 60(10), 537-544 (2011).
    • (2011) J. Oleo. Sci. , vol.60 , Issue.10 , pp. 537-544
    • Yu, R.K.1    Tsai, Y.T.2    Ariga, T.3    Yanagisawa, M.4
  • 105
    • 0038532523 scopus 로고    scopus 로고
    • Role of tumor-associated gangliosides in cancer progression
    • DOI 10.1016/S0300-9084(03)00006-3
    • Birkle S, Zeng G, Gao L, Yu RK, Aubry J. Role of tumor-associated gangliosides in cancer progression. Biochimie 85(3-4), 455-463 (2003). (Pubitemid 36626016)
    • (2003) Biochimie , vol.85 , Issue.3-4 , pp. 455-463
    • Birkle, S.1    Zeng, G.2    Gao, L.3    Yu, R.K.4    Aubry, J.5
  • 107
    • 78650730811 scopus 로고    scopus 로고
    • NGcGM3 ganglioside: A privileged target for cancer vaccines
    • Fernandez LE, Gabri MR, Guthmann MD et al. NGcGM3 ganglioside: a privileged target for cancer vaccines. Clin. Dev. Immunol. 2010, 814397 (2010).
    • (2010) Clin. Dev. Immunol. , vol.2010 , pp. 814397
    • Fernandez, L.E.1    Gabri, M.R.2    Guthmann, M.D.3
  • 108
    • 77950509620 scopus 로고    scopus 로고
    • A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases
    • Hirsch HA, Iliopoulos D, Joshi A et al. A transcriptional signature and common gene networks link cancer with lipid metabolism and diverse human diseases. Cancer Cell 17(4), 348-361 (2010).
    • (2010) Cancer Cell , vol.17 , Issue.4 , pp. 348-361
    • Hirsch, H.A.1    Iliopoulos, D.2    Joshi, A.3


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