15-Hydroxyprostaglandin dehydrogenase associates with poor prognosis in breast cancer, induces epithelial-mesenchymal transition, and promotes cell migration in cultured breast cancer cells

Journal of Pathology

Volumn 226, Issue 4, 2012, Pages 674-686

  Lehtinen, Laura ^a   Vainio, Paula ^a   Wikman, Harriet ^b   Reemts, Johannes ^b   Hilvo, Mika ^a   Issa, Rana ^b   Pollari, Sirkku ^a   Brandt, Burkhard ^c   Oresic, Matej ^a   Pantel, Klaus ^b   Kallioniemi, Olli ^a,d   Iljin, Kristiina ^a  

^a VTT TECHNICAL RESEARCH CENTRE OF FINLAND   (Finland)

^b UNIVERSITY MEDICAL CENTER HAMBURG EPPENDORF   (Germany)

^c UNIVERSITY HOSPITAL SCHLESWIG HOLSTEIN   (Germany)

^d UNIVERSITY OF HELSINKI   (Finland)

Author keywords

arachidonic acid; breast cancer; HPGD; mesenchymal epithelial transition; metastasis

Indexed keywords

15 HYDROXYPROSTAGLANDIN DEHYDROGENASE; ARACHIDONIC ACID; AROMATIC HYDROCARBON RECEPTOR; F ACTIN; MESSENGER RNA; PROSTAGLANDIN E2; PROTEIN CDC42; RAC1 PROTEIN; TRANSFORMING GROWTH FACTOR BETA; VIMENTIN;

ARTICLE; BREAST CANCER; CANCER RELAPSE; CELL MIGRATION; CONTROLLED STUDY; DISEASE FREE SURVIVAL; EPITHELIAL MESENCHYMAL TRANSITION; FEMALE; GENE; GENE OVEREXPRESSION; GENE SILENCING; HPGD GENE; HUMAN; HUMAN CELL; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA INTERFERENCE; SIGNAL TRANSDUCTION; TISSUE MICROARRAY; VALIDATION PROCESS;

ADENOCARCINOMA; ARACHIDONIC ACID; BREAST NEOPLASMS; CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; CELL SURVIVAL; EPITHELIAL-MESENCHYMAL TRANSITION; FEMALE; GENE EXPRESSION REGULATION, NEOPLASTIC; GENE SILENCING; GERMANY; HUMANS; HYDROXYPROSTAGLANDIN DEHYDROGENASES; LYMPH NODES; PROGNOSIS; SURVIVAL RATE; TISSUE ARRAY ANALYSIS; WOUND HEALING;

EID: 84856746129     PISSN: 00223417     EISSN: 10969896     Source Type: Journal    
DOI: 10.1002/path.3956     Document Type: Article

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